Surgical molecular navigation with ratiometric activatable cell penetrating peptide for intraoperative identification and resection of small salivary gland cancers

Head and Neck

Volumn 38, Issue 5, 2016, Pages 715-723

  Hussain, Timon ^a   Savariar, Elamprakash N ^a   Diaz Perez, Julio A ^a   Messer, Karen ^b   Pu, Minya ^b   Tsien, Roger Y ^a   Nguyen, Quyen T ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

fluorescence guided surgery; long term survival; molecular imaging; molecular navigation; ratiometric activatable cell penetrating peptide (RACPP)

Indexed keywords

CELL PENETRATING PEPTIDE; RATIOMETRIC ACTIVATABLE CELL PENETRATING PEPTIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER SURGERY; CANCER SURVIVAL; FEMALE; FLUORESCENCE; HISTOPATHOLOGY; MOUSE; NONHUMAN; OPERATION DURATION; PRIORITY JOURNAL; SALIVARY GLAND CANCER; SENSITIVITY AND SPECIFICITY; TUMOR FREE SURVIVAL; ANIMAL; COMPUTER ASSISTED SURGERY; DIAGNOSTIC IMAGING; DISEASE FREE SURVIVAL; DISEASE MODEL; MOLECULAR IMAGING; PROCEDURES; RECEIVER OPERATING CHARACTERISTIC; SALIVARY GLAND NEOPLASMS;

ANIMALS; CELL-PENETRATING PEPTIDES; DISEASE MODELS, ANIMAL; DISEASE-FREE SURVIVAL; FEMALE; FLUORESCENCE; MICE; MOLECULAR IMAGING; OPERATIVE TIME; ROC CURVE; SALIVARY GLAND NEOPLASMS; SURGERY, COMPUTER-ASSISTED;

EID: 84932090598     PISSN: 10433074     EISSN: 10970347     Source Type: Journal    
DOI: 10.1002/hed.23946     Document Type: Article

References (40)

