High Rab27A expression indicates favorable prognosis in CRC

Diagnostic Pathology

Volumn 10, Issue 1, 2015, Pages

  Shi, Chuanbing ^a   Yang, Xiaojun ^b   Ni, Yijiang ^c   Hou, Ning ^d   Xu, Li ^d   Zhan, Feng ^e   Zhu, Huijun ^f   Xiong, Lin ^b,g   Chen, Pingsheng ^a  

^a MEDICAL SCHOOL OF SOUTHEAST UNIVERSITY   (China)

^b THE SECOND AFFILIATED HOSPITAL OF NANJING MEDICAL UNIVERSITY   (China)

^c THE AFFILIATED CHANGZHOU NO 2 PEOPLE S HOSPITAL OF NANJING MEDICAL UNIVERSITY   (China)

^d JIANGSU CANCER HOSPITAL   (China)

^e YIXING PEOPLE S HOSPITAL   (China)

^f NANTONG UNIVERSITY   (China)

^g NANJING MEDICAL UNIVERSITY   (China)

Author keywords

CRC; IHC; Metastasis; Prognosis; qPCR; Rab27A

Indexed keywords

MESSENGER RNA; RAB PROTEIN; RAB27A PROTEIN, HUMAN; TUMOR MARKER;

AGED; CELL DIFFERENTIATION; CHI SQUARE DISTRIBUTION; COLON RESECTION; COLORECTAL NEOPLASMS; ENZYMOLOGY; FEMALE; GENETICS; HUMAN; IMMUNOHISTOCHEMISTRY; KAPLAN MEIER METHOD; MALE; MIDDLE AGED; MORTALITY; MULTIVARIATE ANALYSIS; PATHOLOGY; PREDICTIVE VALUE; PROPORTIONAL HAZARDS MODEL; REAL TIME POLYMERASE CHAIN REACTION; RETROSPECTIVE STUDY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RISK FACTOR; TIME FACTOR; TREATMENT OUTCOME; UPREGULATION;

AGED; BIOMARKERS, TUMOR; CELL DIFFERENTIATION; CHI-SQUARE DISTRIBUTION; COLECTOMY; COLORECTAL NEOPLASMS; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; KAPLAN-MEIER ESTIMATE; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; PREDICTIVE VALUE OF TESTS; PROPORTIONAL HAZARDS MODELS; RAB GTP-BINDING PROTEINS; REAL-TIME POLYMERASE CHAIN REACTION; RETROSPECTIVE STUDIES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RISK FACTORS; RNA, MESSENGER; TIME FACTORS; TREATMENT OUTCOME; UP-REGULATION;

EID: 84931272541     PISSN: None     EISSN: 17461596     Source Type: Journal    
DOI: 10.1186/s13000-015-0303-3     Document Type: Article

References (34)

1. Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. Global cancer statistics. CA: a cancer journal for clinicians. 2011;61(2):69-90.
2. Huang CW, Tsai HL, Chen YT, Huang CM, Ma CJ, Lu CY, et al. The prognostic values of EGFR expression and KRAS mutation in patients with synchronous or metachronous metastatic colorectal cancer. BMC cancer. 2013;13:599.
3. Fang YJ, Wu XJ, Zhao Q, Li LR, Lu ZH, Ding PR, et al. Hospital-based colorectal cancer survival trend of different tumor locations from 1960s to 2000s. PloS one. 2013;8(9), e73528.
4. Kleespies A, Fuessl KE, Seeliger H, Eichhorn ME, Muller MH, Rentsch M, et al. Determinants of morbidity and survival after elective non-curative resection of stage IV colon and rectal cancer. Int J Colorectal Dis. 2009;24(9):1097-109.
5. Platell C, Ng S, O'Bichere A, Tebbutt N. Changing management and survival in patients with stage IV colorectal cancer. Diseases of the colon and rectum. 2011;54(2):214-9.
6. Karoui M, Roudot-Thoraval F, Mesli F, Mitry E, Aparicio T, Des Guetz G, et al. Primary colectomy in patients with stage IV colon cancer and unresectable distant metastases improves overall survival: results of a multicentric study. Diseases of the colon and rectum. 2011;54(8):930-8.
7. Atkin WS, Edwards R, Kralj-Hans I, Wooldrage K, Hart AR, Northover JM, et al. Once-only flexible sigmoidoscopy screening in prevention of colorectal cancer: a multicentre randomised controlled trial. Lancet. 2010;375(9726):1624-33.
8. Chen C, Wang L, Liao Q, Huang Y, Ye H, Chen F, et al. Hypermethylation of EDNRB promoter contributes to the risk of colorectal cancer. Diagnostic pathology. 2013;8:199.
9. Li Y, Wei J, Xu C, Zhao Z, You T. Prognostic significance of cyclin d1 expression in colorectal cancer: a meta-analysis of observational studies. PloS one. 2014;9(4), e94508.
10. Stenmark H. Rab GTPases as coordinators of vesicle traffic. Nature reviews Molecular cell biology. 2009;10(8):513-25.
11. Hutagalung AH, Novick PJ. Role of Rab GTPases in membrane traffic and cell physiology. Physiological reviews. 2011;91(1):119-49.
12. Fukuda M. Rab27 effectors, pleiotropic regulators in secretory pathways. Traffic. 2013;14(9):949-63.
13. Van Gele M, Dynoodt P, Lambert J. Griscelli syndrome: a model system to study vesicular trafficking. Pigment cell & melanoma research. 2009;22(3):268-82.
14. Wang JS, Wang FB, Zhang QG, Shen ZZ, Shao ZM. Enhanced expression of Rab27A gene by breast cancer cells promoting invasiveness and the metastasis potential by secretion of insulin-like growth factor-II. Molecular cancer research: MCR. 2008;6(3):372-82.
15. Montel V, Huang TY, Mose E, Pestonjamasp K, Tarin D. Expression profiling of primary tumors and matched lymphatic and lung metastases in a xenogeneic breast cancer model. The American journal of pathology. 2005;166(5):1565-79.
16. Wu X, Hu A, Zhang M, Chen Z. Effects of Rab27a on proliferation, invasion, and anti-apoptosis in human glioma cell. Tumour biology: the journal of the International Society for Oncodevelopmental Biology and Medicine. 2013;34(4):2195-203.
17. Bobrie A, Krumeich S, Reyal F, Recchi C, Moita LF, Seabra MC, et al. Rab27a supports exosome-dependent and -independent mechanisms that modify the tumor microenvironment and can promote tumor progression. Cancer research. 2012;72(19):4920-30.
18. Wang H, Zhao Y, Zhang C, Li M, Jiang C, Li Y. Rab27a was identified as a prognostic biomaker by mRNA profiling, correlated with malignant progression and subtype preference in gliomas. PloS one. 2014;9(2), e89782.
19. Dong WW, Mou Q, Chen J, Cui JT, Li WM, Xiao WH. Differential expression of Rab27A/B correlates with clinical outcome in hepatocellular carcinoma. World journal of gastroenterology: WJG. 2012;18(15):1806-13.
20. Luo B, Yun X, Fan R, Lin YD, He SJ, Zhang QM, et al. Cancer testis antigen OY-TES-1 expression and serum immunogenicity in colorectal cancer: its relationship to clinicopathological parameters. International journal of clinical and experimental pathology. 2013;6(12):2835-45.
21. Fu M, Fan W, Pu X, Ni H, Zhang W, Chang F, et al. Elevated expression of SHIP2 correlates with poor prognosis in non-small cell lung cancer. International journal of clinical and experimental pathology. 2013;6(10):2185-91.
22. Fu M, Gu X, Ni H, Zhang W, Chang F, Gong L, et al. High expression of inositol polyphosphate phosphatase-like 1 associates with unfavorable survival in hepatocellular carcinoma. International journal of clinical and experimental pathology. 2013;6(11):2515-22.
23. Mao Y, Zhang DW, Zhu H, Lin H, Xiong L, Cao Q, et al. LMP1 and LMP2A are potential prognostic markers of extranodal NK/T-cell lymphoma, nasal type (ENKTL). Diagnostic pathology. 2012;7:178.
24. Zhang H, Qiu J, Ye C, Yang D, Gao L, Su Y, et al. ROR1 expression correlated with poor clinical outcome in human ovarian cancer. Scientific reports. 2014;4:5811.
25. Lin H, Zhang H, Wang J, Lu M, Zheng F, Wang C, et al. A novel human Fab antibody for Trop2 inhibits breast cancer growth in vitro and in vivo. International journal of cancer Journal international du cancer. 2014;134(5):1239-49.
26. Zhu H, Lu J, Wang X, Zhang H, Tang X, Zhu J, et al. Upregulated ZO-1 correlates with favorable survival of gastrointestinal stromal tumor. Medical oncology. 2013;30(3):631.
27. Gu X, Fu M, Ge Z, Zhan F, Ding Y, Ni H, et al. High expression of MAGE-A9 correlates with unfavorable survival in hepatocellular carcinoma. Scientific reports. 2014;4:6625.
28. Cheng KW, Lahad JP, Kuo WL, Lapuk A, Yamada K, Auersperg N, et al. The RAB25 small GTPase determines aggressiveness of ovarian and breast cancers. Nature medicine. 2004;10(11):1251-6.
29. Fan Y, Xin XY, Chen BL, Ma X. Knockdown of RAB25 expression by RNAi inhibits growth of human epithelial ovarian cancer cells in vitro and in vivo. Pathology. 2006;38(6):561-7.
30. Hou Q, Wu YH, Grabsch H, Zhu Y, Leong SH, Ganesan K, et al. Integrative genomics identifies RAB23 as an invasion mediator gene in diffuse-type gastric cancer. Cancer research. 2008;68(12):4623-30.
31. Hendrix A, Maynard D, Pauwels P, Braems G, Denys H, Van den Broecke R, et al. Effect of the secretory small GTPase Rab27B on breast cancer growth, invasion, and metastasis. Journal of the National Cancer Institute. 2010;102(12):866-80.
32. Zeelenberg IS, Ostrowski M, Krumeich S, Bobrie A, Jancic C, Boissonnas A, et al. Targeting tumor antigens to secreted membrane vesicles in vivo induces efficient antitumor immune responses. Cancer research. 2008;68(4):1228-35.
33. Taylor DD, Gercel-Taylor C. Exosomes/microvesicles: mediators of cancer-associated immunosuppressive microenvironments. Seminars in immunopathology. 2011;33(5):441-54.
34. Peinado H, Aleckovic M, Lavotshkin S, Matei I, Costa-Silva B, Moreno-Bueno G, et al. Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET. Nature medicine. 2012;18(6):883-91.