A genome-wide association study of behavioral disinhibition

Behavior Genetics

Volumn 43, Issue 5, 2013, Pages 363-373

  McGue, Matt ^a,d   Zhang, Yiwei ^b   Miller, Michael B ^a   Basu, Saonli ^b   Vrieze, Scott ^c   Hicks, Brian ^c   Malone, Steve ^a   Oetting, William S ^a   Iacono, William G ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

^b UNIVERSITY OF MINNESOTA   (United States)

^c UNIVERSITY OF MICHIGAN   (United States)

^d UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

Author keywords

Behavioral disinhibition; GCTA; GWAS; Missing heritability

Indexed keywords

ILLICIT DRUG; NICOTINE;

ADOLESCENT; ADULT; ALCOHOL CONSUMPTION; ALCOHOLISM; ANALYTICAL EQUIPMENT; ARTICLE; BEHAVIORAL DISINHIBITION; CAUCASIAN; CONTROLLED STUDY; DRUG DEPENDENCE; FEMALE; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOTYPE PHENOTYPE CORRELATION; HERITABILITY; HUMAN; MAJOR CLINICAL STUDY; MALE; MOLECULAR PATHOLOGY; PERSONALITY; SINGLE NUCLEOTIDE POLYMORPHISM; TOBACCO DEPENDENCE;

EID: 84883486939     PISSN: 00018244     EISSN: 15733297     Source Type: Journal    
DOI: 10.1007/s10519-013-9606-x     Document Type: Article

References (53)

