Molecular Characterization of the Fecal Microbiota in Patients with Nonalcoholic Steatohepatitis - A Longitudinal Study

PLoS ONE

Volumn 8, Issue 4, 2013, Pages

  Wong, Vincent Wai Sun ^a   Tse, Chi Hang ^a   Lam, Tommy Tsan Yuk ^b   Wong, Grace Lai Hung ^a   Chim, Angel Mei Ling ^a   Chu, Winnie Chiu Wing ^a   Yeung, David Ka Wai ^a   Law, Patrick Tik Wan ^a   Kwan, Hoi Shan ^a   Yu, Jun ^a   Sung, Joseph Jao Yiu ^a   Chan, Henry Lik Yuen ^a  

^a CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

^b UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

PROBIOTIC AGENT; RNA 16S; TRIACYLGLYCEROL;

ADULT; AGED; ALLISONELLA; ANAEROSPOROBACTER; ARTICLE; BACTERIAL INFECTION; BACTERIUM; BACTEROIDETES; BIODIVERSITY; CLINICAL ARTICLE; CONTROLLED STUDY; FAECALIBACTERIUM; FECAL DYSBIOSIS; FECES MICROFLORA; FEMALE; FIRMICUTES; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; INTESTINE FLORA; INTRAHEPATIC TRIGLYCERIDE CONTENT; LONGITUDINAL STUDY; MALE; MEDICAL PARAMETERS; MICROBIAL DIVERSITY; NONALCOHOLIC FATTY LIVER; PARABACTEROIDES; POPULATION ABUNDANCE; PROTON NUCLEAR MAGNETIC RESONANCE; PYROSEQUENCING; ADOLESCENT; BACTERIA; CASE CONTROL STUDY; FATTY LIVER; FECES; GENETICS; ISOLATION AND PURIFICATION; MICROBIOLOGY; MICROFLORA; MIDDLE AGED; PHYLOGENY; YOUNG ADULT;

ALLISONELLA; BACTERIA (MICROORGANISMS); BACTEROIDETES; FAECALIBACTERIUM; FIRMICUTES;

ADOLESCENT; ADULT; AGED; BACTERIA; CASE-CONTROL STUDIES; FATTY LIVER; FECES; FEMALE; HUMANS; LONGITUDINAL STUDIES; MALE; MICROBIOTA; MIDDLE AGED; PHYLOGENY; YOUNG ADULT;

EID: 84876740446     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0062885     Document Type: Article

References (44)

