Asymmetric dimethylarginine and l-arginine levels in neonatal sepsis and septic shock

Journal of Maternal-Fetal and Neonatal Medicine

Volumn 28, Issue 8, 2015, Pages 977-982

  Aydemir, Ozge ^a   Ozcan, Beyza ^a   Yucel, Husniye ^a   Yagmur Bas, Ahmet ^a   Demirel, Nihal ^a  

^a Etlik Zübeyde Hanim Women's Health Teaching and Research Hospital   (Turkey)

Author keywords

Asymmetric dimethylarginine; l arginine; Neonatal sepsis; Newborn; Septic shock

Indexed keywords

ARGININE; N(G),N(G) DIMETHYLARGININE; BIOLOGICAL MARKER; N,N-DIMETHYLARGININE;

AMINO ACID ANALYSIS; AMINO ACID BLOOD LEVEL; ARGININE BLOOD LEVEL; ARTICLE; CLINICAL ARTICLE; CLINICAL ASSESSMENT; CLINICAL RISK INDEX FOR BABIES SCORE; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE SEVERITY; FEMALE; HUMAN; HUMAN CELL; INFANT; LABORATORY TEST; MALE; MULTIPLE ORGAN FAILURE; N(G),N(G) DIMETHYLARGININE BLOOD LEVEL; NEWBORN; NEWBORN DEATH; NEWBORN SEPSIS; PRIORITY JOURNAL; PROSPECTIVE STUDY; SCORING SYSTEM; SEPTIC SHOCK; SURVIVOR; ANALOGS AND DERIVATIVES; BLOOD; CASE CONTROL STUDY; CLINICAL TRIAL; MORTALITY; PROGNOSIS; SEPSIS; SEVERITY OF ILLNESS INDEX; SHOCK, SEPTIC;

ARGININE; BIOMARKERS; CASE-CONTROL STUDIES; FEMALE; HUMANS; INFANT, NEWBORN; MALE; MULTIPLE ORGAN FAILURE; PROGNOSIS; PROSPECTIVE STUDIES; SEPSIS; SEVERITY OF ILLNESS INDEX; SHOCK, SEPTIC;

EID: 84930919621     PISSN: 14767058     EISSN: 14764954     Source Type: Journal    
DOI: 10.3109/14767058.2014.939950     Document Type: Article

References (29)

