Differential distribution of IL28B.rs12979860 single-nucleotide polymorphism among Egyptian healthcare workers with and without a hepatitis C virus-specific cellular immune response

Archives of Virology

Volumn 160, Issue 7, 2015, Pages 1741-1750

  Abdelwahab, Sayed F ^a,b,c   Zakaria, Zainab ^b   Sobhy, Maha ^b   Hamdy, Shaimaa ^b   Mahmoud, Mohamed A ^d   Mikhail, Nabiel ^e   Allam, Walaa R ^b   Rewisha, Eman ^d   Waked, Imam ^d  

^a MINIA UNIVERSITY   (Egypt)

^b Holding Company for Biological Products and Vaccines   (Egypt)

^c Department of Microbiology ^*  (Saudi Arabia)

^d MENOUFIA UNIVERSITY   (Egypt)

^e ASSIUT UNIVERSITY   (Egypt)

Author keywords

[No Author keywords available]

Indexed keywords

HEPATITIS C VIRUS;

HEPATITIS ANTIBODIES; IL28B PROTEIN, HUMAN; INTERLEUKINS;

ADULT; ALLELES; COHORT STUDIES; FEMALE; GENETICS; HEPACIVIRUS; HEPATITIS C; HUMANS; IMMUNITY, CELLULAR; IMMUNOLOGY; MALE; MICROBIOLOGY; MIDDLE AGED; PHYSIOLOGY; POLYMORPHISM, SINGLE NUCLEOTIDE; YOUNG ADULT;

ADULT; ALLELES; COHORT STUDIES; FEMALE; HEPACIVIRUS; HEPATITIS ANTIBODIES; HEPATITIS C; HUMANS; IMMUNITY, CELLULAR; INTERLEUKINS; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; YOUNG ADULT;

EID: 84930863803     PISSN: 03048608     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00705-015-2446-7     Document Type: Article

References (54)

