Immunophenotypic features of metastatic lymph node tumors to predict recurrence in N2 lung squamous cell carcinoma

Cancer Science

Volumn 105, Issue 7, 2014, Pages 905-911

  Matsuwaki, Rie ^a,b   Ishii, Genichiro ^a   Zenke, Yoshitaka ^a   Neri, Shinya ^a   Aokage, Keiju ^a   Hishida, Tomoyuki ^a   Yoshida, Junji ^a   Fujii, Satoshi ^a   Kondo, Haruhiko ^b   Goya, Tomoyuki ^b   Nagai, Kanji ^a   Ochiai, Atsushi ^a  

^a NATIONAL CANCER CENTER HOSPITAL EAST   (Japan)

^b KYORIN UNIVERSITY   (Japan)

Author keywords

Cancer associated fibroblasts; Lung squamous cell carcinoma; Metastatic lymph node tumors; Recurrence; Tumor microenvironment

Indexed keywords

CAVEOLIN; CD44V ANTIGEN; CLUSTERIN; THY 1 ANTIGEN; UVOMORULIN;

ADULT; AGED; ARTICLE; CANCER PROGNOSIS; CANCER RECURRENCE; EPITHELIUM CELL; FEMALE; FIBROBLAST; HUMAN; HUMAN TISSUE; IMMUNOPHENOTYPING; LUNG CARCINOMA; LYMPH NODE METASTASIS; MALE; MESENCHYME CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; SQUAMOUS CELL CARCINOMA;

CANCER-ASSOCIATED FIBROBLASTS; LUNG SQUAMOUS CELL CARCINOMA; METASTATIC LYMPH NODE TUMORS; RECURRENCE; TUMOR MICROENVIRONMENT;

AGED; ANTIGENS, THY-1; CARCINOMA, SQUAMOUS CELL; CLUSTERIN; EPITHELIAL-MESENCHYMAL TRANSITION; FEMALE; FIBROBLASTS; HOMEODOMAIN PROTEINS; HUMANS; LUNG NEOPLASMS; LYMPHATIC METASTASIS; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; NEOPLASM RECURRENCE, LOCAL; NEOPLASTIC STEM CELLS; PREDICTIVE VALUE OF TESTS; PROGNOSIS; REPRESSOR PROTEINS; TUMOR MARKERS, BIOLOGICAL; TUMOR MICROENVIRONMENT;

EID: 84904256074     PISSN: 13479032     EISSN: 13497006     Source Type: Journal    
DOI: 10.1111/cas.12434     Document Type: Article

References (35)

