P7, a novel antagonist of corticotropin releasing factor receptor type 1 (CRFR1) screened from phage display library

Biochemical and Biophysical Research Communications

Volumn 463, Issue 3, 2015, Pages 200-204

  Yu, Jinmei ^a   Zhuo, Rengong ^a   Peng, Peng ^a   Liu, Xiaoyan ^a   Yan, Haitao ^a   Zhang, Shuzhuo ^a   Zheng, Jianquan ^a   Wei, Xiaoli ^a   Ma, Xiaoyun ^a  

^a BEIJING INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY   (China)

Author keywords

CRF; CRFR1; CRFR2; Peptide antagonist; Phage display

Indexed keywords

CORTICOTROPIN RELEASING FACTOR; CORTICOTROPIN RELEASING FACTOR ANTAGONIST; CORTICOTROPIN RELEASING FACTOR RECEPTOR 1; CORTICOTROPIN RELEASING FACTOR RECEPTOR 1 ANTAGONIST; CORTICOTROPIN RELEASING FACTOR RECEPTOR 2; P7; POLYPEPTIDE; UNCLASSIFIED DRUG; CORTICOTROPIN RELEASING FACTOR RECEPTOR; CYCLIC AMP; PEPTIDE; PEPTIDE LIBRARY;

ARTICLE; BINDING AFFINITY; BINDING COMPETITION; BIOPANNING; CONTROLLED STUDY; DRUG BINDING SITE; DRUG RECEPTOR BINDING; DRUG SCREENING; HEK293 CELL LINE; HUMAN; HUMAN CELL; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; PEPTIDE LIBRARY; PHAGE DISPLAY; PRIORITY JOURNAL; AMINO ACID SEQUENCE; ANTAGONISTS AND INHIBITORS; CHEMISTRY; METABOLISM; PROTEIN TERTIARY STRUCTURE;

AMINO ACID SEQUENCE; CYCLIC AMP; HEK293 CELLS; HUMANS; PEPTIDE LIBRARY; PEPTIDES; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, CORTICOTROPIN-RELEASING HORMONE;

EID: 84930930281     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2015.05.021     Document Type: Article

References (32)

