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Volumn 6, Issue MAY, 2015, Pages

SarA based novel therapeutic candidate against Staphylococcus aureus associated with vascular graft infections

Author keywords

Molecular docking; Multi drug resistance; Quorum sensing; SarA; Staphylococcus aureus; Vascular graft associated infection; Virulence gene expression

Indexed keywords

4 [(2,4 DIFLUROBENZYL)AMINO] CYCLOHEXANOL; CYCLOHEXANOL DERIVATIVE; DNA BINDING PROTEIN; FIBRONECTIN BINDING PROTEIN; FLUORESCEIN ISOTHIOCYANATE; HEMOLYSIN; RNA; STAPHYLOCOCCAL ACCESSORY REGULATOR A; UNCLASSIFIED DRUG;

EID: 84931273062     PISSN: None     EISSN: 1664302X     Source Type: Journal    
DOI: 10.3389/fmicb.2015.00416     Document Type: Article
Times cited : (52)

References (37)
  • 1
    • 84865203688 scopus 로고    scopus 로고
    • A pilot study of a triple antimicrobial-bonded Dacron graft for the prevention of aortic graft infection
    • Aboshady, I., Raad, I., Shah, A. S., Vela, D., Dvorak, T., Safi, H. J., et al. (2012). A pilot study of a triple antimicrobial-bonded Dacron graft for the prevention of aortic graft infection. J. Vasc. Surg. 3, 794-801. doi: 10.1016/j.jvs.2012.02.008.
    • (2012) J. Vasc. Surg , vol.3 , pp. 794-801
    • Aboshady, I.1    Raad, I.2    Shah, A.S.3    Vela, D.4    Dvorak, T.5    Safi, H.J.6
  • 2
    • 78049430385 scopus 로고    scopus 로고
    • Control of the Staphylococcus aureus toxic shock tst promoter by the global regulator SarA
    • Andrey, D. O. (2010). Control of the Staphylococcus aureus toxic shock tst promoter by the global regulator SarA. J. Bacteriol. 192, 6077-6085. doi: 10.1128/JB.00146-10.
    • (2010) J. Bacteriol , vol.192 , pp. 6077-6085
    • Andrey, D.O.1
  • 3
    • 84862873111 scopus 로고    scopus 로고
    • Biofilm formation in Staphylococcus implant infections. A review of molecular mechanisms and implications for biofilm-resistant materials
    • Arciola, C. R., Campoccia, D., Speziale, P., Montanaro, L., and Costerton, J. W. (2012). Biofilm formation in Staphylococcus implant infections. A review of molecular mechanisms and implications for biofilm-resistant materials. Biomaterials 33, 5967-5982. doi: 10.1016/j.biomaterials.2012.05.031.
    • (2012) Biomaterials , vol.33 , pp. 5967-5982
    • Arciola, C.R.1    Campoccia, D.2    Speziale, P.3    Montanaro, L.4    Costerton, J.W.5
  • 4
    • 84884993949 scopus 로고    scopus 로고
    • An insight into pleiotropic regulators Agr and Sar: molecular probes paving the new way for antivirulent therapy
    • Arya, R., and Princy, S. A. (2013a). An insight into pleiotropic regulators Agr and Sar: molecular probes paving the new way for antivirulent therapy. Future Microbiol. 10, 1339-1353. doi: 10.2217/fmb.13.92.
    • (2013) Future Microbiol , vol.10 , pp. 1339-1353
    • Arya, R.1    Princy, S.A.2
  • 5
    • 84879684887 scopus 로고    scopus 로고
    • Computational approach to design small molecule inhibitors and identify SarA as a potential therapeutic candidate
    • Arya, R., and Princy, S. A. (2013b). Computational approach to design small molecule inhibitors and identify SarA as a potential therapeutic candidate. Med. Chem. Res. 22, 1856-1865. doi: 10.1007/s00044-012-0185-9.
