BM-MSCs promote prostate cancer progression via the conversion of normal fibroblasts to cancer-associated fibroblasts

International Journal of Oncology

Volumn 47, Issue 2, 2015, Pages 719-727

  Wen, Simeng ^a,b   Niu, Yuanjie ^a   Yeh, Shuyuan ^b   Chang, Chawnshang ^b,c  

^a TIANJIN MEDICAL UNIVERSITY   (China)

^b UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

^c CHINA MEDICAL UNIVERSITY   (Taiwan)

Author keywords

Bone marrow derived mesenchymal stem cell; Cancer associated fibroblast; Prostate cancer; TGF 1

Indexed keywords

TRANSFORMING GROWTH FACTOR BETA1; TGFB1 PROTEIN, HUMAN; TGFB1 PROTEIN, MOUSE;

ARTICLE; BONE MARROW DERIVED MESENCHYMAL STEM CELL; CANCER ASSOCIATED FIBROBLAST; CELL GROWTH; CELL INFILTRATION; CELL INVASION; CONTROLLED STUDY; CYTOKINE RELEASE; EPITHELIUM CELL; FIBROBLAST; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROSTATE CANCER; ANIMAL; CANCER TRANSPLANTATION; CELL LINE; CELL TRANSFORMATION; COCULTURE; CYTOLOGY; DISEASE COURSE; GENE EXPRESSION REGULATION; GENETICS; MALE; MESENCHYMAL STROMA CELL; MOUSE; PATHOLOGY; PHYSIOLOGY; PROSTATE TUMOR; SECRETION (PROCESS); TUMOR INVASION;

ANIMALS; CELL LINE; CELL TRANSFORMATION, NEOPLASTIC; COCULTURE TECHNIQUES; DISEASE PROGRESSION; FIBROBLASTS; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MALE; MESENCHYMAL STROMAL CELLS; MICE; NEOPLASM INVASIVENESS; NEOPLASM TRANSPLANTATION; PROSTATIC NEOPLASMS; TRANSFORMING GROWTH FACTOR BETA1;

EID: 84932632378     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo.2015.3060     Document Type: Article

References (30)

