-
1
-
-
0003964363
-
Cancer Facts & Figures 2014
-
Accessed Oct. 1, 2014
-
American Cancer Society. Cancer Facts & Figures 2014. 2014. http://www.cancer.org/research/cancerfactsstatistics/cancerfactsfigures2014/. Accessed Oct. 1, 2014.
-
(2014)
-
-
-
2
-
-
84914176528
-
Nivolumab (anti-PD-1; BMS-936558, ONO-4538) in combination with sunitinib or pazopanib in patients (pts) with metastatic renal cell carcinoma (mRCC)
-
abstr 5010
-
Amin A, Plimack ER, Infante JR, ErnstoffMS, Rini BI, Mcdermott DF, Knox JJ, Pal SK, Voss MH, Sharma P, Kollmannsberger CK, Heng DYC, Sprattin JL, Shen Y, Kurland JF, Gagnier P, Hammers HJ. Nivolumab (anti-PD-1; BMS-936558, ONO-4538) in combination with sunitinib or pazopanib in patients (pts) with metastatic renal cell carcinoma (mRCC). J Clin Oncol 32:5s (suppl; abstr 5010), 2014.
-
(2014)
J Clin Oncol
, vol.32
, pp. 5s
-
-
Amin, A.1
Plimack, E.R.2
Infante, J.R.3
Ernstoff, M.S.4
Rini, B.I.5
Mcdermott, D.F.6
Knox, J.J.7
Pal, S.K.8
Voss, M.H.9
Sharma, P.10
Kollmannsberger, C.K.11
Heng, D.Y.C.12
Sprattin, J.L.13
Shen, Y.14
Kurland, J.F.15
Gagnier, P.16
Hammers, H.J.17
-
3
-
-
84907613231
-
Phase 2, multicenter, safety and efficacy study of pidilizumab in patients with metastatic melanoma
-
abstr 9001
-
Atkins MB, Kudchadkar RR, Sznol M, Mcdermott DF, Lotem M, Schacther J, Wolchok JD, Urba WJ, Kuzel T, Schuchter LM, SlingluffCL, ErnstoffMS, Fay JW, Friedlander PA, Gajewski T, Zarour H, Rotem-Yehudar R, Sosman JA. Phase 2, multicenter, safety and efficacy study of pidilizumab in patients with metastatic melanoma. J Clin Oncol 32:5s (suppl; abstr 9001), 2014.
-
(2014)
J Clin Oncol
, vol.32
, pp. 5s
-
-
Atkins, M.B.1
Kudchadkar, R.R.2
Sznol, M.3
Mcdermott, D.F.4
Lotem, M.5
Schacther, J.6
Wolchok, J.D.7
Urba, W.J.8
Kuzel, T.9
Schuchter, L.M.10
Slingluff, C.L.11
Ernstoff, M.S.12
Fay, J.W.13
Friedlander, P.A.14
Gajewski, T.15
Zarour, H.16
Rotem-Yehudar, R.17
Sosman, J.A.18
-
4
-
-
33744792341
-
Enterocolitis in patients with cancer after antibody blockade of cytotoxic T-lymphocyte-associated antigen 4
-
Beck KE, Blansfield JA, Tran KQ, Feldman AL, Hughes MS, Royal RE, Kammula US, Topalian SL, Sherry RM, Kleiner D, Quezado M, Lowy I, Yellin M, Rosenberg SA, Yang JC. Enterocolitis in patients with cancer after antibody blockade of cytotoxic T-lymphocyte-associated antigen 4. J Clin Oncol 24(15):2283-2289, 2006.
-
(2006)
J Clin Oncol
, vol.24
, Issue.15
, pp. 2283-2289
-
-
Beck, K.E.1
Blansfield, J.A.2
Tran, K.Q.3
Feldman, A.L.4
Hughes, M.S.5
Royal, R.E.6
Kammula, U.S.7
Topalian, S.L.8
Sherry, R.M.9
Kleiner, D.10
Quezado, M.11
Lowy, I.12
Yellin, M.13
Rosenberg, S.A.14
Yang, J.C.15
-
5
-
-
49649114804
-
Phase I safety and pharmacokinetic study of CT-011, a humanized antibody interacting with PD-1, in patients with advanced hematologic malignancies
-
Berger R, Rotem-Yehudar R, Slama G, Landes S, Kneller A, Leiba M, Koren-Michowitz M, Shimoni A, Nagler A. Phase I safety and pharmacokinetic study of CT-011, a humanized antibody interacting with PD-1, in patients with advanced hematologic malignancies. Clin Cancer Res 14(10):3044-3051, 2008.
-
(2008)
Clin Cancer Res
, vol.14
, Issue.10
, pp. 3044-3051
-
-
Berger, R.1
Rotem-Yehudar, R.2
Slama, G.3
Landes, S.4
Kneller, A.5
Leiba, M.6
Koren-Michowitz, M.7
Shimoni, A.8
Nagler, A.9
-
6
-
-
77954899030
-
Phase I study of single-agent anti-programmed death-1 (MDX-1106) in refractory solid tumors: safety, clinical activity, pharmacodynamics, and immunologic correlates
-
Brahmer JR, Drake CG, Wollner I, Powderly JD, Picus J, Sharfman WH, Stankevich E, Pons A, Salay TM, Mcmiller TL, Gilson MM, Wang C, Selby M, Taube JM, Anders R, Chen L, Korman AJ, Pardoll DM, Lowy I, Topalian SL. Phase I study of single-agent anti-programmed death-1 (MDX-1106) in refractory solid tumors: safety, clinical activity, pharmacodynamics, and immunologic correlates. J Clin Oncol 28(19):3167-3175, 2010.
-
(2010)
J Clin Oncol
, vol.28
, Issue.19
, pp. 3167-3175
-
-
Brahmer, J.R.1
Drake, C.G.2
Wollner, I.3
Powderly, J.D.4
Picus, J.5
Sharfman, W.H.6
Stankevich, E.7
Pons, A.8
Salay, T.M.9
Mcmiller, T.L.10
Gilson, M.M.11
Wang, C.12
Selby, M.13
Taube, J.M.14
Anders, R.15
Chen, L.16
Korman, A.J.17
Pardoll, D.M.18
Lowy, I.19
Topalian, S.L.20
more..