    • (2013) Med. Chem. Res , vol.22 , pp. 1856-1865
    • Arya, R.1    Princy, S.A.2
  • 6
    • 0037213770 scopus 로고    scopus 로고
    • Prevention of Staphylococcus aureus biofilm on dialysis catheters and adherence to human cells
    • Balaban, N., Gov, Y., Bitler, A., and Boelaert, J. R. (2003). Prevention of Staphylococcus aureus biofilm on dialysis catheters and adherence to human cells. Kidney Int. 63, 340-345. doi: 10.1046/j.1523-1755.2003.00733.x.
    • (2003) Kidney Int , vol.63 , pp. 340-345
    • Balaban, N.1    Gov, Y.2    Bitler, A.3    Boelaert, J.R.4
  • 7
    • 84870572070 scopus 로고    scopus 로고
    • Infection in prosthetic material
    • Barnes, R., and Chetter, I. (2012). Infection in prosthetic material. Surgery (Oxford) 30, 667-672. doi: 10.1016/j.mpsur.2012.10.002.
    • (2012) Surgery (Oxford) , vol.30 , pp. 667-672
    • Barnes, R.1    Chetter, I.2
  • 8
    • 77956523972 scopus 로고    scopus 로고
    • Epistatic relationships between sarA and agr in Staphylococcus aureus biofilm formation
    • Beenken, K. E., Mrak, L. N., Griffin, L. M., Zielinska, A. K., Shaw, L. N., Rice, K. C., et al. (2010). Epistatic relationships between sarA and agr in Staphylococcus aureus biofilm formation. PLoS ONE 5:e10790. doi: 10.1371/journal.pone.0010790.
    • (2010) PLoS ONE , vol.5
    • Beenken, K.E.1    Mrak, L.N.2    Griffin, L.M.3    Zielinska, A.K.4    Shaw, L.N.5    Rice, K.C.6
  • 9
    • 79959274525 scopus 로고    scopus 로고
    • The effect of bacterial infection on the biomechanical properties of biological mesh in a rat model
    • Bellows, C. F., Wheatley, B. M., Moroz, K., Rosales, S. C., and Morici, L. A. (2011). The effect of bacterial infection on the biomechanical properties of biological mesh in a rat model. PLoS ONE 6:e21228. doi: 10.1371/journal.pone.0021228.
    • (2011) PLoS ONE , vol.6
    • Bellows, C.F.1    Wheatley, B.M.2    Moroz, K.3    Rosales, S.C.4    Morici, L.A.5
  • 10
    • 77956321151 scopus 로고    scopus 로고
    • Identification of genes involved in polysaccharide-independent Staphylococcus aureus biofilm formation
    • Boles, B. R., Thoendel, M., Roth, A. J., and Horswill, A. R. (2010). Identification of genes involved in polysaccharide-independent Staphylococcus aureus biofilm formation. PLoS ONE 5:e10146. doi: 10.1371/journal.pone.0010146.
    • (2010) PLoS ONE , vol.5
    • Boles, B.R.1    Thoendel, M.2    Roth, A.J.3    Horswill, A.R.4
  • 11
    • 84864461105 scopus 로고    scopus 로고
    • Contribution of the Staphylococcus aureus Atl AM and GL Murein hydrolase activities in cell division, autolysis, and biofilm formation
    • Bose, J. L., Lehman, M. K., Fey, P. D., and Bayles, K. W. (2012). Contribution of the Staphylococcus aureus Atl AM and GL Murein hydrolase activities in cell division, autolysis, and biofilm formation. PLoS ONE 7:e42244. doi: 10.1371/journal.pone.0042244.
    • (2012) PLoS ONE , vol.7
    • Bose, J.L.1    Lehman, M.K.2    Fey, P.D.3    Bayles, K.W.4
  • 12
    • 80052396610 scopus 로고    scopus 로고
    • Vancomycin activates σ (B) in vancomycin-resistant Staphylococcus aureus resulting in the enhancement of cytotoxicity
    • Chen, H. Y., Chen, C. C., Fang, C. S., Hsieh, Y. T., Lin, M. H., and Shu, J. C. (2011). Vancomycin activates σ (B) in vancomycin-resistant Staphylococcus aureus resulting in the enhancement of cytotoxicity. PLoS ONE 6:e24472. doi: 10.1371/journal.pone.0024472.