1. Wong VW, Chu WC, Wong GL, Chan RS, Chim AM, et al. (2012) Prevalence of non-alcoholic fatty liver disease and advanced fibrosis in Hong Kong Chinese: a population study using proton-magnetic resonance spectroscopy and transient elastography. Gut 61: 409-415.
2. Xu C, Yu C, Xu L, Miao M, Li Y, (2010) High serum uric acid increases the risk for nonalcoholic Fatty liver disease: a prospective observational study. PLoS One 5: e11578.
3. Ascha MS, Hanouneh IA, Lopez R, Tamimi TA, Feldstein AF, et al. (2010) The incidence and risk factors of hepatocellular carcinoma in patients with nonalcoholic steatohepatitis. Hepatology 51: 1972-1978.
4. Bhala N, Angulo P, van der Poorten D, Lee E, Hui JM, et al. (2011) The natural history of nonalcoholic fatty liver disease with advanced fibrosis or cirrhosis: an international collaborative study. Hepatology 54: 1208-1216.
5. Wong VW, Wong GL, Choi PC, Chan AW, Li MK, et al. (2010) Disease progression of non-alcoholic fatty liver disease: a prospective study with paired liver biopsies at 3 years. Gut 59: 969-974.
6. Targher G, Day CP, Bonora E, (2010) Risk of cardiovascular disease in patients with nonalcoholic fatty liver disease. N Engl J Med 363: 1341-1350.
7. Wong VW, Wong GL, Yip GW, Lo AO, Limquiaco J, et al. (2011) Coronary artery disease and cardiovascular outcomes in patients with non-alcoholic fatty liver disease. Gut 60: 1721-1727.
8. Miele L, Valenza V, La Torre G, Montalto M, Cammarota G, et al. (2009) Increased intestinal permeability and tight junction alterations in nonalcoholic fatty liver disease. Hepatology 49: 1877-1887.
9. Harte AL, da Silva NF, Creely SJ, McGee KC, Billyard T, et al. (2010) Elevated endotoxin levels in non-alcoholic fatty liver disease. J Inflamm (Lond) 7: 15.
10. Verdam FJ, Rensen SS, Driessen A, Greve JW, Buurman WA, (2011) Novel evidence for chronic exposure to endotoxin in human nonalcoholic steatohepatitis. J Clin Gastroenterol 45: 149-152.
11. Spruss A, Kanuri G, Wagnerberger S, Haub S, Bischoff SC, et al. (2009) Toll-like receptor 4 is involved in the development of fructose-induced hepatic steatosis in mice. Hepatology 50: 1094-1104.
12. Wagnerberger S, Spruss A, Kanuri G, Volynets V, Stahl C, et al. (2012) Toll-like receptors 1-9 are elevated in livers with fructose-induced hepatic steatosis. Br J Nutr 107: 1727-1738.
13. Li Z, Yang S, Lin H, Huang J, Watkins PA, et al. (2003) Probiotics and antibodies to TNF inhibit inflammatory activity and improve nonalcoholic fatty liver disease. Hepatology 37: 343-350.
14. Ma X, Hua J, Li Z, (2008) Probiotics improve high fat diet-induced hepatic steatosis and insulin resistance by increasing hepatic NKT cells. J Hepatol 49: 821-830.
15. Aller R, De Luis DA, Izaola O, Conde R, Gonzalez Sagrado M, et al. (2011) Effect of a probiotic on liver aminotransferases in nonalcoholic fatty liver disease patients: a double blind randomized clinical trial. Eur Rev Med Pharmacol Sci 15: 1090-1095.
16. Malaguarnera M, Vacante M, Antic T, Giordano M, Chisari G, et al. (2012) Bifidobacterium longum with fructo-oligosaccharides in patients with non alcoholic steatohepatitis. Dig Dis Sci 57: 545-553.
17. Wong VW, Won GL, Chim AM, Chu WC, Yeung DK, et al. (2013) Treatment of nonalcoholic steatohepatitis with probiotics. A proof-of-concept study. Ann Hepatol 12: 256-262.
18. Gill SR, Pop M, Deboy RT, Eckburg PB, Turnbaugh PJ, et al. (2006) Metagenomic analysis of the human distal gut microbiome. Science 312: 1355-1359.
19. Ley RE, Turnbaugh PJ, Klein S, Gordon JI, (2006) Microbial ecology: human gut microbes associated with obesity. Nature 444: 1022-1023.
20. Turnbaugh PJ, Hamady M, Yatsunenko T, Cantarel BL, Duncan A, et al. (2009) A core gut microbiome in obese and lean twins. Nature 457: 480-484.
21. Qin J, Li Y, Cai Z, Li S, Zhu J, et al. (2012) A metagenome-wide association study of gut microbiota in type 2 diabetes. Nature 490: 55-60.
22. Larsen N, Vogensen FK, van den Berg FW, Nielsen DS, Andreasen AS, et al. (2010) Gut microbiota in human adults with type 2 diabetes differs from non-diabetic adults. PLoS One 5: e9085.
