Neutrophil and monocyte toll-like receptor 4, CD11b and reactive oxygen intermediates, and neuroimaging outcomes in preterm infants

Pediatric Research

Volumn 78, Issue 1, 2015, Pages 82-90

  O'Hare, Fiona M ^a,b,c,d   Watson, William ^b,c   O'Neill, Amanda ^b,c   Grant, Tim ^b,c   Onwuneme, Chike ^a,b,c,d   Donoghue, Veronica ^a,e   Mooney, Eoghan ^a   Downey, Paul ^a   Murphy, John ^a   Twomey, Anne ^a   Molloy, Eleanor J ^a,b,c,f,g,h  

^a NATIONAL MATERNITY HOSPITAL   (Ireland)

^b UNIVERSITY COLLEGE DUBLIN   (Ireland)

^c UNIVERSITY COLLEGE DUBLIN   (Ireland)

^d CHI Crumlin   (Ireland)

^e CHILDREN S UNIVERSITY HOSPITAL   (Ireland)

^f OUR LADY S CHILDREN S HOSPITAL   (Ireland)

^g ROYAL COLLEGE OF SURGEONS IN IRELAND   (Ireland)

^h TRINITY COLLEGE DUBLIN   (Ireland)

Author keywords

[No Author keywords available]

Indexed keywords

CD11B ANTIGEN; REACTIVE OXYGEN INTERMEDIATE; REACTIVE OXYGEN METABOLITE; TOLL LIKE RECEPTOR 4; UNCLASSIFIED DRUG; ITGAM PROTEIN, HUMAN; LIPOPOLYSACCHARIDE; OXYGEN; TLR4 PROTEIN, HUMAN;

ARTICLE; CEREBROVASCULAR ACCIDENT; CONTROLLED STUDY; ENDOTOXIN DETECTION; FEMALE; FLOW CYTOMETRY; GESTATIONAL AGE; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IMMUNOMODULATION; INFANT; INFLAMMATORY DISEASE; LEUKOCYTE ACTIVATION; MAJOR CLINICAL STUDY; MALE; MONOCYTE; NEUROIMAGING; NEUTROPHIL; NEWBORN; NUCLEAR MAGNETIC RESONANCE IMAGING; OUTCOME ASSESSMENT; PREMATURITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; TISSUE INJURY; ULTRASOUND; ADULT; BLOOD; BRAIN INJURY; CELL MEMBRANE; CHEMISTRY; CYTOLOGY; GENE EXPRESSION REGULATION; METABOLISM;

ADULT; ANTIGENS, CD11B; BRAIN INJURIES; CELL MEMBRANE; FEMALE; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; HUMANS; INFANT, NEWBORN; INFANT, PREMATURE; LIPOPOLYSACCHARIDES; MAGNETIC RESONANCE IMAGING; MALE; MONOCYTES; NEUROIMAGING; NEUTROPHILS; OXYGEN; REACTIVE OXYGEN SPECIES; TOLL-LIKE RECEPTOR 4;

EID: 84931843587     PISSN: 00313998     EISSN: 15300447     Source Type: Journal    
DOI: 10.1038/pr.2015.66     Document Type: Article

References (40)

