Noninferiority trials: Is a new treatment almost as effective as another?

JAMA - Journal of the American Medical Association

Volumn 313, Issue 23, 2015, Pages 2371-2372

  Kaji, Amy H ^a,b,c   Lewis, Roger J ^a,b,c,d  

^a HARBOR UCLA MEDICAL CENTER   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c LOS ANGELES BIOMEDICAL RESEARCH INSTITUTE   (United States)

^d LLC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT;

ACUTE APPENDICITIS; APPENDECTOMY; ATTRIBUTABLE RISK; COMPARATIVE EFFECTIVENESS; COMPUTER ASSISTED TOMOGRAPHY; HUMAN; INTENTION TO TREAT ANALYSIS; MULTICENTER STUDY (TOPIC); NULL HYPOTHESIS; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); SHORT SURVEY; TREATMENT OUTCOME; CLINICAL TRIAL (TOPIC); METHODOLOGY; PROCEDURES; THERAPY;

CLINICAL TRIALS AS TOPIC; HUMANS; RESEARCH DESIGN; THERAPEUTICS;

EID: 84931095567     PISSN: 00987484     EISSN: 15383598     Source Type: Journal    
DOI: 10.1001/jama.2015.6645     Document Type: Short Survey

References (7)

1. Salminen P, Paajanen H, Rautio T, et al. Antibiotic therapy vs appendectomy for treatment of uncomplicated acute appendicitis: the APPAC randomized clinical trial. JAMA. doi: 10.1001/jama.2015.6154.
2. Young KD, Lewis RJ. What is confidence? I: the use and interpretation of confidence intervals. Ann Emerg Med. 1997;30(3):307-310.
3. Kaji AH, Lewis RJ. Are we looking for superiority, equivalence, or noninferiority? Ann Emerg Med. 2010;55(5):408-411.
4. Mulla SM, Scott IA, Jackevicius CA, et al. How to use a non-inferiority trial: Users' Guides to the Medical Literature. JAMA. 2012;308:2605-2611.
5. Tamayo-Sarver JH, Albert JM, Tamayo-Sarver M, Cydulka RK. Advanced statistics: how to determine whether your intervention is different, at least as effective as, or equivalent. Acad Emerg Med. 2005;12(6):536-542.
6. Piaggio G, Elbourne DR, Altman DG, Pocock SJ, Evans SJW; CONSORT Group. Reporting of noninferiority and equivalence randomized trials: an extension of the CONSORT statement. JAMA. 2006;295(10):1152-1160.
7. Wilms IM, De Hoog DE, De Visser DC, Janzing HM. Appendectomy vs antibiotic treatment for acute appendicitis. Cochrane Database Syst Rev. 2011;(11): CD008359.