1. Agrawal A, Edenberg HJ, Foroud T, Bierut LJ, Dunne G, Hinrichs AL, Dick DM (2006) Association of GABRA2 with drug dependence in the collaborative study of the genetics of alcoholism sample. Behav Genet 36(5):640-650. doi: 10.1007/s10519-006-9069-4
2. Allen HL, Estrada K, Lettre G, Berndt SI, Weedon MN, Rivadeneira F, Procardis C (2010) Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature 467(7317):832-838
3. Bergen SE, Gardner CO, Kendler KS (2007) Age-related changes in heritability of behavioral phenotypes over adolescence and young adulthood: a meta-analysis. Twin Res Hum Genet 10(3):423-433. doi: 10.1375/twin.10.3.423
4. Bosker FJ, Hartman CA, Nolte IM, Prins BP, Terpstra P, Posthuma D, Nolen WA (2011) Poor replication of candidate genes for major depressive disorder using genome-wide association data. Mol Psychiatry 16(5):516-532. doi: 10.1038/mp.2010.38
5. Burton PR, Clayton DG, Cardon LR, Craddock N, Deloukas P, Duncanson A (2007) Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature 447(7145):661-678. doi: 10.1038/nature05911
6. Collins AL, Kim Y, Sklar P, O'Donovan MC, Sullivan PF, International Schizophrenia Consortium (2012) Hypothesis-driven candidate genes for schizophrenia compared to genome-wide association results. Psychol Med 42(3):607-616. doi: 10.1017/s0033291711001607
7. Corley RP, Zeiger JS, Crowley T, Ehringer MA, Hewitt JK, Hopfer CJ, Krauter K (2008) Association of candidate genes with antisocial drug dependence in adolescents. Drug Alcohol Depend 96(1-2):90-98. doi: 10.1016/j.drugalcdep. 2008.02.004
8. Davies G, Tenesa A, Payton A, Yang J, Harris SE, Liewald D, Deary IJ (2011) Genome-wide association studies establish that human intelligence is highly heritable and polygenic. Mol Psychiatry 16(10):996-1005
9. Dick DM, Bierut L, Hinrichs A, Fox L, Bucholz KK, Kramer J, Foroud T (2006) The role of GABRA2 in risk for conduct disorder and alcohol and drug dependence across developmental stages. Behav Genet 36(4):577-590
10. Dick DM, Agrawal A, Wang JC, Hinrichs A, Bertelsen S, Bucholz KK, Bierut LJ (2007) Alcohol dependence with comorbid drug dependence: genetic and phenotypic associations suggest a more severe form of the disorder with stronger genetic contribution to risk. Addiction 102(7):1131-1139
11. Dick DM, Aliev F, Wang JC, Grucza RA, Schuckit M, Kuperman S, Goate A (2008) Using dimensional models of externalizing psychopathology to aid in gene identification. Arch Gen Psychiatry 65(3):310-318
12. Dick DM, Latendresse SJ, Lansford JE, Budde JP, Goate A, Dodge KA, Bates JE (2009) Role of GABRA2 in trajectories of externalizing behavior across development and evidence of moderation by parental monitoring. Arch Gen Psychiatry 66(6):649-657
13. Dick DM, Aliev F, Krueger RF, Edwards A, Agrawal A, Lynskey M, Consortia G (2011) Genome-wide association study of conduct disorder symptomatology. Mol Psychiatry 16(8):800-808. doi: 10.1038/mp.2010.73
14. Drgon T, D'Addario C, Uhl GR (2006) Linkage disequilibrium, haplotype and association studies of a chromosome 4 GABA receptor gene cluster: candidate gene variants for addictions. Am J Med Genet B Neuropsychiatr Genet 141B(8):854-860. doi: 10.1002/ajmg.b.30349
15. Furberg H, Kim Y, Dackor J, Boerwinkle E, Franceschini N, Ardissino D, Sullivan PF (2010) Genome-wide meta-analyses identify multiple loci associated with smoking behavior. Nat Genet 42(5):441-447. doi: 10.1038/ng.571
16. Gorenstein EE, Newman JP (1980) Disinhibitory psychopathology: a new perspective and model for research. Psychol Rev 87(3):301-315. doi: 10.1037/0033-295x.87.3.301
17. Hicks BM, Krueger RF, Iacono WG, McGue M, Patrick CJ (2004) Family transmission and heritability of externalizing disorders: a twin-family study. Arch Gen Psychiatry 61(9):922-928
18. Hicks BM, Schalet BD, Malone SM, Iacono WG, McGue M (2011) Psychometric and genetic architecture of substance use disorder and behavioral disinhibition measures for gene association studies. Behav Genet 41(4):459-475. doi: 10.1007/s10519-010-9417-2
19. Hodgkinson CA, Yuan QP, Xu K, Shen PH, Heinz E, Lobos EA, Goldman D (2008) Addictions biology: haplotype-based analysis for 130 candidate genes on a single array. Alcohol Alcohol 43(5):505-515. doi: 10.1093/alcalc/agn032
20. Iacono WG, Malone SM, McGue M (2008) Behavioral disinhibition and the development of early-onset addiction: common and specific influences. Annu Rev Clin Psychol 4:325-348
21. Kendler KS, Prescott CA, Myers J, Neale MC (2003) The structure of genetic and environmental factors for common psychiatric and substance use disorders in men and women. Arch Gen Psychiatry 60:929-937
22. Kendler KS, Kalsi G, Holmans PA, Sanders AR, Aggen SH, Dick DM, Gejman PV (2011) Genomewide association analysis of symptoms of alcohol dependence in the molecular genetics of schizophrenia (MGS2) control sample. Alcohol Clin Exp Res 35(5):963-975
23. Kohli MA, Lucae S, Saemann PG, Schmidt MV, Demirkan A, Hek K, Binder EB (2011) The neuronal transporter gene SLC6A15 confers risk to major depression. Neuron 70(2):252-265. doi: 10.1016/j.neuron.2011.04.005
24. Krueger RF (1999) The structure of common mental disorders. Arch Gen Psychiatry 56:921-926
25. Krueger RF, Hicks BM, Patrick CJ, Carlson SR, Iacono WG, McGue M (2002) Etiologic connections among substance dependence, antisocial behavior, and personality: modeling the externalizing spectrum. J Abnorm Psychol 111(3):411-424
26. Krystal JH, Staley J, Mason G, Petrakis IL, Kaufman J, Harris RA, Lappalainen J (2006) Gamma-aminobutyric acid type A receptors and alcoholism: intoxication, dependence, vulnerability, and treatment. Arch Gen Psychiatry 63(9):957-968