1. W. Vale, J. Spiess, C. Rivier, and J. Rivier Characterization of a 41-residue ovine hypothalamic peptide that stimulates secretion of corticotropin and beta-endorphin Science 213 1981 1394 1397
2. T.L. Bale, and W.W. Vale CRF and CRF receptors: role in stress responsivity and other behaviors Annu Rev. Pharmacol. Toxicol. 44 2004 525 557
3. A. Korosi, and T.Z. Baram The central corticotropin releasing factor system during development and adulthood Eur. J. Pharmacol. 583 2008 204 214
4. T. Steckler, and F. Holsboer Corticotropin-releasing hormone receptor subtypes and emotion Biol. Psychiatry 46 1999 1480 1508
5. M.A. Zmijewski, and A.T. Slominski Emerging role of alternative splicing of CRF1 receptor in CRF signaling Acta Biochim. Pol. 57 2010 1 13
6. J. Wang, and S. Li Corticotropin-releasing factor family and its receptors: tumor therapeutic targets? Biochem. Biophys. Res. Commun. 362 2007 785 788
7. B.J. Kim, and H.P. Jones Implications of corticotropin releasing factor in targeted anticancer therapy J. Pharm. Pract. 23 2010 86 90
8. J.M. Aubry CRF system and mood disorders J. Chem. Neuroanat. 54 2013 20 24
9. L. Regev, and T.Z. Baram Corticotropin releasing factor in neuroplasticity Front. Neuroendocrinol. 35 2014 171 179
10. C.L. Haass-Koffler, and S.E. Bartlett Stress and addiction: contribution of the corticotropin releasing factor (CRF) system in neuroplasticity Front. Mol. Neurosci. 5 2012 91
11. A.T. Slominski, M.A. Zmijewski, B. Zbytek, D.J. Tobin, T.C. Theoharides, and J. Rivier Key role of CRF in the skin stress response system Endocr. Rev. 34 2013 827 884
12. H. Zhu, J. Wang, J. Li, and S. Li Corticotropin-releasing factor family and its receptors: pro-inflammatory or anti-inflammatory targets in the periphery? Inflamm. Res. 60 2011 715 721
13. R. Buckinx, D. Adriaensen, L.V. Nassauw, and J.P. Timmermans Corticotrophin-releasing factor, related peptides, and receptors in the normal and inflamed gastrointestinal tract Front. Neurosci. 5 2011 54
14. E.P. Zorrilla, M.L. Logrip, and G.F. Koob Corticotropin releasing factor: a key role in the neurobiology of addiction Front. Neuroendocrinol. 35 2014 234 244
15. C. Rivier Role of hypothalamic corticotropin-releasing factor in mediating alcohol-induced activation of the rat hypothalamic-pituitary-adrenal axis Front. Neuroendocrinol. 35 2014 221 233
16. E.P. Zorrilla, M. Heilig, H. de Wit, and Y. Shaham Behavioral, biological, and chemical perspectives on targeting CRF(1) receptor antagonists to treat alcoholism Drug Alcohol Depend. 128 2013 175 186
17. C. Zhang, C.C. Kuo, S.H. Moghadam, L. Monte, K.C. Rice, and R.A. Rissman Corticotropin-releasing factor receptor-1 antagonism reduces oxidative damage in an Alzheimer's disease transgenic mouse model J. Alzheimers Dis. 2015 Feb3 [ePub ahead of print]
18. T.W. Lovenberg, C.W. Liaw, D.E. Grigoriadis, W. Clevenger, D.T. Chalmers, E.B. De Souza, and T. Oltersdorf Cloning and characterization of a functionally distinct corticotropin-releasing factor receptor subtype from rat brain Proc. Natl. Acad. Sci. U S A 92 1995 836 840
19. S.Y. Hsu, and A.J. Hsueh Human stresscopin and stresscopin-related peptide are selective ligands for the type 2 corticotropin-releasing hormone receptor Nat. Med. 7 2001 605 611
20. S.R. Hoare Mechanisms of peptide and nonpeptide ligand binding to class B G-protein-coupled receptors Drug Discov. Today 10 2005 417 427
21. J.E. Rivier, and C.L. Rivier Corticotropin-releasing factor peptide antagonists: design, characterization and potential clinical relevance Front. Neuroendocrinol. 35 2014 161 170
22. J.P. Williams Corticotropin-releasing factor 1 receptor antagonists: a patent review Expert Opin. Ther. Pat. 23 2013 1057 1068
23. D.P. McGregor Discovering and improving novel peptide therapeutics Curr. Opin. Pharmacol. 8 2008 616 619
24. S.R. Hoare, S.K. Sullivan, D.A. Schwarz, N. Ling, W.W. Vale, P.D. Crowe, and D.E. Grigoriadis Ligand affinity for amino-terminal and juxtamembrane domains of the corticotropin releasing factor type I receptor: regulation by G-protein and nonpeptide antagonists Biochemistry 43 2004 3996 4011
25. J. Yu, X. Ma, H. Sun, H. Yan, and J. Zheng Soluble expression of EC1 fragment of human corticotropin-releasing factor receptor I in prokaryotic system Lett. Biotechnol. 22 2011 675 678
26. R.L. Hauger, V. Risbrough, O. Brauns, and a.F.M. Dautzenberg Corticotropin releasing factor (CRF) receptor signaling in the central nervous system: new molecular targets CNS Neurol. Disord. Drug Targets 5 4 2006 453 479
27. A.A. Pioszak, N.R. Parker, K. Suino-Powell, and H.E. Xu Molecular recognition of corticotropin-releasing factor by its G-protein-coupled receptor CRFR1 J. Biol. Chem. 283 2008 32900 32912
28. S. Wille, S. Sydow, M.R. Palchaudhuri, J. Spiess, and F.M. Dautzenberg Identification of amino acids in the N-terminal domain of corticotropin-releasing factor receptor 1 that are important determinants of high-affinity ligand binding J. Neurochem. 72 1999 388 395
29. M.H. Perrin, M.R. DiGruccio, S.C. Koerber, J.E. Rivier, K.S. Kunitake, D.L. Bain, W.H. Fischer, and W.W. Vale A soluble form of the first extracellular domain of mouse type 2beta corticotropin-releasing factor receptor reveals differential ligand specificity J. Biol. Chem. 278 2003 15595 15600
30. E. Im Multi-facets of corticotropin-releasing factor in modulating inflammation and angiogenesis J. Neurogastroenterol. Motil. 21 2015 25 32
31. E. Im Corticotropin-releasing hormone and its biological diversity toward angiogenesis Intest. Res. 12 2014 96 102
32. E. Im, S.H. Rhee, Y.S. Park, C. Fiocchi, Y. Tache, and C. Pothoulakis Corticotropin-releasing hormone family of peptides regulates intestinal angiogenesis Gastroenterology 138 2010 2457-2467, 2467 e2451-2455