The role of varenicline on alcohol-primed self-administration and seeking behavior in rats

Psychopharmacology

Volumn 232, Issue 14, 2015, Pages 2443-2454

  Randall, Patrick A ^a   Jaramillo, Anel A ^a,b   Frisbee, Suzanne ^a   Besheer, Joyce ^a,b  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

Alcoholism; Chantix; Drinking; Ethanol; Nicotine; Priming; Reinstatement

Indexed keywords

ALCOHOL; SUCROSE; VARENICLINE; WATER; CENTRAL DEPRESSANT AGENT;

ALCOHOL CONSUMPTION; ANALYSIS OF VARIANCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DISCRIMINATIVE STIMULUS; DOSE RESPONSE; DRUG SEEKING BEHAVIOR; DRUG SELF ADMINISTRATION; LOCOMOTION; LONG EVANS RAT; MAINTENANCE THERAPY; MALE; MOTOR DYSFUNCTION; NONHUMAN; POST HOC ANALYSIS; PRIORITY JOURNAL; RAT; REINFORCEMENT; SENSITIVITY ANALYSIS; SMOKING CESSATION; TRAINING; ANIMAL; CRAVING; DISCRIMINATION LEARNING; DRINKING BEHAVIOR; DRUG EFFECTS; MOTOR ACTIVITY;

ALCOHOL DRINKING; ANIMALS; CENTRAL NERVOUS SYSTEM DEPRESSANTS; CRAVING; DISCRIMINATION LEARNING; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG-SEEKING BEHAVIOR; ETHANOL; MOTOR ACTIVITY; RATS; RATS, LONG-EVANS; SELF ADMINISTRATION; VARENICLINE;

EID: 84932192508     PISSN: 00333158     EISSN: 14322072     Source Type: Journal    
DOI: 10.1007/s00213-015-3878-1     Document Type: Article

References (55)