1. Siegel R, Naishadham D and Jemal A: Cancer statistics, 2013. CA Cancer J Clin 63: 11-30, 2013.
2. Liao D, Luo Y, Markowitz D, Xiang R and Reisfeld RA: Cancer associated fibroblasts promote tumor growth and metastasis by modulating the tumor immune microenvironment in a 4T1 murine breast cancer model. PLoS One 4: e7965, 2009.
3. Zhu P, Baek SH, Bourk EM, Ohgi KA, Garcia-Bassets I, Sanjo H, Akira S, Kotol PF, Glass CK, Rosenfeld MG, et al: Macrophage/ cancer cell interactions mediate hormone resistance by a nuclear receptor derepression pathway. Cell 124: 615-629, 2006.
4. Zeng Y, Opeskin K, Goad J and Williams ED: Tumor-induced activation of lymphatic endothelial cells via vascular endothelial growth factor receptor-2 is critical for prostate cancer lymphatic metastasis. Cancer Res 66: 9566-9575, 2006.
5. Gabbiani G, Ryan GB and Majne G: Presence of modified fibroblasts in granulation tissue and their possible role in wound contraction. Experientia 27: 549-550, 1971.
6. Tomasek JJ, Gabbiani G, Hinz B, Chaponnier C and Brown RA: Myofibroblasts and mechano-regulation of connective tissue remodelling. Nat Rev Mol Cell Biol 3: 349-363, 2002.
7. Franco OE, Shaw AK, Strand DW and Hayward SW: Cancer associated fibroblasts in cancer pathogenesis. Semin Cell Dev Biol 21: 33-39, 2010.
8. Zhao H and Peehl DM: Tumor-promoting phenotype of CD90hi prostate cancer-associated fibroblasts. Prostate 69: 991-1000, 2009.
9. Luo J, Ok Lee S, Liang L, Huang CK, Li L, Wen S and Chang C: Infiltrating bone marrow mesenchymal stem cells increase prostate cancer stem cell population and metastatic ability via secreting cytokines to suppress androgen receptor signaling. Oncogene 33: 2768-2778, 2014.
10. Huang CK, Tsai MY, Luo J, Kang HY, Lee SO and Chang C: Suppression of androgen receptor enhances the self-renewal of mesenchymal stem cells through elevated expression of EGFR. Biochim Biophys Acta 1833: 1222-1234, 2013.
11. Slavin S, Yeh CR, Da J, Yu S, Miyamoto H, Messing EM, Guancial E and Yeh S: Estrogen receptor in cancer-associated fibroblasts suppresses prostate cancer invasion via modulation of thrombospondin 2 and matrix metalloproteinase 3. Carcinogenesis 35: 1301-1309, 2014.
12. Tuxhorn JA, Ayala GE, Smith MJ, Smith VC, Dang TD and Rowley DR: Reactive stroma in human prostate cancer: induction of myofibroblast phenotype and extracellular matrix remodeling. Clin Cancer Res 8: 2912-2923, 2002.
13. Reinertsen T, Halgunset J, Viset T, Flatberg A, Haugsmoen LL and Skogseth H: Gene expressional changes in prostate fibroblasts from cancerous tissue. APMIS 120: 558-571, 2012.
14. Cirri P and Chiarugi P: Cancer associated fibroblasts: The dark side of the coin. Am J Cancer Res 1: 482-497, 2011.
15. H aubeiss S, Schmid JO, Mürdter TE, Sonnenberg M, Friedel G, van der Kuip H and Aulitzky WE: Dasatinib reverses cancerassociated fibroblasts (CAFs) from primary lung carcinomas to a phenotype comparable to that of normal fibroblasts. Mol Cancer 9: 168, 2010.
16. Ishii K, Mizokami A, Tsunoda T, Iguchi K, Kato M, Hori Y, Arima K, Namiki M and Sugimura Y: Heterogenous induction of carcinoma-associated fibroblast-like differentiation in normal human prostatic fibroblasts by co-culturing with prostate cancer cells. J Cell Biochem 112: 3604-3611, 2011.
17. Cirri P and Chiarugi P: Cancer-associated-fibroblasts and tumour cells: A diabolic liaison driving cancer progression. Cancer Metastasis Rev 31: 195-208, 2012.
18. Miyamoto H, Messing EM and Chang C: Androgen deprivation therapy for prostate cancer: Current status and future prospects. Prostate 61: 332-353, 2004.
19. Niu Y, Altuwaijri S, Lai KP, Wu CT, Ricke WA, Messing EM, Yao J, Yeh S and Chang C: Androgen receptor is a tumor suppressor and proliferator in prostate cancer. Proc Natl Acad Sci USA 105: 12182-12187, 2008.
20. Lee SO, Tian J, Huang CK, Ma Z, Lai KP, Hsiao H, Jiang M, Yeh S and Chang C: Suppressor role of androgen receptor in proliferation of prostate basal epithelial and progenitor cells. J Endocrinol 213: 173-182, 2012.
21. Wang X, Lee SO, Xia S, Jiang Q, Luo J, Li L, Yeh S and Chang C: Endothelial cells enhance prostate cancer metastasis via IL-6-androgen receptor-TGF-MMP-9 signals. Mol Cancer Ther 12: 1026-1037, 2013.
22. Izumi K, Fang LY, Mizokami A, Namiki M, Li L, Lin WJ and Chang C: Targeting the androgen receptor with siRNA promotes prostate cancer metastasis through enhanced macrophage recruitment via CCL2/CCR2-induced STAT3 activation. EMBO Mol Med 5: 1383-1401, 2013.
23. Gonda TA, Varro A, Wang TC and Tycko B: Molecular biology of cancer-associated fibroblasts: Can these cells be targeted in anti-cancer therapy? Semin Cell Dev Biol 21: 2-10, 2010.
24. Navab R, Strumpf D, Bandarchi B, Zhu CQ, Pintilie M, Ramnarine VR, Ibrahimov E, Radulovich N, Leung L, Barczyk M, et al: Prognostic gene-expression signature of carcinoma-associated fibroblasts in non-small cell lung cancer. Proc Natl Acad Sci USA 108: 7160-7165, 2011.
25. Zeisberg EM, Potenta S, Xie L, Zeisberg M and Kalluri R: Discovery of endothelial to mesenchymal transition as a source for carcinomaassociated fibroblasts. Cancer Res 67: 10123-10128, 2007.
26. Mishra PJ, Mishra PJ, Humeniuk R, Medina DJ, Alexe G, Mesirov JP, Ganesan S, Glod JW and Banerjee D: Carcinomaassociated fibroblast-like differentiation of human mesenchymal stem cells. Cancer Res 68: 4331-4339, 2008.
27. Direkze NC, Hodivala-Dilke K, Jeffery R, Hunt T, Poulsom R, Oukrif D, Alison MR and Wright NA: Bone marrow contribution to tumor-associated myofibroblasts and fibroblasts. Cancer Res 64: 8492-8495, 2004.
28. Comite P, Cobianchi L, Avanzini MA, Zonta S, Mantelli M, Achille V, De Martino M, Cansolino L, Ferrari C, Alessiani M, et al: Isolation and ex vivo expansion of bone marrow-derived porcine mesenchymal stromal cells: Potential for application in an experimental model of solid organ transplantation in large animals. Transplant Proc 42: 1341-1343, 2010.
29. Zhang H, Chen Z and Bie P: Bone marrow-derived mesenchymal stem cells as immunosuppressants in liver transplantation: A review of current data. Transfus Med Rev 26: 129-141, 2012.
30. Placencio VR, Li X, Sherrill TP, Fritz G and Bhowmick NA: Bone marrow derived mesenchymal stem cells incorporate into the prostate during regrowth. PLoS One 5: e12920, 2010