1. Goldstraw P, Crowley J, Chansky K et al. The IASLC Lung Cancer Staging Project: proposals for the revision of the TNM stage groupings in the forthcoming (seventh) edition of the TNM Classification of malignant tumors. J Thorac Oncol 2007; 2: 706-14.
2. Hanagiri T, Takenaka M, Oka S et al. Clinical significance in the number of involved lymph nodes in patients that underwent surgery for pathological stage III-N2 non-small cell lung cancer. J Cardiothorac Surg 2011; 6: 144.
3. Sereno M, Esteban IR, Zambrana F et al. Squamous-cell carcinoma of the lungs: is it really so different? Crit Rev Oncol Hematol 2012; 84: 327-39.
4. Fiala O, Pesek M, Finek J et al. Gene mutations in squamous cell NSCLC: insignificance of EGFR, KRAS and PIK3CA mutations in prediction of EGFR-TKI treatment efficacy. Anticancer Res 2013; 33: 1705-11.
5. Ito M, Ishii G, Nagai K et al. Prognostic impact of cancer-associated stromal cells in patients with stage I lung adenocarcinoma. Chest 2012; 142: 151-8.
6. Hirayama S, Ishii G, Nagai K et al. Prognostic impact of CD204-positive macrophages in lung squamous cell carcinoma: possible contribution of CD204-positive macrophages to the tumor-promoting microenvironment. J Thorac Oncol 2012; 7: 1790-7.
7. Neri S, Ishii G, Taira T et al. Recruitment of podoplanin positive cancer-associated fibroblasts in metastatic lymph nodes predicts poor prognosis in pathological N2 stage III lung adenocarcinoma. Ann Surg Oncol 2012; 19: 3953-62.
8. Bailey KM, Liu J. Caveolin-1 up-regulation during epithelial to mesenchymal transition is mediated by focal adhesion kinase. J Biol Chem 2008; 283: 13714-24.
9. Masuelli L, Budillon A, Marzocchella L et al. Caveolin-1 overexpression is associated with simultaneous abnormal expression of the E-cadherin/alpha-beta catenins complex and multiple ErbB receptors and with lymph nodes metastasis in head and neck squamous cell carcinomas. J Cell Physiol 2012; 227: 3344-53.
10. Harada K, Miyake H, Kusuda Y et al. Expression of epithelial-mesenchymal transition markers in renal cell carcinoma: impact on prognostic outcomes in patients undergoing radical nephrectomy. BJU Int 2012; 110: E1131-7.
11. Shiota M, Zardan A, Takeuchi A et al. Clusterin mediates TGF-beta-induced epithelial-mesenchymal transition and metastasis via Twist1 in prostate cancer cells. Cancer Res 2012; 72: 5261-72.
12. Koay MH, Crook M, Stewart CJ. Cyclin D1, E-cadherin and beta-catenin expression in FIGO Stage IA cervical squamous carcinoma: diagnostic value and evidence for epithelial-mesenchymal transition. Histopatholog 2012; 61: 1125-33.
13. Sakamoto K, Imanishi Y, Tomita T et al. Overexpression of SIP1 and downregulation of E-cadherin predict delayed neck metastasis in stage I/II oral tongue squamous cell carcinoma after partial glossectomy. Ann Surg Oncol 2012; 19: 612-9.
14. Cai MY, Luo RZ, Chen JW et al. Overexpression of ZEB2 in peritumoral liver tissue correlates with favorable survival after curative resection of hepatocellular carcinoma. PLoS ONE 2012; 7: e32838.
15. Kurahara H, Takao S, Maemura K et al. Epithelial-mesenchymal transition and mesenchymal-epithelial transition via regulation of ZEB-1 and ZEB-2 expression in pancreatic cancer. J Surg Oncol 2012; 105: 655-61.
16. Dimou A, Neumeister V, Agarwal S et al. Measurement of aldehyde dehydrogenase 1 expression defines a group with better prognosis in patients with non-small cell lung cancer. Am J Pathol 2012; 181: 1436-42.
17. Okudela K, Woo T, Mitsui H et al. Expression of the potential cancer stem cell markers, CD133, CD44, ALDH1, and beta-catenin, in primary lung adenocarcinoma-their prognostic significance. Pathol Int 2012; 62: 792-801.
18. Shi J, Zhou Z, Di W et al. Correlation of CD44v6 expression with ovarian cancer progression and recurrence. BMC Cancer 2013; 13: 182.
19. Atsumi N, Ishii G, Kojima M et al. Podoplanin, a novel marker of tumor-initiating cells in human squamous cell carcinoma. Biochem Biophys Res Commun 2008; 373: 36-41.
20. Shimada Y, Ishii G, Nagai K et al. Expression of podoplanin, CD44, and p63 in squamous cell carcinoma of the lung. Cancer Sci 2009; 100: 2054-9.
21. Rahadiani N, Ikeda J, Makino T et al. Tumorigenic role of podoplanin in esophageal squamous-cell carcinoma. Ann Surg Oncol 2010; 17: 1311-23.
22. Nishijima N, Ishii G, Nagai K et al. Cancer-initiating cell marker-positive cells generate metastatic tumors that recapitulate the histology of the primary tumors. Pathol Int 2013; 63: 94-101.
23. Goetz JG, Minguet S, Navarro-Lerida I et al. Biomechanical remodeling of the microenvironment by stromal caveolin-1 favors tumor invasion and metastasis. Cell 2011; 146: 148-63.
24. Niu ZH, Wang Y, Chun B et al. Secretory clusterin (sCLU) overexpression is associated with resistance to preoperative neoadjuvant chemotherapy in primary breast cancer. Eur Rev Med Pharmacol Sci 2013; 17: 1337-44.
25. Tang KH, Dai YD, Tong M et al. A CD90(+) tumor-initiating cell population with an aggressive signature and metastatic capacity in esophageal cancer. Cancer Res 2013; 73: 2322-32.
26. Kawase A, Ishii G, Nagai K et al. Podoplanin expression by cancer associated fibroblasts predicts poor prognosis of lung adenocarcinoma. Int J Cancer 2008; 123: 1053-9.
27. Hoshino A, Ishii G, Ito T et al. Podoplanin-positive fibroblasts enhance lung adenocarcinoma tumor formation: podoplanin in fibroblast functions for tumor progression. Cancer Res 2011; 71: 4769-79.
28. Ono S, Ishii G, Nagai K et al. Podoplanin-positive cancer-associated fibroblasts could have prognostic value independent of cancer cell phenotype in stage I lung squamous cell carcinoma: usefulness of combining analysis of both cancer cell phenotype and cancer-associated fibroblast phenotype. Chest 2013; 143: 963-70.
29. Mori T, Hirota T, Ohashi Y et al. Significance of histologic type of primary lesion and metastatic lymph nodes as a prognostic factor in stage III colon cancer. Dis Colon Rectum 2006; 49: 982-92.
30. Fukuse T, Hirata T, Naiki H et al. Prognostic significance of proliferative activity in pN2 non-small-cell lung carcinomas and their mediastinal lymph node metastases. Ann Surg 2000; 232: 112-8.
31. Vered M, Dayan D, Yahalom R et al. Cancer-associated fibroblasts and epithelial-mesenchymal transition in metastatic oral tongue squamous cell carcinoma. Int J Cancer 2010; 127: 1356-62.
32. Yeung TM, Buskens C, Wang LM et al. Myofibroblast activation in colorectal cancer lymph node metastases. Br J Cancer 2013; 108: 2106-15.
33. Schoppmann SF, Berghoff A, Dinhof C et al. Podoplanin-expressing cancer-associated fibroblasts are associated with poor prognosis in invasive breast cancer. Breast Cancer Res Treat 2012; 134: 237-44.
34. Hassan MK, Watari H, Han Y et al. Clusterin is a potential molecular predictor for ovarian cancer patient's survival: targeting clusterin improves response to paclitaxel. J Exp Clin Cancer Res 2011; 30: 113.
35. Fang Y, Wei J, Cao J et al. Protein expression of ZEB2 in renal cell carcinoma and its prognostic significance in patient survival. PLoS ONE 2013; 8: e62558.