1. Anker JJ, Carroll ME (2010) Reinstatement of cocaine seeking induced by drugs, cues, and stress in adolescent and adult rats. Psychopharmacology (Berl) 208:211-222
2. Besheer J, Grondin JJ, Salling MC, Spanos M, Stevenson RA, Hodge CW (2009) Interoceptive effects of alcohol require mGlu5 receptor activity in the nucleus accumbens. J Neurosci 29:9582-9591
3. Besheer J, Grondin JJ, Cannady R, Sharko AC, Faccidomo S, Hodge CW (2010) Metabotropic glutamate receptor 5 activity in the nucleus accumbens is required for the maintenance of ethanol self-administration in a rat genetic model of high alcohol intake. Biol Psychiatry 67:812-822
4. Besheer J, Fisher KR, Cannady R, Grondin JJ, Hodge CW (2012) Intra-amygdala inhibition of ERK(1/2) potentiates the discriminative stimulus effects of alcohol. Behav Brain Res 228:398-405
5. Besheer J, Fisher KR, Lindsay TG, Cannady R (2013) Transient increase in alcohol self-administration following a period of chronic exposure to corticosterone. Neuropharmacology 72:139-147
6. Besheer J, Fisher KR, Jaramillo AA, Frisbee S, Cannady R (2014) Stress hormone exposure reduces mGluR5 expression in the nucleus accumbens: functional implications for interoceptive sensitivity to alcohol. Neuropsychopharmacology 39:2376-2386
7. Bigelow GE, Griffiths RR, Liebson IA (1977) Pharmacological influences upon human ethanol self-administration. Adv Exp Med Biol 85B:523-538
8. Cahill K, Stead LF, Lancaster T (2012) Nicotine receptor partial agonists for smoking cessation. Cochrane Database Syst Rev 4, CD006103
9. Cannady R, Fisher KR, Durant B, Besheer J, Hodge CW (2013) Enhanced AMPA receptor activity increases operant alcohol self-administration and cue-induced reinstatement. Addict Biol 18:54-65
10. Chatterjee S, Bartlett SE (2010) Neuronal nicotinic acetylcholine receptors as pharmacotherapeutic targets for the treatment of alcohol use disorders. CNS Neurol Disord Drug Targets 9:60-76
11. Childs E, Roche DJ, King AC, de Wit H (2012) Varenicline potentiates alcohol-induced negative subjective responses and offsets impaired eye movements. Alcohol Clin Exp Res 36:906-914
12. Chutuape MA, de Wit H (1994) Relationship between subjective effects and drug preferences: ethanol and diazepam. Drug Alcohol Depend 34:243-251
13. Coe JW, Brooks PR, Vetelino MG, Wirtz MC, Arnold EP, Huang J, Sands SB, Davis TI, Lebel LA, Fox CB, Shrikhande A, Heym JH, Schaeffer E, Rollema H, Lu Y, Mansbach RS, Chambers LK, Rovetti CC, Schulz DW, Tingley FD 3rd, O'Neill BT (2005) Varenicline: an alpha4beta2 nicotinic receptor partial agonist for smoking cessation. J Med Chem 48:3474-3477
14. Colpaert FC (1987) Drug discrimination in behavioral toxicology. Zentralbl Bakteriol Mikrobiol Hyg B 185:48-51
15. Colpaert FC, Niemegeers CJ, Janssen PA (1979) Discriminative stimulus properties of cocaine: neuropharmacological characteristics as derived from stimulus generalization experiments. Pharmacol Biochem Behav 10:535-546
16. Czachowski CL, Legg BH, Samson HH (2003) Assessment of sucrose and ethanol reinforcement: the across-session breakpoint procedure. Physiol Behav 78:51-59
17. Czachowski CL, Prutzman S, DeLory MJ (2006) Volume and dose effects of experimenter- administered ethanol preloads on ethanol seeking and self-administration. Alcohol 40:35-40
18. Dani JA, Harris RA (2005) Nicotine addiction and comorbidity with alcohol abuse and mental illness. Nat Neurosci 8:1465-1470
19. de Wit H, Chutuape MA (1993) Increased ethanol choice in social drinkers following ethanol preload. Behav Pharmacol 4:29-36
20. Desai RI, Bergman J (2014) Methamphetamine-like discriminative-stimulus effects of nicotinic agonists. J Pharmacol Exp Ther 348:478-488
21. DiChiara TJ, Reinhart PH (1995) Distinct effects of Ca2+ and voltage on the activation and deactivation of cloned Ca(2+)-activated K+ channels. J Physiol 489(Pt 2):403-418
22. Erwin BL, Slaton RM (2014) Varenicline in the treatment of alcohol use disorders. Ann Pharmacother 48:1445-1455
23. Falk DE, Yi HY, Hiller-Sturmhofel S (2006) An epidemiologic analysis of co-occurring alcohol and tobacco use and disorders: findings from the National Epidemiologic Survey on Alcohol and Related Conditions. Alcohol Res Health 29:162-171
24. Fattore L, Spano MS, Cossu G, Deiana S, Fratta W (2003) Cannabinoid mechanism in reinstatement of heroin-seeking after a long period of abstinence in rats. Eur J Neurosci 17:1723-1726
25. Feduccia AA, Simms JA, Mill D, Yi HY, Bartlett SE (2014) Varenicline decreases ethanol intake and increases dopamine release via neuronal nicotinic acetylcholine receptors in the nucleus accumbens. Br J Pharmacol 171:3420-3431
26. Fucito LM, Toll BA, Wu R, Romano DM, Tek E, O'Malley SS (2011) A preliminary investigation of varenicline for heavy drinking smokers. Psychopharmacology (Berl) 215:655-663
27. Gass JT, Olive MF (2007) Reinstatement of ethanol-seeking behavior following intravenous self-administration in Wistar rats. Alcohol Clin Exp Res 31:1441-1445
28. Gerber GJ, Stretch R (1975) Drug-induced reinstatement of extinguished self-administration behavior in monkeys. Pharmacol Biochem Behav 3:1055-1061
