A genome-wide approach to children's aggressive behavior: The EAGLE consortium

American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics

Volumn 171, Issue 5, 2016, Pages 562-572

  Pappa, Irene ^a,b   St Pourcain, Beate ^c   Benke, Kelly ^d   Cavadino, Alana ^e,f   Hakulinen, Christian ^g   Nivard, Michel G ^h,i   Nolte, Ilja M ^j   Tiesler, Carla M T ^k,l   Bakermans Kranenburg, Marian J ^m   Davies, Gareth E ⁿ   Evans, David M ^o   Geoffroy, Marie Claude ^e,p   Grallert, Harald ^k   Groen Blokhuis, Maria M ^h,q   Hudziak, James J ^r,s   Kemp, John P ^c,o   Keltikangas Järvinen, Liisa ^g   McMahon, George ^c,o   Mileva Seitz, Viara R ^a   Motazedi, Ehsan ^b   Power, Christine ^e   Raitakari, Olli T ^t   Ring, Susan M ^c   Rivadeneira, Fernando ^s   Rodriguez, Alina ^u   Scheet, Paul A ^v   Seppälä, Ilkka ^w   Snieder, Harold ^j   Standl, Marie ^k   Thiering, Elisabeth ^k,l   Timpson, Nicholas J ^c   Veenstra, René ^x   Velders, Fleur P ^b   Whitehouse, Andrew J O ^y   Smith, George Davey ^c   Heinrich, Joachim ^k   Hypponen, Elina ^a,z,aa   Lehtimäki, Terho ^w   Middeldorp, Christel M ^h,i,q   Oldehinkel, Albertine J ^j   Pennell, Craig E ^ab   Boomsma, Dorret I ^h   Tiemeier, Henning ^b,s   more..

^a ERASMUS UNIVERSITY ROTTERDAM   (Netherlands)

^b ERASMUS MEDICAL CENTER   (Netherlands)

^c UNIVERSITY OF BRISTOL   (United Kingdom)

^d JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

^e UNIVERSITY COLLEGE LONDON   (United Kingdom)

^f QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^g UNIVERSITY OF HELSINKI   (Finland)

^h VU UNIVERSITY AMSTERDAM   (Netherlands)

ⁱ Amsterdam ^*  (Netherlands)

^j UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^k INSTITUTE OF EPIDEMIOLOGY   (Germany)

^l LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^m LEIDEN UNIVERSITY   (Netherlands)

ⁿ Avera Health   (United States)

^o UNIVERSITY OF QUEENSLAND   (Australia)

^p MCGILL UNIVERSITY   (Canada)

^q VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^r UNIVERSITY OF VERMONT   (United States)

^s SOPHIA CHILDREN S HOSPITAL   (Netherlands)

^t UNIVERSITY OF TURKU   (Finland)

^u IMPERIAL COLLEGE LONDON   (United Kingdom)

^v UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^w TAMPERE UNIVERSITY OF TECHNOLOGY   (Finland)

^x UNIVERSITY OF GRONINGEN   (Netherlands)

^y UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^z UNIVERSITY OF SOUTH AUSTRALIA   (Australia)

^aa SOUTH AUSTRALIAN HEALTH AND MEDICAL RESEARCH INSTITUTE   (Australia)

^ab UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

more..

Author keywords

aggression; childhood; genome wide complex trait analysis (GCTA); meta analysis; population based

Indexed keywords

ADOLESCENT; AGGRESSION; ARTICLE; AVPR1A GENE; CHILD; CHILD BEHAVIOR; CONTROLLED STUDY; DEVELOPMENTAL STAGE; GENE; GENE FREQUENCY; GENE LOCUS; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC SCREENING; GENETIC VARIABILITY; GENOME ANALYSIS; GENOME WIDE COMPLEX TRAIT ANALYSIS; GENOME-WIDE ASSOCIATION STUDY; HUMAN; PRIORITY JOURNAL; QUESTIONNAIRE; SINGLE NUCLEOTIDE POLYMORPHISM; BEHAVIOR; BEHAVIOR GENETICS; FEMALE; GENETIC ASSOCIATION STUDY; GENETIC PREDISPOSITION; GENETIC VARIATION; GENETICS; MALE; PHYSIOLOGY; PROCEDURES; PSYCHOLOGY;

AVPR1A PROTEIN, HUMAN; VASOPRESSIN RECEPTOR;

