Duration of action of hypertonic saline on mucociliary clearance in the normal lung

Journal of Applied Physiology

Volumn 118, Issue 12, 2015, Pages 1483-1490

  Bennett, W D ^a   Wu, J ^a   Fuller, F ^a   Balcazar, J R ^a   Zeman, K L ^a   Duckworth, H ^a   Donn, K H ^b   O'Riordan, T G ^c   Boucher, R C ^a   Donaldson, S H ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b Parion Sciences   (United States)

^c GILEAD SCIENCES INC   (United States)

Author keywords

Airway secretions; Hypertonic saline; Mucus clearance

Indexed keywords

RADIOPHARMACEUTICAL AGENT; SODIUM CHLORIDE;

ADULT; BRONCHUS; DIAGNOSTIC IMAGING; DRUG EFFECTS; FEMALE; FORCED EXPIRATORY VOLUME; HUMAN; INHALATIONAL DRUG ADMINISTRATION; LUNG; MALE; METABOLISM; MUCOCILIARY CLEARANCE; MUCUS; NORMAL HUMAN; SCINTISCANNING; YOUNG ADULT;

ADMINISTRATION, INHALATION; ADULT; BRONCHI; FEMALE; FORCED EXPIRATORY VOLUME; HEALTHY VOLUNTEERS; HUMANS; LUNG; MALE; MUCOCILIARY CLEARANCE; MUCUS; RADIONUCLIDE IMAGING; RADIOPHARMACEUTICALS; SALINE SOLUTION, HYPERTONIC; YOUNG ADULT;

EID: 84932189096     PISSN: 87507587     EISSN: 15221601     Source Type: Journal    
DOI: 10.1152/japplphysiol.00404.2014     Document Type: Article

References (47)