23. Backhed F, Ding H, Wang T, Hooper LV, Koh GY, et al. (2004) The gut microbiota as an environmental factor that regulates fat storage. Proc Natl Acad Sci U S A 101: 15718-15723.
24. Spencer MD, Hamp TJ, Reid RW, Fischer LM, Zeisel SH, et al. (2011) Association between composition of the human gastrointestinal microbiome and development of fatty liver with choline deficiency. Gastroenterology 140: 976-986.
25. Chalasani N, Younossi Z, Lavine JE, Diehl AM, Brunt EM, et al. (2012) The diagnosis and management of non-alcoholic fatty liver disease: practice Guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association. Hepatology 55: 2005-2023.
26. Kleiner DE, Brunt EM, Van Natta M, Behling C, Contos MJ, et al. (2005) Design and validation of a histological scoring system for nonalcoholic fatty liver disease. Hepatology 41: 1313-1321.
27. Wong VW, Wong GL, Tsang SW, Fan T, Chu WC, et al. (2011) High prevalence of colorectal neoplasm in patients with non-alcoholic steatohepatitis. Gut 60: 829-836.
28. Liu Z, Lozupone C, Hamady M, Bushman FD, Knight R, (2007) Short pyrosequencing reads suffice for accurate microbial community analysis. Nucleic Acids Res 35: e120.
29. Andersson AF, Lindberg M, Jakobsson H, Backhed F, Nyren P, et al. (2008) Comparative analysis of human gut microbiota by barcoded pyrosequencing. PLoS One 3: e2836.
30. Cole JR, Wang Q, Cardenas E, Fish J, Chai B, et al. (2009) The Ribosomal Database Project: improved alignments and new tools for rRNA analysis. Nucleic Acids Res 37: D141-145.
31. Wang Q, Garrity GM, Tiedje JM, Cole JR, (2007) Naive Bayesian classifier for rapid assignment of rRNA sequences into the new bacterial taxonomy. Appl Environ Microbiol 73: 5261-5267.
32. Xia J, Wishart DS, (2011) Web-based inference of biological patterns, functions and pathways from metabolomic data using MetaboAnalyst. Nat Protoc 6: 743-760.
33. Nawrocki EP, Kolbe DL, Eddy SR, (2009) Infernal 1.0: inference of RNA alignments. Bioinformatics 25: 1335-1337.
34. Price MN, Dehal PS, Arkin AP, (2010) FastTree 2-approximately maximum-likelihood trees for large alignments. PLoS One 5: e9490.
35. Hamady M, Lozupone C, Knight R, (2010) Fast UniFrac: facilitating high-throughput phylogenetic analyses of microbial communities including analysis of pyrosequencing and PhyloChip data. ISME J 4: 17-27.
36. Turnbaugh PJ, Ley RE, Mahowald MA, Magrini V, Mardis ER, et al. (2006) An obesity-associated gut microbiome with increased capacity for energy harvest. Nature 444: 1027-1031.
37. Saulnier DM, Riehle K, Mistretta TA, Diaz MA, Mandal D, et al. (2011) Gastrointestinal microbiome signatures of pediatric patients with irritable bowel syndrome. Gastroenterology 141: 1782-1791.
38. Rajilic-Stojanovic M, Biagi E, Heilig HG, Kajander K, Kekkonen RA, et al. (2011) Global and deep molecular analysis of microbiota signatures in fecal samples from patients with irritable bowel syndrome. Gastroenterology 141: 1792-1801.
39. de Wit N, Derrien M, Bosch-Vermeulen H, Oosterink E, Keshtkar S, et al. (2012) Saturated fat stimulates obesity and hepatic steatosis and affects gut microbiota composition by an enhanced overflow of dietary fat to the distal intestine. Am J Physiol Gastrointest Liver Physiol 303: G589-599.
40. Serino M, Luche E, Gres S, Baylac A, Berge M, et al. (2012) Metabolic adaptation to a high-fat diet is associated with a change in the gut microbiota. Gut 61: 543-553.
41. Zhu L, Baker SS, Gill C, Liu W, Alkhouri R, et al. (2013) Characterization of gut microbiomes in nonalcoholic steatohepatitis (NASH) patients: A connection between endogenous alcohol and NASH. Hepatology 57: 601-609.
42. Sokol H, Pigneur B, Watterlot L, Lakhdari O, Bermudez-Humaran LG, et al. (2008) Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patients. Proc Natl Acad Sci U S A 105: 16731-16736.
43. Nardone G, Compare D, Liguori E, Di Mauro V, Rocco A, et al. (2010) Protective effects of Lactobacillus paracasei F19 in a rat model of oxidative and metabolic hepatic injury. Am J Physiol Gastrointest Liver Physiol 299: G669-676.
44. Qin J, Li R, Raes J, Arumugam M, Burgdorf KS, et al. (2010) A human gut microbial gene catalogue established by metagenomic sequencing. Nature 464: 59-65.