-
7
-
-
61449090474
-
Phase I/II trial of tremelimumab in patients with metastatic melanoma
-
Camacho LH, Antonia S, Sosman J, Kirkwood JM, Gajewski TF, Redman B, Pavlov D, Bulanhagui C, Bozon VA, Gomez-Navarro J, Ribas A. Phase I/II trial of tremelimumab in patients with metastatic melanoma. J Clin Oncol 27(7):1075-1081, 2009.
-
(2009)
J Clin Oncol
, vol.27
, Issue.7
, pp. 1075-1081
-
-
Camacho, L.H.1
Antonia, S.2
Sosman, J.3
Kirkwood, J.M.4
Gajewski, T.F.5
Redman, B.6
Pavlov, D.7
Bulanhagui, C.8
Bozon, V.A.9
Gomez-Navarro, J.10
Ribas, A.11
-
8
-
-
84880264878
-
Clinical activity, safety, and biomarkers of MPDL3280A, an engineered PD-L1 antibody in patients with metastatic renal cell carcinoma (mRCC)
-
abstr 4505
-
Cho DC, Sosman JA, Sznol M, Gordon MS, Hollebecque A, Mcdermott DF, Delord JP, Rhee IP, Mokatrin A, Kowantez M, Funke RP, Fine GD, Powles T. Clinical activity, safety, and biomarkers of MPDL3280A, an engineered PD-L1 antibody in patients with metastatic renal cell carcinoma (mRCC). J Clin Oncol 31 (suppl; abstr 4505), 2013.
-
(2013)
J Clin Oncol
, vol.31
-
-
Cho, D.C.1
Sosman, J.A.2
Sznol, M.3
Gordon, M.S.4
Hollebecque, A.5
Mcdermott, D.F.6
Delord, J.P.7
Rhee, I.P.8
Mokatrin, A.9
Kowantez, M.10
Funke, R.P.11
Fine, G.D.12
Powles, T.13
-
9
-
-
84921742040
-
Immunomodulatory activity of nivolumab in previously treated and untreated metastatic renal cell carcinoma (mRCC): Biomarker-based results from a randomized clinical trial
-
abstr 5012
-
Choueiri TK, Fishman MN, Escudier B, Kim JJ, Kluger H, Stadler WM, Perez-Gracia JL, Mcneel DG, Curti BD, Harrison MR, Plimack ER, Appleman LJ, Fong L, Drake CG, Cohen LJ, Srivastava S, Jure-Kunkel M, Hong Q, Kurland JF, Sznol M. Immunomodulatory activity of nivolumab in previously treated and untreated metastatic renal cell carcinoma (mRCC): Biomarker-based results from a randomized clinical trial. J Clin Oncol 32:5s (suppl; abstr 5012), 2014.
-
(2014)
J Clin Oncol
, vol.32
, pp. 5s
-
-
Choueiri, T.K.1
Fishman, M.N.2
Escudier, B.3
Kim, J.J.4
Kluger, H.5
Stadler, W.M.6
Perez-Gracia, J.L.7
Mcneel, D.G.8
Curti, B.D.9
Harrison, M.R.10
Plimack, E.R.11
Appleman, L.J.12
Fong, L.13
Drake, C.G.14
Cohen, L.J.15
Srivastava, S.16
Jure-Kunkel, M.17
Hong, Q.18
Kurland, J.F.19
Sznol, M.20
more..
-
10
-
-
18944385751
-
Immunotherapy for advanced renal cell cancer
-
Coppin C, Porzsolt F, Awa A, Kumpf J, Coldman A, Wilt T. Immunotherapy for advanced renal cell cancer. Cochrane Database Syst Rev (1):CD001425, 2005.
-
(2005)
Cochrane Database Syst Rev
, Issue.1
, pp. CD001425
-
-
Coppin, C.1
Porzsolt, F.2
Awa, A.3
Kumpf, J.4
Coldman, A.5
Wilt, T.6
-
11
-
-
36748999428
-
Prognostic factors related to clinical response in patients with metastatic melanoma treated by CTL-associated antigen-4 blockade
-
Downey SG, Klapper JA, Smith FO, Yang JC, Sherry RM, Royal RE, Kammula US, Hughes MS, Allen TE, Levy CL. Prognostic factors related to clinical response in patients with metastatic melanoma treated by CTL-associated antigen-4 blockade. Clin Cancer Res 13(22):6681-6688, 2007.
-
(2007)
Clin Cancer Res
, vol.13
, Issue.22
, pp. 6681-6688
-
-
Downey, S.G.1
Klapper, J.A.2
Smith, F.O.3
Yang, J.C.4
Sherry, R.M.5
Royal, R.E.6
Kammula, U.S.7
Hughes, M.S.8
Allen, T.E.9
Levy, C.L.10
-
12
-
-
84880706331
-
Survival, safety, and response duration results of nivolumab (Anti-PD-1; BMS-936558; ONO-4538) in a phase I trial in patients with previously treatedmetastatic renal cell carcinoma (mRCC): long-term patient followup
-
abstr 4514
-
Drake CG, Mcdermott DF, Sznol M. Survival, safety, and response duration results of nivolumab (Anti-PD-1; BMS-936558; ONO-4538) in a phase I trial in patients with previously treatedmetastatic renal cell carcinoma (mRCC): long-term patient followup. J Clin Oncol 31 (suppl; abstr 4514), 2013.
-
(2013)
J Clin Oncol
, vol.31
-
-
Drake, C.G.1
Mcdermott, D.F.2
Sznol, M.3
-
13
-
-
0036852241
-
Cancer immunoediting: from immunosurveillance to tumor escape
-
Dunn GP, Bruce AT, Ikeda H, Old LJ, Schreiber RD. Cancer immunoediting: from immunosurveillance to tumor escape. Nat Immunol 3(11):991-998, 2002.
