Discovery of a novel trans-1,4-dioxycyclohexane GPR119 agonist series

Bioorganic and Medicinal Chemistry Letters

Volumn 25, Issue 15, 2015, Pages 3034-3038

  Han, Sangdon ^a   Narayanan, Sanju ^a   Kim, Sun Hee ^a   Calderon, Imelda ^a   Zhu, Xiuwen ^a   Kawasaki, Andrew ^a   Yue, Dawei ^a   Lehmann, Juerg ^a   Wong, Amy ^a   Buzard, Daniel J ^a   Semple, Graeme ^a   Carroll, Chris ^a   Chu, Zhi Liang ^a   Al Sharmma, Hussein ^a   Shu, Hsin Hui ^a   Tung, Shiu Feng ^a   Unett, David J ^a   Behan, Dominic P ^a   Yoon, Woo Hyun ^a   Morgan, Michael ^a   Usmani, Khawja A ^a   Chen, Chuan ^a   Sadeque, Abu ^a   Leonard, James N ^a   Jones, Robert M ^a   more..

^a ARENA PHARMACEUTICALS   (United States)

Author keywords

GDIR; GPR119 agonist; T2DM; Trans 1,4 dioxycyclohexane

Indexed keywords

1,4 DIOXYCYCLOHEXANE; CYCLOHEXANE DERIVATIVE; G PROTEIN COUPLED RECEPTOR 119 AGONIST; GLUCOSE; HEMOGLOBIN A1C; SITAGLIPTIN; UNCLASSIFIED DRUG; ANTIDIABETIC AGENT; G PROTEIN COUPLED RECEPTOR; GLUCOSE BLOOD LEVEL; GPR119 PROTEIN, HUMAN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; DRUG DESIGN; DRUG EFFICACY; DRUG POTENCY; DRUG SYNTHESIS; GLUCOSE BLOOD LEVEL; HUMAN; HUMAN CELL; MALE; MOUSE; NONHUMAN; ORAL GLUCOSE TOLERANCE TEST; RAT; STRUCTURE ACTIVITY RELATION; AGONISTS; ANALYSIS; ANIMAL; BLOOD; CHEMISTRY; DIABETES MELLITUS, TYPE 2; METABOLISM; ORAL DRUG ADMINISTRATION; SPRAGUE DAWLEY RAT; ZUCKER RAT;

RODENTIA;

ADMINISTRATION, ORAL; ANIMALS; BLOOD GLUCOSE; CYCLOHEXANES; DIABETES MELLITUS, TYPE 2; HUMANS; HYPOGLYCEMIC AGENTS; MALE; MICE; RATS, SPRAGUE-DAWLEY; RATS, ZUCKER; RECEPTORS, G-PROTEIN-COUPLED; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84930930681     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2015.04.102     Document Type: Article

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