What are the effects of proton pump inhibitors on the small intestine?

World Journal of Gastroenterology

Volumn 21, Issue 22, 2015, Pages 6817-6819

  Fujimori, Shunji ^a  

^a NIPPON MEDICAL SCHOOL   (Japan)

Author keywords

Dysbiosis; Nonsteroidal anti inflammatory drug; Proton pump inhibitors; Small intestinal bacterial overgrowth; Small intestine

Indexed keywords

NONSTEROID ANTIINFLAMMATORY AGENT; PREBIOTIC AGENT; PROBIOTIC AGENT; PROTON PUMP INHIBITOR; LANSOPRAZOLE; OMEPRAZOLE;

AUTOIMMUNE DISEASE; BACTERIAL OVERGROWTH; CLOSTRIDIUM DIFFICILE INFECTION; DIABETES MELLITUS; DRUG EFFECT; DYSBIOSIS; FECES MICROFLORA; GASTRECTOMY; HUMAN; INFLAMMATORY BOWEL DISEASE; INTESTINE FLORA; INTESTINE INJURY; NONALCOHOLIC FATTY LIVER; OBESITY; POSTOPERATIVE PERIOD; REVIEW; SMALL INTESTINE; BACTERIAL GROWTH; DIGESTIVE SYSTEM ULCER; DISEASE EXACERBATION; FECAL MICROBIOTA TRANSPLANTATION; GASTROINTESTINAL DISEASE; META ANALYSIS (TOPIC); NONHUMAN; ORGANISMAL INTERACTION; REFLUX ESOPHAGITIS; SURGICAL PATIENT; SYSTEMATIC REVIEW (TOPIC); SYSTEMIC DISEASE; ANIMAL; DRUG EFFECTS; DRUG INTERACTION; METABOLISM; MICROBIOLOGY; PATHOLOGY; RISK FACTOR;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; DRUG INTERACTIONS; DYSBIOSIS; HUMANS; INTESTINE, SMALL; PROTON PUMP INHIBITORS; RISK FACTORS;

EID: 84930848857     PISSN: 10079327     EISSN: 22192840     Source Type: Journal    
DOI: 10.3748/wjg.v21.i22.6817     Document Type: Review

References (21)