-
(2002)
Nat Immunol
, vol.3
, Issue.11
, pp. 991-998
-
-
Dunn, G.P.1
Bruce, A.T.2
Ikeda, H.3
Old, L.J.4
Schreiber, R.D.5
-
14
-
-
84867646045
-
Novel molecular targets for the therapy of renal cell carcinoma
-
Elfiky AA, Sonpavde G. Novel molecular targets for the therapy of renal cell carcinoma. Discov Med 13(73):461-471, 2012.
-
(2012)
Discov Med
, vol.13
, Issue.73
, pp. 461-471
-
-
Elfiky, A.A.1
Sonpavde, G.2
-
15
-
-
84934963226
-
Pembrolizumab
-
Accessed Oct. 16, 2014
-
FDA. Pembrolizumab. http://www.fda.gov/Drugs/InformationOnDrugs/ApprovedDrugs/ucm412861.htm. 2014. Accessed Oct. 16, 2014.
-
(2014)
-
-
-
16
-
-
0028929682
-
Results of treatment of 255 patients with metastatic renal cell carcinoma who received high-dose recombinant interleukin-2 therapy
-
Fyfe G, Fisher RI, Rosenberg SA, Sznol M, Parkinson DR, Louie AC. Results of treatment of 255 patients with metastatic renal cell carcinoma who received high-dose recombinant interleukin-2 therapy. J Clin Oncol 13(3):688-696, 1995.
-
(1995)
J Clin Oncol
, vol.13
, Issue.3
, pp. 688-696
-
-
Fyfe, G.1
Fisher, R.I.2
Rosenberg, S.A.3
Sznol, M.4
Parkinson, D.R.5
Louie, A.C.6
-
17
-
-
42649145828
-
Epidemiologic and socioeconomic burden of metastatic renal cell carcinoma (mRCC): a literature review
-
Gupta K, Miller JD, Li JZ, Russell MW, Charbonneau C. Epidemiologic and socioeconomic burden of metastatic renal cell carcinoma (mRCC): a literature review. Cancer Treat Rev 34(3):193-205, 2008.
-
(2008)
Cancer Treat Rev
, vol.34
, Issue.3
, pp. 193-205
-
-
Gupta, K.1
Miller, J.D.2
Li, J.Z.3
Russell, M.W.4
Charbonneau, C.5
-
18
-
-
84879759020
-
Safety and tumor responses with lambrolizumab (anti-PD-1) in melanoma
-
Hamid O, Robert C, Daud A, Hodi FS, Hwu WJ, Kefford R, Wolchok JD, Hersey P, Joseph RW, Weber JS, Dronca R, Gangadhar TC, Patnaik A, Zarour H, Joshua AM, Gergich K, Elassaiss-Schaap J, Algazi A, Mateus C, Boasberg P, et al. Safety and tumor responses with lambrolizumab (anti-PD-1) in melanoma. N Engl J Med 369(2):134-144, 2013.
-
(2013)
N Engl J Med
, vol.369
, Issue.2
, pp. 134-144
-
-
Hamid, O.1
Robert, C.2
Daud, A.3
Hodi, F.S.4
Hwu, W.J.5
Kefford, R.6
Wolchok, J.D.7
Hersey, P.8
Joseph, R.W.9
Weber, J.S.10
Dronca, R.11
Gangadhar, T.C.12
Patnaik, A.13
Zarour, H.14
Joshua, A.M.15
Gergich, K.16
Elassaiss-Schaap, J.17
Algazi, A.18
Mateus, C.19
Boasberg, P.20
more..
-
19
-
-
84914148032
-
Phase I study of nivolumab in combination with ipilimumab in metastatic renal cell carcinoma
-
abstr 4504
-
Hammers H, Plimack ER, Infante JR, ErnstoffMS, Rini BI, Mcdermott B, Razak AR, Pal SK, Voss MH, Sharma P, Kollmannsberger C, Heng DY, Spratlin J, Shen Y, Kurland J, Gagnier P, Amin A. Phase I study of nivolumab in combination with ipilimumab in metastatic renal cell carcinoma. ASCO Annual Meeting. J Clin Oncol 32:5s (suppl; abstr 4504), 2014.
-
(2014)
ASCO Annual Meeting. J Clin Oncol
, vol.32
, pp. 5s
-
-
Hammers, H.1
Plimack, E.R.2
Infante, J.R.3
Ernstoff, M.S.4
Rini, B.I.5
Mcdermott, B.6
Razak, A.R.7
Pal, S.K.8
Voss, M.H.9
Sharma, P.10
Kollmannsberger, C.11
Heng, D.Y.12
Spratlin, J.13
Shen, Y.14
Kurland, J.15
Gagnier, P.16
Amin, A.17
-
20
-
-
77954801079
-
Improved survival with ipilimumab in patients with metastatic melanoma
-
Hodi FS, O'day SJ, Mcdermott DF, Weber RW, Sosman JA, Haanen JB, Gonzalez R, Robert C, Schadendorf D, Hassel JC. Improved survival with ipilimumab in patients with metastatic melanoma. N Engl J Med 363(8):711-723, 2010.
-
(2010)
N Engl J Med
, vol.363
, Issue.8
, pp. 711-723
-
-
Hodi, F.S.1
O'day, S.J.2
Mcdermott, D.F.3
Weber, R.W.4
Sosman, J.A.5
Haanen, J.B.6
Gonzalez, R.7
Robert, C.8
Schadendorf, D.9
Hassel, J.C.10
-
21
-
-
84888352977
-
Clinical and pharmacodynamic (PD) results of a phase I trial with AMP-224 (B7-DC Fc) that binds to the PD-1 receptor
-
abstr 3044
-
Infante JR, Powderly JD, Burris HA, Kittaneh M, Grice JH, Smothers JF, Brett S, Fleming ME, May R, Marshall S, Devenport M, Pillemer S, Pardoll DM, Chen L, Langermann S, Lorusso P. Clinical and pharmacodynamic (PD) results of a phase I trial with AMP-224 (B7-DC Fc) that binds to the PD-1 receptor. J Clin Oncol 31 (suppl; abstr 3044), 2013.
