Discovery of substituted 1,4-dihydroquinolines as novel promising class of P-glycoprotein inhibitors: First structure-activity relationships and bioanalytical studies

Bioorganic and Medicinal Chemistry Letters

Volumn 25, Issue 15, 2015, Pages 3005-3008

  Hemmer, Marc ^a   Krawczyk, Sören ^a   Simon, Ina ^a   Hilgeroth, Andreas ^a  

^a MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

Author keywords

1 4 Dihydroquinolines; Mdr reversal; P gp inhibitor; Structure activity relationships; Substrate properties

Indexed keywords

DIHYDROQUINOLINE DERIVATIVE; GLYCOPROTEIN P INHIBITOR; MULTIDRUG RESISTANCE PROTEIN; 1,4-DIHYDROQUINOLINE; QUINOLINE DERIVATIVE;

ANALYTIC METHOD; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG SCREENING; FLOW CYTOMETRY; FLUORESCENCE; HYDROGEN BOND; IC50; MOUSE; MULTIDRUG RESISTANCE; NONHUMAN; STRUCTURE ACTIVITY RELATION; ANIMAL; ANTAGONISTS AND INHIBITORS; CHEMISTRY; DRUG EFFECTS; DRUG RESISTANCE; HUMAN; METABOLISM; NEOPLASMS; TUMOR CELL LINE;

ANIMALS; CELL LINE, TUMOR; DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, NEOPLASM; HUMANS; MICE; NEOPLASMS; P-GLYCOPROTEINS; QUINOLINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84930929003     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2015.05.018     Document Type: Article

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