Ectopic expression of anti-HIV-1 shRNAs protects CD8+ T cells modified with CD4ζ CAR from HIV-1 infection and alleviates impairment of cell proliferation

Biochemical and Biophysical Research Communications

Volumn 463, Issue 3, 2015, Pages 216-221

  Kamata, Masakazu ^a   Kim, Patrick Y ^a   Ng, Hwee L ^a   Ringpis, Gene Errol E ^a,c   Kranz, Emiko ^a   Chan, Joshua ^a   O'Connor, Sean ^a   Yang, Otto O ^a,b   Chen, Irvin S Y ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b AIDS HEALTHCARE FOUNDATION   (United States)

^c Calimmune Australia Inc   (United States)

Author keywords

CD4 ; Chimeric antigen receptor (CAR); HIV 1; Immunotherapy; shRNA

Indexed keywords

ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; CD4 ZETA CHIMERIC ANTIGEN RECEPTOR; CHIMERIC ANTIGEN RECEPTOR; LENTIVIRUS VECTOR; SHORT HAIRPIN RNA; UNCLASSIFIED DRUG; CD4 ANTIGEN; SMALL INTERFERING RNA;

ARTICLE; CD8+ T LYMPHOCYTE; CELL FUNCTION; CELL GROWTH; CELL PROLIFERATION; CELL PROTECTION; CYTOKINE PRODUCTION; CYTOPATHOGENIC EFFECT; FLOW CYTOMETRY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; IN VITRO STUDY; IN VIVO STUDY; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; CELL CULTURE; CELL ENGINEERING; GENE EXPRESSION; GENETICS; HIV INFECTIONS; HUMAN IMMUNODEFICIENCY VIRUS 1; IMMUNOLOGY; IMMUNOTHERAPY; VIROLOGY;

HUMAN IMMUNODEFICIENCY VIRUS 1;

ANTIGENS, CD4; CD8-POSITIVE T-LYMPHOCYTES; CELL ENGINEERING; CELL PROLIFERATION; CELLS, CULTURED; GENE EXPRESSION; HIV INFECTIONS; HIV-1; HUMANS; IMMUNOTHERAPY; RNA, SMALL INTERFERING;

EID: 84930925774     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2015.05.026     Document Type: Article

References (38)