1. Abdel-Aziz F, Habib M, Mohamed MK, Abdel-Hamid M, Gamil F, Madkour S, Mikhail NN, Thomas D, Fix AD, Strickland GT, Anwar W, Sallam I (2000) Hepatitis C virus (HCV) infection in a community in the Nile Delta: population description and HCV prevalence. Hepatology 32:111–115
2. Abdel-Hamid M, El-Daly M, Molnegren V, El-Kafrawy S, Abdel-Latif S, Esmat G, Strickland GT, Loffredo C, Albert J, Widell A (2007) Genetic diversity in hepatitis C virus in Egypt and possible association with hepatocellular carcinoma. J Gen Virol 88:1526–1531
3. Abdelwahab S, Rewisha E, Hashem M, Sobhy M, Galal I, Allam WR, Mikhail N, Galal G, El-Tabbakh M, El-Kamary SS, Waked I, Strickland GT (2012) Risk factors for hepatitis C virus infection among Egyptian healthcare workers in a national liver diseases referral centre. Trans R Soc Trop Med Hyg 106:98–103
4. Abdelwahab SF, Zakaria Z, Sobhy M, Rewisha E, Mahmoud MA, Amer MA, Del Sorbo M, Capone S, Nicosia A, Folgori A, Hashem M, El-Kamary SS (2012) Hepatitis C virus-multispecific T-cell responses without viremia or seroconversion among Egyptian health care workers at high risk of infection. Clin Vaccine Immunol 19:780–786
5. Abdelwahab SF, Hashem M, Galal I, Sobhy M, Abdel-Ghaffar TS, Galal G, Mikhail N, El-Kamary SS, Waked I, Strickland GT (2013) Incidence of hepatitis C virus infection among Egyptian healthcare workers at high risk of infection. J Clin Virol 57:24–28
6. Al-Sherbiny M, Osman A, Mohamed N, Shata MT, Abdel-Aziz F, Abdel-Hamid M, Abdelwahab SF, Mikhail N, Stoszek S, Ruggeri L, Folgori A, Nicosia A, Prince AM, Strickland GT (2005) Exposure to hepatitis C virus induces cellular immune responses without detectable viremia or seroconversion. Am J Trop Med Hyg 73:44–49
7. Asselah T, De Muynck S, Broet P, Masliah-Planchon J, Blanluet M, Bieche I, Lapalus M, Martinot-Peignoux M, Lada O, Estrabaud E, Zhang Q, El Ray A, Vidaud D, Ripault MP, Boyer N, Bedossa P, Valla D, Vidaud M, Marcellin P (2012) IL28B polymorphism is associated with treatment response in patients with genotype 4 chronic hepatitis C. J Hepatol 56:527–532
8. Boglione L, Cusato J, De Nicolo A, Cariti G, Allegra S, Ghisetti V, Di Perri G, D’Avolio A (2014) Identification of naive HVC-4 patients who may be treated with pegylated-interferon and ribavirin according to IL28B polymorphisms. Antivir Res 106:105–110
9. Chamberlain RW, Adams N, Saeed AA, Simmonds P, Elliott RM (1997) Complete nucleotide sequence of a type 4 hepatitis C virus variant, the predominant genotype in the Middle East. J Gen Virol 78(Pt 6):1341–1347
10. Derbala M, Rizk NM, Al-Kaabi S, John A, Sharma M, El-dweik N, Yakoob R, Pasic F, Almohanadi M, Alejji K, Abdelmola A, Butt M (2013) The predictive value of IL28B rs12979860, rs11881222 and rs8099917 polymorphisms and IP-10 in the therapeutic response of Egyptian genotype 4 patients. Virology 444:292–300
11. El-Kamary SS, Hashem M, Saleh DA, Abdelwahab SF, Sobhy M, Shebl FM, Shardell MD, Strickland GT, Shata MT (2013) Hepatitis C virus-specific cell-mediated immune responses in children born to mothers infected with hepatitis C virus. J Pediatr 162:148–154
12. El-Zayadi A, Selim O, Dabbous HK, Bianchi F (1994) High frequency of smooth muscle antibodies (SMA) among HCV positive chronic liver disease patients in Egypt. J Egypt Public Health Assoc 69:205–211
13. Frank C, Mohamed MK, Strickland GT, Lavanchy D, Arthur RR, Magder LS, El Khoby T, Abdel-Wahab Y, Aly Ohn ES, Anwar W, Sallam I (2000) The role of parenteral antischistosomal therapy in the spread of hepatitis C virus in Egypt. Lancet 355:887–891
