Metabolic control of respiratory levels in coenzyme Q biosynthesis-deficient Escherichia coli strains leading to fine-tune aerobic lactate fermentation

Biotechnology and Bioengineering

Volumn 112, Issue 8, 2015, Pages 1720-1726

  Wu, Hui ^a,b   Bennett, George N ^b   San, Ka Yiu ^b  

^a EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b Rice University   (United States)

Author keywords

Electron transfer chain; Escherichia coli; Lactate; Metabolic controlling; Ubiquinone

Indexed keywords

BIOCHEMISTRY; BIOSYNTHESIS; CHAINS; COENZYMES; ELECTRON TRANSITIONS; METABOLISM;

BIOSYNTHESIS PATHWAYS; ELECTRON-TRANSFER CHAIN; INTERMEDIATE SUBSTRATES; LACTATE; LACTATE FERMENTATION; LITHOSPERMUM ERYTHRORHIZON; METABOLIC CONTROLLING; UBIQUINONE;

ESCHERICHIA COLI;

4 HYDROXYBENZOIC ACID; GERANYLTRANSFERASE; LACTIC ACID; PYROPHOSPHATE; UBIQUINONE; GERANYL DIPHOSPHATE 4-HYDROXYBENZOATE GERANYLTRANSFERASE; RECOMBINANT PROTEIN; TRANSFERASE;

ANALYTIC METHOD; ARTICLE; BIOSYNTHESIS; CATALYSIS; CELL DENSITY; ELECTRON TRANSPORT; ESCHERICHIA COLI; GENE INACTIVATION; GLUCOSE INTAKE; GLYCOLYSIS; IN VIVO STUDY; LITHOSPERMUM; LITHOSPERMUM ERYTHRORHIZON; METABOLIC REGULATION; NONHUMAN; PROTEIN SYNTHESIS; RESPIRATORY CHAIN; SYNTHETIC BIOLOGY; AEROBIC METABOLISM; DEFICIENCY; ENZYMOLOGY; FERMENTATION; GENETICS; METABOLIC ENGINEERING; METABOLISM; PROCEDURES;

ESCHERICHIA COLI; LITHOSPERMUM ERYTHRORHIZON;

AEROBIOSIS; ALKYL AND ARYL TRANSFERASES; ELECTRON TRANSPORT; ESCHERICHIA COLI; FERMENTATION; LACTIC ACID; LITHOSPERMUM; METABOLIC ENGINEERING; RECOMBINANT PROTEINS; UBIQUINONE;

EID: 84932194766     PISSN: 00063592     EISSN: 10970290     Source Type: Journal    
DOI: 10.1002/bit.25585     Document Type: Article

References (20)

1. Berríos-Rivera SJ, Bennett GN, San KY. 2002. Metabolic engineering of Escherichia coli: Increase of NADH availability by overexpressing an NAD(+)-dependent formate dehydrogenase. Metab Eng 4(3):217-229.
2. Brophy JA, Voigt CA. 2014. Principles of genetic circuit design. Nat Methods 11(5):508-520.
3. Datsenko KA, Wanner BL. 2000. One-step inactivation of chromosomal genes in Escherichia coli K-12 using PCR products. Proc Natl Acad Sci USA 97(12):6640-6645.
4. Guzman LM, Belin D, Carson MJ, Beckwith J. 1995. Tight regulation, modulation, and high-level expression by vectors containing the arabinose PBAD promoter. J Bacteriol 177:4121-4130.
5. Lee PT, Hsu AY, Ha HT, Clarke CF. 1997. A C-methyltransferase involved in both ubiquinone and menaquinone biosynthesis: Isolation and identification of the Escherichia coli ubiE gene. J Bacteriol 179:1748-1754.
6. Lin H, Bennett GN, San KY. 2005. Genetic reconstruction of the aerobic central metabolism in Escherichia coli for the absolute aerobic production of succinate. Biotechnol Bioeng 89:148-156.
7. Hayashi T, Kato T, Furukawa K. 2012. Respiratory chain analysis of Zymomonas mobilis mutants producing high levels of ethanol. Appl Environ Microbiol 78(16):5622-5629.
8. Koch-Koerfges A, Pfelzer N, Platzen L, Oldiges M, Bott M. 2013. Conversion of Corynebacterium glutamicum from an aerobic respiring to an aerobic fermenting bacterium by inactivation of the respiratory chain. Biochim Biophys Acta 1827(6):699-708.
9. Nielsen AA, Segall-Shapiro TH, Voigt CA. 2013. Advances in genetic circuit design: Novel biochemistries, deep part mining, and precision gene expression. Curr Opin Chem Biol 17(6):878-892.
10. Olson EJ, Hartsough LA, Landry BP, Shroff R, Tabor JJ. 2014. Characterizing bacterial gene circuit dynamics with optically programmed gene expression signals. Nat Methods 11(4):449-455.
11. Poon WW, Barkovich RJ, Hsu AY, Frankel A, Lee PT, Shepherd JN, Myles DC, Clarke CF. 1999. Yeast and rat Coq3 and Escherichia coli UbiG polypeptides catalyze both O-methyltransferase steps in coenzyme Q biosynthesis. J Biol Chem 274(31):21665-21672.
12. Portnoy VA, Herrgård MJ, Palsson BØ. 2008. Aerobic fermentation of D-glucose by an evolved cytochrome oxidase-deficient Escherichia coli strain. Appl Environ Microbiol 74(24):7561-7569.
13. San KY, Bennett GN, Wu H. 2014. Metabolic transistors in bacteria. United States patent. Application Number: 14/176, 008.
14. Sharma P, Teixeira de Mattos MJ, Hellingwerf KJ, Bekker M. 2012. On the function of the various quinone species in Escherichia coli. FEBS J 279(18):3364-3373.
15. Steinsiek S, Stagge S, Bettenbrock K. 2014. Analysis of Escherichia coli mutants with a linear respiratory chain. PLoS ONE 9(1):e87307.
16. Stroobant P, Young IG, Gibson F. 1972. Mutants of Escherichia coli K-12 blocked in the final reaction of ubiquinone biosynthesis: Characterization and genetic analysis. J Bacteriol 109(1):134-139.
17. Wallace BJ, Young IG. 1977. Aerobic respiration in mutants of Escherichia coli accumulating quinone analogues of ubiquinone. Biochim Biophys Acta 461:75-83.
18. Yazaki K, Kunihisa M, Fujisaki T, Sato F. 2002. Geranyl diphosphate: 4-hydroxybenzoate geranyltransferase from Lithospermum erythrorhizon. Cloning and characterization of a ket enzyme in shikonin biosynthesis. J Biol Chem 277(8):6240-6246.
19. Young IG, McCann LM, Stroobant P, Gibson F. 1971. Characterization and genetic analysis of mutant strains of Escherichia coli K-12 accumulating the biquinone precursors 2-octaprenyl-6-methoxy-1, 4-benzoquinone and 2-octaprenyl-3-methyl-6-methoxy-1, 4-benzoquinone. J Bacteriol 105(3):769-778.
20. Zhu J, Sánchez A, Bennett GN, San KY. 2011. Manipulating respiratory levels in Escherichia coli for aerobic formation of reduced chemical products. Metab Eng 13(6):704-712.