The use of chemotherapeutics for the treatment of keloid scars

Dermatology Reports

Volumn 7, Issue 2, 2015, Pages 15-19

  Jones, Christopher David ^a   Guiot, Luke ^b   Samy, Mike ^c   Gorman, Mark ^a   Tehrani, Hamid ^d  

^a GLASGOW ROYAL INFIRMARY   (United Kingdom)

^b AYR HOSPITAL   (United Kingdom)

^c ST BARTHOLOMEW S HOSPITAL   (United Kingdom)

^d WHISTON HOSPITAL   (United Kingdom)

Author keywords

Chemotherapeutic agents; Hypertrophic scar; Keloid

Indexed keywords

ANTINEOPLASTIC AGENT; BLEOMYCIN; BOTULINUM TOXIN A; CAMPTOTHECIN; CAPTOPRIL; COLCHICINE; CORTICOSTEROID; DEHYDROXYMETHYLEPOXYQUINOMICIN; FLUOROURACIL; IMIQUIMOD; MITOMYCIN; STEROID; TAMOXIFEN; TRANSFORMING GROWTH FACTOR BETA1; TRIAMCINOLONE ACETATE;

COMBINATION CHEMOTHERAPY; COMPARATIVE EFFECTIVENESS; DRUG EFFICACY; DRUG USE; HUMAN; HYPERTROPHIC SCAR; KELOID; MONOTHERAPY; RECURRENT DISEASE; REVIEW; TREATMENT INDICATION; TREATMENT RESPONSE; WOUND HEALING;

EID: 84931302627     PISSN: 20367392     EISSN: 20367406     Source Type: Journal    
DOI: 10.4081/dr.2015.5880     Document Type: Review

References (49)

