Deletion of aquaporin-4 increases extracellular K+ concentration during synaptic stimulation in mouse hippocampus

Brain Structure and Function

Volumn 220, Issue 4, 2015, Pages 2469-2474

  Haj Yasein, Nadia Nabil ^a   Bugge, Cecilie Elisabeth ^a   Jensen, Vidar ^a   Østby, Ivar ^b   Ottersen, Ole Petter ^a   Hvalby, Øivind ^a   Nagelhus, Erlend Arnulf ^a,c  

^a UNIVERSITY OF OSLO   (Norway)

^b NORWEGIAN UNIVERSITY OF LIFE SCIENCES   (Norway)

^c OSLO UNIVERSITY HOSPITAL   (Norway)

Author keywords

AQP4; Astrocytes; Extracellular space; Glia; K+ homeostasis; Synaptic activation

Indexed keywords

2 AMINO 5 PHOSPHONOVALERIC ACID; 6,7 DINITRO 2,3 QUINOXALINEDIONE; AQUAPORIN 4; POTASSIUM ION; AQP4 PROTEIN, MOUSE; POTASSIUM;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BRAIN COMMISSURE; CONTROLLED STUDY; CORPUS CALLOSUM; EXTRACELLULAR SPACE; FEMALE; GENE DELETION; HIPPOCAMPUS; IMMUNOFLUORESCENCE; IN VIVO STUDY; MALE; MOLECULAR DYNAMICS; MOUSE; NERVE CELL STIMULATION; NERVE FIBER; NONHUMAN; POTASSIUM CELL LEVEL; PRIORITY JOURNAL; STIMULUS; STRATUM PYRAMIDALE; SYNAPSE; WILD TYPE; ANIMAL; DEFICIENCY; ELECTROSTIMULATION; GENETICS; IN VITRO STUDY; ION SELECTIVE ELECTRODE; METABOLISM; PHYSIOLOGY; TRANSGENIC MOUSE;

MUS;

ANIMALS; AQUAPORIN 4; ELECTRIC STIMULATION; EXTRACELLULAR SPACE; HIPPOCAMPUS; IN VITRO TECHNIQUES; ION-SELECTIVE ELECTRODES; MICE; MICE, TRANSGENIC; POTASSIUM; SYNAPSES;

EID: 84933178733     PISSN: 18632653     EISSN: 18632661     Source Type: Journal    
DOI: 10.1007/s00429-014-0767-z     Document Type: Article

References (14)

1. + clearance associated with aquaporin-4 mislocalization: phenotypic defects in brains of alpha-syntrophin-null mice. Proc Natl Acad Sci USA 100:13615–13620
2. Binder DK, Yao X, Zador Z, Sick TJ, Verkman AS, Manley GT (2006) Increased seizure duration and slowed potassium kinetics in mice lacking aquaporin-4 water channels. Glia 53:631–636
3. + spatial buffering contributes to the epileptogenic effect of mutations in the human Kir4.1 gene (KCNJ10). Glia 59:1635–1642
4. Haj-Yasein NN, Jensen V, Ostby I, Omholt SW, Voipio J, Kaila K, Ottersen OP, Hvalby O, Nagelhus EA (2012) Aquaporin-4 regulates extracellular space volume dynamics during high-frequency synaptic stimulation: a gene deletion study in mouse hippocampus. Glia 60:867–874
5. Illarionova NB, Gunnarson E, Li Y, Brismar H, Bondar A, Zelenin S, Aperia A (2010) Functional and molecular interactions between aquaporins and Na, K-ATPase. Neuroscience 168:915–925
6. Kofuji P, Newman EA (2004) Potassium buffering in the central nervous system. Neuroscience 129:1045–1056
7. Nagelhus EA, Ottersen OP (2013) Physiological roles of aquaporin-4 in brain. Physiol Rev 93:1543–1562
8. + siphoning and water transport in rat retinal Muller cells is mediated by a coenrichment of Kir4.1 and AQP4 in specific membrane domains. Glia 26:47–54
9. Nielsen S, Nagelhus EA, Amiry-Moghaddam M, Bourque C, Agre P, Ottersen OP (1997) Specialized membrane domains for water transport in glial cells: high-resolution immunogold cytochemistry of aquaporin-4 in rat brain. J Neurosci 17:171–180
10. + -sensing fluorescent indicator. Nat Methods 2:825–827
11. Strohschein S, Huttmann K, Gabriel S, Binder DK, Heinemann U, Steinhauser C (2011) Impact of aquaporin-4 channels on K(+) buffering and gap junction coupling in the hippocampus. Glia 59:973–980
12. 2+ signaling events elicited by cerebral edema. Proc Natl Acad Sci USA 108:846–851
13. Thrane AS, Takano T, Thrane VR, Wang F, Peng W, Ottersen OP, Nedergaard M, Nagelhus EA (2013) In vivo NADH fluorescence imaging indicates effect of aquaporin-4 deletion on oxygen microdistribution in cortical spreading depression. J Cereb Blood Flow Metab
14. + channel function in brain glial cells. Mol Cell Neurosci 37:1–10