-
(2013)
J Clin Oncol
, vol.31
-
-
Infante, J.R.1
Powderly, J.D.2
Burris, H.A.3
Kittaneh, M.4
Grice, J.H.5
Smothers, J.F.6
Brett, S.7
Fleming, M.E.8
May, R.9
Marshall, S.10
Devenport, M.11
Pillemer, S.12
Pardoll, D.M.13
Chen, L.14
Langermann, S.15
Lorusso, P.16
-
22
-
-
84879579673
-
At the bench: preclinical rationale for CTLA-4 and PD-1 blockade as cancer immunotherapy
-
Intlekofer AM, Thompson CB. At the bench: preclinical rationale for CTLA-4 and PD-1 blockade as cancer immunotherapy. J Leukoc Biol 94(1):25-39, 2013.
-
(2013)
J Leukoc Biol
, vol.94
, Issue.1
, pp. 25-39
-
-
Intlekofer, A.M.1
Thompson, C.B.2
-
23
-
-
42649125225
-
PD-1 and its ligands in tolerance and immunity
-
Keir ME, Butte MJ, Freeman GJ, Sharpe AH. PD-1 and its ligands in tolerance and immunity. Annu Rev Immunol 26:677-704, 2008.
-
(2008)
Annu Rev Immunol
, vol.26
, pp. 677-704
-
-
Keir, M.E.1
Butte, M.J.2
Freeman, G.J.3
Sharpe, A.H.4
-
24
-
-
76049092889
-
Phase II trial of tremelimumab (CP-675,206) in patients with advanced refractory or relapsed melanoma
-
Kirkwood JM, Lorigan P, Hersey P, Hauschild A, Robert C, Mcdermott D, Marshall MA, Gomez-Navarro J, Liang JQ, Bulanhagui CA. Phase II trial of tremelimumab (CP-675,206) in patients with advanced refractory or relapsed melanoma. Clin Cancer Res 16(3):1042-1048, 2010.
-
(2010)
Clin Cancer Res
, vol.16
, Issue.3
, pp. 1042-1048
-
-
Kirkwood, J.M.1
Lorigan, P.2
Hersey, P.3
Hauschild, A.4
Robert, C.5
Mcdermott, D.6
Marshall, M.A.7
Gomez-Navarro, J.8
Liang, J.Q.9
Bulanhagui, C.A.10
-
25
-
-
84938313517
-
Safety and efficacy of MPDL3280A (anti-PDL1) in combination with bevacizumab (bev) and/or chemotherapy (chemo) in patients (pts) with locally advanced or metastatic solid tumors
-
abstr 1049o
-
Lieu C, Bendell J, Powderly JD, Pishvaian MJ, Hochster H, Eckhardt SG, Funke RP, Rossi C, Waterkamp D, Hurwitz H. Safety and efficacy of MPDL3280A (anti-PDL1) in combination with bevacizumab (bev) and/or chemotherapy (chemo) in patients (pts) with locally advanced or metastatic solid tumors. Ann Oncol 25 (suppl 4; abstr 1049o), 2014.
-
(2014)
Ann Oncol
, vol.25
-
-
Lieu, C.1
Bendell, J.2
Powderly, J.D.3
Pishvaian, M.J.4
Hochster, H.5
Eckhardt, S.G.6
Funke, R.P.7
Rossi, C.8
Waterkamp, D.9
Hurwitz, H.10
-
26
-
-
16644401873
-
Randomized phase III trial of high-dose interleukin-2 versus subcutaneous interleukin-2 and interferon in patients with metastatic renal cell carcinoma
-
McDermott DF, Regan MM, Clark JI, Flaherty LE, Weiss GR, Logan TF, Kirkwood JM, Gordon MS, Sosman JA, ErnstoffMS, Tretter CP, Urba WJ, Smith JW, Margolin KA, Mier JW, Gollob JA, Dutcher JP, Atkins MB. Randomized phase III trial of high-dose interleukin-2 versus subcutaneous interleukin-2 and interferon in patients with metastatic renal cell carcinoma. J Clin Oncol 23(1):133-141, 2005.
-
(2005)
J Clin Oncol
, vol.23
, Issue.1
, pp. 133-141
-
-
McDermott, D.F.1
Regan, M.M.2
Clark, J.I.3
Flaherty, L.E.4
Weiss, G.R.5
Logan, T.F.6
Kirkwood, J.M.7
Gordon, M.S.8
Sosman, J.A.9
Ernstoff, M.S.10
Tretter, C.P.11
Urba, W.J.12
Smith, J.W.13
Margolin, K.A.14
Mier, J.W.15
Gollob, J.A.16
Dutcher, J.P.17
Atkins, M.B.18
-
27
-
-
84940487291
-
Immune correlates and long term follow up of a phase Ia study of MPDL3280A, an engineered PD-L1 antibody, in patients with metastatic renal cell carcinoma (mRCC)
-
abstr 809o
-
McDermott DF, Sznol M, Sosman JA, Soria JC, Gordon MS, Hamid O, Delord JP, Fasso M, Wang Y, Bruey J, Fine GD, Powles T. Immune correlates and long term follow up of a phase Ia study of MPDL3280A, an engineered PD-L1 antibody, in patients with metastatic renal cell carcinoma (mRCC). Ann Oncol 25 (Suppl 4; abstr 809o), 2014.
-
(2014)
Ann Oncol
, vol.25
-
-
McDermott, D.F.1
Sznol, M.2
Sosman, J.A.3
Soria, J.C.4
Gordon, M.S.5
Hamid, O.6
Delord, J.P.7
Fasso, M.8
Wang, Y.9
Bruey, J.10
Fine, G.D.11
Powles, T.12
-
28
-
-
33846465547
-
Immunostimulatory monoclonal antibodies for cancer therapy
-
Melero I, Hervas-Stubbs S, Glennie M, Pardoll DM, Chen L. Immunostimulatory monoclonal antibodies for cancer therapy. Nat Rev Cancer 7(2):95-106, 2007.