1. Cheng ET, Nowak KC, Koch RJ. Effect of blended carbon dioxide and erbium: YAG laser energy on preauricular and ear lobule keloid fibroblast secretion of growth factors. Arch Facial Plast Surg 2001;3:252-7.
2. Fitzpatrick RE. Treatment of inflamed hypertrophic scars using intralesional 5-FU. Dermatol Surg 1999;25:224-32.
3. Zhang GY, Gao WY, Li X, et al. Effect of camptothecin on collagen synthesis in fibroblasts from patients with keloid. Ann Plast Surg 2009;63:94-9.
4. Naeini F, Najafian J, Ahmadpour K. Bleomycin tattooing as a promising therapeutic modality in large keloids and hypertrophic scars. Dermatol Surg 2006;32: 1023-30.
5. Wu W, Wang F, Yang K et al. Dexamethasone induction of keloid regression through effective suppression of VEGF expression and keloid fibroblast proliferation. J Invest Dermatol 2006;126: 1264-71.
6. Berman B, Villa A. Imiquimod 5% cream for keloid management. Dermatol Surg 2003;29:1050-1.
7. Asilian A, Darougheh A, Shariati F. New combination of triamcinolone, 5-Fluorouracil, and pulsed-dye laser for treatment of keloid and hypertrophic scars. Dermatol Surg 2006;32:907-15.
8. He S, Liu X, Yang Y, et al. Mechanisms of transforming growth factor ?1/Smad signalling mediated by mitogen-activated protein kinase pathways in keloid fibroblasts. Br J Dermatol 2009;162:538-46.
9. Jacob S, Berman B, Nassiri M, et al. Topical application of imiquimod 5% cream to keloids alters expression genes associated with apoptosis. Br J Dermatol 2003;149:62-5.
10. Stewart IV CE, Kim JY. Application of mitomycin-C for head and neck keloids. Otolaryngol Head Neck Surg 2006;135:946-50.
11. Ladin DA, Hou Z, Patel D, et al. p53 and apoptosis alterations in keloids and keloid fibroblasts. Wound Repair Regen 1998;6:28-37.
12. Rusciani L, Paradisi A, Alfano C, et al. Cryotherapy in the treatment of keloids. J Drugs Dermatol 2006;5:591-5.
13. Cação F, Tanaka V, Messina M. Failure of imiquimod 5% cream to prevent recurrence of surgically excised trunk keloids. Dermatol Surg 2009;35:629-33.
14. Saray Y, Güleç A. Treatment of keloids and hypertrophic scars with dermojet injections of bleomycin: a preliminary study. Int J Dermatol 2005;44:777-84.
15. Xi-Qiao W, Ying-Kai L, Chun Q, et al. A Review of the effectiveness of antimitotic drug injections for hypertrophic scars and keloids. Ann Plastic Surg 2009;63:688-92.
16. Darougheh A, Asilian A, Shariati F. Intralesional triamcinolone alone or in combination with 5-fluorouracil for the treatment of keloid and hypertrophic scars. Clin Exp Dermatol 2007;34:219-23.
17. Hochman B, Locali RF, Matsuoka PK, et al. Intralesional triamcinolone acetonide for keloid treatment: a systematic review. Aesth Plast Surg 2008;32:705-9.
18. Hom DB. Treating the elusive keloid. Arch Otolaryngol Head Neck Surg 2001;127:1140-3.
19. Manuskiatti W, Fitzpatrick R. Treatment response of keloidal and hypertrophic sternotomy scars: comparison among intralesional corticosteroid, 5-fluorouracil, and 585-nm flashlamp-pumped pulsed-dye laser treatments. Arch Dermatol 2002;138:1149-55.
20. Haurani M, Foreman K, Yang J, et al. 5-Fluorouracil treatment of problematic scars. Plast Reconstr Surg 2009;123:139-48.
21. Wang X, Liu Y, Wang Z, et al. Antimitotic drug injections and radiotherapy: a review of the effectiveness of treatment for hypertrophic scars and keloids. Int J Low Extrem Wounds 2008;7:151-9.
22. Nanda S, Reddy B. Intralesional 5-fluorouracil as a treatment modality of keloids. Dermatol Surg 2004;30:54-7.
23. Apikian M, Goodman G. Intralesional 5-fluorouracil in the treatment of keloid scars. Australas J Dermatol 2004;45:140-3.
24. Goldan O, Weissman O, Regev E, et al. Treatment of postdermabrasion facial hypertrophic and keloid scars with intralesional 5-Fluorouracil injections. Aesthetic Plast Surg 2008;32:389-92.
25. Kontochristopoulos G, Stefanaki C, Panagiotopoulos A, et al. Intralesional 5- fluorouracil in the treatment of keloids: an open clinical and histopathologic study. J Am Acad Dermatol 2005;52:474-9.
26. Gupta S, Kalra A. Efficacy and safety of intralesional 5- fluorouracil in the treatment of keloids. Dermatology 2002;204:130-2.
27. Ribeiro FA, Guaraldo L, Borges JP, et al. Clinical and histological healing of surgical wounds treated with mitomycin C. Laryngoscope 2004;114:148-52.
28. Rahbar R, Jones DT, Nuss RC, et al. The role of mitomycin in the prevention and treatment of scar formation in the pediatric aerodigestive tract. Arch Otolaryngol Head Neck Surg 2002;128:401-6.
29. Sewall GK, Robertson KM, Connor NP, et al. Effect of topical mitomycin on skin wound contraction. Arch Facial Plast Surg 2003;5:59-62.
30. Sanders KW, Gage-White L, Stucker FJ. Topical mitomycin C in the prevention of keloid scar recurrence. Arch Facial Plast Surg 2005;7:172-5.
31. Simman R, Alani H, Williams F. Effect of mitomycin C on keloid fibroblasts: an in vitro study. Ann Plast Surg 2003;50:71-6.
32. Espana A, Solano T, Quintanilla E. Bleomycin in the treatment of keloids and hypertrophic scars by multiple needle punctures. Dermatol Surg 2001;27:23-7.
33. Hendricks T, Martens MF, Huyben CM, et al. Inhibition of basal and TGF betainduced fibroblast collagen synthesis by antineoplastic agents. Implications for wound healing. Br J Cancer 1993;67:545-50.
34. Yeowell HN, Marshall MK, Walker LC, et al. Regulation of lysly oxidase mRNA in dermal fibroblasts from normal donors and patients with inherited connective tissue disorders. Arch Biochem Biophys 1994;308: 299-305.
35. Roques C, Téot L. The use of corticosteroids to treat keloids: a review. Int J Lower Extremity Wounds 2008;7:137-45.
36. Donkor P. Head and neck keloid: treatment by core excision and delayed intralesional injection of steroid. J Oral Maxillofac Surg 2007;65:1292-6.
37. Makino S, Mitsutake N, Nakashima M, et al. DHMEQ, a novel NF-kappaB inhibitor, suppresses growth and type I collagen accumulation in keloid fibroblasts. J Dermatol Sci 2008;51:171-80.
38. Diegelmann RF, Bryant CP, Cohen IK. Tissue alpha-globulins in keloid formation. Plast Reconstr Surg 1977;59:418-24.
39. Gira AK, Brown LF, Washington CV, et al. Keloids demonstrate high-level epidermal expression of vascular endothelial growth factor. J Am Acad Dermatol 2004;50:850-3.
40. Hamrick M, Boswell W, Carney D. Successful treatment of earlobe keloids in the pediatric population. J Pediatr Surg 2009;44:286-8.
41. Leventhal D, Furr M, Reiter D. Treatment of keloids and hypertrophic scars: a metaanalysis and review of the literature. Arch Facial Plast Surg 2006;8:362-8.
42. Kaufman J, Berman B. Topical application of imiquimod 5% cream to excision sites is safe and effective in reducing keloid recurrences. J Am Acad Dermatol 2002;47:209-11.
43. Zhibo X, Miaobo Z. View points: intralesional botulinum toxin type A Injection as a new treatment measure for keloids. Plast Reconstr Surg 2009;124:253-79.
44. Mikulec A, Hanasono M, Lum J, et al. Effect of tamoxifen on transforming growth factor beta1 production by keloid and fetal fibroblasts. Arch Facial Plast Surg 2001;3:111-4.
45. Lee TY, Chin GS, Kim WJH, et al. Expression of transforming growth factor-??1, 2 and 3 proteins in keloids. Ann Plast Surg 1999;43:179-84.
46. Mancoll JS, Macauley RL, Phillips LG. The inhibitory effect of tamoxifen on keloid fibroblasts. Surg Forum 1996;47:718-20.
47. Chau D, Mancoll JS, Lee S, et al. Tamoxifen downregulates TGF-b production in keloid fibroblasts. Ann Plast Surg 1998;40:490-3.
48. Ardekani GS, Aghaie S, Nemati MH et al. Treatment of a postburn keloid scar with topical captopril: report of the first case. Plast Reconstr Surg 2009;123:108-27.
49. Dinh Q, Veness M, Richards S. Role of adjuvant radiotherapy in recurrent earlobe keloids. Australas J Dermatol 2004;45:162-6.