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Volumn 141, Issue 8, 2015, Pages 1417-1425

Comparison of the expression levels of molecular markers among the peripheral area and central area of primary tumor and metastatic lymph node tumor in patients with squamous cell carcinoma of the lung

Author keywords

Heterogeneity; Immunohistochemistry; Lung cancer; Postoperative prognosis; Squamous cell carcinoma

Indexed keywords

ALDEHYDE DEHYDROGENASE ISOENZYME 1; CALVASCULIN; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR 2; FIBROBLAST GROWTH FACTOR RECEPTOR 1; HERMES ANTIGEN; HUMAN EPIDERMAL GROWTH FACTOR RECEPTOR 2; TRANSCRIPTION FACTOR SOX2; TUMOR MARKER; UNCLASSIFIED DRUG; UVOMORULIN; VASCULOTROPIN RECEPTOR 2; TUMOR MARKERS, BIOLOGICAL;

EID: 84931561864     PISSN: 01715216     EISSN: 14321335     Source Type: Journal    
DOI: 10.1007/s00432-015-1912-7     Document Type: Article
Times cited : (7)

References (32)
  • 1
    • 1542619697 scopus 로고    scopus 로고
    • HER-2/neu (c-erbB-2) evaluation in primary breast carcinoma by fluorescent in situ hybridization and immunohistochemistry with special focus on intratumor heterogeneity and comparison of invasive and in situ components
    • PID: 15163013
    • Andersson J, Linderholm B, Bergh J, Elmberger G (2004) HER-2/neu (c-erbB-2) evaluation in primary breast carcinoma by fluorescent in situ hybridization and immunohistochemistry with special focus on intratumor heterogeneity and comparison of invasive and in situ components. Appl Immunohistochem Mol Morphol 12:14–20
    • (2004) Appl Immunohistochem Mol Morphol , vol.12 , pp. 14-20
    • Andersson, J.1    Linderholm, B.2    Bergh, J.3    Elmberger, G.4
  • 2
    • 84903994596 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition in lung development and disease: does it exist and is it important?
    • PID: 24334519
    • Bartis D, Mise N, Mahida RY, Eickelberg O, Thickett DR (2013) Epithelial-mesenchymal transition in lung development and disease: does it exist and is it important? Thorax. doi:10.1136/thoraxjnl-2013-204608
    • (2013) Thorax
    • Bartis, D.1    Mise, N.2    Mahida, R.Y.3    Eickelberg, O.4    Thickett, D.R.5
  • 3
    • 84899038560 scopus 로고    scopus 로고
    • The prognostic value of SOX2 expression in non-small cell lung cancer: a meta-analysis
    • COI: 1:CAS:528:DC%2BC3sXhtlGjtLnP, PID: 23990933
    • Chen Y, Huang Y, Huang Y, Chen J, Wang S, Zhou J (2013) The prognostic value of SOX2 expression in non-small cell lung cancer: a meta-analysis. PLoS ONE 8:e71140. doi:10.1371/journal.pone.0071140
    • (2013) PLoS ONE , vol.8 , pp. e71140
    • Chen, Y.1    Huang, Y.2    Huang, Y.3    Chen, J.4    Wang, S.5    Zhou, J.6
  • 4
    • 0031981414 scopus 로고    scopus 로고
    • CD44 and CD44v6 downregulation in clinical prostatic carcinoma: relation to Gleason grade and cytoarchitecture
    • PID: 9492843
    • De Marzo AM, Bradshaw C, Sauvageot J, Epstein JI, Miller GJ (1998) CD44 and CD44v6 downregulation in clinical prostatic carcinoma: relation to Gleason grade and cytoarchitecture. Prostate 34:162–168
    • (1998) Prostate , vol.34 , pp. 162-168
    • De Marzo, A.M.1    Bradshaw, C.2    Sauvageot, J.3    Epstein, J.I.4    Miller, G.J.5
  • 5
    • 84898834589 scopus 로고    scopus 로고
    • EGFR expression in vulvar cancer: clinical implications and tumor heterogeneity
    • PID: 24746196
    • de Melo Maia B et al (2014) EGFR expression in vulvar cancer: clinical implications and tumor heterogeneity. Hum Pathol 45:917–925. doi:10.1016/j.humpath.2014.01.015