    • (2011) PLoS ONE , vol.6
    • Chen, H.Y.1    Chen, C.C.2    Fang, C.S.3    Hsieh, Y.T.4    Lin, M.H.5    Shu, J.C.6
  • 13
    • 0345829221 scopus 로고    scopus 로고
    • Regulation of virulence determinants in vitro and in vivo in Staphylococcus aureus
    • Cheung, A. L., Bayer, A. S., Zhang, G., Gresham, H., and Xiong, Y. Q. (2004). Regulation of virulence determinants in vitro and in vivo in Staphylococcus aureus. FEMS Immunol. Med. Microbiol. 1, 1-9 doi: 10.1016/S0928-8244(03)00309-2.
    • (2004) FEMS Immunol. Med. Microbiol , vol.1 , pp. 1-9
    • Cheung, A.L.1    Bayer, A.S.2    Zhang, G.3    Gresham, H.4    Xiong, Y.Q.5
  • 14
    • 40449127154 scopus 로고    scopus 로고
    • SarA of Staphylococcus aureus binds to the sarA promoter to regulate gene expression
    • Cheung, A. L., Nishina, K., and Manna, A. C. (2008). SarA of Staphylococcus aureus binds to the sarA promoter to regulate gene expression. J. Bacteriol. 190, 2239-2243. doi: 10.1128/JB.01826-07.
    • (2008) J. Bacteriol , vol.190 , pp. 2239-2243
    • Cheung, A.L.1    Nishina, K.2    Manna, A.C.3
  • 15
    • 0033601339 scopus 로고    scopus 로고
    • SarA, a global regulator of virulence determinants in Staphylococcus aureus, binds to a conserved motif essential for sar-dependent gene regulation
    • Chien, Y., Manna, A. C., Projan, S. J., and Cheung, A. L. (1999). SarA, a global regulator of virulence determinants in Staphylococcus aureus, binds to a conserved motif essential for sar-dependent gene regulation. J. Biol. Chem. 52, 37169-37176. doi: 10.1074/jbc.274.52.37169.
    • (1999) J. Biol. Chem , vol.52 , pp. 37169-37176
    • Chien, Y.1    Manna, A.C.2    Projan, S.J.3    Cheung, A.L.4
  • 16
    • 34248663955 scopus 로고    scopus 로고
    • The single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction: twenty-something years on
    • Chomczynski, P., and Sacchi, N. (2006). The single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction: twenty-something years on. Nat. Protoc. 2, 581-585 doi: 10.1038/nprot.2006.83.
    • (2006) Nat. Protoc , vol.2 , pp. 581-585
    • Chomczynski, P.1    Sacchi, N.2
  • 17
    • 84860840108 scopus 로고    scopus 로고
    • Staphylococcus aureus biofilm formation and antibiotic susceptibility tests on polystyrene and metal surfaces
    • Coraça-Huber, D. C., Fille, M., Hausdorfer, J., Pfaller, K., and Nogler, M. (2012). Staphylococcus aureus biofilm formation and antibiotic susceptibility tests on polystyrene and metal surfaces. J. Appl. Microbiol. 112, 1235-1243. doi: 10.1111/j.1365-2672.2012.05288.x.
    • (2012) J. Appl. Microbiol , vol.112 , pp. 1235-1243
    • Coraça-Huber, D.C.1    Fille, M.2    Hausdorfer, J.3    Pfaller, K.4    Nogler, M.5
  • 18
    • 84881660183 scopus 로고    scopus 로고
    • Infection resistance of degradable versus non-degradable biomaterials: an assessment of the potential mechanisms
    • Daghighi, S., Sjollema, J., van der Mei, H. C., Busscher, H. J., and Rochford, E. T. (2013). Infection resistance of degradable versus non-degradable biomaterials: an assessment of the potential mechanisms. Biomaterials 34, 8013-8017. doi: 10.1016/j.biomaterials.2013.07.044.
