Preoperative single-fraction partial breast radiation therapy: A novel phase 1, dose-escalation protocol with radiation response biomarkers

International Journal of Radiation Oncology Biology Physics

Volumn 92, Issue 4, 2015, Pages 846-855

  Horton, Janet K ^a   Blitzblau, Rachel C ^a   Yoo, Sua ^a   Geradts, Joseph ^a   Chang, Zheng ^a   Baker, Jay A ^a   Georgiade, Gregory S ^a   Chen, Wei ^b   Siamakpour Reihani, Sharareh ^a   Wang, Chunhao ^a   Broadwater, Gloria ^b   Groth, Jeff ^a   Palta, Manisha ^a   Dewhirst, Mark ^a   Barry, William T ^c,d   Duffy, Eileen A ^a   Chi, Jen Tsan A ^a   Hwang, E Shelley ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b DUKE CANCER INSTITUTE   (United States)

^c DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d DANA FARBER CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOMARKERS; CELL DEATH; DISEASES; MAGNETIC RESONANCE; MAGNETIC RESONANCE IMAGING; MEDICAL IMAGING; RADIATION; TOXICITY; TUMORS;

BREAST RADIATION THERAPY; DOSE LIMITING TOXICITY; EARLY-STAGE BREAST CANCER; INTENSITY MODULATED RADIATION THERAPY; METHODS AND MATERIALS; PROGESTERONE RECEPTOR; TREATMENT-RELATED MORBIDITIES; VASCULAR PERMEABILITY;

RADIOTHERAPY;

ALLOGRAFT INFLAMMATORY FACTOR 1; ANTINEOPLASTIC AGENT; ANTINEOPLASTIC HORMONE AGONISTS AND ANTAGONISTS; CD48 ANTIGEN; CHEMOKINE RECEPTOR CCR1; LST1 PROTEIN; LY86 PROTEIN; PROTEIN MD 2; TUMOR MARKER; UNCLASSIFIED DRUG; GENETIC MARKER;

ADJUVANT THERAPY; ADULT; AGED; APOPTOSIS; APPLICATION SITE PRURITUS; BLOOD VESSEL PERMEABILITY; BREAST ATROPHY; BREAST CANCER; BREAST CARCINOMA; CANCER ADJUVANT THERAPY; CANCER FATIGUE; CANCER HORMONE THERAPY; CANCER PATIENT; CANCER PROGNOSIS; CANCER RADIOTHERAPY; CANCER RECURRENCE; CANCER SIZE; CANCER SURGERY; CELL DENSITY; CHRONIC TOXICITY; CLINICAL ARTICLE; COMPUTED TOMOGRAPHY SCANNER; CONFERENCE PAPER; CONNECTIVE TISSUE DISEASE; ESTHETICS; ESTROGEN RECEPTOR POSITIVE BREAST CANCER; FEASIBILITY STUDY; FEMALE; FIBROSIS; FOLLOW UP; GENE EXPRESSION REGULATION; HEALTH CARE COST; HUMAN; HUMAN TISSUE; HYPERPIGMENTATION; INFECTION COMPLICATION; INTENSITY MODULATED RADIATION THERAPY; INTRADUCTAL CARCINOMA; LYMPHEDEMA; MASTALGIA; MAXIMUM TOLERATED DOSE; NUCLEAR MAGNETIC RESONANCE IMAGING; NUCLEAR MAGNETIC RESONANCE SCANNER; PARTIAL MASTECTOMY; PATIENT SAFETY; PHASE 1 CLINICAL TRIAL; PREOPERATIVE RADIOTHERAPY; PRIORITY JOURNAL; PROGESTERONE RECEPTOR POSITIVE BREAST CANCER; RADIATION DERMATITIS; RADIATION DOSE ESCALATION; RADIATION INDUCED NEOPLASM; RADIATION INJURY; RADIATION RESPONSE; RADIOTHERAPY PLANNING SYSTEM; REAL TIME TRACKING SYSTEM; SEROMA; SKIN INFECTION; SKIN ULCER; SYSTEMIC THERAPY; TELANGIECTASIA; TREATMENT OUTCOME; TREATMENT RESPONSE; TUMOR IMMUNITY; BREAST NEOPLASMS; CARCINOMA, DUCTAL, BREAST; CARCINOMA, INTRADUCTAL, NONINFILTRATING; CLINICAL TRIAL; GENE EXPRESSION; GENETIC MARKER; GENETICS; MIDDLE AGED; PATHOLOGY; PREOPERATIVE CARE; PROCEDURES; RADIATION DOSE; SEGMENTAL MASTECTOMY;

AGED; BREAST NEOPLASMS; CARCINOMA, DUCTAL, BREAST; CARCINOMA, INTRADUCTAL, NONINFILTRATING; FEASIBILITY STUDIES; FEMALE; GENE EXPRESSION; GENETIC MARKERS; HUMANS; MASTECTOMY, SEGMENTAL; MIDDLE AGED; PREOPERATIVE CARE; RADIATION INJURIES; RADIOTHERAPY DOSAGE; RADIOTHERAPY, INTENSITY-MODULATED;

EID: 84931335546     PISSN: 03603016     EISSN: 1879355X     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2015.03.007     Document Type: Conference Paper

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