1. N. Gulzar, and K.F. Copeland CD8+ T-cells: function and response to HIV infection Curr. HIV Res. 2 2004 23 37
2. A. Joseph, J.H. Zheng, A. Follenzi, T. Dilorenzo, K. Sango, J. Hyman, K. Chen, A. Piechocka-Trocha, C. Brander, E. Hooijberg, D.A. Vignali, B.D. Walker, and H. Goldstein Lentiviral vectors encoding human immunodeficiency virus type 1 (HIV-1)-specific T-cell receptor genes efficiently convert peripheral blood CD8 T lymphocytes into cytotoxic T lymphocytes with potent in vitro and in vivo HIV-1-specific inhibitory activity J. Virol. 82 2008 3078 3089
3. S. Kitchen, B. Levin, G. Bristol, V. Rezek, S. Kim, C. Aguilera-Sandoval, A. Balamurugan, O. Yang, and J. Zack In vivo suppression of HIV by antigen specific T cells derived from engineered hematopoietic stem cells PLoS Pathog. 8 2012 e1002649
4. E. Miyazaki, A. Kawana-Tachikawa, M. Tomizawa, J. Nunoya, T. Odawara, T. Fujii, Y. Shi, G.F. Gao, and A. Iwamoto Highly restricted T-cell receptor repertoire in the CD8+ T-cell response against an HIV-1 epitope with a stereotypic amino acid substitution AIDS 23 2009 651 660
5. R.A. Morgan, M.E. Dudley, and S.A. Rosenberg Adoptive cell therapy: genetic modification to redirect effector cell specificity Cancer J. 16 2010 336 341
6. C.S. Hinrichs, and S.A. Rosenberg Exploiting the curative potential of adoptive T-cell therapy for cancer Immunol. Rev. 257 2014 56 71
7. S. Gill, and C.H. June Going viral: chimeric antigen receptor T-cell therapy for hematological malignancies Immunol. Rev. 263 2015 68 89
8. H.C. Ertl, J. Zaia, S.A. Rosenberg, C.H. June, G. Dotti, J. Kahn, L.J. Cooper, J. Corrigan-Curay, and S.E. Strome Considerations for the clinical application of chimeric antigen receptor T cells: observations from a recombinant DNA Advisory Committee Symposium held June 15, 2010 Cancer Res. 71 2011 3175 3181
9. A.C. Tran, D. Zhang, R. Byrn, and M.R. Roberts Chimeric zeta-receptors direct human natural killer (NK) effector function to permit killing of NK-resistant tumor cells and HIV-infected T lymphocytes J. Immunol. 155 1995 1000 1009
10. O. Yang, A. Tran, S. Kalams, R. Johnson, M. Roberts, and B. Walker Lysis of HIV-1-infected cells and inhibition of viral replication by universal receptor T cells Proc. Natl. Acad. Sci. U. S. A. 94 1997 11478 11483
11. N. Bitton, G. Gorochov, P. Debre, and Z. Eshhar Gene therapy approaches to HIV-infection: immunological strategies: use of T bodies and universal receptors to redirect cytolytic T-cells Front. Biosci. 4 1999 D386 D393
12. R. Mitsuyasu, P. Anton, S. Deeks, D. Scadden, E. Connick, M. Downs, A. Bakker, M. Roberts, C. June, S. Jalali, A. Lin, R. Pennathur-Das, and K. Hege Prolonged survival and tissue trafficking following adoptive transfer of CD4zeta gene-modified autologous CD4(+) and CD8(+) T cells in human immunodeficiency virus-infected subjects Blood 96 2000 785 793
13. R. Walker, C. Bechtel, V. Natarajan, M. Baseler, K. Hege, J. Metcalf, R. Stevens, A. Hazen, R. Blaese, C. Chen, S. Leitman, J. Palensky, J. Wittes, R. Davey Jr., J. Falloon, M. Polis, J. Kovacs, D. Broad, B. Levine, M. Roberts, H. Masur, and H. Lane Long-term in vivo survival of receptor-modified syngeneic T cells in patients with human immunodeficiency virus infection Blood 96 2000 467 474
14. S. Deeks, B. Wagner, P. Anton, R. Mitsuyasu, D. Scadden, C. Huang, C. Macken, D. Richman, C. Christopherson, C. June, R. Lazar, D. Broad, S. Jalali, and K. Hege A phase II randomized study of HIV-specific T-cell gene therapy in subjects with undetectable plasma viremia on combination antiretroviral therapy Mol. Ther. 5 2002 788 797
15. W.Y. Lin, and M.R. Roberts Developmental dissociation of T cells from B, NK, and myeloid cells revealed by MHC class II-specific chimeric immune receptors bearing TCR-zeta or FcR-gamma chain signaling domains Blood 100 2002 3045 3048
16. M.E. Severino, P.T. Sarkis, B.D. Walker, and O.O. Yang Chimeric immune receptor T cells bypass class I requirements and recognize multiple cell types relevant in HIV-1 infection Virology 306 2003 371 375
17. S. Masiero, C. Del Vecchio, R. Gavioli, G. Mattiuzzo, M.G. Cusi, L. Micheli, F. Gennari, A. Siccardi, W.A. Marasco, G. Palu, and C. Parolin T-cell engineering by a chimeric T-cell receptor with antibody-type specificity for the HIV-1 gp120 Gene Ther. 12 2005 299 310
