In Vitro Inhibitory Effects of 8-O-Demethylmaritidine and Undulatine on Acetylcholinesterase and Their Predicted Penetration across the Blood-Brain Barrier

Journal of Natural Products

Volumn 78, Issue 6, 2015, Pages 1189-1192

  Cahlíková, Lucie ^a   Pérez, Daniel I ^b   Štěpánková, Šárka ^c   Chlebek, Jakub ^a   Šafratová, Marcela ^a   Hošt'Álková, Anna ^a   Opletal, Lubomír ^a  

^a Charles University in Prague Faculty of Pharmacy   (Czech Republic)

^b CENTRO DE INVESTIGACIONES BIOLÓGICAS   (Spain)

^c UNIVERSITY OF PARDUBICE   (Czech Republic)

Author keywords

[No Author keywords available]

Indexed keywords

8 O DEMETHYLMARITIDINE; ACETYLCHOLINESTERASE; AMARYLLIDACEAE ALKALOID; ATENOLOL; CAFFEINE; CHOLINESTERASE INHIBITOR; DESIPRAMINE; ENOXACIN; GALANTAMINE; HYDROCORTISONE; PIROXICAM; PROMAZINE; TESTOSTERONE; UNCLASSIFIED DRUG; UNDULATINE; VERAPAMIL; 8-DEMETHYLMARITIDINE;

ANALYTIC METHOD; ARTICLE; BLOOD BRAIN BARRIER; CONTROLLED STUDY; DRUG MECHANISM; DRUG PENETRATION; ENZYME ACTIVITY; ENZYME INHIBITION; IN VITRO STUDY; PARALLEL ARTIFICIAL MEMBRANE PERMEABILITY ASSAY; PROTON NUCLEAR MAGNETIC RESONANCE; ALZHEIMER DISEASE; CHEMICAL STRUCTURE; DRUG EFFECTS; HUMAN; METABOLISM; TRANSPORT AT THE CELLULAR LEVEL;

AMARYLLIDACEAE;

ACETYLCHOLINESTERASE; ALZHEIMER DISEASE; AMARYLLIDACEAE ALKALOIDS; BIOLOGICAL TRANSPORT; BLOOD-BRAIN BARRIER; CHOLINESTERASE INHIBITORS; HUMANS; IN VITRO TECHNIQUES; MOLECULAR STRUCTURE;

EID: 84933055757     PISSN: 01633864     EISSN: 15206025     Source Type: Journal    
DOI: 10.1021/acs.jnatprod.5b00191     Document Type: Article

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