-
(2007)
Nat Rev Cancer
, vol.7
, Issue.2
, pp. 95-106
-
-
Melero, I.1
Hervas-Stubbs, S.2
Glennie, M.3
Pardoll, D.M.4
Chen, L.5
-
29
-
-
84878570297
-
Phase I study of tremelimumab (CP-675 206) plus PF-3512676 (CPG 7909) in patients with melanoma or advanced solid tumours
-
Millward M, Underhill C, Lobb S, Mcburnie J, Meech SJ, Gomez-Navarro J, Marshall MA, Huang B, Mather CB. Phase I study of tremelimumab (CP-675 206) plus PF-3512676 (CPG 7909) in patients with melanoma or advanced solid tumours. Br J Cancer 108(10):1998-2004, 2013.
-
(2013)
Br J Cancer
, vol.108
, Issue.10
, pp. 1998-2004
-
-
Millward, M.1
Underhill, C.2
Lobb, S.3
Mcburnie, J.4
Meech, S.J.5
Gomez-Navarro, J.6
Marshall, M.A.7
Huang, B.8
Mather, C.B.9
-
30
-
-
84882781441
-
Pazopanib versus sunitinib in metastatic renal-cell carcinoma
-
Motzer RJ, Hutson TE, Cella D, Reeves J, Hawkins R, Guo J, Nathan P, Staehler M, De Souza P, Merchan JR, Boleti E, Fife K, Jin J, Jones R, Uemura H, De Giorgi U, Harmenberg U, Wang J, Sternberg CN, Deen K, et al. Pazopanib versus sunitinib in metastatic renal-cell carcinoma. N Engl J Med 369(8):722-731, 2013.
-
(2013)
N Engl J Med
, vol.369
, Issue.8
, pp. 722-731
-
-
Motzer, R.J.1
Hutson, T.E.2
Cella, D.3
Reeves, J.4
Hawkins, R.5
Guo, J.6
Nathan, P.7
Staehler, M.8
De Souza, P.9
Merchan, J.R.10
Boleti, E.11
Fife, K.12
Jin, J.13
Jones, R.14
Uemura, H.15
De Giorgi, U.16
Harmenberg, U.17
Wang, J.18
Sternberg, C.N.19
Deen, K.20
more..
-
31
-
-
79952787098
-
NCCN Clinical Practice Guidelines in Oncology: Kidney Cancer. Version 1. 2015
-
Accessed Oct. 1
-
Motzer RJ, Jonasch E, Agarwal N. NCCN Clinical Practice Guidelines in Oncology: Kidney Cancer. Version 1. 2015. National Comprehensive Cancer Network. http://www.nccn.org/professionals/physician_gls/f_guidelines.asp. Accessed Oct. 1, 2014.
-
(2014)
National Comprehensive Cancer Network.
-
-
Motzer, R.J.1
Jonasch, E.2
Agarwal, N.3
-
32
-
-
84921732739
-
Nivolumab for Metastatic Renal Cell Carcinoma: Results of a Randomized Phase II Trial
-
epub ahead of print, Dec. 1
-
Motzer RJ, Rini BI, McDermott DF, Redman BG, Kuzel TM, Harrison MR, Vaishampayan UN, Drabkin HA, George S, Logan TF, Margolin KA, Plimack ER, Lambert AM, Waxman IM, Hammers HJ. Nivolumab for Metastatic Renal Cell Carcinoma: Results of a Randomized Phase II Trial. J Clin Oncol, epub ahead of print, Dec. 1, 2014.
-
(2014)
J Clin Oncol
-
-
Motzer, R.J.1
Rini, B.I.2
McDermott, D.F.3
Redman, B.G.4
Kuzel, T.M.5
Harrison, M.R.6
Vaishampayan, U.N.7
Drabkin, H.A.8
George, S.9
Logan, T.F.10
Margolin, K.A.11
Plimack, E.R.12
Lambert, A.M.13
Waxman, I.M.14
Hammers, H.J.15
-
33
-
-
84940562547
-
SEER Stat Fact Sheets: Kidney and renal pelvis cancer
-
Accessed Oct. 1, 2014
-
National Cancer Institute. SEER Stat Fact Sheets: Kidney and renal pelvis cancer. Surveillance, Epidemiology, and End Results Program. 2014. http://seer.cancer.gov/statfacts/html/kidrp.html. Accessed Oct. 1, 2014.
-
(2014)
Surveillance, Epidemiology, and End Results Program
-
-
-
34
-
-
7144227930
-
Recombinant human interleukin-2, recombinant human interferon alfa-2a, or both in metastatic renal-cell carcinoma. Groupe Francais d'Immunotherapie
-
Negrier S, Escudier B, Lasset C, Douillard JY, Savary J, Chevreau C, Ravaud A, Mercatello A, Peny J, Mousseau M, Philip T, Tursz T. Recombinant human interleukin-2, recombinant human interferon alfa-2a, or both in metastatic renal-cell carcinoma. Groupe Francais d'Immunotherapie. N Engl J Med 338(18):1272-1278, 1998.
-
(1998)
N Engl J Med
, vol.338
, Issue.18
, pp. 1272-1278
-
-
Negrier, S.1
Escudier, B.2
Lasset, C.3
Douillard, J.Y.4
Savary, J.5
Chevreau, C.6
Ravaud, A.7
Mercatello, A.8
Peny, J.9
Mousseau, M.10
Philip, T.11
Tursz, T.12
-
35
-
-
36849035139
-
Targeting cytotoxic T-lymphocyte antigen-4 (CTLA-4)
-
O'Day SJ, Hamid O, Urba WJ. Targeting cytotoxic T-lymphocyte antigen-4 (CTLA-4). Cancer 110(12):2614-2627, 2007.
-
(2007)
Cancer
, vol.110
, Issue.12
, pp. 2614-2627
-
-
O'Day, S.J.1
Hamid, O.2
Urba, W.J.3
-
36
-
-
84893965118
-
Immune modulation in cancer with antibodies
-
Page DB, Postow MA, Callahan MK, Allison JP, Wolchok JD. Immune modulation in cancer with antibodies. Annu Rev Med 65:185-202, 2014.
