Weight loss prior to lung transplantation is associated with improved survival

Journal of Heart and Lung Transplantation

Volumn 34, Issue 5, 2015, Pages 651-657

  Chandrashekaran, Satish ^a   Keller, Cesar A ^a   Kremers, Walter K ^b   Peters, Steve G ^b   Hathcock, Matthew A ^b   Kennedy, Cassie C ^b  

^a MAYO CLINIC   (United States)

^b MAYO CLINIC   (United States)

Author keywords

Lung transplantation; Obesity; Patient selection; Survival; Weight loss

Indexed keywords

PREDNISONE;

ARTICLE; ARTIFICIAL VENTILATION; BODY MASS; BRONCHIECTASIS; CHRONIC OBSTRUCTIVE LUNG DISEASE; COHORT ANALYSIS; FEMALE; FIBROSING ALVEOLITIS; GRAFT RECIPIENT; HUMAN; INTENSIVE CARE; LENGTH OF STAY; LUNG FIBROSIS; LUNG TRANSPLANTATION; MAJOR CLINICAL STUDY; MALE; MECHANICAL VENTILATOR; OBESITY; PATIENT SELECTION; PRIORITY JOURNAL; PULMONARY HYPERTENSION; RESPIRATORY FAILURE; RETROSPECTIVE STUDY; SURVIVAL; TREATMENT DURATION; WEIGHT REDUCTION; AGED; CLINICAL TRIAL; EPIDEMIOLOGY; FOLLOW UP; GRAFT REJECTION; GRAFT SURVIVAL; MIDDLE AGED; MORTALITY; MULTICENTER STUDY; PREOPERATIVE PERIOD; PROPORTIONAL HAZARDS MODEL; SURVIVAL RATE; TRENDS; UNITED STATES;

AGED; BODY MASS INDEX; FEMALE; FOLLOW-UP STUDIES; GRAFT REJECTION; GRAFT SURVIVAL; HUMANS; LUNG TRANSPLANTATION; MALE; MIDDLE AGED; PREOPERATIVE PERIOD; PROPORTIONAL HAZARDS MODELS; RETROSPECTIVE STUDIES; SURVIVAL RATE; UNITED STATES; WEIGHT LOSS;

EID: 84933178691     PISSN: 10532498     EISSN: 15573117     Source Type: Journal    
DOI: 10.1016/j.healun.2014.11.018     Document Type: Article

References (25)

1. Scientific Registry of Transplant Recipients. http://www.srtr.org/. Accessed May 14, 2014.
2. Kanasky WF Jr, Anton SD, Rodrigue JR, et al. Impact of body weight on long-term survival after lung transplantation. Chest 2002;121:401-6.
3. Lederer DJ, Wilt JS, D'Ovidio F, et al. Obesity and underweight are associated with an increased risk of death after lung transplantation. Am J Respir Crit Care Med 2009;180:887-95.
4. Allen JG, Arnaoutakis GJ, Weiss ES, et al. The impact of recipient body mass index on survival after lung transplantation. J Heart Lung Transplant 2010;29:1026-33.
5. Diamond JM, Lee JC, Kawut SM, et al. Clinical risk factors for primary graft dysfunction after lung transplantation. Am J Respir Crit Care Med 2013;187:527-34.
6. Lederer DJ, Kawut SM, Wickersham N, et al. Obesity and primary graft dysfunction after lung transplantation: the Lung Transplant Outcomes Group Obesity Study. Am J Respir Crit Care Med 2011;184:1055-61.
7. Orens JB, Estenne M, Arcasoy S, et al. International guidelines for the selection of lung transplant candidates: 2006 update - a consensus report from the Pulmonary Scientific Council of the International Society for Heart and Lung Transplantation. J Heart Lung Transplant 2006;25:745-55.
8. Ogden CL, Carroll MD, Curtin LR, et al. Prevalence of overweight and obesity in the United States, 1999-2004. JAMA 2006;295:1549-55.
9. Chandrashekaran C, Keller CA, Kremers WK, et al. Weight loss prior to lung transplantation improves survival. Am J Respir Crit Care Med 2013;187:A6001.
10. Hoy HM, Feurer ID, Alexander S, et al. Negative effects of pretransplant body mass index on physical health-related quality of life after lung transplant. Prog Transplant 2012;22:363-8.
11. Culver DA, Mazzone PJ, Khandwala F, et al. Discordant utility of ideal body weight and body mass index as predictors of mortality in lung transplant recipients. J Heart Lung Transplant 2005;24:137-44.
12. Gammie JS, Cheul Lee J, Pham SM, et al. Cardiopulmonary bypass is associated with early allograft dysfunction but not death after double-lung transplantation. J Thorac Cardiovasc Surg 1998;115:990-7.
13. Benden C, Ridout DA, Edwards LB, et al. Body mass index and its effect on outcome in children after lung transplantation. J Heart Lung Transplant 2013;32:196-201.
14. Hibbert K, Rice M, Malhotra A. Obesity and ARDS. Chest 2012;142:785-90.
15. Tilg H, Moschen AR. Role of adiponectin and PBEF/visfatin as regulators of inflammation: involvement in obesity-associated diseases. Clin Sci Lond 2008;114:275-88.
16. Mancuso P. Obesity and lung inflammation. J Appl Physiol 2010;108:722-8.
17. Shi H, Kokoeva MV, Inouye K, et al. TLR4 links innate immunity and fatty acid-induced insulin resistance. J Clin Invest 2006;116:3015-25.
18. Jain M, Budinger GR, Lo A, et al. Leptin promotes fibroproliferative acute respiratory distress syndrome by inhibiting peroxisome proliferator-activated receptor-gamma. Am J Respir Crit Care Med 2011;183:1490-8.
19. Bellmeyer A, Martino JM, Chandel NS, et al. Leptin resistance protects mice from hyperoxia-induced acute lung injury. Am J Respir Crit Care Med 2007;175:587-94.
20. Daud SA, Yusen RD, Meyers BF, et al. Impact of immediate primary lung allograft dysfunction on bronchiolitis obliterans syndrome. Am J Respir Crit Care Med 2007;175:507-13.
21. Whitson BA, Prekker ME, Herrington CS, et al. Primary graft dysfunction and long-term pulmonary function after lung transplantation. J Heart Lung Transplant 2007;26:1004-11.
22. Lagergren J. Influence of obesity on the risk of esophageal disorders. Nat Rev Gastroenterol Hepatol 2011;8:340-7.
23. Mancuso P. Obesity and respiratory infections: Does excess adiposity weigh down host defense? Pulm Pharmacol Ther 2013;26:412-9.
24. Bobadilla JL, Jankowska-Gan E, Xu Q, et al. Reflux-induced collagen type V sensitization: potential mediator of bronchiolitis obliterans syndrome. Chest 2010;138:363-70.
25. Palmer SM, Miralles AP, Howell DN, et al. Gastroesophageal reflux as a reversible cause of allograft dysfunction after lung transplantation. Chest 2000;118:1214-7.