KCNJ10 (Kir4.1) is expressed in the basolateral membrane of the cortical thick ascending limb

American Journal of Physiology - Renal Physiology

Volumn 308, Issue 11, 2015, Pages F1288-F1296

  Zhang, Chengbiao ^a,b   Wang, Lijun ^b   Su, Xiao Tong ^b   Lin, Dao Hong ^b   Wang, Wen Hui ^b  

^a XUZHOU MEDICAL UNIVERSITY   (China)

^b NEW YORK MEDICAL COLLEGE   (United States)

Author keywords

EAST SeSAME syndrome; Kir.4.1; Kir5.1; NKCC2

Indexed keywords

POTASSIUM CHANNEL; POTASSIUM CHANNEL KIR4.1; SODIUM POTASSIUM CHLORIDE COTRANSPORTER 2; UNCLASSIFIED DRUG; INWARDLY RECTIFYING POTASSIUM CHANNEL; KCNJ10 (CHANNEL); SLC12A1 PROTEIN, MOUSE; SODIUM;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BASOLATERAL MEMBRANE; CELL ATTACHED PATCH CLAMP; CELL MEMBRANE POTENTIAL; CONTROLLED STUDY; CORTICAL THICK ASCENDING LIMB; HENLE LOOP; IMMUNOHISTOCHEMISTRY; KIDNEY CORTEX; KIDNEY DISTAL TUBULE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; WHOLE CELL PATCH CLAMP; ANIMAL; CELL MEMBRANE; ION TRANSPORT; KNOCKOUT MOUSE; LIMB; MEMBRANE POTENTIAL; METABOLISM; PHYSIOLOGY;

ANIMALS; CELL MEMBRANE; EXTREMITIES; ION TRANSPORT; KIDNEY TUBULES, DISTAL; MEMBRANE POTENTIALS; MICE, KNOCKOUT; POTASSIUM CHANNELS, INWARDLY RECTIFYING; SODIUM; SOLUTE CARRIER FAMILY 12, MEMBER 1;

EID: 84930848803     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.00687.2014     Document Type: Article

References (29)