14. Freeman AJ, Ffrench RA, Post JJ, Harvey CE, Gilmour SJ, White PA, Marinos G, van Beek I, Rawlinson WD, Lloyd AR (2004) Prevalence of production of virus-specific interferon-gamma among seronegative hepatitis C-resistant subjects reporting injection drug use. J Infect Dis 190:1093–1097
15. Ge D, Fellay J, Thompson AJ, Simon JS, Shianna KV, Urban TJ, Heinzen EL, Qiu P, Bertelsen AH, Muir AJ, Sulkowski M, McHutchison JG, Goldstein DB (2009) Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance. Nature 461:399–401
16. Guerra J, Garenne M, Mohamed MK, Fontanet A (2012) HCV burden of infection in Egypt: results from a nationwide survey. J Viral Hepat 19:560–567
17. Hashem M, El-Karaksy H, Shata MT, Sobhy M, Helmy H, El-Naghi S, Galal G, Ali ZZ, Esmat G, Abdelwahab SF, Strickland GT, El-Kamary SS (2011) Strong hepatitis C virus (HCV)-specific cell-mediated immune responses in the absence of viremia or antibodies among uninfected siblings of HCV chronically infected children. J Infect Dis 203:854–861
18. Kamal SM, Amin A, Madwar M, Graham CS, He Q, Al Tawil A, Rasenack J, Nakano T, Robertson B, Ismail A, Koziel MJ (2004) Cellular immune responses in seronegative sexual contacts of acute hepatitis C patients. J Virol 78:12252–12258
19. Kamal SM, Kassim SK, Ahmed AI, Mahmoud S, Bahnasy KA, Hafez TA, Aziz IA, Fathelbab IF, Mansour HM (2014) Host and viral determinants of the outcome of exposure to HCV infection genotype 4: a large longitudinal study. Am J Gastroenterol 109:199–211
20. Kennedy PT, Urbani S, Moses RA, Amadei B, Fisicaro P, Lloyd J, Maini MK, Dusheiko G, Ferrari C, Bertoletti A (2006) The influence of T cell cross-reactivity on HCV-peptide specific human T cell response. Hepatology 43:602–611
21. Knapp S, Warshow U, Ho KM, Hegazy D, Little AM, Fowell A, Alexander G, Thursz M, Cramp M, Khakoo SI (2011) A polymorphism in IL28B distinguishes exposed, uninfected individuals from spontaneous resolvers of HCV infection. Gastroenterology 141:320–325, 325 e321–e322
22. Knapp S, Zakaria Z, Hashem M, Zaghla H, Khakoo SI, Waked I, Thursz M, Abdelwahab SF (2015) Influence of IFNL3.rs12979860 and IFNL4.ss469415590 polymorphism on clearance of hepatitis C virus infection among Egyptians. Hepatol Int. doi:10.1007/s12072-015-9619-z
23. Koziel MJ, Wong DK, Dudley D, Houghton M, Walker BD (1997) Hepatitis C virus-specific cytolytic T lymphocyte and T helper cell responses in seronegative persons. J Infect Dis 176:859–866
24. Kubitschke A, Bahr MJ, Aslan N, Bader C, Tillmann HL, Sarrazin C, Greten T, Wiegand J, Manns MP, Wedemeyer H (2007) Induction of hepatitis C virus (HCV)-specific T cells by needle stick injury in the absence of HCV-viraemia. Eur J Clin Invest 37:54–64
25. Kurbanov F, Abdel-Hamid M, Latanich R, Astemborski J, Mohamed M, Mikhail NM, El-Daly M, El-Kafrawy S, Thomas DL, Thio CL (2011) Genetic polymorphism in IL28B is associated with spontaneous clearance of hepatitis C virus genotype 4 infection in an Egyptian cohort. J Infect Dis 204:1391–1394
26. Mahfouz EM, Mossalam FA, Abdel-Rahman SM, Abood SA, Abdelwahab SF (2008) Assessment of needlestick injuries and related knowledge among health care workers participating in an infection control-training program at EI Minia University Hospital. Egypt J Community Med 26:81–93
27. McOmish F, Yap PL, Dow BC, Follett EA, Seed C, Keller AJ, Cobain TJ, Krusius T, Kolho E, Naukkarinen R et al (1994) Geographical distribution of hepatitis C virus genotypes in blood donors: an international collaborative survey. J Clin Microbiol 32:884–892
