Gastric-type expression signature in serrated pathway-associated colorectal tumors

Human Pathology

Volumn 46, Issue 5, 2015, Pages 643-656

  Kim, Jung Ho ^a   Kim, Kyung Ju ^b   Rhee, Ye Young ^b   Bae, Jeong Mo ^b   Cho, Nam Yun ^b   Lee, Hye Seung ^c   Kang, Gyeong Hoon ^b  

^a Seoul National University Boramae Hospital   (South Korea)

^b Seoul National University   (South Korea)

^c Seoul National University Bundang Hospital   (South Korea)

Author keywords

Colorectal cancer; Gastric differentiation; Immunohistochemistry; Serrated pathway; Serrated polyp

Indexed keywords

ANXA10 PROTEIN; BIOLOGICAL MARKER; CAUDAL TYPE HOMEOBOX 2; CLDN18 PROTEIN; CTSE PROTEIN; CYTOKERATIN 20; MUCIN 5AC; MUCIN 6; PROTEIN; TRANSCRIPTION FACTOR CDX2; UNCLASSIFIED DRUG; VSIG1 PROTEIN; TUMOR MARKER;

ADULT; ARTICLE; COLORECTAL CARCINOMA; COLORECTAL POLYP; COLORECTAL TUMOR; CONTROLLED STUDY; FEMALE; GASTRIC MUCOSA; GENE EXPRESSION PROFILING; GENE FREQUENCY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MALE; RECTUM MUCOSA; ADENOMA; AGED; COLON POLYP; COLORECTAL NEOPLASMS; PATHOLOGY; PROCEDURES; STOMACH;

ADENOMA; AGED; COLONIC POLYPS; COLORECTAL NEOPLASMS; HUMANS; IMMUNOHISTOCHEMISTRY; STOMACH; TUMOR MARKERS, BIOLOGICAL;

EID: 84930972294     PISSN: 00468177     EISSN: 15328392     Source Type: Journal    
DOI: 10.1016/j.humpath.2015.01.003     Document Type: Article

References (21)

1. F.T. Bosman, F. Carneiro, R.H. Hruban, and N.D. Theise World Health Organization. International Agency for Research on Cancer. WHO classification of tumours of the digestive system 2010 International Agency for Research on Cancer Lyon
2. M. Bettington, N. Walker, A. Clouston, I. Brown, B. Leggett, and V. Whitehall The serrated pathway to colorectal carcinoma: current concepts and challenges Histopathology 62 2013 367 386
3. D.K. Rex, D.J. Ahnen, J.A. Baron, and et al. Serrated lesions of the colorectum: review and recommendations from an expert panel Am J Gastroenterol 107 2012 1315 1329 [quiz 4, 30]
4. D.H. Gonzalo, K.K. Lai, B. Shadrach, and et al. Gene expression profiling of serrated polyps identifies annexin A10 as a marker of a sessile serrated adenoma/polyp J Pathol 230 2013 420 429
5. D.A. Delker, B.M. McGettigan, P. Kanth, and et al. RNA sequencing of sessile serrated colon polyps identifies differentially expressed genes and immunohistochemical markers PLoS One 9 2014 e88367
6. S.R. Owens, S.I. Chiosea, and S.F. Kuan Selective expression of gastric mucin MUC6 in colonic sessile serrated adenoma but not in hyperplastic polyp aids in morphological diagnosis of serrated polyps Mod Pathol 21 2008 660 669
7. A.N. Bartley, P.A. Thompson, J.A. Buckmeier, and et al. Expression of gastric pyloric mucin, MUC6, in colorectal serrated polyps Mod Pathol 23 2010 169 176
8. K. Fujita, M. Hirahashi, H. Yamamoto, and et al. Mucin core protein expression in serrated polyps of the large intestine Virchows Arch 457 2010 443 449
9. J.A. Gibson, H.P. Hahn, A. Shahsafaei, and R.D. Odze MUC expression in hyperplastic and serrated colonic polyps: lack of specificity of MUC6 Am J Surg Pathol 35 2011 742 749
10. T. Yao, T. Kouzuki, M. Kajiwara, N. Matsui, M. Oya, and M. Tsuneyoshi "Serrated" adenoma of the colorectum, with reference to its gastric differentiation and its malignant potential J Pathol 187 1999 511 517
11. M. Koike, K. Inada, H. Nakanishi, A. Matsuura, S. Nakamura, and M. Tatematsu Cellular differentiation status of epithelial polyps of the colorectum: the gastric foveolar cell-type in hyperplastic polyps Histopathology 42 2003 357 364
12. M.D. Walsh, M. Clendenning, E. Williamson, and et al. Expression of MUC2, MUC5AC, MUC5B, and MUC6 mucins in colorectal cancers and their association with the CpG island methylator phenotype Mod Pathol 26 2013 1642 1656
13. J.H. Tsai, Y.L. Lin, Y.C. Cheng, and et al. Aberrant expression of annexin A10 is closely related to gastric phenotype in serrated pathway to colorectal carcinoma Mod Pathol 28 2015 268 278
14. J.H. Kim, Y.Y. Rhee, J.M. Bae, N.Y. Cho, and G.H. Kang Loss of CDX2/CK20 expression is associated with poorly differentiated carcinoma, the CpG island methylator phenotype, and adverse prognosis in microsatellite-unstable colorectal cancer Am J Surg Pathol 37 2013 1532 1541
15. J.H. Kim, K.J. Kim, Y.Y. Rhee, and et al. Expression status of wild-type HSP110 correlates with HSP110 T17 deletion size and patient prognosis in microsatellite-unstable colorectal cancer Mod Pathol 27 2014 443 453
16. J.H. Kim, and G.H. Kang Annexin A10 expression in microsatellite-unstable colorectal cancers: is it specific to sporadic tumors? Am J Surg Pathol 38 2014 1577 1579
17. K. Sentani, N. Sakamoto, F. Shimamoto, K. Anami, N. Oue, and W. Yasui Expression of olfactomedin 4 and claudin-18 in serrated neoplasia of the colorectum: a characteristic pattern is associated with sessile serrated lesion Histopathology 62 2013 1018 1027
18. F. Ponten, K. Jirstrom, and M. Uhlen The human protein atlas - a tool for pathology J Pathol 216 2008 387 393
19. H.O. Wiland IV, B. Shadrach, D. Allende, and et al. Morphologic and molecular characterization of traditional serrated adenomas of the distal colon and rectum Am J Surg Pathol 38 2014 1290 1297
20. J.H. Kim, Y.Y. Rhee, K.J. Kim, N.Y. Cho, H.S. Lee, and G.H. Kang Annexin A10 expression correlates with serrated pathway features in colorectal carcinoma with microsatellite instability APMIS 122 2014 1187 1195
21. R.K. Pai, B.L. Shadrach, P. Carver, and et al. Immunohistochemistry for annexin A10 can distinguish sporadic from Lynch syndrome-associated microsatellite-unstable colorectal carcinoma Am J Surg Pathol 38 2014 518 525