    • (2014) Hum Pathol , vol.45 , pp. 917-925
    • de Melo Maia, B.1
  • 6
    • 4644278868 scopus 로고    scopus 로고
    • Altered E-cadherin and epidermal growth factor receptor expressions are associated with patient survival in lung cancer: a study utilizing high-density tissue microarray and immunohistochemistry
    • COI: 1:CAS:528:DC%2BD2cXmsVOitrY%3D, PID: 14739904
    • Deeb G, Wang J, Ramnath N, Slocum HK, Wiseman S, Beck A, Tan D (2004) Altered E-cadherin and epidermal growth factor receptor expressions are associated with patient survival in lung cancer: a study utilizing high-density tissue microarray and immunohistochemistry. Mod Pathol 17:430–439. doi:10.1038/modpathol.3800041
    • (2004) Mod Pathol , vol.17 , pp. 430-439
    • Deeb, G.1    Wang, J.2    Ramnath, N.3    Slocum, H.K.4    Wiseman, S.5    Beck, A.6    Tan, D.7
  • 7
    • 84884640093 scopus 로고    scopus 로고
    • Correlation of breast cancer axillary lymph node metastases with stem cell mutations
    • PID: 23884447
    • Donovan CA et al (2013) Correlation of breast cancer axillary lymph node metastases with stem cell mutations. JAMA Surg 148:873–878. doi:10.1001/jamasurg.2013.3028
    • (2013) JAMA Surg , vol.148 , pp. 873-878
    • Donovan, C.A.1
  • 8
    • 33746932547 scopus 로고    scopus 로고
    • E-cadherin expression pattern in primary colorectal carcinomas and their metastases reflects disease outcome
    • COI: 1:CAS:528:DC%2BD28XptVamu78%3D, PID: 16865770
    • Elzagheid A et al (2006) E-cadherin expression pattern in primary colorectal carcinomas and their metastases reflects disease outcome. World J Gastroenterol 12:4304–4309
    • (2006) World J Gastroenterol , vol.12 , pp. 4304-4309
    • Elzagheid, A.1
  • 9
    • 0028851930 scopus 로고
    • CD44 isoforms correlate with cellular differentiation but not with prognosis in human breast cancer
    • COI: 1:STN:280:DyaK28%2Fmt1ajtw%3D%3D, PID: 7585612
    • Friedrichs K et al (1995) CD44 isoforms correlate with cellular differentiation but not with prognosis in human breast cancer. Cancer Res 55:5424–5433
    • (1995) Cancer Res , vol.55 , pp. 5424-5433
    • Friedrichs, K.1
  • 10
    • 0037663758 scopus 로고    scopus 로고
    • Clinicopathologic characteristics of peripheral squamous cell carcinoma of the lung
    • PID: 12826890
    • Funai K et al (2003) Clinicopathologic characteristics of peripheral squamous cell carcinoma of the lung. Am J Surg Pathol 27:978–984
    • (2003) Am J Surg Pathol , vol.27 , pp. 978-984
    • Funai, K.1
  • 11
    • 84873197678 scopus 로고    scopus 로고
    • Frequent intratumoral heterogeneity of EGFR gene copy gain in non-small cell lung cancer
    • PID: 23238037
    • Grob TJ et al (2013) Frequent intratumoral heterogeneity of EGFR gene copy gain in non-small cell lung cancer. Lung Cancer 79:221–227. doi:10.1016/j.lungcan.2012.11.009
    • (2013) Lung Cancer , vol.79 , pp. 221-227
    • Grob, T.J.1
  • 12
    • 33646860505 scopus 로고    scopus 로고
    • Comparison of the epidermal growth factor receptor gene and protein in primary non-small-cell-lung cancer and metastatic sites: implications for treatment with EGFR-inhibitors
    • COI: 1:STN:280:DC%2BD283nslegtQ%3D%3D, PID: 16524970
    • Italiano A et al (2006) Comparison of the epidermal growth factor receptor gene and protein in primary non-small-cell-lung cancer and metastatic sites: implications for treatment with EGFR-inhibitors. Ann Oncol 17:981–985. doi:10.1093/annonc/mdl038