ADOLESCENT; AGGRESSION; BEHAVIOR; CHILD; FEMALE; GENETIC ASSOCIATION STUDIES; GENETIC PREDISPOSITION TO DISEASE; GENETIC VARIATION; GENETICS, BEHAVIORAL; GENOME-WIDE ASSOCIATION STUDY; HUMANS; MALE; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, VASOPRESSIN; SURVEYS AND QUESTIONNAIRES;

EID: 84931088167     PISSN: 15524841     EISSN: 1552485X     Source Type: Journal    
DOI: 10.1002/ajmg.b.32333     Document Type: Article

References (56)

1. Achenbach TM, Rescorla LA. 2000. Manual for the ASEBA preschool forms and profiles.
2. Achenbach TM, Rescorla LA. 2001. ASEBA school age forms and profiles. Burlington: ASEBA.
3. Alink LR, Mesman J, van Zeijl J, Stolk MN, Juffer F, Koot HM, Bakermans-Kranenburg MJ, van Ijzendoorn MH. 2006. The early childhood aggression curve: Development of physical aggression in 10- to 50-month-old children. Child Dev 77(4):954–966.
4. American Psychiatric Association. 2013. Diagnostic and statistical manual of mental disorders. Arlington, VA: American Psychiatric Publishing.
5. Bakermans-Kranenburg MJ, van IJzendoorn MH. 2006. Gene-environment interaction of the dopamine D4 receptor (DRD4) and observed maternal insensitivity predicting externalizing behavior in preschoolers. Dev Psychobiol 48(5):406–409.
6. Balciuniene J, Feng NP, Iyadurai K, Hirsch B, Charnas L, Bill BR, Easterday MC, Staaf J, Oseth L, Czapansky-Beilman D, et al. 2007. Recurrent 10q22-q23 deletions: A genomic disorder on 10q associated with cognitive and behavioral abnormalities. Am J Hum Genet 80(5):938–947.
7. Charles R, Sakurai T, Takahashi N, Elder GA, Gama Sosa MA, Young LJ, Buxbaum JD. 2014. Introduction of the human AVPR1A gene significantly alters brain receptor expression patterns, and may enhance aspects of social behavior in transgenic mice. Dis Model Mech 7(8):1013–1022.
8. Craig IW, Halton KE. 2009. Genetics of human aggressive behaviour. Hum Genet 126(1):101–113.
9. Dick DM, Li TK, Edenberg HJ, Hesselbrock V, Kramer J, Kuperman S, Porjesz B, Bucholz K, Goate A, Nurnberger J, et al. 2004. A genome-wide screen for genes influencing conduct disorder. Mol Psychiatry 9(1):81–86.
10. Dishion T. 2014. In: Lewis M, Rudolph KD, editors. A developmental model of aggression and violence: Microsocial and macrosocial dynamics within an ecological framework. Springer US: Handbook of Developmental Psychopathology. pp 449–465.
11. EAGLE consortium (http://research.lunefeld.ca/eagle). Lunefeld-Tanenbaum Research Institute. (accessed June 4, 2015).
12. Ebstein RP, Knafo A, Mankuta D, Chew SH, Lai PS. 2012. The contributions of oxytocin and vasopressin pathway genes to human behavior. Horm Behav 61(3):359–379.
13. Faraway JJ. 2005. Extending the linear model with R: Generalized linear, mixed effects and nonparametric regression models. Boca Raton, FL: Chapman & Hall/CRC.
14. Ferris CF, Melloni RH, Jr., Koppel G, Perry KW, Fuller RW, Delville Y. 1997. Vasopressin/serotonin interactions in the anterior hypothalamus control aggressive behavior in golden hamsters. J Neurosci 17(11):4331–4340.
15. Goodman R, Scott S. 1999. Comparing the strengths and difficulties questionnaire and the child behavior checklist: Is small beautiful? J Abnorm Child Psychol 27(1):17–24.
16. Hamshere ML, Langley K, Martin J, Agha SS, Stergiakouli E, Anney RJ, Buitelaar J, Faraone SV, Lesch KP, Neale BM, et al. 2013. High loading of polygenic risk for ADHD in children with comorbid aggression. Am J Psychiatry 170(8):909–916.
17. Hudziak JJ, van Beijsterveldt CE, Bartels M, Rietveld MJ, Rettew DC, Derks EM, Boomsma DI. 2003. Individual differences in aggression: Genetic analyses by age, gender, and informant in 3-, 7-, and 10-year-old Dutch twins. Behav Genet 33(5):575–589.