1. Argiris A, Karamouzis MV, Raben D, Ferris RL,. Head and neck cancer. Lancet 2008; 371: 1695-1709.
2. Lee YY, Wong KT, King AD, Ahuja AT,. Imaging of salivary gland tumours. Eur J Radiol 2008; 66: 419-436.
3. Woolgar JA, Triantafyllou A,. A histopathological appraisal of surgical margins in oral and oropharyngeal cancer resection specimens. Oral Oncol 2005; 41: 1034-1043.
4. McMahon J, O'Brien CJ, Pathak I, et al., Influence of condition of surgical margins on local recurrence and disease-specific survival in oral and oropharyngeal cancer. Br J Oral Maxillofac Surg 2003; 41: 224-231.
5. Cook JA, Jones AS, Phillips DE, Soler Lluch E,. Implications of tumour in resection margins following surgical treatment of squamous cell carcinoma of the head and neck. Clin Otolaryngol Allied Sci 1993; 18: 37-41.
6. Haque R, Contreras R, McNicoll MP, Eckberg EC, Petitti DB,. Surgical margins and survival after head and neck cancer surgery. BMC Ear Nose Throat Disord 2006; 6: 2.
7. Keereweer S, Sterenborg HJ, Kerrebijn JD, Van Driel PB, Baatenburg de Jong RJ, Löwik CW,. Image-guided surgery in head and neck cancer: current practice and future directions of optical imaging. Head Neck 2012; 34: 120-126.
8. Frangioni JV,. New technologies for human cancer imaging. J Clin Oncol 2008; 26: 4012-4021.
9. Nguyen QT, Olson ES, Aguilera TA, et al., Surgery with molecular fluorescence imaging using activatable cell-penetrating peptides decreases residual cancer and improves survival. Proc Natl Acad Sci U S A 2010; 107: 4317-4322.
10. Rosenthal EL, Matrisian LM,. Matrix metalloproteases in head and neck cancer. Head Neck 2006; 28: 639-648.
11. Hauff SJ, Raju SC, Orosco RK, et al., Matrix-metalloproteinases in head and neck carcinoma-cancer genome atlas analysis and fluorescence imaging in mice. Otolaryngol Head Neck Surg 2014; 151: 612-618.
12. Savariar EN, Felsen CN, Nashi N, et al., Real-time in vivo molecular detection of primary tumors and metastases with ratiometric activatable cell-penetrating peptides. Cancer Res 2013; 73: 855-864.
13. Nguyen QT, Tsien RY,. Fluorescence-guided surgery with live molecular navigation-a new cutting edge. Nat Rev Cancer 2013; 13: 653-662.
14. Stummer W, Pichlmeier U, Meinel T, et al., Fluorescence-guided surgery with 5-aminolevulinic acid for resection of malignant glioma: a randomised controlled multicentre phase III trial. Lancet Oncol 2006; 7: 392-401.
15. Widhalm G, Wolfsberger S, Minchev G, et al., 5-Aminolevulinic acid is a promising marker for detection of anaplastic foci in diffusely infiltrating gliomas with nonsignificant contrast enhancement. Cancer 2010; 116: 1545-1552.
16. Gotoh K, Yamada T, Ishikawa O, et al., A novel image-guided surgery of hepatocellular carcinoma by indocyanine green fluorescence imaging navigation. J Surg Oncol 2009; 100: 75-79.
17. van Dam GM, Themelis G, Crane LM, et al., Intraoperative tumor-specific fluorescence imaging in ovarian cancer by folate receptor-α targeting: first in-human results. Nat Med 2011; 17: 1315-1319.
18. Reddy NP, Miyamoto S, Araki K, et al., A novel orthotopic mouse model of head and neck cancer with molecular imaging. Laryngoscope 2011; 121: 1202-1207.
19. Miyamoto S, Sperry S, Yamashita T, Reddy NP, O'Malley BW Jr, Li D,. Molecular imaging assisted surgery improves survival in a murine head and neck cancer model. Int J Cancer 2012; 131: 1235-1242.
20. Loja MN, Luo Z, Greg Farwell D, et al., Optical molecular imaging detects changes in extracellular pH with the development of head and neck cancer. Int J Cancer 2013; 132: 1613-1623.
21. Keereweer S, Kerrebijn JD, van Driel PB, et al., Optical image-guided surgery-where do we stand? Mol Imaging Biol 2011;13: 199-207.
22. Kulbersh BD, Duncan RD, Magnuson JS, Skipper JB, Zinn K, Rosenthal EL,. Sensitivity and specificity of fluorescent immunoguided neoplasm detection in head and neck cancer xenografts. Arch Otolaryngol Head Neck Surg 2007; 133: 511-515.
23. Rosenthal EL, Kulbersh BD, Duncan RD, et al., In vivo detection of head and neck cancer orthotopic xenografts by immunofluorescence. Laryngoscope 2006; 116: 1636-1641.
24. Gleysteen JP, Newman JR, Chhieng D, Frost A, Zinn KR, Rosenthal EL,. Fluorescent labeled anti-EGFR antibody for identification of regional and distant metastasis in a preclinical xenograft model. Head Neck 2008; 30: 782-789.
25. Heath CH, Deep NL, Sweeny L, Zinn KR, Rosenthal EL,. Use of panitumumab-IRDye800 to image microscopic head and neck cancer in an orthotopic surgical model. Ann Surg Oncol 2012; 19: 3879-3887.
26. Jinga DC, Blidaru A, Condrea I, et al., MMP-9 and MMP-2 gelatinases and TIMP-1 and TIMP-2 inhibitors in breast cancer: correlations with prognostic factors. J Cell Mol Med 2006; 10: 499-510.
27. Määttä M, Soini Y, Liakka A, Autio-Harmainen H,. Differential expression of matrix metalloproteinase (MMP)-2, MMP-9, and membrane type 1-MMP in hepatocellular and pancreatic adenocarcinoma: implications for tumor progression and clinical prognosis. Clin Cancer Res 2000; 6: 2726-2734.
28. Bauvois B,. New facets of matrix metalloproteinases MMP-2 and MMP-9 as cell surface transducers: outside-in signaling and relationship to tumor progression. Biochim Biophys Acta 2012; 1825: 29-36.
29. Egeblad M, Werb Z,. New functions for the matrix metalloproteinases in cancer progression. Nat Rev Cancer 2002; 2: 161-174.
30. Curry JM, Sprandio J, Cognetti D, et al., Tumor microenvironment in head and neck squamous cell carcinoma. Semin Oncol 2014; 41: 217-234.
31. Keereweer S, Mol IM, Vahrmeijer AL, et al., Dual wavelength tumor targeting for detection of hypopharyngeal cancer using near-infrared optical imaging in an animal model. Int J Cancer 2012; 131: 1633-1640.
32. Baeten J, Haller J, Shih H, Ntziachristos V,. In vivo investigation of breast cancer progression by use of an internal control. Neoplasia 2009; 11: 220-227.
33. Waltonen JD, Ozer E, Schuller DE, Agrawal A,. Tonsillectomy vs. deep tonsil biopsies in detecting occult tonsil tumors. Laryngoscope 2009; 119: 102-106.
34. Nagel TH, Hinni ML, Hayden RE, Lott DG,. Transoral laser microsurgery for the unknown primary: role for lingual tonsillectomy. Head Neck 2014; 36: 942-946.
35. Koch M, Zenk J, Iro H,. Long-term results of morbidity after parotid gland surgery in benign disease. Laryngoscope 2010; 120: 724-730.
36. Yabuuchi H, Fukuya T, Tajima T, Hachitanda Y, Tomita K, Koga M,. Salivary gland tumors: diagnostic value of gadolinium-enhanced dynamic MR imaging with histopathologic correlation. Radiology 2003; 226: 345-354.
37. Massoud TF, Gambhir SS,. Molecular imaging in living subjects: seeing fundamental biological processes in a new light. Genes Dev 2003; 17: 545-580.
38. Hricak H, Wang L, Wei DC, et al., The role of preoperative endorectal magnetic resonance imaging in the decision regarding whether to preserve or resect neurovascular bundles during radical retropubic prostatectomy. Cancer 2004; 100: 2655-2663.
39. Junaid M, Choudhary MM, Sobani ZA, et al., A comparative analysis of toluidine blue with frozen section in oral squamous cell carcinoma. World J Surg Oncol 2012; 10: 57.
40. Roder C, Bender B, Ritz R, et al., Intraoperative visualization of residual tumor: the role of perfusion-weighted imaging in a high-field intraoperative magnetic resonance scanner. Neurosurgery 2013; 72 (2 Suppl Operative):ons151-ons158; discussion ons158.