-
(2014)
Annu Rev Med
, vol.65
, pp. 185-202
-
-
Page, D.B.1
Postow, M.A.2
Callahan, M.K.3
Allison, J.P.4
Wolchok, J.D.5
-
37
-
-
84877038380
-
Ipilimumab-induced acute severe colitis treated by infliximab
-
Pages C, Gornet JM, Monsel G, Allez M, Bertheau P, Bagot M, Lebbe C, Viguier M. Ipilimumab-induced acute severe colitis treated by infliximab. Melanoma Res 23(3):227-230, 2013.
-
(2013)
Melanoma Res
, vol.23
, Issue.3
, pp. 227-230
-
-
Pages, C.1
Gornet, J.M.2
Monsel, G.3
Allez, M.4
Bertheau, P.5
Bagot, M.6
Lebbe, C.7
Viguier, M.8
-
38
-
-
84858766182
-
The blockade of immune checkpoints in cancer immunotherapy
-
Pardoll DM. The blockade of immune checkpoints in cancer immunotherapy. Nat Rev Cancer 12(4):252-264, 2012.
-
(2012)
Nat Rev Cancer
, vol.12
, Issue.4
, pp. 252-264
-
-
Pardoll, D.M.1
-
39
-
-
77956496386
-
B7-H1/CD80 interaction is required for the induction and maintenance of peripheral T-cell tolerance
-
Park J-J, Omiya R, Matsumura Y, Sakoda Y, Kuramasu A, Augustine MM, Yao S, Tsushima F, Narazaki H, Anand S. B7-H1/CD80 interaction is required for the induction and maintenance of peripheral T-cell tolerance. Blood 116(8):1291-1298, 2010.
-
(2010)
Blood
, vol.116
, Issue.8
, pp. 1291-1298
-
-
Park, J.-J.1
Omiya, R.2
Matsumura, Y.3
Sakoda, Y.4
Kuramasu, A.5
Augustine, M.M.6
Yao, S.7
Tsushima, F.8
Narazaki, H.9
Anand, S.10
-
40
-
-
84871196652
-
Phase I study of MK-3475 (anti-PD-1 monoclonal antibody) in patients with advanced solid tumors
-
abstr 2512
-
Patnaik A, Kang SP, Tolcher AW, Rasco DW, Papadopoulos KP, Beeram M, Drengler R, Chen C, Smith L, Perez C, Gergich K, Lehnert M. Phase I study of MK-3475 (anti-PD-1 monoclonal antibody) in patients with advanced solid tumors. J Clin Oncol 30 (suppl; abstr 2512), 2012.
-
(2012)
J Clin Oncol
, vol.30
-
-
Patnaik, A.1
Kang, S.P.2
Tolcher, A.W.3
Rasco, D.W.4
Papadopoulos, K.P.5
Beeram, M.6
Drengler, R.7
Chen, C.8
Smith, L.9
Perez, C.10
Gergich, K.11
Lehnert, M.12
-
41
-
-
84907543029
-
Efficacy and safety of the anti-PD-1 monoclonal antibody MK-3475 in 411 patients (pts) with melanoma (MEL)
-
abstr LBA9000
-
Ribas A, Hodi FS, Kefford R, Hamid O, Daud A, Wolchok JD, Hwu WJ, Gangadhar TC, Patnaik A, Joshua AM, Hersey P, Weber JS, Dronca R, Zarour H, Gergich K, Li XN, Iannone R, Kang SP, Ebbinghaus SW, Robert C. Efficacy and safety of the anti-PD-1 monoclonal antibody MK-3475 in 411 patients (pts) with melanoma (MEL). J Clin Oncol 32:5s (suppl; abstr LBA9000), 2014.
-
(2014)
J Clin Oncol
, vol.32
, pp. 5s
-
-
Ribas, A.1
Hodi, F.S.2
Kefford, R.3
Hamid, O.4
Daud, A.5
Wolchok, J.D.6
Hwu, W.J.7
Gangadhar, T.C.8
Patnaik, A.9
Joshua, A.M.10
Hersey, P.11
Weber, J.S.12
Dronca, R.13
Zarour, H.14
Gergich, K.15
Li, X.N.16
Iannone, R.17
Kang, S.P.18
Ebbinghaus, S.W.19
Robert, C.20
more..
-
42
-
-
84874605864
-
Phase III randomized clinical trial comparing tremelimumab with standard-of-care chemotherapy in patients with advanced melanoma
-
Ribas A, Kefford R, Marshall MA, Punt CJ, Haanen JB, Marmol M, Garbe C, Gogas H, Schachter J, Linette G, Lorigan P, Kendra KL, Maio M, Trefzer U, Smylie M, Mcarthur GA, Dreno B, Nathan PD, Mackiewicz J, Kirkwood JM, et al. Phase III randomized clinical trial comparing tremelimumab with standard-of-care chemotherapy in patients with advanced melanoma. J Clin Oncol 31(5):616-622, 2013.
-
(2013)
J Clin Oncol
, vol.31
, Issue.5
, pp. 616-622
-
-
Ribas, A.1
Kefford, R.2
Marshall, M.A.3
Punt, C.J.4
Haanen, J.B.5
Marmol, M.6
Garbe, C.7
Gogas, H.8
Schachter, J.9
Linette, G.10
Lorigan, P.11
Kendra, K.L.12
Maio, M.13
Trefzer, U.14
Smylie, M.15
Mcarthur, G.A.16
Dreno, B.17
Nathan, P.D.18
Mackiewicz, J.19
Kirkwood, J.M.20
more..
-
43
-
-
79551717184
-
Phase 1 dose-escalation trial of tremelimumab plus sunitinib in patients with metastatic renal cell carcinoma
-
Rini BI, Stein M, Shannon P, Eddy S, Tyler A, Stephenson JJ Jr, Catlett L, Huang B, Healey D, Gordon M. Phase 1 dose-escalation trial of tremelimumab plus sunitinib in patients with metastatic renal cell carcinoma. Cancer 117(4):758-767, 2011.
