Identification of small-molecule inhibitors of calcineurin-NFATc signaling that mimic the PxIxIT motif of Calcineurin binding partners

Science Signaling

Volumn 8, Issue 382, 2015, Pages

  Matsoukas, Minos Timotheos ^a   Aranguren Ibáñez, Álvaro ^b   Lozano, Teresa ^c   Nunes, Virginia ^d   Lasarte, Juan Josí ^c   Pardo, Leonardo ^a   Pírez Riba, Mercè ^b  

^a UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

^b BELLVITGE BIOMEDICAL RESEARCH INSTITUTE IDIBELL   (Spain)

^c UNIVERSITY OF NAVARRA   (Spain)

^d UNIVERSITY OF BARCELONA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

CALCINEURIN; CALCINEURIN A; CALCINEURIN INHIBITOR; PHOSPHATASE; TRANSCRIPTION FACTOR NFAT; UNCLASSIFIED DRUG; NFATC1 PROTEIN, HUMAN;

ARTICLE; CD4+ T LYMPHOCYTE; CELL NUCLEUS; CELL PROLIFERATION; ENZYME ACTIVITY; HUMAN; HUMAN CELL; IMMUNOSUPPRESSIVE TREATMENT; IN VITRO STUDY; PHARMACOPHORE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN LOCALIZATION; CHEMISTRY; CYTOLOGY; DRUG EFFECTS; GENETICS; HEK293 CELL LINE; METABOLISM; PROTEIN MOTIF; SIGNAL TRANSDUCTION;

AMINO ACID MOTIFS; CALCINEURIN; CALCINEURIN INHIBITORS; CD4-POSITIVE T-LYMPHOCYTES; HEK293 CELLS; HUMANS; NFATC TRANSCRIPTION FACTORS; SIGNAL TRANSDUCTION;

EID: 84932633290     PISSN: 19450877     EISSN: 19379145     Source Type: Journal    
DOI: 10.1126/scisignal.2005918     Document Type: Article

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