1. Haque KN. Definitions of bloodstream infection in the newborn. Pediatr Crit Care Med 2005;6:45-9.
2. Kermorvant-Duchemin E, Laborie S, Rabilloud M, et al. Outcome and prognostic factors in neonates with septic shock. Pediatr Crit Care Med 2008;9:186-91.
3. Aird WC. The role of the endothelium in severe sepsis and multiple organ dysfunction syndrome. Blood 2003;101:3765-7.
4. Pohl U, Wagner K, de Wit C. Endothelium-derived nitric oxide in the control of tissue perfusion and oxygen supply: physiological and pathophysiological implications. Eur Heart J 1993;14:93-8.
5. Moncada S, Higgs A. The L-arginine-nitric oxide pathway. N Engl J Med 1993;329:2002-12.
6. Vincent JL, Zhang H, Szabo C, Preiser JC. Effects of nitric oxide in septic shock. Am J Respir Crit Care Med 2000;161:1781-5.
7. De Cruz SJ, Kenyon NJ, Sandrock CE. Bench-to-bedside review: The role of nitric oxide in sepsis. Expert Rev Respir Med 2009;3: 511-21.
8. Kilbourn R. The discovery of nitric oxide as a key mediator in septic shock. Sepsis 1998;1:85-91.
9. López A, Lorente JA, Steingrub J, et al. Multiple-center, randomized, placebo-controlled, double-blind study of the nitric oxide synthase inhibitor 546C88: effect on survival in patients with septic shock. Crit Care Med 2004;32:21-30.
10. Vallance P, Leone A, Calver A, et al. Accumulation of an endogenous inhibitor of nitric oxide synthesis in chronic renal failure. Lancet 1992;339:572-5.
11. O'Dwyer MJ, Dempsey F, Crowley V, et al. Septic shock is correlated with asymmetrical dimethyl arginine levels, which may be influenced by a polymorphism in the dimethylarginine dimethylaminohydrolase II gene: A prospective observational study. Crit Care 2006;10:139.
12. Davis JS, Darcy CJ, Yeo TW, et al. Asymmetric dimethylarginine, endothelial nitric oxide bioavailability and mortality in sepsis. PLoS One 2011;6:17260.
13. Argaman Z, Young VR, Noviski N, et al. Arginine and nitric oxide metabolism in critically ill septic pediatric patients. Crit Care Med 2003;31:591-7.
14. Davis JS, Anstey NM. Is plasma arginine concentration decreased in patients with sepsis? A systematic review and meta-analysis. Crit Care Med 2011;39:380-5.
15. Goldstein B, Giroir B, Randolph A. International pediatric sepsis consensus conference: definitions for sepsis and organ dysfunction in pediatrics. Pediatr Crit Care Med 2005;6:2-8.
16. Cardounel AJ, Cui H, Samouilov A, et al. Evidence for the pathophysiological role of endogenous methylarginines in regulation of endothelial NO production and vascular function. J Biol Chem 2007;282:879-87.
17. Böger RH, Sullivan LM, Schwedhelm E, et al. Plasma asymmetric dimethylarginine and incidence of cardiovascular disease and death in the community. Circulation 2009;119:1592-600.
18. Goonasekera CD, Rees DD, Woolard P, et al. Nitric oxide synthase inhibitors and hypertension in children and adolescents. J Hypertens 1997;15:901-9.
19. Brooks ER, Langman CB, Wang S, et al. Methylated arginine derivatives in children and adolescents with chronic kidney disease. Pediatr Nephrol 2009;24:129-34.
20. Tain YL, Huang LT. Asymmetric dimethylarginine: clinical applications in pediatric medicine. J Formos Med Assoc 2011; 110:70-7.
21. Alfiero Bordigato M, Piva D, Di Gangi IM, et al. Asymmetric dimethylarginine in ELBW newborns exposed to chorioamnionitis. Early Hum Dev 2011;87:143-5.
22. Weiss SL, Haymond S, Ralay Ranaivo H, et al. Evaluation of asymmetric dimethylarginine, arginine, and carnitine metabolism in pediatric sepsis. Pediatr Crit Care Med 2012;13: 210-18.
23. Leiper J, Murray-Rust J, McDonald N, Vallance P. S-nitrosylation of dimethylarginine dimethylaminohydrolase regulates enzyme activity: further interactions between nitric oxide synthase and dimethylarginine dimethylaminohydrolase. Proc Natl Acad Sci U S A 2002;99:13527-32.
24. Richir MC, Siroen MP, van Elburg RM, et al. Low plasma concentrations of arginine and asymmetric dimethylarginine in premature infants with necrotizing enterocolitis. Br J Nutr 2007;97: 906-11.
25. Nijveldt RJ, Teerlink T, van Leeuwen PA. The asymmetrical dimethylarginine (ADMA)-multiple organ failure hypothesis. Clin Nutr 2003;22:99-104.
26. Leiper J, Vallance P. The synthesis and metabolism of asymmetric dimethyarginine (ADMA). Eur J Clin Pharmacol 2006;62:33-8.
27. Druml W, Heinzel G, Kleinberger G. Amino acid kinetics in patients with sepsis. Am J Clin Nutr 2001;73:908-13.
28. Luiking YC, Poeze M, Ramsay G, Deutz NE. Reduced citrulline production in sepsis is related to diminished de novo arginine and nitric oxide production. Am J Clin Nutr 2009;89: 142-52.
29. Oladipo OO, Weindel AL, Saunders AN, Dietzen DJ. Impact of premature birth and critical illness on neonatal range of plasma amino acid concentrations determined by LC-MS/MS. Mol Genet Metab 2011;104:476-9.