1. Alexis NE, Hu SC, Zeman K, Alter T, Bennett WD. Induced sputum derives from the central airways: confirmation using a radiolabeled aerosol bolus delivery technique. Am J Resp Crit Care Med 164: 1964-1970, 2001.
2. Ballard ST, Trout L, Mehta A, Inglis SK. Liquid secretion inhibitors reduce mucociliary transport in glandular airways. Am J Physiol Lung Cell Mol Physiol 283: L329-L335, 2002.
3. Bennett WD, Alexis NE, Almond M, Herbst M, Zeman KL, Peden DB. Effect of inhaled endotoxin on mucociliary clearance and airway inflammation in mild smokers and nonsmokers. J Aerosol Med Pulm Drug Deliv 27: 459-465, 2014.
4. Bennett WD, Herbst M, Alexis NE, Zeman KL, Wu J, Hernandez ML, Peden DB. Effect of inhaled dust-mite allergen on regional particle deposition and mucociliary clearance in allergic asthmatics. Clin Experim Allergy 41: 1719-1728, 2011.
5. Bennett WD, Laube BL, Corcoran T, Zeman K, Sharpless G, Thomas K, Wu J, Mogayzel PJ Jr, Pilewski J, Donaldson S. Multisite comparison of mucociliary and cough clearance measures using standardized methods. J Aerosol Med Pulm Drug Deliv 26: 157-164, 2013.
6. Berger J, Albert RE, Sanborn K, Lippmann M. Effects of atropine and methacholine on deposition and clearance of inhaled particles in the donkey. J Toxicol Environ Health 4: 587-604, 1978.
7. Bermbach S, Weinhold K, Roeder T, Petersen F, Kugler C, Goldmann T, Rupp J, König P. Mechanisms of cilia-driven transport in the airways in the absence of mucus. Am J Respir Cell Mol Biol 51: 56-67, 2014.
8. Boek WM, Keles N, Graamans K, Huizing EH. Physiologic and hypertonic saline solutions impair ciliary activity in vitro. Laryngoscope 109: 396-399, 1999.
9. Button B, Cai LH, Ehre C, Kesimer M, Hill DB, Sheehan JK, Boucher RC, Rubinstein M. A periciliary brush promotes the lung health by separating the mucus layer from airway epithelia. Science 24: 937-941, 2012.
10. Davis MA, Jones AG, Trindade H. A rapid and accurate method for sizing radio-colloids. J Nucl Med 15: 923, 1974.
11. Daviskas E, Anderson SD, Gonda I, Eberl S, Meikle S, Seale JP, Bautovich G. Inhalation of hypertonic saline aerosol enhances mucociliary clearance in asthmatic and healthy subjects. Eur Respir J 9: 725-732, 1996.
12. Donaldson SH, Bennett WD, Zeman KL, Knowles MR, Tarran R, Boucher RC. Mucus clearance and lung function in cystic fibrosis with hypertonic saline. N Engl J Med 354: 241-250, 2006.
13. Elkins MR, Robinson M, Rose BR, Harbour C, Moriarty CP, Marks GB, Belousova EG, Xuan W, Bye PT. A controlled trial of long-term inhaled hypertonic saline in patients with cystic fibrosis. N Engl J Med 354: 229-240, 2006.
14. Eng PA, Morton J, Douglass JA, Riedler J, Wilson J, Robertson CF. Short-term efficacy of ultrasonically nebulized hypertonic saline in cystic fibrosis. Pediatr Pulmonol 21: 77-83, 1996.
15. Gerber V, Gehr P, Straub R, Frenz M, King M, Im Hof V. Mucus quality on horse tracheal epithelium: microscopic grading based on transparency. Respir Physiol 107: 67-74, 1997.
16. Hilding A. The physiology of drainage of nasal mucus I. The flow of the mucus currents through the drainage system of the nasal mucosa and its relation to ciliary activity. Arch Otolaryngol 15: 92-100, 1932.
17. Hirsh AJ, Sabater JR, Zamurs A, Smith RT, Paradiso AM, Hopkins S, Abraham WM, Boucher RC. Evaluation of second generation amiloride analogs as therapy for cystic fibrosis lung disease. Pharmacol Exp Ther 311: 929-938, 2004.
18. Hirsh AJ, Zhang J, Zamurs A, Fleegle J, Thelin WR, Caldwell RA, Sabater JR, Abraham WM, Donowitz M, Cha B, Johnson KB, St George JA, Johnson MR, Boucher RC. Pharmacological properties of N-(3,5-diamino-6-chloropyrazine-2-carbonyl)-N=-4-[4-(2,3-dihydroxypropoxy)phenyl]butyl-guanidine methanesulfonate (552-02), a novel epithelial sodium channel blocker with potential clinical efficacy for cystic fibrosis lung disease. J Pharmacol Exp Ther 325: 77-88, 2008.
19. Hirsh AJ, St George J, Thelin W, Stapleton K, Montgomery B, Boucher R, Johnson MR. GS 9411: a potential aerosol pharmacotherapy for CF. Am J Resp Crit Care Med 179: A1195, 2009.
20. Iravani J, Van As A. Mucus transport in the tracheobronchial tree of normal and bronchitic rats. J Pathol 106: 81-93, 1972.
21. Kim CS, Eldridge MA. Aerosol deposition in the airway model with excessive mucus secretions. J Appl Physiol 59: 1766-1772, 1985.
22. Lioté H, Zahm JM, Pierrot D, Puchelle E. Role of mucus and cilia in nasal mucociliary clearance in healthy subjects. Am Rev Respir Dis 140: 132-136, 1989.
23. Lucas AM, Douglas LC. Principles underlying ciliary activity in the respiratory tract 2. A comparison of nasal clearance in man, monkey and other mammals. Archs Otolaryngol 20: 518-541, 1934.