27. Lee SH, DeCandia TR, Ripke S, Yang J, Sullivan PF, Goddard ME, Mol Genetics S (2012) Estimating the proportion of variation in susceptibility to schizophrenia captured by common SNPs. Nat Genet 44(3):247-250. doi: 10.1038/ng.1108
28. Li X, Basu S, Miller MB, Iacono WG, McGue M (2011) A rapid generalized least squares model for a genome-wide quantitative trait association analysis in families. Hum Hered 71(1):67-82
29. Liu JZ, McRae AF, Nyholt DR, Medland SE, Wray NR, Brown KM, Investigators A (2010) A versatile gene-based test for genome-wide association studies. Am J Hum Genet 87(1):139-145. doi: 10.1016/j.ajhg.2010.06.009
30. Manolio TA, Collins FS, Cox NJ, Goldstein DB, Hindorff LA, Hunter DJ, Visscher PM (2009) Finding the missing heritability of complex diseases. Nature 461(7265):747-753
31. Miller MB, Basu S, Cunningham JM, Eskin E, Malone SM, Oetting WS, McGue M (2012) The minnesota center for twin and family research genome-wide association study. Twin Res Hum Genet 15(6):767-774
32. Mobascher A, Rujescu D, Mittelstrass K, Giegling I, Lamina C, Nitz B, Winterer G (2010) Association of a variant in the muscarinic acetylcholine receptor 2 gene (CHRM2) with nicotine addiction. Am J Med Genet B Neuropsychiatr Genet 153B(2):684-690. doi: 10.1002/ajmg.b.31011
33. Neale MC, Boker SM, Xie G, Maes HH (1999) Mx: statistical modeling, 5th edn. Department of Psychiatry, Richmond
34. Panagiotou OA, Ioannidis JP, Genome-Wide Significance (2012) What should the genome-wide significance threshold be? Empirical replication of borderline genetic associations. Int J Epidemiol 41(1):273-286. doi: 10.1093/ije/dyr178
35. Price AL, Patterson NJ, Plenge RM, Weinblatt ME, Shadick NA, Reich D (2006) Principal components analysis corrects for stratification in genome-wide association studies. Nat Genet 38(8):904-909
36. Quay HC (1997) Inhibition and attention deficit hyperactivity disorder. J Abnorm Child Psychol 25(1):7-13. doi: 10.1023/a:1025799122529
37. Reynolds B, Fields S (2012) Delay discounting by adolescents experimenting with cigarette smoking. Addiction 107(2):417-424. doi: 10.1111/j.1360-0443.2011.03644.x
38. Saccone SF, Bierut LJ, Chesler EJ, Kalivas PW, Lerman C, Saccone NL, Rutter JL (2009) Supplementing high-density SNP microarrays for additional coverage of disease-related genes: addiction as a paradigm. PLoS One 4(4):e5225. doi: 10.1371/journal.pone.0005225
39. Saccone NL, Culverhouse RC, Schwantes-An TH, Cannon DS, Chen XN, Cichon S, Bierut LJ (2010) Multiple independent loci at chromosome 15q25.1 affect smoking quantity: a meta-analysis and comparison with lung cancer and COPD. PLoS Genet 6(8):e1001053. doi: 10.1371/journal.pgen.1001053
40. Schol-Gelok S, Janssens A, Tiemeier H, Liu F, Lopez-Leon S, Zorkoltseva IV, van Duijn CM (2010) A genome-wide screen for depression in two independent Dutch populations. Biol Psychiatry 68(2):187-196. doi: 10.1016/j.biopsych.2010. 01.033
41. Schumann G, Coin LJ, Lourdusamy A, Charoen P, Berger KH, Stacey D, Elliott P (2011) Genome-wide association and genetic functional studies identify autism susceptibility candidate 2 gene (AUTS2) in the regulation of alcohol consumption. Proc Natl Acad Sci USA 108(17):7119-7124. doi: 10.1073/pnas. 1017288108
42. Sher KJ, Bartholow BD, Wood MD (2000) Personality and substance use disorders: a prospective study. J Consult Clin Psychol 68(5):818-829. doi: 10.1037//0022-006x.68.5.818
43. Speliotes EK, Willer CJ, Berndt SI, Monda KL, Thorleifsson G, Jackson AU (2010) Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet 42(11):937-948
44. Sullivan PF (2007) Spurious genetic associations. Biol Psychiatry 61(10):1121-1126. doi: 10.1016/j.biopsych.2006.11.010
45. Thorgeirsson TE, Gudbjartsson DF, Surakka I, Vink JM, Amin N, Geller F, Consortium E (2010) Sequence variants at CHRNB3-CHRNA6 and CYP2A6 affect smoking behavior. Nat Genet 42(5):448-453
46. Vinkhuyzen AAE, Pedersen NL, Yang J, Lee SH, Magnusson PKE, Iacono WG, Wray NR (2012) Common SNPs explain some of the variation in the personality dimensions of neuroticism and extraversion. Transl Psychiatry 2:e102. doi: 10.1038/tp.2012.27
47. Visscher PM, Yang JA, Goddard ME (2010) A commentary on common SNPs explain a large proportion of the heritability for human height' by Yang et al. (2010). Twin Res Hum Genet 13(6):517-524. doi: 10.1375/twin.13.6.517
48. Visscher PM, Brown MA, McCarthy MI, Yang J (2012) Five years of GWAS discovery. Am J Hum Genet 90(1):7-24. doi: 10.1016/j.ajhg.2011.11.029
49. Vollebergh WAM, Iedema J, Bijl RV, de Graaf R, Smit F, Ormel J (2001) The structure and stability of common mental disorders: the NEMESIS study. Arch Gen Psychiatry 58(6):597-603
50. Vrieze SI, McGue M, Iacono WG (2012) The interplay of genes and adolescent development in substance use disorders: leveraging findings from GWAS meta-analyses to test developmental hypotheses about nicotine consumption. Hum Genet 131(6):791-801. doi: 10.1007/s00439-012-1167-1
51. Yang JA, Benyamin B, McEvoy BP, Gordon S, Henders AK, Nyholt DR, Visscher PM (2010) Common SNPs explain a large proportion of the heritability for human height. Nat Genet 42(7):565-569. doi: 10.1038/ng.608
52. Yang JA, Lee SH, Goddard ME, Visscher PM (2011) GCTA: a tool for genome-wide complex trait analysis. Am J Hum Genet 88(1):76-82. doi: 10.1016/j.ajhg.2010.11.011
53. Young SE, Stallings MC, Corley RP, Krauter KS, Hewitt JK (2000) Genetic and environmental influences on behavioral disinhibition. Am J Med Genet 96(5):684-695