-
(2011)
Cancer
, vol.117
, Issue.4
, pp. 758-767
-
-
Rini, B.I.1
Stein, M.2
Shannon, P.3
Eddy, S.4
Tyler, A.5
Stephenson, J.J.6
Catlett, L.7
Huang, B.8
Healey, D.9
Gordon, M.10
-
44
-
-
84908354848
-
Anti-programmed-death-receptor-1 treatment with pembrolizumab in ipilimumab-refractory advanced melanoma: a randomised dose-comparison cohort of a phase 1 trial
-
Robert C, Ribas A, Wolchok JD, Hodi FS, Hamid O, Kefford R, Weber JS, Joshua AM, Hwu WJ, Gangadhar TC, Patnaik A, Dronca R, Zarour H, Joseph RW, Boasberg P, Chmielowski B, Mateus C, Postow MA, Gergich K, Elassaiss-Schaap J, et al. Anti-programmed-death-receptor-1 treatment with pembrolizumab in ipilimumab-refractory advanced melanoma: a randomised dose-comparison cohort of a phase 1 trial. Lancet 384(9948):1109-1117, 2014.
-
(2014)
Lancet
, vol.384
, Issue.9948
, pp. 1109-1117
-
-
Robert, C.1
Ribas, A.2
Wolchok, J.D.3
Hodi, F.S.4
Hamid, O.5
Kefford, R.6
Weber, J.S.7
Joshua, A.M.8
Hwu, W.J.9
Gangadhar, T.C.10
Patnaik, A.11
Dronca, R.12
Zarour, H.13
Joseph, R.W.14
Boasberg, P.15
Chmielowski, B.16
Mateus, C.17
Postow, M.A.18
Gergich, K.19
Elassaiss-Schaap, J.20
more..
-
45
-
-
79959772576
-
Ipilimumab plus dacarbazine for previously untreated metastatic melanoma
-
Robert C, Thomas L, Bondarenko I, O'day S, M DJ, Garbe C, Lebbe C, Baurain JF, Testori A, Grob JJ, Davidson N, Richards J, Maio M, Hauschild A, Miller WH Jr, Gascon P, Lotem M, Harmankaya K, Ibrahim R, Francis S, et al. Ipilimumab plus dacarbazine for previously untreated metastatic melanoma. N Engl J Med 364(26):2517-2526, 2011.
-
(2011)
N Engl J Med
, vol.364
, Issue.26
, pp. 2517-2526
-
-
Robert, C.1
Thomas, L.2
Bondarenko, I.3
O'day, S.4
Dj, M.5
Garbe, C.6
Lebbe, C.7
Baurain, J.F.8
Testori, A.9
Grob, J.J.10
Davidson, N.11
Richards, J.12
Maio, M.13
Hauschild, A.14
Miller, W.H.15
Gascon, P.16
Lotem, M.17
Harmankaya, K.18
Ibrahim, R.19
Francis, S.20
more..
-
46
-
-
84873494926
-
Cautious optimism surrounds early clinical data for PD-1 blocker
-
Sheridan C. Cautious optimism surrounds early clinical data for PD-1 blocker. Nat Biotechnol 30(8):729-730, 2012.
-
(2012)
Nat Biotechnol
, vol.30
, Issue.8
, pp. 729-730
-
-
Sheridan, C.1
-
47
-
-
84856069688
-
Safety and efficacy of combination immunotherapy with interferon alfa-2b and tremelimumab in patients with stage IV melanoma
-
Tarhini AA, Cherian J, Moschos SJ, Tawbi HA, Shuai Y, Gooding WE, Sander C, Kirkwood JM. Safety and efficacy of combination immunotherapy with interferon alfa-2b and tremelimumab in patients with stage IV melanoma. J Clin Oncol 30(3):322-328, 2012.
-
(2012)
J Clin Oncol
, vol.30
, Issue.3
, pp. 322-328
-
-
Tarhini, A.A.1
Cherian, J.2
Moschos, S.J.3
Tawbi, H.A.4
Shuai, Y.5
Gooding, W.E.6
Sander, C.7
Kirkwood, J.M.8
-
48
-
-
84859158384
-
Targeting the PD-1/B7-H1(PD-L1) pathway to activate anti-tumor immunity
-
Topalian SL, Drake CG, Pardoll DM. Targeting the PD-1/B7-H1(PD-L1) pathway to activate anti-tumor immunity. Curr Opin Immunol 24(2):207-212, 2012a.
-
(2012)
Curr Opin Immunol
, vol.24
, Issue.2
, pp. 207-212
-
-
Topalian, S.L.1
Drake, C.G.2
Pardoll, D.M.3
-
49
-
-
84862859820
-
Safety, activity, and immune correlates of anti-PD-1 antibody in cancer
-
Topalian SL, Hodi FS, Brahmer JR, Gettinger SN, Smith DC, Mcdermott DF, Powderly JD, Carvajal RD, Sosman JA, Atkins MB, Leming PD, Spigel DR, Antonia SJ, Horn L, Drake CG, Pardoll DM, Chen L, Sharfman WH, Anders RA, Taube JM, et al. Safety, activity, and immune correlates of anti-PD-1 antibody in cancer. N Engl J Med 366(26):2443-2454, 2012b.
-
(2012)
N Engl J Med
, vol.366
, Issue.26
, pp. 2443-2454
-
-
Topalian, S.L.1
Hodi, F.S.2
Brahmer, J.R.3
Gettinger, S.N.4
Smith, D.C.5
Mcdermott, D.F.6
Powderly, J.D.7
Carvajal, R.D.8
Sosman, J.A.9
Atkins, M.B.10
Leming, P.D.11
Spigel, D.R.12
Antonia, S.J.13
Horn, L.14
Drake, C.G.15
Pardoll, D.M.16
Chen, L.17
Sharfman, W.H.18
Anders, R.A.19
Taube, J.M.20
more..
-
50
-
-
0028791059
-
Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4
-
Waterhouse P, Penninger JM, Timms E, Wakeham A, Shahinian A, Lee KP, Thompson CB, Griesser H, Mak TW. Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4. Science 270(5238):985-988, 1995.