24. Matsui H, Randell SH, Peretti SW, Davis CW, Boucher RC. Coordinated clearance of periciliary liquid and mucus from airway surfaces. J Clin Invest 102: 1125-1131, 1998.
25. Matsui H, Grubb BR, Tarran R, Randell SH, Gatzy JT, Davis CW, Boucher RC. Evidence for periciliary liquid layer depletion, not abnormal ion composition, in the pathogenesis of cystic fibrosis airways disease. Cell 95: 1005-1015, 1998.
26. Min YG, Lee KS, Yun JB, Rhee CS, Rhyoo C, Koh YY, Yi WJ, Park KS. Hypertonic saline decreases ciliary movement in human nasal epithelium in vitro. Otolaryngol Head Neck Surg 124: 313-316, 2001.
27. Newman S, Bennett WD, Biddiscombe M, Devadason SG, Dolovich MB, Fleming J, Haeussermann S, Kietzig C, Kuehl PJ, Laube BL, Sommerer K, Taylor G, Usmani OS, Zeman KL. Standardization of techniques for using planar (2D) imaging for aerosol deposition assessment of orally inhaled products. J Aerosol Med Pulm Drug Deliv 25, Suppl 1: S10-S28, 2012.
28. Nowell JA, Tyler WS. Scanning electron microscopy of the surface morphology of mammalian lungs. Am Rev Respir Dis 103: 313-328, 1971.
29. Olivier KN, Bennett WD, Geary CA, Hohneker KW, Zeman KL, Edwards LJ, Boucher RC, Knowles MR. Acute safety and effects of mucociliary clearance of aerosolized uridine 5′-triphosphate +/- amiloride in normal human adults. Am J Resp Crit Care Med 154: 217-223, 1996.
30. O'Riordan TG, Donn KH, Hodsman P, Ansede JH, Newcomb T, Lewis SA, Flitter WD, White VS, Johnson MR, Montgomery AB, Warnock DG, Boucher RC. Acute hyperkalemia associated with inhalation of a potent ENaC antagonist: Phase 1 Trial of GS-9411. J Aerosol Med Pulm Drug Deliv 27: 200-208, 2014.
31. Pavia D, Thomson ML, Clarke SW. Enhanced clearance of secretions from the human lung after the administration of hypertonic saline aerosol. Am Rev Respir Dis 117: 199-203, 1978.
32. Robinson M, Regnis JA, Bailey DL, King M, Bautovich GJ, Bye PT. Effect of hypertonic saline, amiloride, and cough on mucociliary clearance in patients with cystic fibrosis. Am J Respir Crit Care Med 153: 1503-1509, 1996.
33. Robinson M, Hemming AL, Regnis JA, et al. Effect of increasing doses of hypertonic saline on mucociliary clearance in patients with cystic fibrosis. Thorax 52: 900-903, 1997.
34. Sackner MA, Rosen MJ, Wanner A. Estimation of tracheal mucous velocity by bronchofiberscopy. J Appl Physiol 34: 495-499, 1973.
35. Sood N, Bennett WD, Zeman K, et al. Increasing concentration of inhaled saline with or without amiloride: effect on mucociliary clearance in normal subjects. Am J Respir Crit Care Med 167: 158-163, 2003.
36. Spungin B, Silberberg A. Stimulation of mucus secretion, cillary activity, and transport on frog palate epithelium. Am J Physiol Cell Physiol 247: C299-C308, 1984.
37. Sturgess JM. The mucous lining of major bronchi in the rabbit lung. Am Rev Respir Dis 115: 819-827, 1977.
38. Tarran R, Grubb BR, Parsons D, Picher M, Hirsch AJ, Davis CW, Boucher RC. The CF salt controversy: In vivo observations and therapeutic approaches. Mol Cell 8: 149-158, 2001.
39. Van As A. Pulmonary airway clearance mechanisms: a reappraisal. Am Rev Respir Dis 115: 721-726, 1977.
40. Wanner A, Salathe M, O'Riordan TG. Mucociliary clearance in the airways. Am J Resp Crit Care Med 154: 1868-1902, 1996.
41. Wills PJ, Hall RL, Chan W, Cole PJ. Sodium chloride increases the ciliary transportability of cystic fibrosis and bronchiectasis sputum on the mucus-depleted bovine trachea. J Clin Invest 99: 9-13, 1997.
42. Wills PJ, Garcia Suarez MJ, Rutman A, Wilson R, Cole PJ. The ciliary transportability of sputum is slow on the mucus-depleted bovine trachea. Am J Respir Crit Care Med 151: 1255-1258, 1995.
43. Winters SL, Daza AV, Yeates DB. Direct and indirect manipulation of mucosal Na and Cl on the mucociliary transport system in the anesthetized dog. Am Rev Respir Dis 147: 296, 1993.
44. Yaghi A, Zaman A, Dolovich MB. The direct effect of hyperosmolar agents on ciliary beating of human bronchial epithelial cells. J Aerosol Med Pulm Drug Deliv 25: 88-95, 2012.
45. Yeates DB, Aspin N, Levison H, Jones MT, Bryan AC. Mucociliary tracheal transport rates in man. J Appl Physiol 39: 487-495, 1975.
46. Zeman KL, Wu J, Donaldson SH, Bennett WD. Comparison of 133 xenon ventilation equilibrium scan (XV) and 99m technetium transmission (TT) scan for use in regional lung analysis by 2D Gamma scintigraphy in healthy and cystic fibrosis lungs. J Aerosol Med Pulm Drug Deliv 26: 94-100, 2013.
47. Zeman KL, Wu J, Bennett WD. Targeting aerosolized drugs to the conducting airways using very large particles and extremely slow inhalations. J Aerosol Med Pulm Drug Deliv 23: 363-369, 2010.