Analysis of IL28B variants in an Egyptian population defines the 20 Kilobases minimal region involved in spontaneous clearance of hepatitis C virus

PLoS ONE

Volumn 7, Issue 6, 2012, Pages

  Pedergnana, Vincent ^a,b   Abdel Hamid, Mohamed ^c,d   Guergnon, Julien ^e   Mohsen, Amira ^f   Le Fouler, Lénaïg ^g   Theodorou, Ioannis ^e   Mohamed, Mostafa Kamal ^f   Fontanet, Arnaud ^g,h   Plancoulaine, Sabine ^a,b   Abel, Laurent ^a,b,i  

^a IMAGINE INSTITUTE   (France)

^b UNIVERSITÉ PARIS DESCARTES   (France)

^c NATIONAL HEPATOLOGY AND TROPICAL MEDICINE RESEARCH INSTITUTE   (Egypt)

^d Minia Faculty of Medicine   (Egypt)

^e INSERM   (France)

^f AIN SHAMS UNIVERSITY   (Egypt)

^g INSTITUT PASTEUR   (France)

^h Bioinformatique et Chimie Moléculaire   (France)

ⁱ ROCKEFELLER UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; INTERLEUKIN 28B; LYSINE;

ADOLESCENT; ADULT; AMINO ACID SUBSTITUTION; ARTICLE; COHORT ANALYSIS; EGYPTIAN; ETHNIC GROUP; GENE FREQUENCY; GENE LINKAGE DISEQUILIBRIUM; GENETIC ANALYSIS; GENETIC VARIABILITY; GENOTYPE; HEPATITIS C; HEPATITIS C VIRUS; HUMAN; IL28B GENE; MAJOR CLINICAL STUDY; POPULATION GENETICS; PREVALENCE; SINGLE NUCLEOTIDE POLYMORPHISM; VIRAL CLEARANCE;

EGYPT; GENOTYPE; HEPACIVIRUS; HUMANS; INTERLEUKINS; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 84862267413     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0038578     Document Type: Article

References (22)

1. World Health Organisation website. Available: http://www.who.int/mediacentre/factsheets/fs164/en/. Accessed 2012 May 23.
2. Thomas DL, Astemborski J, Rai RM, Anania FA, Schaeffer M, et al. (2000) The natural history of hepatitis C virus infection: host, viral, and environmental factors. Jama 284: 450-456.
3. Balagopal A, Thomas DL, Thio CL, (2010) IL28B and the control of hepatitis C virus infection. Gastroenterology 139: 1865-1876.
4. Rauch A, Gaudieri S, Thio C, Bochud PY, (2009) Host genetic determinants of spontaneous hepatitis C clearance. Pharmacogenomics 10: 1819-1837.
5. Thomas DL, Thio CL, Martin MP, Qi Y, Ge D, et al. (2009) Genetic variation in IL28B and spontaneous clearance of hepatitis C virus. Nature 461: 798-801.
6. Suppiah V, Moldovan M, Ahlenstiel G, Berg T, Weltman M, et al. (2009) IL28B is associated with response to chronic hepatitis C interferon-alpha and ribavirin therapy. Nat Genet 41: 1100-1104.
7. Tanaka Y, Nishida N, Sugiyama M, Kurosaki M, Matsuura K, et al. (2009) Genome-wide association of IL28B with response to pegylated interferon-alpha and ribavirin therapy for chronic hepatitis C. Nat Genet 41: 1105-1109.
8. Guerra J, Garenne M, Mohamed MK, Fontanet A HCV burden of infection in Egypt: results from a nationwide survey. J Viral Hepat, In press.
9. Sievert W, Altraif I, Razavi HA, Abdo A, Ahmed EA, et al. (2011) A systematic review of hepatitis C virus epidemiology in Asia, Australia and Egypt. Liver Int 31: 61-80.
10. Kurbanov F, Abdel-Hamid M, Latanich R, Astemborski J, Mohamed M, et al. (2011) Genetic Polymorphism in IL28B Is Associated With Spontaneous Clearance of Hepatitis C Virus Genotype 4 Infection in an Egyptian Cohort. J Infect Dis 204: 1391-1394.
11. Plancoulaine S, Mohamed MK, Arafa N, Bakr I, Rekacewicz C, et al. (2008) Dissection of familial correlations in hepatitis C virus (HCV) seroprevalence suggests intrafamilial viral transmission and genetic predisposition to infection. Gut 57: 1268-1274.
12. Darwish MA, Faris R, Darwish N, Shouman A, Gadallah M, et al. (2001) Hepatitis c and cirrhotic liver disease in the Nile delta of Egypt: a community-based study. Am J Trop Med Hyg 64: 147-153.
13. Mohamed MK, Bakr I, El-Hoseiny M, Arafa N, Hassan A, et al. (2006) HCV-related morbidity in a rural community of Egypt. J Med Virol 78: 1185-1189.
14. Strickland GT, Elhefni H, Salman T, Waked I, Abdel-Hamid M, et al. (2002) Role of hepatitis C infection in chronic liver disease in Egypt. Am J Trop Med Hyg 67: 436-442.
15. El Gaafary MM, Rekacewicz C, Abdel-Rahman AG, Allam MF, El Hosseiny M, et al. (2005) Surveillance of acute hepatitis C in Cairo, Egypt. J Med Virol 76: 520-525.
16. Paez Jimenez A, Sharaf Eldin N, Rimlinger F, El-Daly M, El-Hariri H, et al. (2010) HCV iatrogenic and intrafamilial transmission in Greater Cairo, Egypt. Gut 59: 1554-1560.
17. Paez Jimenez A, Mohamed MK, Eldin NS, Seif HA, El Aidi S, et al. (2009) Injection drug use is a risk factor for HCV infection in urban Egypt. PLoS One 4: e7193.
18. Soliman C, Rahman IA, Shawky S, Bahaa T, Elkamhawi S, et al. (2010) HIV prevalence and risk behaviors of male injection drug users in Cairo, Egypt. Aids 24: S33-38.
19. A map of human genome variation from population-scale sequencing. Nature 467: 1061-1073. (2010).
20. di Iulio J, Ciuffi A, Fitzmaurice K, Kelleher D, Rotger M, et al. (2011) Estimating the net contribution of interleukin-28B variation to spontaneous hepatitis C virus clearance. Hepatology 53: 1446-1454.
21. Purcell S, Neale B, Todd-Brown K, Thomas L, Ferreira MA, et al. (2007) PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet 81: 559-575.
22. Ramensky V, Bork P, Sunyaev S, (2002) Human non-synonymous SNPs: server and survey. Nucleic Acids Res 30: 3894-3900.