18. J. Scholler, T.L. Brady, G. Binder-Scholl, W.T. Hwang, G. Plesa, K.M. Hege, A.N. Vogel, M. Kalos, J.L. Riley, S.G. Deeks, R.T. Mitsuyasu, W.B. Bernstein, N.E. Aronson, B.L. Levine, F.D. Bushman, and C.H. June Decade-long safety and function of retroviral-modified chimeric antigen receptor T cells Sci. Transl. Med. 4 2012 132ra153
19. G.K. Sahu, K. Sango, N. Selliah, Q. Ma, G. Skowron, and R.P. Junghans Anti-HIV designer T cells progressively eradicate a latently infected cell line by sequentially inducing HIV reactivation then killing the newly gp120-positive cells Virology 446 2013 268 275
20. S. Imlach, S. McBreen, T. Shirafuji, C. Leen, J.E. Bell, and P. Simmonds Activated peripheral CD8 lymphocytes express CD4 in vivo and are targets for infection by human immunodeficiency virus type 1 J. Virol. 75 2001 11555 11564
21. S.G. Kitchen, Y.D. Korin, M.D. Roth, A. Landay, and J.A. Zack Costimulation of naive CD8(+) lymphocytes induces CD4 expression and allows human immunodeficiency virus type 1 infection J. Virol. 72 1998 9054 9060
22. P. Lusso, A. De Maria, M. Malnati, F. Lori, S.E. DeRocco, M. Baseler, and R.C. Gallo Induction of CD4 and susceptibility to HIV-1 infection in human CD8+ T lymphocytes by human herpesvirus 6 Nature 349 1991 533 535
23. G. Ringpis, S. Shimizu, H. Arokium, J. Camba-Colón, M. Carroll, R. Cortado, Y. Xie, P. Kim, A. Sahakyan, E. Lowe, M. Narukawa, F. Kandarian, B. Burke, G. Symonds, D. An, I. Chen, and M. Kamata Engineering HIV-1-resistant T-cells from short-hairpin RNA-expressing hematopoietic stem/progenitor cells in humanized BLT mice PLoS One 7 2012 e53492
24. M. Liang, M. Kamata, K. Chen, N. Pariente, D. An, and I. Chen Inhibition of HIV-1 infection by a unique short hairpin RNA to chemokine receptor 5 delivered into macrophages through hematopoietic progenitor cell transduction J. Gene Med. 12 2010 255 265
25. S. Shimizu, P. Hong, B. Arumugam, L. Pokomo, J. Boyer, N. Koizumi, P. Kittipongdaja, A. Chen, G. Bristol, Z. Galic, J. Zack, O. Yang, I. Chen, B. Lee, and D. An A highly efficient short hairpin RNA potently down-regulates CCR5 expression in systemic lymphoid organs in the hu-BLT mouse model Blood 115 2010 1534 1544
26. S. Shimizu, M. Kamata, P. Kittipongdaja, K. Chen, S. Kim, S. Pang, J. Boyer, F. Qin, D. An, and I. Chen Characterization of a potent non-cytotoxic shRNA directed to the HIV-1 co-receptor CCR5 Genet. Vaccines Ther. 7 2009 8
27. D. An, F. Qin, V. Auyeung, S. Mao, S. Kung, D. Baltimore, and I. Chen Optimization and functional effects of stable short hairpin RNA expression in primary human lymphocytes via lentiviral vectors Mol. Ther. 14 2006 494 504
28. G. Mcintyre, J. Groneman, Y. Yu, A. Jaramillo, S. Shen, and T. Applegate 96 shRNAs designed for maximal coverage of HIV-1 variants Retrovirology 6 2009 55
29. D. An, R. Donahue, M. Kamata, B. Poon, M. Metzger, S. Mao, A. Bonifacino, A. Krouse, J. Darlix, D. Baltimore, F. Qin, and I. Chen Stable reduction of CCR5 by RNAi through hematopoietic stem cell transplant in non-human primates Proc. Natl. Acad. Sci. U. S. A. 104 2007 13110 13115
30. M. Kamata, M. Liang, S. Liu, Y. Nagaoka, and I. Chen Live cell monitoring of hiPSC generation and differentiation using differential expression of endogenous microRNAs PLoS One 5 2010 e11834
31. D.F. Purcell, and M.A. Martin Alternative splicing of human immunodeficiency virus type 1 mRNA modulates viral protein expression, replication, and infectivity J. Virol. 67 1993 6365 6378
32. V. Planelles, F. Bachelerie, J.B. Jowett, A. Haislip, Y. Xie, P. Banooni, T. Masuda, and I.S. Chen Fate of the human immunodeficiency virus type 1 provirus in infected cells: a role for vpr J. Virol. 69 1995 5883 5889
33. B.D. Jamieson, G.M. Aldrovandi, V. Planelles, J.B. Jowett, L. Gao, L.M. Bloch, I.S. Chen, and J.A. Zack Requirement of human immunodeficiency virus type 1 nef for in vivo replication and pathogenicity J. Virol. 68 1994 3478 3485
34. B. Poon, J.B. Jowett, S.A. Stewart, R.W. Armstrong, G.M. Rishton, and I.S. Chen Human immunodeficiency virus type 1 vpr gene induces phenotypic effects similar to those of the DNA alkylating agent, nitrogen mustard J. Virol. 71 1997 3961 3971
35. Z.F. Rosenberg, and A.S. Fauci Immunopathogenic mechanisms of HIV infection Clin. Immunol. Immunopathol. 50 1989 S149 S156
36. B. Macchi, M.A. Petruzzelli, and V. De Laurenzi Biological aspects of HIV infection La Clin. Ter. 140 1992 169 177
37. R.F. Garry Potential mechanisms for the cytopathic properties of HIV AIDS 3 1989 683 694
38. J.M. Costin Cytopathic mechanisms of HIV-1 Virol. J. 4 2007 100