Brief report: Main contribution of DRB1∗04:05 among the shared epitope alleles and involvement of DRB1 amino acid position 57 in association with joint destruction in anti-citrullinated protein antibody-positive rheumatoid arthritis

Arthritis and Rheumatology

Volumn 67, Issue 7, 2015, Pages 1744-1750

  Terao, Chikashi ^a   Yano, Koichiro ^b   Ikari, Katsunori ^b   Furu, Moritoshi ^a   Yamakawa, Noriyuki ^a   Yoshida, Shinji ^b   Hashimoto, Motomu ^a   Ito, Hiromu ^a   Fujii, Takao ^a   Ohmura, Koichiro ^a   Yurugi, Kimiko ^c   Miura, Yasuo ^c   Maekawa, Taira ^c   Taniguchi, Atsuo ^b   Momohara, Shigeki ^b   Yamanaka, Hisashi ^b   Mimori, Tsuneyo ^a   Matsuda, Fumihiko ^a  

^a KYOTO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b TOKYO WOMEN'S MEDICAL UNIVERSITY   (Japan)

^c KYOTO UNIVERSITY HOSPITAL   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC CITRULLINATED PEPTIDE ANTIBODY; EPITOPE; HLA DRB1 ANTIGEN; SERINE; AMINO ACID; ANTIIDIOTYPIC ANTIBODY; CYCLIC CITRULLINATED PEPTIDE; CYCLOPEPTIDE; HLA-DRB1*04:05 ANTIGEN;

ADULT; ALLELE; AMINO ACID SEQUENCE; ARTICLE; DISEASE ASSOCIATION; FEMALE; HUMAN; JAPANESE (PEOPLE); JOINT DESTRUCTION; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS; AGED; ASIAN CONTINENTAL ANCESTRY GROUP; BLOOD; COMPARATIVE STUDY; ETHNOLOGY; GENETIC PREDISPOSITION; GENETICS; GENOTYPE; HAND JOINT; IMMUNOLOGY; JAPAN; PATHOLOGY; RADIOGRAPHY; REGRESSION ANALYSIS;

ADULT; AGED; ALLELES; AMINO ACIDS; ANTIBODIES, ANTI-IDIOTYPIC; ARTHRITIS, RHEUMATOID; ASIAN CONTINENTAL ANCESTRY GROUP; EPITOPES; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HAND JOINTS; HLA-DRB1 CHAINS; HUMANS; JAPAN; MALE; MIDDLE AGED; PEPTIDES, CYCLIC; REGRESSION ANALYSIS; SERINE;

EID: 84933056549     PISSN: 23265191     EISSN: 23265205     Source Type: Journal    
DOI: 10.1002/art.39105     Document Type: Article

References (20)

