An insight into the relationships between prohepcidin, iron deficiency anemia, and interleukin-6 values in pediatric Helicobacter pylori gastritis

European Journal of Pediatrics

Volumn 174, Issue 7, 2015, Pages 903-910

  Emiralioglu, Nagehan ^a   Yenicesu, Idil ^b   Sari, Sinan ^b   Egritas, Odul ^b   Poyraz, Aylar ^b   Pasaoglu, Ozge Tugce ^b   Celik, Bulent ^b   Dalgic, Buket ^b  

^a HACETTEPE UNIVERSITY   (Turkey)

^b GAZI UNIVERSITY   (Turkey)

Author keywords

Gastritis; Helicobacter pylori; Iron deficiency anemia; Prohepcidin

Indexed keywords

FERRITIN; HEPCIDIN; INTERLEUKIN 6; PROHEPCIDIN; ANTIINFECTIVE AGENT; HEMOGLOBIN; PROTON PUMP INHIBITOR;

ADOLESCENT; ANTIBIOTIC THERAPY; ARTICLE; BLOOD CELL COUNT; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; ERADICATION THERAPY; FEMALE; FERRITIN BLOOD LEVEL; GASTROINTESTINAL ENDOSCOPY; HELICOBACTER INFECTION; HELICOBACTER PYLORI; HEMATOCRIT; HEMOGLOBIN BLOOD LEVEL; HUMAN; IRON BINDING CAPACITY; IRON BLOOD LEVEL; IRON DEFICIENCY ANEMIA; IRON METABOLISM; MALE; MEAN CORPUSCULAR VOLUME; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; ANEMIA, IRON-DEFICIENCY; BLOOD; CASE CONTROL STUDY; COMPLICATION; GASTRITIS; HELICOBACTER INFECTIONS; MICROBIOLOGY;

ADOLESCENT; ANEMIA, IRON-DEFICIENCY; ANTI-BACTERIAL AGENTS; CASE-CONTROL STUDIES; CHILD; ERYTHROCYTE INDICES; FEMALE; FERRITINS; GASTRITIS; HELICOBACTER INFECTIONS; HELICOBACTER PYLORI; HEMATOCRIT; HEMOGLOBINS; HEPCIDINS; HUMANS; INTERLEUKIN-6; MALE; PROTON PUMP INHIBITORS;

EID: 84931566122     PISSN: 03406199     EISSN: 14321076     Source Type: Journal    
DOI: 10.1007/s00431-014-2482-4     Document Type: Article

References (37)

