Expansion of human and murine hematopoietic stem and progenitor cells ex vivo without genetic modification using MYC and Bcl-2 fusion proteins

PLoS ONE

Volumn 9, Issue 8, 2014, Pages

  Bird, Gregory A ^a   Polsky, Avital ^b   Estes, Patricia ^a   Hanlon, Teri ^b   Hamilton, Haley ^b   Morton, John J ^b   Gutman, Jonathan ^b   Jimeno, Antonio ^b   Turner, Brian C ^a,b   Refaeli, Yosef ^a,b  

^a Taiga Biotechnologies Inc ^*  (United States)

^b UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GRANULOCYTE COLONY STIMULATING FACTOR; HYBRID PROTEIN; MYC PROTEIN; PROTEIN BCL 2; TRANSACTIVATOR PROTEIN; IL2RG PROTEIN, MOUSE; INTERLEUKIN 2 RECEPTOR GAMMA;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BONE MARROW; CELL RENEWAL; CONTROLLED STUDY; EX VIVO STUDY; FEMALE; HEMATOPOIESIS; HEMATOPOIETIC STEM AND PROGENITOR CELL; HEMATOPOIETIC STEM CELL; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMAN; HUMAN CELL; IN VIVO STUDY; MOUSE; NONHUMAN; STEM CELL EXPANSION; STEM CELL MOBILIZATION; UMBILICAL CORD BLOOD; ANIMAL; BONE MARROW TRANSPLANTATION; C57BL MOUSE; CELL CULTURE; CELL DIFFERENTIATION; CELL PROLIFERATION; CULTURE TECHNIQUE; CYTOLOGY; DEFICIENCY; DRUG EFFECTS; FETUS BLOOD; GENETICS; KNOCKOUT MOUSE; METABOLISM; NONOBESE DIABETIC MOUSE; PROCEDURES; REPRODUCIBILITY; SCID MOUSE; STEM CELL;

ADULT; ANIMALS; BONE MARROW TRANSPLANTATION; CELL CULTURE TECHNIQUES; CELL DIFFERENTIATION; CELL PROLIFERATION; CELLS, CULTURED; FETAL BLOOD; HEMATOPOIETIC STEM CELLS; HUMANS; INTERLEUKIN RECEPTOR COMMON GAMMA SUBUNIT; MICE, INBRED C57BL; MICE, INBRED NOD; MICE, KNOCKOUT; MICE, SCID; PROTO-ONCOGENE PROTEINS C-BCL-2; PROTO-ONCOGENE PROTEINS C-MYC; RECOMBINANT FUSION PROTEINS; REPRODUCIBILITY OF RESULTS; STEM CELLS;

EID: 84932142754     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0105525     Document Type: Article

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