1. Gonçalves LF, Chaiworapongsa T, Romero R. Intrauterine infection and prematurity. Ment Retard Dev Disabil Res Rev 2002;8:3-13.
2. Favrais G, van de Looij Y, Fleiss B, et al. Systemic infammation disrupts the developmental program of white matter. Ann Neurol 2011;70:550-65.
3. Nelson KB, Grether JK, Dambrosia JM, et al. Neonatal cytokines and cerebral palsy in very preterm infants. Pediatr Res 2003;53:600-7.
4. Leviton A, Dammann O, Durum SK. The adaptive immune response in neonatal cerebral white matter damage. Ann Neurol 2005;58:821-8.
5. Deguchi K, Oguchi K, Takashima S. Characteristic neuropathology of leukomalacia in extremely low birth weight infants. Pediatr Neurol 1997;16:296-300.
6. Inder TE, Anderson NJ, Spencer C, Wells S, Volpe JJ. White matter injury in the premature infant: a comparison between serial cranial sonographic and MR fndings at term. AJNR Am J Neuroradiol 2003;24:805-9.
7. Stoll BJ, Hansen NI, Adams-Chapman I, et al.; National Institute of Child Health and Human Development Neonatal Research Network. Neurode-velopmental and growth impairment among extremely low-birth-weight infants with neonatal infection. JAMA 2004;292:2357-65.
8. Nguyen HX, O'Barr TJ, Anderson AJ. Polymorphonuclear leukocytes promote neurotoxicity through release of matrix metalloproteinases, reactive oxygen species, and TNF-alpha. J Neurochem 2007;102:900-12.
9. Gressens P, Le Verche V, Fraser M, et al. Pitfalls in the quest of neuropro-tectants for the perinatal brain. Dev Neurosci 2011;33:189-98.
10. Buonocore G, Perrone S, Bracci R. Free radicals and brain damage in the newborn. Biol Neonate 2001;79:180-6.
11. Carr R. Neutrophil production and function in newborn infants. Br J Hae-matol 2000;110:18-28.
12. Shen CM, Lin SC, Niu DM, Kou YR. Development of monocyte Toll-like receptor 2 and Toll-like receptor 4 in preterm newborns during the frst few months of life. Pediatr Res 2013;73:685-91.
13. Zhang H, Slutsky AS, Vincent JL. Oxygen free radicals in ARDS, septic shock and organ dysfunction. Intensive Care Med 2000;26:474-6.
14. Tsukimori K, Komatsu H, Yoshimura T, et al. Increased infammatory markers are associated with early periventricular leukomalacia. Dev Med Child Neurol 2007;49:587-90.
15. Lehnardt S, Lachance C, Patrizi S, et al. The toll-like receptor TLR4 is necessary for lipopolysaccharide-induced oligodendrocyte injury in the CNS. J Neurosci 2002;22:2478-86.
16. Inder T, Mocatta T, Darlow B, Spencer C, Volpe JJ, Winterbourn C. Elevated free radical products in the cerebrospinal fuid of VLBW infants with cerebral white matter injury. Pediatr Res 2002;52:213-8.
17. Usmani SS, Schlessel JS, Sia CG, Kamran S, Orner SD. Polymorphonuclear leukocyte function in the preterm neonate: efect of chronologic age. Pediatrics 1991;87:675-9.
18. Reddy RK, Xia Y, Hanikýrová M, Ross GD. A mixed population of immature and mature leucocytes in umbilical cord blood results in a reduced expression and function of CR3 (CD11b/CD18). Clin Exp Immunol 1998;114:462-7.
19. Sarafdis K, Drossou-Agakidou V, Kanakoudi-Tsakalidou F, et al. Evidence of early systemic activation and transendothelial migration of neutrophils in neonates with severe respiratory distress syndrome. Pediatr Pulmonol 2001;31:214-9.
20. Chakravarti A, Rusu D, Flamand N, Borgeat P, Poubelle PE. Reprogram-ming of a subpopulation of human blood neutrophils by prolonged exposure to cytokines. Lab Invest 2009;89:1084-99.
21. Colotta F, Re F, Polentarutti N, Sozzani S, Mantovani A. Modulation of granulocyte survival and programmed cell death by cytokines and bacterial products. Blood 1992;80:2012-20.
22. Dransfeld I, Stocks SC, Haslett C. Regulation of cell adhesion molecule expression and function associated with neutrophil apoptosis. Blood 1995;85:3264-73.
23. Koenig JM, Stegner JJ, Schmeck AC, Saxonhouse MA, Kenigsberg LE. Neonatal neutrophils with prolonged survival exhibit enhanced infamma-tory and cytotoxic responsiveness. Pediatr Res 2005;57:424-9.
24. Hagberg H, Peebles D, Mallard C. Models of white matter injury: comparison of infectious, hypoxic-ischemic, and excitotoxic insults. Ment Retard Dev Disabil Res Rev 2002;8:30-8.
25. Bortolussi R, Howlett S, Rajaraman K, Halperin S. Defcient priming activity of newborn cord blood-derived polymorphonuclear neutrophilic gran-ulocytes with lipopolysaccharide and tumor necrosis factor-alpha triggered with formyl-methionyl-leucyl-phenylalanine. Pediatr Res 1993;34:243-8.
26. Gessler P, Nebe T, Birle A, Haas N, Kachel W. Neutrophil respiratory burst in term and preterm neonates without signs of infection and in those with increased levels of C-reactive protein. Pediatr Res 1996;39:843-8.
27. Savill J, Dransfeld I, Gregory C, Haslett C. A blast from the past: clearance of apoptotic cells regulates immune responses. Nat Rev Immunol 2002;2:965-75.
28. Speer CP. New insights into the pathogenesis of pulmonary infammation in preterm infants. Biol Neonate 2001;79:205-9.
29. Serhan CN, Savill J. Resolution of infammation: the beginning programs the end. Nat Immunol 2005;6:1191-7.
30. Fleiss B, Gressens P. Tertiary mechanisms of brain damage: a new hope for treatment of cerebral palsy? Lancet Neurol 2012;11:556-66.
31. Russell GA, Cooke RW. Randomised controlled trial of allopurinol prophylaxis in very preterm infants. Arch Dis Child Fetal Neonatal Ed 1995;73:F27-31.
32. Aizawa H, Makita Y, Sumitomo K, et al. Edaravone diminishes free radicals from circulating neutrophils in patients with ischemic brain attack. Intern Med 2006;45:1-4.
33. Mestan K, Yu Y, Torsen P, et al. Cord blood biomarkers of the fetal infam-matory response. J Matern Fetal Neonatal Med 2009;22:379-87.
34. Vento M, Moro M, Escrig R, et al. Preterm resuscitation with low oxygen causes less oxidative stress, infammation, and chronic lung disease. Pediatrics 2009;124:e439-49.
35. Moss TJ. Respiratory consequences of preterm birth. Clin Exp Pharmacol Physiol 2006;33:280-4.
36. Walsh MC, Kliegman RM. Necrotizing enterocolitis: treatment based on staging criteria. Pediatr Clin North Am 1986;33:179-201.
37. Papile LA, Burstein J, Burstein R, Kofer H. Incidence and evolution of subependymal and intraventricular hemorrhage: a study of infants with birth weights less than 1, 500 gm. J Pediatr 1978;92:529-34.
38. El-Khufash AF, McNamara PJ. Neonatologist-performed functional echo-cardiography in the neonatal intensive care unit. Semin Fetal Neonatal Med 2011;16:50-60.
39. Molloy EJ, O'Neill AJ, Doyle BT, et al. Efects of heat shock and hypoxia on neonatal neutrophil lipopolysaccharide responses: altered apoptosis, Tolllike receptor-4 and CD11b expression compared with adults. Biol Neonate 2006;90:34-9.
40. Smith JA, Weidemann MJ. Further characterization of the neutro-phil oxidative burst by fow cytometry. J Immunol Methods 1993;162: 261-8.