28. Meyer MF, Lehmann M, Cornberg M, Wiegand J, Manns MP, Klade C, Wedemeyer H (2007) Clearance of low levels of HCV viremia in the absence of a strong adaptive immune response. Virol J 4:58
29. Miller FD, Abu-Raddad LJ (2010) Evidence of intense ongoing endemic transmission of hepatitis C virus in Egypt. Proc Natl Acad Sci USA 107:14757–14762
30. Mizukoshi E, Eisenbach C, Edlin BR, Newton KP, Raghuraman S, Weiler-Normann C, Tobler LH, Busch MP, Carrington M, McKeating JA, O’Brien TR, Rehermann B (2008) Hepatitis C virus (HCV)-specific immune responses of long-term injection drug users frequently exposed to HCV. J Infect Dis 198:203–212
31. Mohamoud YA, Mumtaz GR, Riome S, Miller D, Abu-Raddad LJ (2013) The epidemiology of hepatitis C virus in Egypt: a systematic review and data synthesis. BMC Infect Dis 13:288
32. Munier A, Marzouk D, Abravanel F, El-Daly M, Taylor S, Mamdouh R, Eldin WS, El-Arab HE, Sos DG, Momen M, Okasha O, Le Fouler L, El-Hosini M, Izopet J, Rafik M, Albert M, Abdel-Hamid M, Mohamed MK, Delarocque-Astagneau E, Fontanet A (2013) Frequent transient hepatitis C viremia without seroconversion among healthcare workers in Cairo, Egypt. PLoS One 8:e57835
33. Park SH, Veerapu NS, Shin EC, Biancotto A, McCoy JP, Capone S, Folgori A, Rehermann B (2013) Subinfectious hepatitis C virus exposures suppress T cell responses against subsequent acute infection. Nat Med 19:1638–1642
34. Pasha HF, Radwan MI, Hagrass HA, Tantawy EA, Emara MH (2013) Cytokines genes polymorphisms in chronic hepatitis C: impact on susceptibility to infection and response to therapy. Cytokine 61:478–484
35. Pedergnana V, Abdel-Hamid M, Guergnon J, Mohsen A, Le Fouler L, Theodorou I, Mohamed MK, Fontanet A, Plancoulaine S, Abel L (2012) Analysis of IL28B variants in an Egyptian population defines the 20 kilobases minimal region involved in spontaneous clearance of hepatitis C virus. PLoS One 7:e38578
36. Perrella A, Grattacaso S, d’Antonio A, Atripaldi L, Sbreglia C, Gnarini M, Conti P, Vecchiet J, Perrella O (2009) Evidence of hepatitis C virus-specific interferon gamma-positive T cells in health care workers in an infectious disease department. Am J Infect Control 37:426–429
37. Post JJ, Pan Y, Freeman AJ, Harvey CE, White PA, Palladinetti P, Haber PS, Marinos G, Levy MH, Kaldor JM, Dolan KA, Ffrench RA, Lloyd AR, Rawlinson WD (2004) Clearance of hepatitis C viremia associated with cellular immunity in the absence of seroconversion in the hepatitis C incidence and transmission in prisons study cohort. J Infect Dis 189:1846–1855
38. Rafik MM, Hosny Ael D, Abdallah KO, Abbas AA, Abo Shady RA, Soliman DA, Nasr El-Din Rakha KM, Alfedawy SF (2013) TH1 cytokine response to HCV peptides in Egyptian health care workers: a pilot study. Virol J 10:144
39. Rehermann B, Nascimbeni M (2005) Immunology of hepatitis B virus and hepatitis C virus infection. Nat Rev Immunol 5:215–229
40. Roque-Cuellar MC, Sanchez B, Garcia-Lozano JR, Praena-Fernandez JM, Nunez-Roldan A, Aguilar-Reina J (2011) Cellular immune responses and occult infection in seronegative heterosexual partners of chronic hepatitis C patients. J Viral Hepat 18:e541–e549
41. Saleh DA, Shebl F, Abdel-Hamid M, Narooz S, Mikhail N, El-Batanony M, El-Kafrawy S, El-Daly M, Sharaf S, Hashem M, El-Kamary S, Magder LS, Stoszek SK, Strickland GT (2008) Incidence and risk factors for hepatitis C infection in a cohort of women in rural Egypt. Trans R Soc Trop Med Hyg 102:921–928
