Platelet-rich plasma and myofibroblasts: Is the composition the key to success?

Advances in Skin and Wound Care

Volumn 28, Issue 5, 2015, Pages 198-200

  Anitua, Eduardo ^a   Prado, Roberto ^a   Orive, Gorka ^a  

^a Foundation Eduardo Anitua   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL; CELL DIFFERENTIATION; CELL PROLIFERATION; FEMALE; FIBROBLAST; HUMAN; MALE; PHYSIOLOGY; THROMBOCYTE RICH PLASMA;

ANIMALS; CELL DIFFERENTIATION; CELL PROLIFERATION; FEMALE; FIBROBLASTS; HUMANS; MALE; PLATELET-RICH PLASMA;

EID: 84932177306     PISSN: 15277941     EISSN: 15388654     Source Type: Journal    
DOI: 10.1097/01.ASW.0000464706.42760.fe     Document Type: Letter

References (15)

1. Ramos-Torrecillas J, Luna-Bertos E, Manzano-Moreno FJ, Garcia-Martínez O, Ruiz C. Human fibroblast-like cultures in the presence of platelet-rich plasma as a single growth factor source: clinical implications. Adv Skin Wound Care 2014;27:114-20.
2. Anitua E, Zalduendo MM, Prado R, Alkhraisat MH, Orive G. Morphogen and pro-inflammatory cytokine release kinetics fromPRGF-Endoret fibrin scaffolds: evaluation of the effect of leukocyte inclusion. J Biomed Mater Res A 2015;103:1011-20.
3. Kushida S, Kakudo N, Suzuki K, Kusumoto K. Effects of platelet-rich plasma on proliferation and myofibroblastic differentiation in human dermal fibroblasts. Ann Plast Surg 2013;71:219-24.
4. Cáceres M, Hidalgo R, Sanz A, Martínez J, Riera P, Smith PC. Effect of platelet-rich plasma on cell adhesion, cell migration, and myofibroblastic differentiation in human gingival fibroblasts. J Periodontol 2008;79:714-20.
5. Cáceres M, Martínez C, Martínez J, Smith PC. Effects of platelet-rich and-poor plasma on the reparative response of gingival fibroblasts. Clin Oral Implants Res 2012;23:1104-11.
6. Giovanini AF, Gonzaga CC, Zielak JC, et al. Platelet-rich plasma (PRP) impairs the craniofacial bone repair associated with its elevated TGF-A levels andmodulates the co-expression between collagen III and -smooth muscle actin. J Orthop Res 2011;29:457-63.
7. Anitua E, Prado R, Sánchez M, Orive G. Platelet-rich plasma: preparation and formulation. Oper Tech Orthop 2012;22:25-32.
8. Anitua E, Troya M, Orive G. Plasma rich in growth factors promote gingival tissue regeneration by stimulating fibroblast proliferation and migration and by blocking transforming growth factor-beta1Yinduced myodifferentiation. J Periodontol 2012;83:1028-37.
9. Anitua E, Sanchez M, Merayo-Lloves J, de la Fuente M, Muruzabal F, Orive G. Plasma rich in growth factors (PRGF-Endoret) stimulates proliferation and migration of primary keratocytes and conjunctival fibroblasts and inhibits and reverts TGF-beta1Yinduced myodifferentiation. Invest Ophthalmol Vis Sci 2011;52:6066-73.
10. Anitua E, Muruzabal F, Alcalde I, Merayo-Lloves J, Orive G. Plasma rich in growth factors (PRGF-Endoret) stimulates corneal wound healing and reduces haze formation after PRK surgery. Exp Eye Res 2013;115:153-61.
11. Yang X, Chen B, Liu T, Chen X. Reversal of myofibroblast differentiation: a review. Eur J Pharmacol 2014;734:83-90.
12. Wynn TA, Ramalingam TR. Mechanisms of fibrosis: therapeutic translation for fibrotic disease. Nat Med 2012;18:1028-40.
13. Hinz B, Phan SH, Thannickal VJ, et al. Recent developments in myofibroblast biology: paradigms for connective tissue remodeling. Am J Pathol 2012;180:1340-55.
14. Cáceres M, Oyarzun A, Smith PC. Defective wound-healing in aging gingival tissue. J Dent Res 2014;93:691-7.
15. Jun JI, Lau LF. Cellular senescence controls fibrosis in wound healing. Aging (Albany, NY) 2010;2:627-31.