    • (2013) Biomaterials , vol.34 , pp. 8013-8017
    • Daghighi, S.1    Sjollema, J.2    van der Mei, H.C.3    Busscher, H.J.4    Rochford, E.T.5
  • 20
    • 79956219045 scopus 로고    scopus 로고
    • Natural and synthetic cathelicidin peptides with anti-microbial and anti-biofilm activity against Staphylococcus aureus
    • Dean, S. N., Bishop, B. M., and van Hoek, M. L. (2011). Natural and synthetic cathelicidin peptides with anti-microbial and anti-biofilm activity against Staphylococcus aureus. BMC Microbiol. 11:114. doi: 10.1186/1471-2180-11-114.
    • (2011) BMC Microbiol , vol.11 , pp. 114
    • Dean, S.N.1    Bishop, B.M.2    van Hoek, M.L.3
  • 21
    • 84861945038 scopus 로고    scopus 로고
    • Biochemical characterization and evaluation of cytotoxicity of antistaphylococcal chimeric protein P128
    • George, S. E., Chikkamadaiah, R., Durgaiah, M., Joshi, A. A., Thankappan, U. P., Madhusudhana, S. N., et al. (2012). Biochemical characterization and evaluation of cytotoxicity of antistaphylococcal chimeric protein P128. BMC Res Notes 5:280. doi: 10.1186/1756-0500-5-280.
    • (2012) BMC Res Notes , vol.5 , pp. 280
    • George, S.E.1    Chikkamadaiah, R.2    Durgaiah, M.3    Joshi, A.A.4    Thankappan, U.P.5    Madhusudhana, S.N.6
  • 22
    • 0034817722 scopus 로고    scopus 로고
    • RNAIII inhibiting peptide (RIP), a global inhibitor of Staphylococcus aureus pathogenesis: structure and function analysis
    • Gov, Y., Bitler, A., Dell'Acqua, G., Torres, J. V., and Balaban, N. (2001). RNAIII inhibiting peptide (RIP), a global inhibitor of Staphylococcus aureus pathogenesis: structure and function analysis. Peptides 22, 1609-1620. doi: 10.1016/S0196-9781(01)00496-X.
    • (2001) Peptides , vol.22 , pp. 1609-1620
    • Gov, Y.1    Bitler, A.2    Dell'Acqua, G.3    Torres, J.V.4    Balaban, N.5
  • 23
    • 80053610673 scopus 로고    scopus 로고
    • Inhibitory effects of D-amino acids on Staphylococcus aureus biofilm development
    • Hochbaum, A. I., Kolodkin-Gal, I., Foulston, L., Kolter, R., Aizenberg, J., and Losick, R. (2011). Inhibitory effects of D-amino acids on Staphylococcus aureus biofilm development. J. Bacteriol. 193, 5616-5622. doi: 10.1128/JB.05534-11.
    • (2011) J. Bacteriol , vol.193 , pp. 5616-5622
    • Hochbaum, A.I.1    Kolodkin-Gal, I.2    Foulston, L.3    Kolter, R.4    Aizenberg, J.5    Losick, R.6
  • 24
    • 42449117637 scopus 로고    scopus 로고
    • Discovery of a quorum-sensing inhibitor of drug-resistant staphylococcal infections by structure-based virtual screening
    • Kiran, M. D., Adikesavan, N. V., Cirioni, O., Giacometti, A., Silvestri, C., Scalise, G., et al. (2008). Discovery of a quorum-sensing inhibitor of drug-resistant staphylococcal infections by structure-based virtual screening. Mol. Pharmacol. 73, 1578-1586. doi: 10.1124/mol.107.044164.
    • (2008) Mol. Pharmacol , vol.73 , pp. 1578-1586
    • Kiran, M.D.1    Adikesavan, N.V.2    Cirioni, O.3    Giacometti, A.4    Silvestri, C.5    Scalise, G.6
  • 25
    • 0242584876 scopus 로고    scopus 로고
    • Strain-specific association of cytotoxic activity and virulence of clinical Staphylococcus aureus isolates
    • Krut, O., Utermöhlen, O., Schlossherr, X., and Krönke, M. (2003). Strain-specific association of cytotoxic activity and virulence of clinical Staphylococcus aureus isolates. Infect. Immun. 71, 2716-2723. doi: 10.1128/IAI.71.5.2716-2723.2003.