    • (2006) Ann Oncol , vol.17 , pp. 981-985
    • Italiano, A.1
  • 13
    • 84873098547 scopus 로고    scopus 로고
    • Ly6/uPAR-related protein C4.4A as a marker of solid growth pattern and poor prognosis in lung adenocarcinoma
    • COI: 1:CAS:528:DC%2BC3sXht1Kmsrc%3D, PID: 23287851
    • Jacobsen B et al (2013) Ly6/uPAR-related protein C4.4A as a marker of solid growth pattern and poor prognosis in lung adenocarcinoma. J Thorac Oncol 8:152–160. doi:10.1097/JTO.0b013e318279d503
    • (2013) J Thorac Oncol , vol.8 , pp. 152-160
    • Jacobsen, B.1
  • 14
    • 84892803927 scopus 로고    scopus 로고
    • Changes in epidermal growth factor receptor expression during chemotherapy in non-small cell lung cancer
    • COI: 1:CAS:528:DC%2BC3sXhvFCqsLvL, PID: 24326616
    • Jakobsen JN, Santoni-Rugiu E, Sorensen JB (2014) Changes in epidermal growth factor receptor expression during chemotherapy in non-small cell lung cancer. Cancer Chemother Pharmacol 73:131–137. doi:10.1007/s00280-013-2329-0
    • (2014) Cancer Chemother Pharmacol , vol.73 , pp. 131-137
    • Jakobsen, J.N.1    Santoni-Rugiu, E.2    Sorensen, J.B.3
  • 15
    • 84893501411 scopus 로고    scopus 로고
    • Identification of biological properties of intralymphatic tumor related to the development of lymph node metastasis in lung adenocarcinoma
    • PID: 24376714
    • Kirita K et al (2013) Identification of biological properties of intralymphatic tumor related to the development of lymph node metastasis in lung adenocarcinoma. PLoS ONE 8:e83537. doi:10.1371/journal.pone.0083537
    • (2013) PLoS ONE , vol.8 , pp. e83537
    • Kirita, K.1
  • 16
    • 84879805580 scopus 로고    scopus 로고
    • High EpCAM expression is linked to proliferation and lauren classification in gastric cancer
    • PID: 23830302
    • Kroepil F et al (2013) High EpCAM expression is linked to proliferation and lauren classification in gastric cancer. BMC Res Notes 6:253. doi:10.1186/1756-0500-6-253
    • (2013) BMC Res Notes , vol.6 , pp. 253
    • Kroepil, F.1
  • 17
    • 84879066522 scopus 로고    scopus 로고
    • Combined aberrant expression of E-cadherin and S100A4, but not beta-catenin is associated with disease-free survival and overall survival in colorectal cancer patients
    • COI: 1:CAS:528:DC%2BC3sXht1ygurvM, PID: 23783026
    • Lee SJ et al (2013) Combined aberrant expression of E-cadherin and S100A4, but not beta-catenin is associated with disease-free survival and overall survival in colorectal cancer patients. Diagn Pathol 8:99. doi:10.1186/1746-1596-8-99
    • (2013) Diagn Pathol , vol.8 , pp. 99
    • Lee, S.J.1
  • 18
    • 75549083303 scopus 로고    scopus 로고
    • Tumor heterogeneity: causes and consequences
    • COI: 1:CAS:528:DC%2BC3cXktVGltA%3D%3D, PID: 19931353
    • Marusyk A, Polyak K (2010) Tumor heterogeneity: causes and consequences. Biochim Biophys Acta 1805:105–117. doi:10.1016/j.bbcan.2009.11.002
    • (2010) Biochim Biophys Acta , vol.1805 , pp. 105-117
    • Marusyk, A.1    Polyak, K.2
  • 19
    • 84904256074 scopus 로고    scopus 로고
    • Immunophenotypic features of metastatic lymph node tumors to predict recurrence in N2 lung squamous cell carcinoma
    • PID: 24814677
    • Matsuwaki R et al (2014) Immunophenotypic features of metastatic lymph node tumors to predict recurrence in N2 lung squamous cell carcinoma. Cancer Sci. doi:10.1111/cas.12434
    • (2014) Cancer Sci
    • Matsuwaki, R.1
  • 20
    • 84884292392 scopus 로고    scopus 로고