-
(1995)
Science
, vol.270
, Issue.5238
, pp. 985-988
-
-
Waterhouse, P.1
Penninger, J.M.2
Timms, E.3
Wakeham, A.4
Shahinian, A.5
Lee, K.P.6
Thompson, C.B.7
Griesser, H.8
Mak, T.W.9
-
51
-
-
84864052441
-
Management of immune-related adverse events and kinetics of response with ipilimumab
-
Weber JS, Kähler KC, Hauschild A. Management of immune-related adverse events and kinetics of response with ipilimumab. J Clin Oncol 30(21):2691-2697, 2012.
-
(2012)
J Clin Oncol
, vol.30
, Issue.21
, pp. 2691-2697
-
-
Weber, J.S.1
Kähler, K.C.2
Hauschild, A.3
-
52
-
-
84925622262
-
A phase 3 randomized, open-label study of nivolumab (anti-PD-1; BMS-936558; ONO-4538) versus investigator's choice chemotherapy (ICC) in patients with advanced melanoma after prior anti-CTLA-4 therapy
-
Abstract #LBA3_PR
-
Weber JS, Minor DR, D'Angelo S, Hodi FS, Gutzmer R, Neyns B, Hoeller C, Khushalani NI, Miller WH, Grob J, Lao C, Linette G, Grossmann K, Hassel J, Lorigan P, Maio M, Sznol M, Lambert A, Yang A, Larkin J. A phase 3 randomized, open-label study of nivolumab (anti-PD-1; BMS-936558; ONO-4538) versus investigator's choice chemotherapy (ICC) in patients with advanced melanoma after prior anti-CTLA-4 therapy. ESMO Annual Meetings. Abstract #LBA3_PR. 2014.
-
(2014)
ESMO Annual Meetings
-
-
Weber, J.S.1
Minor, D.R.2
D'Angelo, S.3
Hodi, F.S.4
Gutzmer, R.5
Neyns, B.6
Hoeller, C.7
Khushalani, N.I.8
Miller, W.H.9
Grob, J.10
Lao, C.11
Linette, G.12
Grossmann, K.13
Hassel, J.14
Lorigan, P.15
Maio, M.16
Sznol, M.17
Lambert, A.18
Yang, A.19
Larkin, J.20
more..
-
53
-
-
84891373595
-
Safety and activity of PD1 blockade by pidilizumab in combination with rituximab in patients with relapsed follicular lymphoma: a single group, open-label, phase 2 trial
-
Westin JR, Chu F, Zhang M, Fayad LE, Kwak LW, Fowler N, Romaguera J, Hagemeister F, Fanale M, Samaniego F, Feng L, Baladandayuthapani V, Wang Z, Ma W, Gao Y, Wallace M, Vence LM, Radvanyi L, Muzzafar T, Rotem-Yehudar R, et al. Safety and activity of PD1 blockade by pidilizumab in combination with rituximab in patients with relapsed follicular lymphoma: a single group, open-label, phase 2 trial. Lancet Oncol 15(1):69-77, 2014.
-
(2014)
Lancet Oncol
, vol.15
, Issue.1
, pp. 69-77
-
-
Westin, J.R.1
Chu, F.2
Zhang, M.3
Fayad, L.E.4
Kwak, L.W.5
Fowler, N.6
Romaguera, J.7
Hagemeister, F.8
Fanale, M.9
Samaniego, F.10
Feng, L.11
Baladandayuthapani, V.12
Wang, Z.13
Ma, W.14
Gao, Y.15
Wallace, M.16
Vence, L.M.17
Radvanyi, L.18
Muzzafar, T.19
Rotem-Yehudar, R.20
more..
-
54
-
-
84879777241
-
Nivolumab plus ipilimumab in advanced melanoma
-
Wolchok JD, Kluger H, Callahan MK, Postow MA, Rizvi NA, Lesokhin AM, Segal NH, Ariyan CE, Gordon RA, Reed K, Burke MM, Caldwell A, Kronenberg SA, Agunwamba BU, Zhang X, Lowy I, Inzunza HD, Feely W, Horak CE, Hong Q, et al. Nivolumab plus ipilimumab in advanced melanoma. N Engl J Med 369(2):122-133, 2013.
-
(2013)
N Engl J Med
, vol.369
, Issue.2
, pp. 122-133
-
-
Wolchok, J.D.1
Kluger, H.2
Callahan, M.K.3
Postow, M.A.4
Rizvi, N.A.5
Lesokhin, A.M.6
Segal, N.H.7
Ariyan, C.E.8
Gordon, R.A.9
Reed, K.10
Burke, M.M.11
Caldwell, A.12
Kronenberg, S.A.13
Agunwamba, B.U.14
Zhang, X.15
Lowy, I.16
Inzunza, H.D.17
Feely, W.18
Horak, C.E.19
Hong, Q.20
more..
-
55
-
-
37349072460
-
Ipilimumab (anti-CTLA4 antibody) causes regression of metastatic renal cell cancer associated with enteritis and hypophysitis
-
Yang JC, Hughes M, Kammula U, Royal R, Sherry RM, Topalian SL, Suri KB, Levy C, Allen T, Mavroukakis S, Lowy I, White DE, Rosenberg SA. Ipilimumab (anti-CTLA4 antibody) causes regression of metastatic renal cell cancer associated with enteritis and hypophysitis. J Immunother 30(8):825-830, 2007.
-
(2007)
J Immunother
, vol.30
, Issue.8
, pp. 825-830
-
-
Yang, J.C.1
Hughes, M.2
Kammula, U.3
Royal, R.4
Sherry, R.M.5
Topalian, S.L.6
Suri, K.B.7
Levy, C.8
Allen, T.9
Mavroukakis, S.10
Lowy, I.11
White, D.E.12
Rosenberg, S.A.13
-
56
-
-
44349150012
-
Inhibitory B7-family molecules in the tumour microenvironment
-
Zou W, Chen L. Inhibitory B7-family molecules in the tumour microenvironment. Nat Rev Immunol 8(6):467-477, 2008.
-
(2008)
Nat Rev Immunol
, vol.8
, Issue.6
, pp. 467-477
-
-
Zou, W.1
Chen, L.2
|