1. Terao C, Hashimoto M, Yamamoto K, Murakami K, Ohmura K, Nakashima R, et al., Three groups in the 28 joints for rheumatoid arthritis synovitis: analysis using more than 17,000 assessments in the KURAMA database. PLoS One 2013; 8: e59341.
2. MacGregor AJ, Snieder H, Rigby AS, Koskenvuo M, Kaprio J, Aho K, et al., Characterizing the quantitative genetic contribution to rheumatoid arthritis using data from twins. Arthritis Rheum 2000; 43: 30-7.
3. Knevel R, Grondal G, Huizinga TW, Visser AW, Jonsson H, Vikingsson A, et al., Genetic predisposition of the severity of joint destruction in rheumatoid arthritis: a population-based study. Ann Rheum Dis 2012; 71: 707-9.
4. Terao C, Ohmura K, Katayama M, Takahashi M, Kokubo M, Diop G, et al., Myelin basic protein as a novel genetic risk factor in rheumatoid arthritis-a genome-wide study combined with immunological analyses. PLoS One 2011; 6: e20457.
5. Gregersen PK, Silver J, Winchester RJ., The shared epitope hypothesis: an approach to understanding the molecular genetics of susceptibility to rheumatoid arthritis. Arthritis Rheum 1987; 30: 1205-13.
6. Gao X, Gazit E, Livneh A, Stastny P., Rheumatoid arthritis in Israeli Jews: shared sequences in the third hypervariable region of DRB1 alleles are associated with susceptibility. J Rheumatol 1991; 18: 801-3.
7. Tezenas du Montcel S, Michou L, Petit-Teixeira E, Osorio J, Lemaire I, Lasbleiz S, et al., New classification of HLA-DRB1 alleles supports the shared epitope hypothesis of rheumatoid arthritis susceptibility [published erratum appears in Arthritis Rheum 2005:52:3659]. Arthritis Rheum 2005; 52: 1063-8.
8. Raychaudhuri S, Sandor C, Stahl EA, Freudenberg J, Lee HS, Jia X, et al., Five amino acids in three HLA proteins explain most of the association between MHC and seropositive rheumatoid arthritis. Nat Genet 2012; 44: 291-6.
9. Suzuki T, Ikari K, Yano K, Inoue E, Toyama Y, Taniguchi A, et al., PADI4 and HLA-DRB1 are genetic risks for radiographic progression in RA patients, independent of ACPA status: results from the IORRA cohort study. PLoS One 2013; 8: e61045.
10. Ohmura K, Terao C, Maruya E, Katayama M, Matoba K, Shimada K, et al., Anti-citrullinated peptide antibody-negative RA is a genetically distinct subset: a definitive study using only bone-erosive ACPA-negative rheumatoid arthritis. Rheumatology (Oxford) 2010; 49: 2298-304.
11. Scherer HU, van der Woude D, Willemze A, Trouw LA, Knevel R, Syversen SW, et al., Distinct ACPA fine specificities, formed under the influence of HLA shared epitope alleles, have no effect on radiographic joint damage in rheumatoid arthritis. Ann Rheum Dis 2011; 70: 1461-4.
12. Vander Cruyssen B, Hoffman IE, Peene I, Union A, Mielants H, Meheus L, et al., Prediction models for rheumatoid arthritis during diagnostic investigation: evaluation of combinations of rheumatoid factor, anti-citrullinated protein/peptide antibodies and the human leucocyte antigen-shared epitope. Ann Rheum Dis 2007; 66: 364-9.
13. Balandraud N, Picard C, Reviron D, Landais C, Toussirot E, Lambert N, et al., HLA-DRB1 genotypes and the risk of developing anti citrullinated protein antibody (ACPA) positive rheumatoid arthritis. PLoS One 2013; 8: e64108.
14. Terao C, Ikari K, Ohmura K, Suzuki T, Iwamoto T, Takasugi K, et al., Quantitative effect of HLA-DRB1 alleles to ACPA levels in Japanese rheumatoid arthritis: no strong genetic impact of shared epitope to ACPA levels after stratification of HLA-DRB1∗09:01. Ann Rheum Dis 2012; 71: 1095-7.
15. Yamanaka H, Tohma S., Potential impact of observational cohort studies in Japan on rheumatoid arthritis research and practice. Mod Rheumatol 2006; 16: 75-6.
16. Aletaha D, Neogi T, Silman AJ, Funovits J, Felson DT, Bingham CO III, et al., 2010 rheumatoid arthritis classification criteria: an American College of Rheumatology/European League Against Rheumatism collaborative initiative. Arthritis Rheum 2010; 62: 2569-81.
17. Van der Heijde DM. How to read radiographs according to the Sharp/van der Heijde method [corrected and republished in J Rheumatol 2000;27:261-3]. J Rheumatol 1999; 26: 743-5.
18. Terao C, Ohmura K, Kochi Y, Ikari K, Maruya E, Katayama M, et al., A large-scale association study identified multiple HLA-DRB1 alleles associated with ACPA-negative rheumatoid arthritis in Japanese subjects. Ann Rheum Dis 2011; 70: 2134-9.
19. Terao C, Yoshifuji H, Ohmura K, Murakami K, Kawabata D, Yurugi K, et al., Association of Takayasu arteritis with HLA-B 67:01 and two amino acids in HLA-B protein. Rheumatology (Oxford) 2013; 52: 1769-74.
20. Okada Y, Kim K, Han B, Pillai NE, Ong RT, Saw WY, et al., Risk for ACPA-positive rheumatoid arthritis is driven by shared HLA amino acid polymorphisms in Asian and European populations. Hum Mol Genet 2014; 23: 6916-26.