29. Ginsburg BC, Lamb RJ (2013) Effects of varenicline on ethanol- and food-maintained responding in a concurrent access procedure. Alcohol Clin Exp Res 37:1228-1233
30. Ginsburg BC, Lamb RJ (2014) Relative potency of varenicline or fluvoxamine to reduce responding for ethanol versus food depends on the presence or absence of concurrently earned food. Alcohol Clin Exp Res 38:860-870
31. Grant BF (1998) Age at smoking onset and its association with alcohol consumption and DSM-IV alcohol abuse and dependence: results from the National Longitudinal Alcohol Epidemiologic Survey. J Subst Abuse 10:59-73
32. Hendrickson LM, Zhao-Shea R, Pang X, Gardner PD, Tapper AR (2010) Activation of alpha4∗nAChRs is necessary and sufficient for varenicline-induced reduction of alcohol consumption. J Neurosci 30:10169-10176
33. Hobbs M, Remington B, Glautier S (2005) Dissociation of wanting and liking for alcohol in humans: a test of the incentive-sensitisation theory. Psychopharmacology (Berl) 178:493-499
34. Hodgson R, Rankin H, Stockwell T (1979) Alcohol dependence and the priming effect. Behav Res Ther 17:379-387
35. Jackson A, Duka T, Stephens DN (2003) Effects of alcohol and lorazepam during extinction of alcohol self-administration in rats. J Psychopharmacol 17:293-299
36. Kaminski BJ, Weerts EM (2014) The effects of varenicline on alcohol seeking and self-administration in baboons. Alcohol Clin Exp Res 38:376-383
37. Kirk JM, de Wit H (2000) Individual differences in the priming effect of ethanol in social drinkers. J Stud Alcohol 61:64-71
38. Le AD, Quan B, Juzytch W, Fletcher PJ, Joharchi N, Shaham Y (1998) Reinstatement of alcohol-seeking by priming injections of alcohol and exposure to stress in rats. Psychopharmacology (Berl) 135:169-174
39. Le AD, Poulos CX, Harding S, Watchus J, Juzytsch W, Shaham Y (1999) Effects of naltrexone and fluoxetine on alcohol self-administration and reinstatement of alcohol seeking induced by priming injections of alcohol and exposure to stress. Neuropsychopharmacology 21:435-444
40. LeSage MG, Shelley D, Ross JT, Carroll FI, Corrigall WA (2009) Effects of the nicotinic receptor partial agonists varenicline and cytisine on the discriminative stimulus effects of nicotine in rats. Pharmacol Biochem Behav 91:461-467
41. Liang J, Olsen RW (2014) Alcohol use disorders and current pharmacological therapies: the role of GABAA receptors. Acta Pharmacol Sin 35:981-993
42. Litten RZ, Ryan ML, Fertig JB, Falk DE, Johnson B, Dunn KE, Green AI, Pettinati HM, Ciraulo DA, Sarid-Segal O, Kampman K, Brunette MF, Strain EC, Tiouririne NA, Ransom J, Scott C, Stout R (2013) A double-blind, placebo-controlled trial assessing the efficacy of varenicline tartrate for alcohol dependence. J Addict Med 7:277-286
43. Ludwig AM, Wikler A (1974) "Craving" and relapse to drink. Q J Stud Alcohol 35:108-130
44. McKee SA, Falba T, O'Malley SS, Sindelar J, O'Connor PG (2007) Smoking status as a clinical indicator for alcohol misuse in US adults. Arch Intern Med 167:716-721
45. McKee SA, Harrison EL, O'Malley SS, Krishnan-Sarin S, Shi J, Tetrault JM, Picciotto MR, Petrakis IL, Estevez N, Balchunas E (2009) Varenicline reduces alcohol self-administration in heavy-drinking smokers. Biol Psychiatry 66:185-190
46. Mitchell JM, Teague CH, Kayser AS, Bartlett SE, Fields HL (2012) Varenicline decreases alcohol consumption in heavy-drinking smokers. Psychopharmacology (Berl) 223:299-306
47. Panlilio LV, Hogarth L, Shoaib M (2014) Concurrent access to nicotine and sucrose in rats. Psychopharmacology (Berl)
48. Rollema H, Hajos M, Seymour PA, Kozak R, Majchrzak MJ, Guanowsky V, Horner WE, Chapin DS, Hoffmann WE, Johnson DE, McLean S, Freeman J, Williams KE (2009) Preclinical pharmacology of the alpha4beta2 nAChR partial agonist varenicline related to effects on reward, mood and cognition. Biochem Pharmacol 78:813-824
49. Samson HH, Chappell A (2002) Reinstatement of ethanol seeking responding after ethanol self-administration. Alcohol 26:95-101
50. Samson HH, Czachowski CL (2003) Behavioral measures of alcohol self-administration and intake control: rodent models. Int Rev Neurobiol 54:107-143
51. Steensland P, Simms JA, Holgate J, Richards JK, Bartlett SE (2007) Varenicline, an alpha4beta2 nicotinic acetylcholine receptor partial agonist, selectively decreases ethanol consumption and seeking. Proc Natl Acad Sci U S A 104:12518-12523
52. Stolerman I (1992) Drugs of abuse: behavioural principles, methods and terms. Trends Pharmacol Sci 13:170-176
53. Stretch R, Gerber GJ (1973) Drug-induced reinstatement of amphetamine self-administration behaviour in monkeys. Can J Psychol 27:168-177
54. Vosler PS, Bombace JC, Kosten TA (2001) A discriminative two-lever test of dizocilpine's ability to reinstate ethanol-seeking behavior. Life Sci 69:591-598
55. Wouda JA, Riga D, De Vries W, Stegeman M, van Mourik Y, Schetters D, Schoffelmeer AN, Pattij T, De Vries TJ (2011) Varenicline attenuates cue-induced relapse to alcohol, but not nicotine seeking, while reducing inhibitory response control. Psychopharmacology (Berl) 216:267-277