1. Wallace JL, Syer S, Denou E, de Palma G, Vong L, McKnight W, Jury J, Bolla M, Bercik P, Collins SM, Verdu E, Ongini E. Proton pump inhibitors exacerbate NSAID-induced small intestinal injury by inducing dysbiosis. Gastroenterology 2011; 141: 1314-1322, 1322.e1-5 [PMID: 21745447 DOI: 10.1053/j.gastro.2011.06.075]
2. Goldstein JL, Eisen GM, Lewis B, Gralnek IM, Zlotnick S, Fort JG. Video capsule endoscopy to prospectively assess small bowel injury with celecoxib, naproxen plus omeprazole, and placebo. Clin Gastroenterol Hepatol 2005; 3: 133-141 [PMID: 15704047]
3. Fujimori S, Seo T, Gudis K, Ehara A, Kobayashi T, Mitsui K, Yonezawa M, Tanaka S, Tatsuguchi A, Sakamoto C. Prevention of nonsteroidal anti-inflammatory drug-induced small-intestinal injury by prostaglandin: a pilot randomized controlled trial evaluated by capsule endoscopy. Gastrointest Endosc 2009; 69: 1339-1346 [PMID: 19243767 DOI: 10.1016/j.gie.2008.08.017]
4. Fujimori S, Takahashi Y, Seo T, Gudis K, Ehara A, Kobayashi T, Mitsui K, Yonezawa M, Tanaka S, Tatsuguchi A, Sakamoto C. Prevention of traditional NSAID-induced small intestinal injury: recent preliminary studies using capsule endoscopy. Digestion 2010; 82: 167-172 [PMID: 20588029 DOI: 10.1159/000308361]
5. Lanas A, Ferrandez A. NSAID-induced gastrointestinal damage: current clinical management and recommendations for prevention. Chin J Dig Dis 2006; 7: 127-133 [PMID: 16808792]
6. Bai K. On the mechanism of cereobiogen readjustment to dysbiosis. Prog Clin Biol Res 1985; 181: 169-170 [PMID: 3927307]
7. Kanareykina SK, Misautova AA, Zlatkina AR, Levina EN. Proteus dysbioses in patients with ulcerative colitis. Nahrung 1987; 31: 557-561 [PMID: 3657933]
8. Knoke M, Bernhardt H. Clinical significance of changes of flora in the upper digestive tract. Infection 1989; 17: 255-258 [PMID: 2767770]
9. Ruseler-van Embden JG, Schouten WR, van Lieshout LM. Pouchitis: result of microbial imbalance? Gut 1994; 35: 658-664 [PMID: 8200561]
10. Tamboli CP, Neut C, Desreumaux P, Colombel JF. Dysbiosis in inflammatory bowel disease. Gut 2004; 53: 1-4 [PMID: 14684564]
11. Tilg H, Moschen AR. Microbiota and diabetes: an evolving relationship. Gut 2014; 63: 1513-1521 [PMID: 24833634 DOI: 10.1136/gutjnl-2014-306928]
12. Wong VW, Tse CH, Lam TT, Wong GL, Chim AM, Chu WC, Yeung DK, Law PT, Kwan HS, Yu J, Sung JJ, Chan HL. Molecular characterization of the fecal microbiota in patients with nonalcoholic steatohepatitis-a longitudinal study. PLoS One 2013; 8: e62885 [PMID: 23638162 DOI: 10.1371/journal.pone.0062885]
13. Henao-Mejia J, Elinav E, Jin C, Hao L, Mehal WZ, Strowig T, Thaiss CA, Kau AL, Eisenbarth SC, Jurczak MJ, Camporez JP, Shulman GI, Gordon JI, Hoffman HM, Flavell RA. Inflammasomemediated dysbiosis regulates progression of NAFLD and obesity. Nature 2012; 482: 179-185 [PMID: 22297845 DOI: 10.1038/ nature10809]
14. McLean MH, Dieguez D, Miller LM, Young HA. Does the microbiota play a role in the pathogenesis of autoimmune diseases? Gut 2015; 64: 332-341 [PMID: 25416067 DOI: 10.1136/ gutjnl-2014-308514]
15. Spiegel BM, Chey WD, Chang L. Bacterial overgrowth and irritable bowel syndrome: unifying hypothesis or a spurious consequence of proton pump inhibitors? Am J Gastroenterol 2008; 103: 2972-2976 [PMID: 19086951 DOI: 10.1111/ j.1572-0241.2008.01992]
16. Lo WK, Chan WW. Proton pump inhibitor use and the risk of small intestinal bacterial overgrowth: a meta-analysis. Clin Gastroenterol Hepatol 2013; 11: 483-490 [PMID: 23270866 DOI: 10.1016/j.cgh.2012.12.011]
17. Paik CN, Choi MG, Lim CH, Park JM, Chung WC, Lee KM, Jun KH, Song KY, Jeon HM, Chin HM, Park CH, Chung IS. The role of small intestinal bacterial overgrowth in postgastrectomy patients. Neurogastroenterol Motil 2011; 23: e191-e196 [PMID: 21324050 DOI: 10.1111/j.1365-2982.2011.01686]
18. Cunningham R, Dale B, Undy B, Gaunt N. Proton pump inhibitors as a risk factor for Clostridium difficile diarrhoea. J Hosp Infect 2003; 54: 243-245 [PMID: 12855243]
19. Tleyjeh IM, Bin Abdulhak AA, Riaz M, Alasmari FA, Garbati MA, AlGhamdi M, Khan AR, Al Tannir M, Erwin PJ, Ibrahim T, Allehibi A, Baddour LM, Sutton AJ. Association between proton pump inhibitor therapy and clostridium difficile infection: a contemporary systematic review and meta-analysis. PLoS One 2012; 7: e50836 [PMID: 23236397 DOI: 10.1371/journal. pone.0050836]
20. Khoruts A, Dicksved J, Jansson JK, Sadowsky MJ. Changes in the composition of the human fecal microbiome after bacteriotherapy for recurrent Clostridium difficile-associated diarrhea. J Clin Gastroenterol 2010; 44: 354-360 [PMID: 20048681 DOI: 10.1097/ MCG.0b013e3181c87e02]
21. Petrof EO, Khoruts A. From stool transplants to next-generation microbiota therapeutics. Gastroenterology 2014; 146: 1573-1582 [PMID: 24412527 DOI: 10.1053/j.gastro.2014.01.004]