18. Lauren J, Airaksinen MS, Saarma M, Timmusk T. 2003. A novel gene family encoding leucine-rich repeat transmembrane proteins differentially expressed in the nervous system. Genomics 81(4):411–421.
19. Lewis M, Sullivan ASM. 1990. Violation of expectancy, loss of control, and anger expressions in young infants. Dev Psychol 5(26):745–751.
20. Liu JZ, McRae AF, Nyholt DR, Medland SE, Wray NR, Brown KM, Investigators A, Hayward NK, Montgomery GW, Visscher PM, et al. 2010. A versatile gene-based test for genome-wide association studies. Am J Hum Genet 87(1):139–145.
21. Liu YD, Zhu M, Lin L, Fan XL, Piao ZY, Jiang XM. 2014. Deficiency of Trim27 protects dopaminergic neurons from apoptosis in the neurotoxin model of Parkinson's disease. Brain Res 1588:17–24.
22. Mandy W, Roughan L, Skuse D. 2013. Three dimensions of oppositionality in autism spectrum disorder. J Abnorm Child Psychol 42(2):291–300.
23. McGue M, Zhang Y, Miller MB, Basu S, Vrieze S, Hicks B, Malone S, Oetting WS, Iacono WG. 2013. A genome-wide association study of behavioral disinhibition. Behav Genet 43(5):363–373.
24. Merjonen P, Keltikangas-Jarvinen L, Jokela M, Seppala I, Lyytikainen LP, Pulkki-Raback L, Kivimaki M, Elovainio M, Kettunen J, Ripatti S, et al. 2011. Hostility in adolescents and adults: A genome-wide association study of the Young Finns. Transl Psychiatry 1:e11.
25. NICHD Early Child Care Research Network, Arsenio WF. 2004. Trajectories of physical aggression from toddlerhood to middle childhood: Predictors, correlates, and outcomes. Monogr Soc Res Child Dev 69(4):1–143.
26. Najman JM, Williams GM, Nikles J, Spence S, Bor W, O'Callaghan M, Le Brocque R, Andersen MJ, Shuttlewood GJ. 2001. Bias influencing maternal reports of child behaviour and emotional state. Soc Psychiatry Psychiatr Epidemiol 36(4):186–194.
27. Oades RD, Lasky-Su J, Christiansen H, Faraone SV, Sonuga-Barke EJ, Banaschewski T, Chen W, Anney RJ, Buitelaar JK, Ebstein RP, et al. 2008. The influence of serotonin- and other genes on impulsive behavioral aggression and cognitive impulsivity in children with attention-deficit/hyperactivity disorder (ADHD): Findings from a family-based association test (FBAT) analysis. Behav Brain Funct 4:48.
28. Parrott AM, Mathews MB. 2007. Novel rapidly evolving hominid RNAs bind nuclear factor 90 and display tissue-restricted distribution. Nucleic Acids Res 35(18):6249–6258.
29. Pope AW, Bierman KL. 1999. Predicting adolescent peer problems and antisocial activities: The relative roles of aggression and dysregulation. Dev Psychol 35(2):335–346.
30. R Development Core Team. 2013. R: A language and environment for statistical computing. Vienna, Austria: R Foundation for Statistical Computing.
31. Raine A. 2002. Biosocial studies of antisocial and violent behavior in children and adults: A review. J Abnorm Child Psychol 30(4):311–326.
32. Schaeffer CM, Petras H, Ialongo N, Poduska J, Kellam S. 2003. Modeling growth in boys' aggressive behavior across elementary school: Links to later criminal involvement, conduct disorder, and antisocial personality disorder. Dev Psychol 39(6):1020–1035.
33. Scheet P, Ehli EA, Xiao X, van Beijsterveldt CE, Abdellaoui A, Althoff RR, Hottenga JJ, Willemsen G, Nelson KA, Huizenga PE, et al. 2012. Twins, tissue, and time: An assessment of SNPs and CNVs. Twin Res Hum Genet 15(6):737–745.
34. Siddiqui TJ, Tari PK, Connor SA, Zhang P, Dobie FA, She K, Kawabe H, Wang YT, Brose N, Craig AM. 2013. An LRRTM4-HSPG complex mediates excitatory synapse development on dentate gyrus granule cells. Neuron 79(4):680–695.
35. St Pourcain B, Whitehouse AJ, Ang WQ, Warrington NM, Glessner JT, Wang K, Timpson NJ, Evans DM, Kemp JP, Ring SM, et al. 2013. Common variation contributes to the genetic architecture of social communication traits. Mol Autism 4(1):34.
