Incidence, nature and mortality of cytomegalovirus infection after double-unit cord blood transplant

Leukemia and Lymphoma

Volumn 56, Issue 6, 2015, Pages 1799-1805

  Dahi, Parastoo B ^a,b   Perales, Miguel A ^a,b   Devlin, Sean M ^a   Olson, Amanda ^a   Lubin, Marissa ^a   Gonzales, Anne Marie ^a   Scaradavou, Andromachi ^a   Kernan, Nancy A ^a   O'Reilly, Richard J ^a   Giralt, Sergio ^a,b   Jakubowski, Ann ^a,b   Koehne, Guenther ^a,b   Papadopoulos, Esperanza B ^a,b   Ponce, Doris M ^a,b   Sauter, Craig ^a,b   Papanicolaou, Genovefa ^a   Barker, Juliet N ^a,b  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

Allogeneic transplant; Cord blood; Cytomegalovirus; Transplant related mortality

Indexed keywords

ACICLOVIR; CALCINEURIN INHIBITOR; CORTICOSTEROID; CYCLOSPORIN A; FOSCARNET; GANCICLOVIR; GRANULOCYTE COLONY STIMULATING FACTOR; MYCOPHENOLATE MOFETIL; THYMOCYTE ANTIBODY; VALGANCICLOVIR; VIRUS DNA;

ADOLESCENT; ADULT; AGED; ANTIVIRAL THERAPY; ARTICLE; BLOOD TRANSFUSION; CHICKENPOX; CHILD; CYTOMEGALOVIRUS INFECTION; DISEASE FREE SURVIVAL; FEMALE; GRAFT VERSUS HOST REACTION; HERPES SIMPLEX; HUMAN; LUNG LAVAGE; MAJOR CLINICAL STUDY; MALE; OXYGEN THERAPY; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RETROSPECTIVE STUDY; TREATMENT FAILURE; UMBILICAL CORD BLOOD TRANSPLANTATION; VIRUS PNEUMONIA; VIRUS REACTIVATION; ADVERSE EFFECTS; BLOOD; CORD BLOOD STEM CELL TRANSPLANTATION; CYTOMEGALOVIRUS; CYTOMEGALOVIRUS INFECTIONS; GASTROINTESTINAL DISEASES; GENETICS; HEMATOLOGIC NEOPLASMS; INCIDENCE; INFANT; ISOLATION AND PURIFICATION; MIDDLE AGED; MULTIVARIATE ANALYSIS; OUTCOME ASSESSMENT; PHYSIOLOGY; PNEUMONIA; PRESCHOOL CHILD; PROCEDURES; PROPORTIONAL HAZARDS MODEL; STATISTICS AND NUMERICAL DATA; VIREMIA; VIROLOGY; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; CHILD; CHILD, PRESCHOOL; CORD BLOOD STEM CELL TRANSPLANTATION; CYTOMEGALOVIRUS; CYTOMEGALOVIRUS INFECTIONS; DISEASE-FREE SURVIVAL; DNA, VIRAL; GASTROINTESTINAL DISEASES; HEMATOLOGIC NEOPLASMS; HUMANS; INCIDENCE; INFANT; MIDDLE AGED; MULTIVARIATE ANALYSIS; OUTCOME ASSESSMENT (HEALTH CARE); PNEUMONIA; PROPORTIONAL HAZARDS MODELS; VIREMIA; YOUNG ADULT;

EID: 84932137708     PISSN: 10428194     EISSN: 10292403     Source Type: Journal    
DOI: 10.3109/10428194.2014.963079     Document Type: Article

References (22)