    • Lack of claudin-7 is a strong predictor of regional recurrence in oral and oropharyngeal squamous cell carcinoma
    • COI: 1:CAS:528:DC%2BC3sXht1ylsL%2FO, PID: 23953778
    • Melchers LJ et al (2013) Lack of claudin-7 is a strong predictor of regional recurrence in oral and oropharyngeal squamous cell carcinoma. Oral Oncol 49:998–1005. doi:10.1016/j.oraloncology.2013.07.008
    • (2013) Oral Oncol , vol.49 , pp. 998-1005
    • Melchers, L.J.1
  • 21
    • 84895855915 scopus 로고    scopus 로고
    • Expression profiles of HER2, EGFR, MET and FGFR2 in a large cohort of patients with gastric adenocarcinoma
    • Nagatsuma AK, Aizawa M, Kuwata T, Doi T, Ohtsu A, Fujii H, Ochiai A (2014) Expression profiles of HER2, EGFR, MET and FGFR2 in a large cohort of patients with gastric adenocarcinoma. Gastric Cancer. doi:10.1007/s10120-014-0360-4
    • (2014) Gastric Cancer
    • Nagatsuma, A.K.1    Aizawa, M.2    Kuwata, T.3    Doi, T.4    Ohtsu, A.5    Fujii, H.6    Ochiai, A.7
  • 22
    • 84868121108 scopus 로고    scopus 로고
    • Recruitment of podoplanin positive cancer-associated fibroblasts in metastatic lymph nodes predicts poor prognosis in pathological N2 stage III lung adenocarcinoma
    • PID: 22669451
    • Neri S et al (2012) Recruitment of podoplanin positive cancer-associated fibroblasts in metastatic lymph nodes predicts poor prognosis in pathological N2 stage III lung adenocarcinoma. Ann Surg Oncol 19:3953–3962. doi:10.1245/s10434-012-2421-4
    • (2012) Ann Surg Oncol , vol.19 , pp. 3953-3962
    • Neri, S.1
  • 23
    • 84861678334 scopus 로고    scopus 로고
    • C4.4A is associated with tumor budding and epithelial-mesenchymal transition of colorectal cancer
    • COI: 1:CAS:528:DC%2BC38XnslKhsbs%3D, PID: 22404718
    • Oshiro R et al (2012) C4.4A is associated with tumor budding and epithelial-mesenchymal transition of colorectal cancer. Cancer Sci 103:1155–1164. doi:10.1111/j.1349-7006.2012.02263.x
    • (2012) Cancer Sci , vol.103 , pp. 1155-1164
    • Oshiro, R.1
  • 24
    • 84855311144 scopus 로고    scopus 로고
    • EGFR expression as a predictor of survival for first-line chemotherapy plus cetuximab in patients with advanced non-small-cell lung cancer: analysis of data from the phase 3 FLEX study
    • COI: 1:CAS:528:DC%2BC38XkslSmtA%3D%3D, PID: 22056021
    • Pirker R et al (2012) EGFR expression as a predictor of survival for first-line chemotherapy plus cetuximab in patients with advanced non-small-cell lung cancer: analysis of data from the phase 3 FLEX study. Lancet Oncol 13:33–42. doi:10.1016/s1470-2045(11)70318-7
    • (2012) Lancet Oncol , vol.13 , pp. 33-42
    • Pirker, R.1
  • 25
    • 16544377303 scopus 로고    scopus 로고
    • Epidermal growth factor receptor (EGFR) status in primary colorectal tumors does not correlate with EGFR expression in related metastatic sites: implications for treatment with EGFR-targeted monoclonal antibodies
    • COI: 1:CAS:528:DC%2BD2MXhtFOj, PID: 15570078
    • Scartozzi M, Bearzi I, Berardi R, Mandolesi A, Fabris G, Cascinu S (2004) Epidermal growth factor receptor (EGFR) status in primary colorectal tumors does not correlate with EGFR expression in related metastatic sites: implications for treatment with EGFR-targeted monoclonal antibodies. J Clin Oncol 22:4772–4778. doi:10.1200/JCO.2004.00.117
    • (2004) J Clin Oncol , vol.22 , pp. 4772-4778
    • Scartozzi, M.1    Bearzi, I.2    Berardi, R.3    Mandolesi, A.4    Fabris, G.5    Cascinu, S.6
  • 26
    • 34347345073 scopus 로고    scopus 로고