    • (2003) Infect. Immun , vol.71 , pp. 2716-2723
    • Krut, O.1    Utermöhlen, O.2    Schlossherr, X.3    Krönke, M.4
  • 26
    • 84902080318 scopus 로고    scopus 로고
    • Factors predictive of treatment failure in staphylococcal prosthetic vascular graft infections: a prospective observational cohort study: impact of rifampin
    • Legout, L., Delia, P., Sarraz-Bournet, B., Rouyer, C., Massongo, M., Valette, M., et al. (2014). Factors predictive of treatment failure in staphylococcal prosthetic vascular graft infections: a prospective observational cohort study: impact of rifampin. BMC Infect. Dis. 14:228. doi: 10.1186/1471-2334-14-228.
    • (2014) BMC Infect. Dis , vol.14 , pp. 228
    • Legout, L.1    Delia, P.2    Sarraz-Bournet, B.3    Rouyer, C.4    Massongo, M.5    Valette, M.6
  • 27
    • 84858698369 scopus 로고    scopus 로고
    • Characteristics and prognosis in patients with prosthetic vascular graft infection: a prospective observational cohort study
    • Legout, L., Sarraz-Bournet, B., D'Elia, P. V., Devos, P., Pasquet, A., Caillaux, M., et al. (2012). Characteristics and prognosis in patients with prosthetic vascular graft infection: a prospective observational cohort study. Clin. Microbiol. Infect. 18, 352-358. doi: 10.1111/j.1469-0691.2011.03618.x.
    • (2012) Clin. Microbiol. Infect , vol.18 , pp. 352-358
    • Legout, L.1    Sarraz-Bournet, B.2    D'Elia, P.V.3    Devos, P.4    Pasquet, A.5    Caillaux, M.6
  • 28
    • 84965186589 scopus 로고    scopus 로고
    • Staphylococcus aureus biofilms: recent developments in biofilm dispersal
    • Lister, J. S., and Horswill, A. R. (2014). Staphylococcus aureus biofilms: recent developments in biofilm dispersal. Front. Cell. Infect. Microbiol. 4:178. doi: 10.3389/fcimb.2014.00178.
    • (2014) Front. Cell. Infect. Microbiol , vol.4 , pp. 178
    • Lister, J.S.1    Horswill, A.R.2
  • 29
    • 33144478753 scopus 로고    scopus 로고
    • Structural and function analyses of the global regulatory protein SarA from Staphylococcus aureus
    • Liu, Y., Manna, A. C., Pan, C. H., Kriksunov, I. A., Thiel, D. J., Cheung, A. L., et al. (2006). Structural and function analyses of the global regulatory protein SarA from Staphylococcus aureus. Proc. Natl. Acad. Sci. U.S.A. 103, 2392-2397. doi: 10.1073/pnas.0510439103.
    • (2006) Proc. Natl. Acad. Sci. U.S.A , vol.103 , pp. 2392-2397
    • Liu, Y.1    Manna, A.C.2    Pan, C.H.3    Kriksunov, I.A.4    Thiel, D.J.5    Cheung, A.L.6
  • 30
    • 70349318569 scopus 로고    scopus 로고
    • Aryl rhodanines specifically inhibit staphylococcal and enterococcal biofilm formation
    • Opperman, T. J., Kwasny, S. M., Williams, J. D., Khan, A. R., Peet, N. P., Moir, D. T., et al. (2012). Aryl rhodanines specifically inhibit staphylococcal and enterococcal biofilm formation. Antimicrob. Agents Chemother. 53, 4357-4367. doi: 10.1128/AAC.00077-09.
    • (2012) Antimicrob. Agents Chemother , vol.53 , pp. 4357-4367
    • Opperman, T.J.1    Kwasny, S.M.2    Williams, J.D.3    Khan, A.R.4    Peet, N.P.5    Moir, D.T.6
  • 32
    • 33645210668 scopus 로고    scopus 로고
    • Characterizing the effect of the Staphylococcus aureus virulence factor regulator, SarA, on log-phase mRNA half-lives
    • Roberts, C., Anderson, K. L., Murphy, E., Projan, S. J., Mounts, W., Hurlburt, B., et al. (2006). Characterizing the effect of the Staphylococcus aureus virulence factor regulator, SarA, on log-phase mRNA half-lives. J. Bacteriol. 188, 2593-2603 doi: 10.1128/JB.188.7.2593-2603.2006.
