Antimicrobial efficacy of granulysin-derived synthetic peptides in acne vulgaris

International Journal of Dermatology

Volumn 54, Issue 7, 2015, Pages 853-862

  Lim, Hee Sun ^a   Chun, Seung Min ^a   Soung, Min Gyu ^b,c   Kim, Jenny ^d   Kim, Seong Jin ^a  

^a Chonnam National University Medical School   (South Korea)

^b Chungnam National University   (South Korea)

^c Hannam University   (South Korea)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; ASPARTIC ACID; CYSTEINE; GRANULYSIN; GRANULYSIN DERIVED PEPTIDE; METHIONINE; UNCLASSIFIED DRUG; ANTIINFECTIVE AGENT; ANTIINFLAMMATORY AGENT; ANTIMICROBIAL CATIONIC PEPTIDE; GNLY PROTEIN, HUMAN; T LYMPHOCYTE ANTIGEN;

ACNE VULGARIS; ADULT; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANTIMICROBIAL ACTIVITY; ARTICLE; BACTERICIDAL ACTIVITY; CLINICAL ARTICLE; COMEDO; DISEASE CLASSIFICATION; DRUG EFFICACY; DRUG SYNTHESIS; FEMALE; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; HUMAN; IN VITRO STUDY; MALE; PROPIONIBACTERIUM ACNES; PUSTULE; TREATMENT DURATION; TREATMENT OUTCOME; CHEMICAL STRUCTURE; DRUG EFFECTS; FACIAL DERMATOSES; INTRADERMAL DRUG ADMINISTRATION; MICROBIAL SENSITIVITY TEST; SEVERITY OF ILLNESS INDEX; SYNTHESIS; YOUNG ADULT;

ACNE VULGARIS; ADMINISTRATION, CUTANEOUS; ADULT; ANTI-INFECTIVE AGENTS; ANTI-INFLAMMATORY AGENTS; ANTIGENS, DIFFERENTIATION, T-LYMPHOCYTE; ANTIMICROBIAL CATIONIC PEPTIDES; FACIAL DERMATOSES; FEMALE; HUMANS; MALE; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; PROPIONIBACTERIUM ACNES; SEVERITY OF ILLNESS INDEX; YOUNG ADULT;

EID: 84932192814     PISSN: 00119059     EISSN: 13654632     Source Type: Journal    
DOI: 10.1111/ijd.12756     Document Type: Article

References (26)

1. Zasloff M. Antimicrobial peptides of multicellular organisms. Nature 2002; 24: 389-395.
2. Cooper AJ. Systematic review of Propionibacterium acnes resistance to systemic antibiotics. Med J Aust 1998; 169: 259-261.
3. Coates P, Vyakrnam S, Eady EA, et al. Prevalence of antibiotic-resistant propionibacteria on the skin of acne patients: 10-year surveillance data and snapshot distribution study. Br J Dermatol 2002; 146: 840-848.
4. Ross JI, Snelling AM, Carnegie E, et al. Antibiotic-resistant acne: lessons from Europe. Br J Dermatol 2003; 148: 467-478.
5. Ochoa MT, Stenger S, Sieling PA, et al. T cell release of granulysin contributes to host defense in leprosy. Nat Med 2001; 7: 174-179.
6. McInturff JE, Wang SJ, Machleidt T, et al. Granulysin-derived peptides demonstrate antimicrobial and anti-inflammatory effects against Propionibacterium acnes. J Invest Dermatol 2005; 125: 256-263.
7. Zouboulis CC. Acne and sebaceous gland function. Clin Dermatol 2004; 22: 360-366.
8. Fields GB, Noble RL. Solid phase peptide synthesis utilizing 9-fluorenylmethoxycarbonyl amino acids. Int J Pept Protein Res 1990; 35: 161-214.
9. Wang Z, Choice E, Kaspar A, et al. Bactericidal and tumoricidal activities of synthetic peptides derived from granulysin. J Immunol 2000; 165: 1486-1490.
10. Sung KJ, Rho YS, Choi EH, et al. Korean acne grading system. Korean J Dermatol 2004; 42: 1241-1247.
11. Ernst WA, Thoma-Uszynski S, Teitelbaum R, et al. Granulysin, a T cell product, kills bacteria by altering membrane permeability. J Immunol 2000; 165: 7102-7108.
12. Hausman RE, Cooper GM. The Cell: A Molecular Approach. Washington, DC: ASM Press, 2004: 51.
13. Bechinger BE. The structure, dynamics and orientation of antimicrobial peptides in membranes by multidimensional solid-state NMR spectroscopy. Biochim Biophys Acta 1999; 1462: 157-183.
14. Shai Y. Mechanism of the binding, insertion and destabilization of phospholipid bilayer membranes by α-helical antimicrobial and cell non-selective membrane-lytic peptides. Biochim Biophys Acta 1999; 1462: 55-70.
15. Jongstra J, Schall TJ, Dyer BJ, et al. The isolation and sequence of a novel gene from a human functional T cell line. J Exp Med 1987; 165: 601-614.
16. Boman HG, Agerberth B, Boman A. Mechanisms of action on Escherichia coli of cecropin P1 and PR-39, two antibacterial peptides from pig intestine. Infect Immun 1993; 61: 2978-2984.
17. Kragol G, Lovas S, Varadi G, et al. The antibacterial peptide pyrrhocoricin inhibits the ATPase actions of DnaK and prevents chaperone-assisted protein folding. Biochemistry 2001; 40: 3016-3026.
18. Hancock RE, Chapple DS. Peptide antibiotics. Antimicrob Agents Chemother 1999; 43: 1317-1323.
19. Marta Guarna M, Coulson R, Rubinchik E. Anti-inflammatory activity of cationic peptides: application to the treatment of acne vulgaris. FEMS Microbiol Lett 2006; 257: 1-6.
20. Gough M, Hancock RE, Kelly NM. Antiendotoxin activity of cationic peptide antimicrobial agents. Infect Immun 1996; 64: 4922-4927.
21. Hanson DA, Kaspar AA, Poulain FR, et al. Biosynthesis of granulysin, a novel cytolytic molecule. Mol Immunol 1999; 36: 413-422.
22. Anderson DH, Sawaya MR, Cascio D, et al. Granulysin crystal structure and a structure-derived lytic mechanism. J Mol Biol 2003; 325: 355-365.
23. Peña SV, Krensky AM. Granulysin, a new human cytolytic granule-associated protein with possible involvement in cell-mediated cytotoxicity. Semin Immunol 1997; 9: 117-125.
24. Kaspar AA, Okada S, Kumar J, et al. A distinct pathway of cell-mediated apoptosis initiated by granulysin. J Immunol 2001; 167: 350-356.
25. Bos JD, Meinardi MM. The 500 Dalton rule for the skin penetration of chemical compounds and drugs. Exp Dermatol 2000; 9: 165-169.
26. Harder J, Tsuruta D, Murakami M, et al. What is the role of antimicrobial peptides (AMP) in acne vulgaris? Exp Dermatol 2013; 22: 386-391.