1. Bandulik S, Schmidt K, Bockenhauer D, Zdebik AA, Humberg E, Kleta R, Warth R, Reichold M. The salt-wasting phenotype of EAST syndrome, a disease with multifaceted symptoms linked to the KCNJ10 K channel. Pflügers Arch 461: 423–435, 2011
2. Bockenhauer D, Feather S, Stanescu HC, Bandulik S, Zdebik AA, Reichold M, Tobin J, Lieberer E, Sterner C, Landoure G, Arora R, Sirimanna T, Thompson D, Cross JH, van’t Hoff W, Al Masri O, Tullus K, Yeung S, Anikster Y, Klootwijk E, Hubank M, Dillon MJ, Heitzmann D, Arcos-Burgos M, Knepper MA, Dobbie A, Gahl WA, Warth R, Sheridan E, Kleta R. Epilepsy, ataxia, sensorineural deafness, tubulopathy, and KCNJ10 mutations. N Engl J Med 360: 1960–1970, 2009
3. Frindt G, Sackin H, Palmer LG. Whole cell currents in rat cortical collecting tubule: low-Na diet increases amiloride-sensitive conductance. Am J Physiol Renal Fluid Electrolyte Physiol 258: F562–F567, 1990
4. Greger R. Ion transport mechanisms in thick ascending limb of Henle’s loop of mammalian nephron. Physiol Rev 65: 760–797, 1985
5. Gu R, Jin Y, Zhai Y, Yang L, Zhang C, Li W, Wang L, Kong S, Zhang Y, Yang B, Wang WH. PGE2 inhibits basolateral 50 pS potassium channels in the thick ascending limb of the rat kidney. Kidney Int 74: 478–485, 2008
6. Gu R, Wang J, Zhang Y, Li W, Xu Y, Shan H, Wang WH, Yang B. Adenosine stimulates the basolateral 50 pS K channels in the thick ascending limb of the rat kidney. Am J Physiol Renal Physiol 293: F299–F305, 2007
7. Hebert SC, Andreoli TE. Control of NaCl transport in the thick ascending limb. Am J Physiol Renal Fluid Electrolyte Physiol 246: F745–F756, 1984
8. Hebert SC, Desir G, Giebisch G, Wang W. Molecular diversity and regulation of renal potassium channels. Physiol Rev 85: 319–371, 2005
9. Hebert SC, Gamba G. Molecular cloning and characterization of the diuretic-sensitive electroneutral sodium-(potassium)-chloride cotransporters. Clin Investig 72: 692–694, 1994
10. Kofuji P, Ceelen P, Zahs KR, Surbeck LW, Lester HA, Newman EA. Genetic inactivation of an inwardly rectifying potassium channel (Kir4.1 subunit) in mice: phenotypic impact in retina. J Neurosci 20: 5733–5740, 2000
11. Lachheb S, Cluzeaud F, Bens M, Genete M, Hibino H, Lourdel S, Kurachi Y, Vandewalle A, Teulon J, Paulais M. Kir4.1/Kir5.1 channel forms the major K+ channel in the basolateral membrane of mouse renal collecting duct principal cells. Am J Physiol Renal Physiol 294: F1398–F1407, 2008
12. Lourdel S, Paulais M, Cluzeaud F, Bens M, Tanemoto M, Kurachi Y, Vandewalle A, Teulon J. An inward rectifier K+ channel at the basolateral membrane of the mouse distal convoluted tubule: similarities with Kir4-Kir5.1 heteromeric channels. J Physiol 538: 391–404, 2002
13. Neusch C, Rozengurt N, Jacobs RE, Lester HA, Kofuji P. Kir4.1 potassium channel subunit is crucial for oligodendrocyte development and in vivo myelination. J Neurosci 21: 5429–5438, 2001
14. Paulais M, Lourdel S, Teulon J. Properties of an inwardly rectifying K_ channel in the basolateral membrane of mouse TAL. Am J Physiol Renal Physiol 282: F866–F876, 2002
15. Paulais M, Bloch-Faure M, Picard N, Jacques T, Ramakrishnan SK, Keck M, Sohet F, Eladari D, Houillier P, Lourdel SP, Teulon J, Tucker SJ. Renal phenotype in mice lacking the Kir5.1 (Kcnj16) K_ channel subunit contrasts with that observed in SeSAME/EAST syndrome. Proc Natl Acad Sci USA 108: 10361–10366, 2011
16. Paulais M, Lachheb S, Teulon J. A Na+- and Cl-activated K+ channel in the thick ascending limb of mouse kidney. J Gen Physiol 127: 205–215, 2006
17. Pessia M, Tucker SJ, Lee K, Bond CT, Adelman JP. Subunit positional effects revealed by novel heteromeric inwardly rectifying K+ channels. EMBO J 15: 2980–2987, 1996
18. Piala AT, Moon TM, Akella R, He HX, Cobb MH, Goldsmith EJ. Chloride sensing by WNK1 involves inhibition of autophosphosphorylation. Sci Signal 7: ra41, 2014
19. Ponce-Coria J, San Cristobal P, Kahle KT, Vazquez N, Pacheco- Alvarez D, los Heros P, Juarez P, Munoz E, Michel G, Bobadilla NA, Gimenez I, Lifton RP, Hebert SC, Gamba G. Regulation of NKCC2 by a chloride-sensing mechanism involving the WNK3 and SPAK kinases. Proc Natl Acad Sci USA 105: 8458–8463, 2008
20. Reichold M, Zdebik AA, Lieberer E, Rapedius M, Schmidt K, Bandulik S, Sterner C, Tegtmeier I, Penton D, Baukrowitz T, Hulton SA, Witzgall R, Ben Zeev B, Howie AJ, Kleta R, Bockenhauer D, Warth R. KCNJ10 gene mutations causing EAST syndrome (epilepsy, ataxia, sensorineural deafness, and tubulopathy) disrupt channel function. Proc Natl Acad Sci USA 107: 14490–14495, 2010
21. San Cristobal P, Pacheco-Alvarez D, Richardson C, Ring AM, Vazquez N, Rafiqi FH, Chari D, Kahle KT, Leng Q, Bobadilla NA, Hebert SC, Alessi DR, Lifton RP, Gamba G. Angiotensin II signaling increases activity of the renal Na-Cl cotransporter through a WNK4-SPAK-dependent pathway. Proc Natl Acad Sci USA 106: 4384–4389, 2009
22. Sasaki S, Imai M. Effects of vasopressin on water and NaCl transport across the in vitro perfused medullary thick ascending limb of Henle’s loop of mouse, rat, and rabbit kidneys. Pflügers Arch 383: 215–221, 1980
23. Schlatter E. Antidiuretic hormone regulation of electrolyte transport in the distal nephron. Renal Physiol Biochem 12: 65–84, 1989
24. Scholl UI, Choi M, Liu T, Ramaekers VT, Hausler MG, Grimmer J, Tobe SW, Farhi A, Nelson-Williams C, Lifton RP. Seizures, sensorineural deafness, ataxia, mental retardation, and electrolyte imbalance (SeSAME syndrome) caused by mutations in KCNJ10. Proc Natl Acad Sci USA 106: 5842–5847, 2009
25. Sun A, Grossman EB, Lombardi M, Hebert SC. Vasopressin alters the mechansim of apical Cl- entry from Na+:Cl- to Na+:K+:2Cl- cotransport in mouse medullary thick ascending limb. J Membr Biol 120: 83–94, 1991
26. Teulon J, Paulias M, Bouthier M. A Ca2+-activated cation-selective channel in the basolateral membrane of the cortical thick ascending limb of Henle’s loop of the mouse. Biochim Biophys Acta 905: 125–132, 1987
27. Wang L, Zhang C, Su XT, Lin D, Wang WH. Disruption of caveolin-1 inhibits the basolateral K+ channels in the distal convoluted tubule and impairs the renal K+ and Mg2+ transport. J Am Soc Nephrol [Epub ahead of print]
28. Zhang C, Wang L, Thomas S, Wang K, Lin DH, Rinehart J, Wang WH. Src-family protein tyrosine kinase regulates the basolateral K channel in the distal convoluted tubule (DCT) by phosphorylation of KCNJ10. J Biol Chem 288: 26135–26146, 2013
29. Zhang C, Wang L, Zhang J, Su XT, Lin DH, Scholl UI, Giebisch G, Lifton RP, Wang WH. KCNJ10 determines the expression of the apical Na-Cl cotransporter (NCC) in the early distal convoluted tubule (DCT1). Proc Natl Acad Sci USA 111: 11864–11869, 2014.