1. Barabino A (2002) Helicobacter pylori-related iron deficiency anemia: a review. Helicobacter 7(2):71–75
2. Barabino A, Dufour C, Marino CE, Claudiani F, De Alessandri A (1999) Unexplained refractory iron-deficiency anemia associated with Helicobacter pylori gastric infection in children: further clinical evidence. J Pediatr Gastroenterol Nutr 28(1):116–119
3. Baysoy G, Ertem D, Ademoglu E, Kotiloglu E, Keskin S, Pehlivanoglu E (2004) Gastric histopathology, iron status and iron deficiency anemia in children with Helicobacter pylori infection. J Pediatr Gastroenterol Nutr 38(2):146–151
4. Beutler E (2007) Hepcidin mimetics from microorganisms? A possible explanation for the effect of Helicobacter pylori on iron homeostasis. Blood Cells Mol Dis 38(1):54–55, discussion 56
5. Bohr UR, Annibale B, Franceschi F, Roccarina D, Gasbarrini A (2007) Extragastric manifestations of Helicobacter pylori infection—other Helicobacters. Helicobacter 12(Suppl 1):45–53
6. Caliskan Y, Yelken B, Ozkok A, Gorgulu N, Yazici H, Telci A, Yildiz A (2012) Lower serum prohepcidin levels associated with lower iron and erythropoietin requirements in hemodialysis patients with chronic hepatitis C. BMC Nephrol 13:56
7. Capurso G, Lahner E, Marcheggiano A, Caruana P, Carnuccio A, Bordi C, Delle Fave G, Annibale B (2001) Involvement of the corporal mucosa and related changes in gastric acid secretion characterize patients with iron deficiency anaemia associated with Helicobacter pylori infection. Aliment Pharmacol Ther 15(11):1753–1761
8. Cardenas VM, Mulla ZD, Ortiz M, Graham DY (2006) Iron deficiency and Helicobacter pylori infection in the United States. Am J Epidemiol 163(2):127–134
9. Cherian S, Forbes DA, Cook AG, Sanfilippo FM, Kemna EH, Swinkels DW, Burgner DP (2008) An insight into the relationships between hepcidin, anemia, infections and inflammatory cytokines in pediatric refugees: a cross-sectional study. PLoS ONE 3(12):e4030
10. Costa E, Swinkels DW, Laarakkers CM, Rocha-Pereira P, Rocha S, Reis F, Teixeira F, Miranda V, do Sameiro Faria M, Loureiro A, Quintanilha A, Belo L, Santos-Silva A (2009) Hepcidin serum levels and resistance to recombinant human erythropoietin therapy in haemodialysis patients. Acta Haematol 122(4):226–229
11. Dallalio G, Fleury T, Means RT (2003) Serum hepcidin in clinical specimens. Br J Haematol 122(6):996–1000
12. Dogan Y, Erkan T, Onal Z, Usta M, Dogusoy G, Cokugras FC, Kutlu T (2012) Lactoferrin levels in the gastric tissue of Helicobacter pylori-positive and -negative patients and its effect on anemia. Mediat Inflamm 2012:214581
13. DuBois S, Kearney DJ (2005) Iron-deficiency anemia and Helicobacter pylori infection: a review of the evidence. Am J Gastroenterol 100(2):453–459
14. Figura N, Franceschi F, Santucci A, Bernardini G, Gasbarrini G, Gasbarrini A (2010) Extragastric manifestations of Helicobacter pylori infection. Helicobacter 15(Suppl 1):60–68
15. Ganz T, Nemeth E (2011) The hepcidin-ferroportin system as a therapeutic target in anemias and iron overload disorders. Hematology Am Soc Hematol Educ Program 2011:538–542
16. Ganz T, Olbina G, Girelli D, Nemeth E, Westerman M (2008) Immunoassay for human serum hepcidin. Blood 112(10):4292–4297
17. Ge R, Sun X (2012) Iron trafficking system in Helicobacter pylori. Biometals 25(2):247–258
18. Goddard AF, James MW, McIntyre AS, Scott BB (2011) Guidelines for the management of iron deficiency anaemia. Gut 60(10):1309–1316
19. Hershko C, Ronson A (2009) Iron deficiency, Helicobacter infection and gastritis. Acta Haematol 122(2–3):97–102
20. Kemna EH, Tjalsma H, Podust VN, Swinkels DW (2007) Mass spectrometry-based hepcidin measurements in serum and urine: analytical aspects and clinical implications. Clin Chem 53(4):620–628
21. Kulaksiz H, Gehrke SG, Janetzko A, Rost D, Bruckner T, Kallinowski B, Stremmel W (2004) Pro-hepcidin: expression and cell specific localisation in the liver and its regulation in hereditary haemochromatosis, chronic renal insufficiency, and renal anaemia. Gut 53(5):735–743
22. Lee SY, Song EY, Yun YM, Yoon SY, Cho YH, Kim SY, Lee MH (2010) Serum prohepcidin levels in Helicobacter pylori-infected patients with iron deficiency anemia. Korean J Intern Med 25(2):195–200
23. Murphy AT, Witcher DR, Luan P, Wroblewski VJ (2007) Quantitation of hepcidin from human and mouse serum using liquid chromatography tandem mass spectrometry. Blood 110(3):1048–1054
24. Oustamanolakis P, Koutroubakis IE, Messaritakis I, Malliaraki N, Sfiridaki A, Kouroumalis EA (2011) Serum hepcidin and prohepcidin concentrations in inflammatory bowel disease. Eur J Gastroenterol Hepatol 23(3):262–268
25. Ozkasap S, Yarali N, Isik P, Bay A, Kara A, Tunc B (2013) The role of prohepcidin in anemia due to Helicobacter pylori infection. Pediatr Hematol Oncol 30:425–431
26. Pacifico L, Anania C, Osborn JF, Ferraro F, Chiesa C (2010) Consequences of Helicobacter pylori infection in children. World J Gastroenterol 16(41):5181–5194
27. Pellicano R, Rizzetto M (2004) Is hepcidin the bridge linking Helicobacter pylori and anemia of chronic infection? A research proposal. Panminerva Med 46(3):165–169
28. Rasquin A, Di Lorenzo C, Forbes D, Guiraldes E, Hyams JS, Staiano A, Walker LS (2006) Childhood functional gastrointestinal disorders: child/adolescent. Gastroenterology 130(5):1527–1537
29. Realdi G, Dore MP, Fastame L (1999) Extradigestive manifestations of Helicobacter pylori infection: fact and fiction. Dig Dis Sci 44(2):229–236
30. Sato Y, Yoneyama O, Azumaya M, Takeuchi M, Sasaki SY, Yokoyama J, Shioji K, Kawauchi Y, Hashimoto S, Nishigaki Y, Kobayashi M, Sugimura K, Honma T, Narisawa R, Aoyagi Y (2014) The relationship between iron deficiency in patients with Helicobacter pylori-infected nodular gastritis and the serum prohepcidin level. Helicobacter. doi:10.1111/hel.12170
31. Schwarz P, Kubler JA, Strnad P, Muller K, Barth TF, Gerloff A, Feick P, Peyssonnaux C, Vaulont S, Adler G, Kulaksiz H (2012) Hepcidin is localised in gastric parietal cells, regulates acid secretion and is induced by Helicobacter pylori infection. Gut 61(2):193–201
32. Schwarz P, Strnad P, von Figura G, Janetzko A, Krayenbuhl P, Adler G, Kulaksiz H (2011) A novel monoclonal antibody immunoassay for the detection of human serum hepcidin. J Gastroenterol 46(5):648–656
33. Suzuki H, Franceschi F, Nishizawa T, Gasbarrini A (2011) Extragastric manifestations of Helicobacter pylori infection. Helicobacter 16(Suppl 1):65–69
34. Theil EC (2011) Iron homeostasis and nutritional iron deficiency. J Nutr 141(4):724S–728S
35. Wilson DB (2009) Disorders of iron metabolism and sideroblastic anemia. In: Orkin SH, Nathan DG, Ginsburg D, Look AT, Fisher DE, Lux SE (eds) Nathan and Oski’s hematology of infancy and childhood, 7th edn. Saunders, Philadelphia, pp 522–542
36. Xia W, Zhang X, Wang J, Sun C, Wu L (2012) Survey of anaemia and Helicobacter pylori infection in adolescent girls in Suihua, China, and enhancement of iron intervention effects by H. pylori eradication. Br J Nutr 108(2):357–362
37. Young MF, Glahn RP, Ariza-Nieto M, Inglis J, Olbina G, Westerman M, O’Brien KO (2009) Serum hepcidin is significantly associated with iron absorption from food and supplemental sources in healthy young women. Am J Clin Nutr 89(2):533–538