Stabilization of HAC1 influenza vaccine by spray drying: Formulation development and process scale-up

Pharmaceutical Research

Volumn 31, Issue 11, 2014, Pages 3006-3018

  Zhu, Changcheng ^a   Shoji, Yoko ^b   McCray, Scott ^c   Burke, Michael ^c   Hartman, Caitlin E ^b   Chichester, Jessica A ^b   Breit, Jeff ^c   Yusibov, Vidadi ^b   Chen, Dexiang ^a   Lal, Manjari ^a  

^a PATH   (United States)

^b Fraunhofer USA Inc   (United States)

^c Bend Research Incorporated   (United States)

Author keywords

pilot scale up; spray drying; thermostable; vaccines

Indexed keywords

EXCIPIENT; H1N1 VIRUS HEMAGGLUTININ; INFLUENZA VACCINE; INFLUENZA VIRUS HEMAGGLUTININ; POWDER; VIRUS ANTIGEN;

ANIMAL; BAGG ALBINO MOUSE; CHEMISTRY; DRUG STABILITY; DRUG STORAGE; HUMAN; IMMUNOLOGY; INFLUENZA; INFLUENZA VIRUS A H1N1; MEDICINAL CHEMISTRY; MOUSE; PHARMACEUTICS; POWDER; PROCEDURES; TEMPERATURE;

ANIMALS; ANTIGENS, VIRAL; CHEMISTRY, PHARMACEUTICAL; DRUG STABILITY; DRUG STORAGE; EXCIPIENTS; HEMAGGLUTININ GLYCOPROTEINS, INFLUENZA VIRUS; HUMANS; INFLUENZA A VIRUS, H1N1 SUBTYPE; INFLUENZA VACCINES; INFLUENZA, HUMAN; MICE; MICE, INBRED BALB C; POWDERS; TECHNOLOGY, PHARMACEUTICAL; TEMPERATURE;

EID: 84932092338     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-014-1394-3     Document Type: Article

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