    • Epidermal growth factor receptor (EGFR) downstream signalling pathway in primary colorectal tumours and related metastatic sites: optimising EGFR-targeted treatment options
    • COI: 1:CAS:528:DC%2BD2sXmvV2msL0%3D, PID: 17579627
    • Scartozzi M, Bearzi I, Berardi R, Mandolesi A, Pierantoni C, Cascinu S (2007) Epidermal growth factor receptor (EGFR) downstream signalling pathway in primary colorectal tumours and related metastatic sites: optimising EGFR-targeted treatment options. Br J Cancer 97:92–97. doi:10.1038/sj.bjc.6603847
    • (2007) Br J Cancer , vol.97 , pp. 92-97
    • Scartozzi, M.1    Bearzi, I.2    Berardi, R.3    Mandolesi, A.4    Pierantoni, C.5    Cascinu, S.6
  • 27
    • 0032719303 scopus 로고    scopus 로고
    • Histologic grade and CD44 are independent predictors of axillary lymph node invasion in early (T1) breast cancer
    • COI: 1:STN:280:DC%2BD3c%2Fjs1yktw%3D%3D, PID: 10567878
    • Schneider J et al (1999) Histologic grade and CD44 are independent predictors of axillary lymph node invasion in early (T1) breast cancer. Tumour Biol 20:319–330
    • (1999) Tumour Biol , vol.20 , pp. 319-330
    • Schneider, J.1
  • 28
  • 29
    • 84891790725 scopus 로고    scopus 로고
    • Putative stem cell markers in non-small-cell lung cancer: a clinicopathologic characterization
    • COI: 1:CAS:528:DC%2BC3sXhvFyrtLzN, PID: 24346092
    • Sterlacci W, Savic S, Fiegl M, Obermann E, Tzankov A (2014) Putative stem cell markers in non-small-cell lung cancer: a clinicopathologic characterization. J Thorac Oncol 9:41–49. doi:10.1097/jto.0000000000000021
    • (2014) J Thorac Oncol , vol.9 , pp. 41-49
    • Sterlacci, W.1    Savic, S.2    Fiegl, M.3    Obermann, E.4    Tzankov, A.5
  • 30
    • 62849126658 scopus 로고    scopus 로고
    • The expression of E-cadherin at the invasive tumor front of oral squamous cell carcinoma: immunohistochemical and RT-PCR analysis with clinicopathological correlation
    • PID: 19327640
    • Wang X, Zhang J, Fan M, Zhou Q, Deng H, Aisharif MJ, Chen X (2009) The expression of E-cadherin at the invasive tumor front of oral squamous cell carcinoma: immunohistochemical and RT-PCR analysis with clinicopathological correlation. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 107:547–554. doi:10.1016/j.tripleo.2008.11.021
    • (2009) Oral Surg Oral Med Oral Pathol Oral Radiol Endod , vol.107 , pp. 547-554
    • Wang, X.1    Zhang, J.2    Fan, M.3    Zhou, Q.4    Deng, H.5    Aisharif, M.J.6    Chen, X.7
  • 31
    • 79960050099 scopus 로고    scopus 로고
    • Alveolar space filling ratio as a favorable prognostic factor in small peripheral squamous cell carcinoma of the lung
    • PID: 21216489
    • Watanabe Y et al (2011) Alveolar space filling ratio as a favorable prognostic factor in small peripheral squamous cell carcinoma of the lung. Lung Cancer 73:217–221. doi:10.1016/j.lungcan.2010.12.001
    • (2011) Lung Cancer , vol.73 , pp. 217-221
    • Watanabe, Y.1
  • 32
    • 84880051618 scopus 로고    scopus 로고
    • Metastatic lymph node CHIP expression is a potential prognostic marker for resected esophageal squamous cell carcinoma patients
    • PID: 23429937
    • Wen J, Luo KJ, Hu Y, Yang H, Fu JH (2013) Metastatic lymph node CHIP expression is a potential prognostic marker for resected esophageal squamous cell carcinoma patients. Ann Surg Oncol 20:1668–1675. doi:10.1245/s10434-012-2733-4
    • (2013) Ann Surg Oncol , vol.20 , pp. 1668-1675
    • Wen, J.1    Luo, K.J.2    Hu, Y.3    Yang, H.4    Fu, J.H.5


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