42. Saleh DA, Shebl FM, El-Kamary SS, Magder LS, Allam A, Abdel-Hamid M, Mikhail N, Hashem M, Sharaf S, Stoszek SK, Strickland GT (2010) Incidence and risk factors for community-acquired hepatitis C infection from birth to 5 years of age in rural Egyptian children. Trans R Soc Trop Med Hyg 104:357–363
43. Scognamiglio P, Accapezzato D, Casciaro MA, Cacciani A, Artini M, Bruno G, Chircu ML, Sidney J, Southwood S, Abrignani S, Sette A, Barnaba V (1999) Presence of effector CD8+ T cells in hepatitis C virus-exposed healthy seronegative donors. J Immunol 162:6681–6689
44. Shebl FM, El-Kamary SS, Saleh DA, Abdel-Hamid M, Mikhail N, Allam A, El-Arabi H, Elhenawy I, El-Kafrawy S, El-Daly M, Selim S, El-Wahab AA, Mostafa M, Sharaf S, Hashem M, Heyward S, Stine OC, Magder LS, Stoszek S, Strickland GT (2009) Prospective cohort study of mother-to-infant infection and clearance of hepatitis C in rural Egyptian villages. J Med Virol 81:1024–1031
45. Simmonds P, Holmes EC, Cha TA, Chan SW, McOmish F, Irvine B, Beall E, Yap PL, Kolberg J, Urdea MS (1993) Classification of hepatitis C virus into six major genotypes and a series of subtypes by phylogenetic analysis of the NS-5 region. J Gen Virol 74(Pt 11):2391–2399
46. Stoszek SK, Abdel-Hamid M, Narooz S, El Daly M, Saleh DA, Mikhail N, Kassem E, Hawash Y, El Kafrawy S, Said A, El Batanony M, Shebl FM, Sayed M, Sharaf S, Fix AD, Strickland GT (2006) Prevalence of and risk factors for hepatitis C in rural pregnant Egyptian women. Trans R Soc Trop Med Hyg 100:102–107
47. Strickland GT, Elhefni H, Salman T, Waked I, Abdel-Hamid M, Mikhail NN, Esmat G, Fix A (2002) Role of hepatitis C infection in chronic liver disease in Egypt. Am J Trop Med Hyg 67:436–442
48. Strickland GT (2006) Liver disease in Egypt: hepatitis C superseded schistosomiasis as a result of iatrogenic and biological factors. Hepatology 43:915–922
49. Talaat M, Kandeel A, El-Shoubary W, Bodenschatz C, Khairy I, Oun S, Mahoney FJ (2003) Occupational exposure to needlestick injuries and hepatitis B vaccination coverage among health care workers in Egypt. Am J Infect Control 31:469–474
50. Tanaka Y, Nishida N, Sugiyama M, Kurosaki M, Matsuura K, Sakamoto N, Nakagawa M, Korenaga M, Hino K, Hige S, Ito Y, Mita E, Tanaka E, Mochida S, Murawaki Y, Honda M, Sakai A, Hiasa Y, Nishiguchi S, Koike A, Sakaida I, Imamura M, Ito K, Yano K, Masaki N, Sugauchi F, Izumi N, Tokunaga K, Mizokami M (2009) Genome-wide association of IL28B with response to pegylated interferon-alpha and ribavirin therapy for chronic hepatitis C. Nat Genet 41:1105–1109
51. Thomas DL, Astemborski J, Rai RM, Anania FA, Schaeffer M, Galai N, Nolt K, Nelson KE, Strathdee SA, Johnson L, Laeyendecker O, Boitnott J, Wilson LE, Vlahov D (2000) The natural history of hepatitis C virus infection: host, viral, and environmental factors. JAMA 284:450–456
52. Thomas DL, Thio CL, Martin MP, Qi Y, Ge D, O’Huigin C, Kidd J, Kidd K, Khakoo SI, Alexander G, Goedert JJ, Kirk GD, Donfield SM, Rosen HR, Tobler LH, Busch MP, McHutchison JG, Goldstein DB, Carrington M (2009) Genetic variation in IL28B and spontaneous clearance of hepatitis C virus. Nature 461:798–801
53. Waked IA, Saleh SM, Moustafa MS, Raouf AA, Thomas DL, Strickland GT (1995) High prevalence of hepatitis C in Egyptian patients with chronic liver disease. Gut 37:105–107
54. Zeremski M, Shu MA, Brown Q, Wu Y, Des Jarlais DC, Busch MP, Talal AH, Edlin BR (2009) Hepatitis C virus-specific T-cell immune responses in seronegative injection drug users. J Viral Hepat 16:10–20