The prelimbic cortex directs attention toward predictive cues during fear learning

Learning and Memory

Volumn 22, Issue 6, 2015, Pages 289-293

  Sharpe, Melissa J ^a   Killcross, Simon ^a  

^a UNIVERSITY OF NEW SOUTH WALES   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL EXPERIMENT; ARTICLE; ASSOCIATION; ATTENTION; AUDITORY STIMULATION; BRAIN FUNCTION; CONDITIONED REFLEX; CONDITIONING; CONTROLLED STUDY; FEAR; INFORMATION RETRIEVAL; LATENT INHIBITION; LEARNING; MEDIAL PREFRONTAL CORTEX; NONHUMAN; PREDICTIVE CUE; PREDICTIVE VALUE; PRELIMBIC CORTEX; PRIORITY JOURNAL; RAT; STIMULUS; STIMULUS RESPONSE; VISUAL STIMULATION; ANIMAL; PHYSIOLOGY; PREFRONTAL CORTEX;

ANIMALS; ATTENTION; CONDITIONING, CLASSICAL; CUES; FEAR; PREFRONTAL CORTEX; RATS;

EID: 84931444387     PISSN: 10720502     EISSN: 15495485     Source Type: Journal    
DOI: 10.1101/lm.038273.115     Document Type: Article

References (25)

1. Balleine BW, Dickinson A. 1998. Goal-directed instrumental action: contingency and incentive learning and their cortical substrates. Neuropharmacology 37: 407-419.
2. Birrell JM, Brown VJ. 2000. Medial frontal cortex mediates perceptual attentional set shifting in the rat. J Neurosci 20: 4320-4324.
3. Burgos-Robles A, Vidal-Gonzalez I, Quirk GJ. 2009. Sustained conditioned responses in prelimbic prefrontal neurons are correlated with fear expression and extinction failure. J Neurosci 29: 8474-8482.
4. Corcoran KA, Quirk GJ. 2007. Activity in prelimbic cortex is necessary for the expression of learned, but not innate, fears. J Neurosci 27: 840-844.
5. Dias R, Honey RC. 2002. Involvement of the rat medial prefrontal cortex in novelty detection. Behav Neurosci 116: 498-503.
6. Floresco SB, Block AE, Tse MTL. 2008. Inactivation of the medial prefrontal cortex of the rat impairs strategy set-shifting, but not reversal learning, using a novel, automated procedure. Behav Brain Res 190: 85-96.
7. Gisquet-Verrier P, Delatour B. 2006. The role of the rat prelimbic/infralimbic cortex in working memory: not involved in the short-term maintenance but in monitoring and processing functions. Neuroscience 141: 585-596.
8. Holland PC. 2000. Trial and intertrial durations in appetitive conditioning in rats. Anim Learn Behav 28: 121-135.
9. Holson RR. 1986. Mesial prefrontal cortical lesions and timidity in rats. I. Reactivity to aversive stimuli. Physiol Behav 37: 221-230.
10. Lacroix L, Spinelli S, Heidbreder CA, Feldon J. 2000. Differential role of the medial and lateral prefrontal cortices in fear and anxiety. Behav Neurosci 114: 1119-1130.
11. Le Pelley ME. 2004. The role of associative history in models of associative learning: a selective review and a hybrid model. Q J Exp Psychol B 57: 193-243.
12. Mackintosh NJ. 1975. A theory of attention: variations in the associability of stimuli with reinforcement. Psychol Rev 82: 276-298.
13. Mackintosh NJ. 1976. Overshadowing and stimulus intensity. Anim Learn Behav 4: 186-192.
14. Mais JHR, Vossen JMH. 1993. Competition for associative strength between a punctate signal and contextual stimuli: effect of signal preexposure versus context preexposure. Behav Processes 30: 29-46.
15. Marquis JP, Killcross S, Haddon JE. 2007. Inactivation of the prelimbic, but not infralimbic, prefrontal cortex impairs the contextual control of response conflict in rats. Eur J Neurosci 25: 559-566.
16. McAllister WR, McAllistair DE,Weldin GH. 1974. Intertrial interval effects in classically conditioning fear to a discrete conditioned stimulus and to situational cues. J Comp Physiol Psychol 87: 582-590.
17. Morgan MA, LeDoux JE. 1995. Differential contribution of dorsal and ventral medial prefrontal cortex to the acquisition and extinction of conditioned fear. Behav Neurosci 109: 681-688.
18. Paxinos G, Watson C. 1998. The rat brain in stereotaxic coordinates. San Diego, CA: Academic press.
19. Pearce JM, Mackintosh NJ. 2010. Two theories of attention: a review and possible integration. In Attention and associative learning (ed. Mitchell CJ, Le Pelley ME), pp. 351-385. Oxford University Press, New York.
20. Rescorla RA. 1984. Signaling inter-trial shocks attenuates their negative effect on conditioned suppression. Bull Psychon Soc 22: 225-228.
21. Rescorla RA, Wagner AR. 1972. A theory of Pavlovian conditioning: variations in the effectiveness of reinforcement and non-reinforcement. In Classical conditioning II: current research and theory (ed. Black AH, Prokasy EF), pp. 64-99. Appleton-Century-Crofts, New York.
22. Rhodes SE, Killcross S. 2007. Lesions of rat infralimbic cortex enhance recovery and reinstatement of an appetitive Pavlovian response. Learn Mem 11: 611-616.
23. Sharpe MJ, Killcross S. 2014. The prelimbic cortex contributes to the down-regulation of attention toward redundant cues. Cereb Cortex 24: 1066-1074.
24. Sharpe MJ, Killcross S. 2015. The prelimbic cortex uses higher-order cues to modulate both the acquisition and expression of conditioned fear. Front Syst Neurosci 8: 235.
25. Sierra-Mercado D, Padilla-Coreano N, Quirk GJ. 2011. Dissociable roles of prelimbic and infralimbic cortices, ventral hippocampus, and basolateral amygdala in the expression and extinction of conditioned fear. Neuropsychopharmacology 36: 529-538.