1. Szabolcs P. T-lymphocyte recovery and function after cord blood transplantation. Immunol Res 2011; 49: 56-69.
2. Chiesa R, Gilmour K, Qasim W, et al. Omission of in vivo T-cell depletion promotes rapid expansion of naive CD4 cord blood lymphocytes and restores adaptive immunity within 2 months after unrelated cord blood transplant. Br J Haematol 2012; 156: 656-666.
3. Sauter C, Abboud M, Jia X, et al. Serious infection risk and immune recovery after double-unit cord blood transplantation without antithymocyte globulin. Biol Blood Marrow Transplant 2011; 17: 1460-1471.
4. van Heijst JW, Ceberio I, Lipuma LB, et al. Quantitative assessment of T cell repertoire recovery after hematopoietic stem cell transplantation. Nat Med 2013; 19: 372-377.
5. Tomonari A, Iseki T, Ooi J, et al. Cytomegalovirus infection following unrelated cord blood transplantation for adult patients:A single institute experience in Japan. Br J Haematol 2003; 121: 304-311.
6. Milano F, Pergam SA, Xie H, et al. Intensive strategy to prevent CMV disease in seropositive umbilical cord blood transplant recipients. Blood 2011; 118: 5689-5696.
7. Beck JC, Wagner JE, DeFor TE, et al. Impact of cytomegalovirus (CMV) reactivation after umbilical cord blood transplantation. Biol Blood Marrow Transplant 2010; 16: 215-222.
8. Walker CM, van Burik JA, De For TE, et al. Cytomegalovirus infection after allogeneic transplantation:comparison of cord blood with peripheral blood and marrow graft sources. Biol Blood Marrow Transplant 2007; 13: 1106-1115.
9. Barker JN, Ponce DM, Devlin SM, et al. Double-unit cord blood transplantation (DCBT) for acute leukemia: high disease-free survival in adults and children with comparable survival in European and minority patients. Biol Blood Marrow Transplant 2013; 19: S354.
10. Barker JN, Byam C, Scaradavou A. How I treat: The selection and acquisition of unrelated cord blood grafts. Blood 2011; 117: 2332-2339.
11. Barker J N, A bboud M, Rice R D, et al. A "n o-wash" albumin-dextran dilution strategy for cord blood unit thaw: high rate of engraftment and a low incidence of serious infusion reactions. Biol Blood Marrow Transplant 2009; 15: 1596-1602.
12. Ponce DM, Sauter C, Devlin S, et al. A novel reduced-intensity conditioning regimen induces a high incidence of sustained donorderived neutrophil and platelet engraftment after double-unit cord blood transplantation. Biol Blood Marrow Transplant 2013; 19: 799-803.
13. Ponce DM, Gonzales A, Lubin M, et al. Graft-versus-host disease after double-unit cord blood transplantation has unique features and an association with engrafting unit-to-recipient HLA match. Biol Blood Marrow Transplant 2013; 19: 904-911.
14. v an Burik J A, Carter S L, Freifeld A G, et al. H igher risk of cytomegalovirus and aspergillus infections in recipients of T celldepleted unrelated bone marrow: Analysis of infectious complications in patients treated with T cell depletion versus immunosuppressive therapy to prevent graft-versus-host disease. Biol Blood Marrow Transplant 2007; 13: 1487-1498.
15. Ljungman P, Griffiths P, Paya C. Definitions of cytomegalovirus infection and disease in transplant recipients. Clin Infect Dis 2002; 34: 1094-1097.
16. Boeckh M, Ljungman P. How I treat cytomegalovirus in hematopoietic cell transplant recipients. Blood 2009; 113: 5711-5719.
17. Winston DJ, Young JA, Pullarkat V, et al. Maribavir prophylaxis for prevention of cytomegalovirus infection in allogeneic stem cell transplant recipients: A multicenter, randomized, double-blind, placebo-controlled, dose-ranging study. Blood 2008; 111: 5403-5410.
18. Marty FM, Winston DJ, Rowley Sea. CMX001 to prevent cytomegalovirus disease in hematopoietic-cell transplantation. N Engl J Med 2013; 369: 1227-1236.
19. Hanley P J, Cruz C R, Savoldo B, et al. F unctionally active virus-specific T cells that target CMV, adenovirus, and EBV can be expanded from naive T-cell populations in cord blood and will target a range of viral epitopes. Blood 2009; 114: 1958-1967.
20. Leen AM, Bollard CM, Mendizabal AM, et al. Multicenter study of banked third-party virus-specific T cells to treat severe viral infections after hematopoietic stem cell transplantation. Blood 2013; 121: 5113-5123.
21. Brown JA, Stevenson K, Kim HT, et al. Clearance of CMV viremia and survival after double umbilical cord blood transplantation in adults depends on reconstitution of thymopoiesis. Blood 2010; 115: 4111-4119.
22. McGoldrick SM, Bleakley ME, Guerrero A, et al. Cytomegalovirus-specific T cells are primed early after cord blood transplant but fail to control virus in vivo. Blood 2013; 121: 2796-2803.