36. St Pourcain B, Skuse DH, Mandy WP, Wang K, Hakonarson H, Timpson NJ, Evans DM, Kemp JP, Ring SM, McArdle WL, et al. 2014. Variability in the common genetic architecture of social-communication spectrum phenotypes during childhood and adolescence. Mol Autism 5(1):18.
37. Takahashi A, Quadros IM, de Almeida RM, Miczek KA. 2012. Behavioral and pharmacogenetics of aggressive behavior. Curr Top Behav Neurosci 12:73–138.
38. Tielbeek JJ, Medland SE, Benyamin B, Byrne EM, Heath AC, Madden PA, Martin NG, Wray NR, Verweij KJ. 2012. Unraveling the genetic etiology of adult antisocial behavior: A genome-wide association study. PLoS ONE 7(10):e45086.
39. Tremblay RE, Nagin DS, Seguin JR, Zoccolillo M, Zelazo PD, Boivin M, Perusse D, Japel C. 2005. Physical aggression during early childhood: Trajectories and predictors. Can Child Adolesc Psychiatr Rev 14(1):3–9.
40. Tremblay RE. 2000. The development of aggressive behaviour during childhood: What have we learned in the past century? Int J Behav Dev 24(2):129–141.
41. Trzaskowski M, Dale PS, Plomin R. 2013. No genetic influence for childhood behavior problems from DNA analysis. J Am Acad Child Adolesc Psychiatry 52(10):1048–1056.
42. Trzaskowski M, Yang J, Visscher PM, Plomin R. 2014. DNA evidence for strong genetic stability and increasing heritability of intelligence from age 7 to 12. Mol Psychiatry 19(3):380–384.
43. Ullah AZD, Lemoine NR, Chelala C. 2012. SNPnexus: A web server for functional annotation of novel and publicly known genetic variants (2012 update). Nucleic Acids Res 40(W1):W65–W70.
44. van Beijsterveldt CE, Bartels M, Hudziak JJ, Boomsma DI. 2003. Causes of stability of aggression from early childhood to adolescence: A longitudinal genetic analysis in Dutch twins. Behav Genet 33(5):591–605.
45. Vassos E, Collier DA, Fazel S. 2013. Systematic meta-analyses and field synopsis of genetic association studies of violence and aggression. Mol Psychiatry 19(4):471-477.
46. Viding E, Price TS, Jaffee SR, Trzaskowski M, Davis OS, Meaburn EL, Haworth CM, Plomin R. 2013. Genetics of callous-unemotional behavior in children. PLoS ONE 8(7):e65789.
47. Visscher PM, Goddard ME. 2015. A general unified framework to assess the sampling variance of heritability estimates using pedigree or marker-based relationships. Genetics 199(1):223–232.
48. Volavka J, Bilder R, Nolan K. 2004. Catecholamines and aggression: The role of COMT and MAO polymorphisms. Ann NY Acad Sci 1036:393–398.
49. Volavka J. 2013. Comorbid personality disorders and violent behavior in psychotic patients. Psychiatr Q 85(1):65–78.
50. White HR, Fite P, Pardini D, Mun EY, Loeber R. 2013. Moderators of the dynamic link between alcohol use and aggressive behavior among adolescent males. J Abnorm Child Psychol 41(2):211–222.
51. Whitlock MC. 2005. Combining probability from independent tests: The weighted Z-method is superior to Fisher's approach. J Evol Biol 18(5):1368–1373.
52. Wilkening S, Chen BW, Bermejo JL, Canzian F. 2009. Is there still a need for candidate gene approaches in the era of genome-wide association studies? Genomics 93(5):415–419.
53. Willer CJ, Li Y, Abecasis GR. 2010. METAL: Fast and efficient meta-analysis of genomewide association scans. Bioinformatics 26(17):2190–2191.
54. Winkler TW, Day FR, Croteau-Chonka DC, Wood AR, Locke AE, Magi R, Ferreira T, Fall T, Graff M, Justice AE, et al. 2014. Quality control and conduct of genome-wide association meta-analyses. Nat Protocols 9(5):1192–1212.
55. Yang J, Lee SH, Goddard ME, Visscher PM. 2011. GCTA: A tool for genome-wide complex trait analysis. Am J Hum Genet 88(1):76–82.
56. Yang J, Lee SH, Goddard ME, Visscher PM. 2013. Genome-wide complex trait analysis (GCTA): Methods, data analyses, and interpretations. Methods Mol Biol 1019:215–236.