    • (2006) J. Bacteriol , vol.188 , pp. 2593-2603
    • Roberts, C.1    Anderson, K.L.2    Murphy, E.3    Projan, S.J.4    Mounts, W.5    Hurlburt, B.6
  • 33
    • 84903487653 scopus 로고    scopus 로고
    • Selective chemical inhibition of agr quorum sensing in Staphylococcus aureus promotes host defense with minimal impact on resistance
    • Sully, E. K., Malachowa, N., Elmore, B. O., Alexander, S. M., Femling, J. K., Gray, B. M., et al. (2014). Selective chemical inhibition of agr quorum sensing in Staphylococcus aureus promotes host defense with minimal impact on resistance. PLoS Pathog. 6:e1004174. doi: 10.1371/journal.ppat.1004174.
    • (2014) PLoS Pathog , vol.6
    • Sully, E.K.1    Malachowa, N.2    Elmore, B.O.3    Alexander, S.M.4    Femling, J.K.5    Gray, B.M.6
  • 34
    • 84904479787 scopus 로고    scopus 로고
    • Insights into α-hemolysin (Hla) evolution and expression among Staphylococcus aureus clones with hospital and community origin
    • Tavares, A., Nielsen, J. B., Boye, K., Rohde, S., Paulo, A. C., Westh, H., et al. (2014). Insights into α-hemolysin (Hla) evolution and expression among Staphylococcus aureus clones with hospital and community origin. PLoS ONE 7:e98634. doi: 10.1371/journal.pone.0098634.
    • (2014) PLoS ONE , vol.7
    • Tavares, A.1    Nielsen, J.B.2    Boye, K.3    Rohde, S.4    Paulo, A.C.5    Westh, H.6
  • 35
    • 23644457820 scopus 로고    scopus 로고
    • SarA positively controls bap-dependent biofilm formation in Staphylococcus aureus
    • Trotonda, M. P., Manna, A. C., Cheung, A. L., Lasa, I., and Penadés, J. R. (2005). SarA positively controls bap-dependent biofilm formation in Staphylococcus aureus. J. Bacteriol. 187, 5790-5798. doi: 10.1128/JB.187.16.5790-5798.2005.
    • (2005) J. Bacteriol , vol.187 , pp. 5790-5798
    • Trotonda, M.P.1    Manna, A.C.2    Cheung, A.L.3    Lasa, I.4    Penadés, J.R.5
  • 36
    • 78650936420 scopus 로고    scopus 로고
    • Staphylococcus epidermidis surfactant peptides promote biofilm maturation and dissemination of biofilm-associated infection in mice
    • Wang, R., Khan, B. A., Cheung, G. Y., Bach, T. H. L., Jameson-Lee, M., Kong, K. F., et al. (2011). Staphylococcus epidermidis surfactant peptides promote biofilm maturation and dissemination of biofilm-associated infection in mice. J. Clin. Invest. 121, 238-248. doi: 10.1172/JCI42520.
    • (2011) J. Clin. Invest , vol.121 , pp. 238-248
    • Wang, R.1    Khan, B.A.2    Cheung, G.Y.3    Bach, T.H.L.4    Jameson-Lee, M.5    Kong, K.F.6
  • 37
    • 0034036997 scopus 로고    scopus 로고
    • Agr-independent regulation of fibronectin binding protein(s) by the regulatory locus sar in Staphylococcus aureus
    • Wolz, C., Pöhlmann-Dietze, P., Steinhuber, A., Chien, Y. T., Manna, A., Van Wamel, W., et al. (2000). Agr-independent regulation of fibronectin binding protein(s) by the regulatory locus sar in Staphylococcus aureus. Mol. Microbiol. 36, 230-243. doi: 10.1046/j.1365-2958.2000.01853.x.
    • (2000) Mol. Microbiol , vol.36 , pp. 230-243
    • Wolz, C.1    Pöhlmann-Dietze, P.2    Steinhuber, A.3    Chien, Y.T.4    Manna, A.5    Van Wamel, W.6


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