Adenocarcinoma of the rectum in patients under age 40 is increasing: Impact of signet-ring cell histology

Diseases of the Colon and Rectum

Volumn 58, Issue 5, 2015, Pages 474-478

  Tawadros, Patrick S ^a   Paquette, Ian M ^b   Hanly, Ann M ^c   Mellgren, Anders F ^d   Rothenberger, David A ^a   Madoff, Robert D ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

^b UNIVERSITY OF CINCINNATI   (United States)

^c ST VINCENT S UNIVERSITY HOSPITAL   (Ireland)

^d UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

Rectal cancer; Signet ring cell histology; Young adults

Indexed keywords

ADULT; AGE; ARTICLE; CANCER EPIDEMIOLOGY; CANCER PROGNOSIS; COHORT ANALYSIS; FEMALE; HUMAN; HUMAN TISSUE; INCIDENCE; MAJOR CLINICAL STUDY; MALE; OVERALL SURVIVAL; RECTUM CARCINOMA; RETROSPECTIVE STUDY; SIGNET RING CARCINOMA; ADENOCARCINOMA; ADENOCARCINOMA, MUCINOUS; AGE DISTRIBUTION; AGED; CANCER REGISTRY; CANCER STAGING; CARCINOMA, SIGNET RING CELL; ETHNIC GROUP; MIDDLE AGED; PATHOLOGY; RECTAL NEOPLASMS; STATISTICS; STATISTICS AND NUMERICAL DATA; UNITED STATES; YOUNG ADULT;

ADENOCARCINOMA; ADENOCARCINOMA, MUCINOUS; ADULT; AGE DISTRIBUTION; AGED; CARCINOMA, SIGNET RING CELL; COHORT STUDIES; ETHNIC GROUPS; FEMALE; HUMANS; INCIDENCE; MALE; MIDDLE AGED; NEOPLASM STAGING; RECTAL NEOPLASMS; RETROSPECTIVE STUDIES; SEER PROGRAM; STATISTICS AS TOPIC; UNITED STATES; YOUNG ADULT;

EID: 84930794231     PISSN: 00123706     EISSN: 15300358     Source Type: Journal    
DOI: 10.1097/DCR.0000000000000318     Document Type: Article

References (15)

1. Zauber AG, Winawer SJ, O'Brien MJ, Colonoscopic polypectomy and long-term prevention of colorectal-cancer deaths. N Engl J Med 2012 366 687 696
2. O'Connell JB, Maggard MA, Liu JH, Etzioni DA, Livingston EH, Ko CY., Rates of colon and rectal cancers are increasing in young adults. Am Surg 2003 69 866 872
3. Meyer JE, Narang T, Schnoll-Sussman FH, Pochapin MB, Christos PJ, Sherr DL., Increasing incidence of rectal cancer in patients aged younger than 40 years: an analysis of the surveillance, epidemiology, and end results database. Cancer 2010 116 4354 4359
4. Siegel RL, Jemal A, Ward EM., Increase in incidence of colorectal cancer among young men and women in the United States. Cancer Epidemiol Biomarkers Prev 2009 18 1695 1698
5. O'Connell JB, Maggard MA, Liu JH, Etzioni DA, Ko CY., Are survival rates different for young and older patients with rectal cancer? Dis Colon Rectum 2004 47 2064 2069
6. Lee PY, Fletcher WS, Sullivan ES, Vetto JT., Colorectal cancer in young patients: characteristics and outcome. Am Surg 1994 60 607 612
7. Kang H, O'Connell JB, Maggard MA, Sack J, Ko CY., A 10-year outcomes evaluation of mucinous and signet-ring cell carcinoma of the colon and rectum. Dis Colon Rectum 2005 48 1161 1168
8. Pande R, Sunga A, Levea C, Significance of signet-ring cells in patients with colorectal cancer. Dis Colon Rectum 2008 51 50 55
9. Sung CO, Seo JW, Kim KM, Do IG, Kim SW, Park CK., Clinical significance of signet-ring cells in colorectal mucinous adenocarcinoma. Mod Pathol 2008 21 1533 1541
10. Becker KF, Atkinson MJ, Reich U, Exon skipping in the E-cadherin gene transcript in metastatic human gastric carcinomas. Hum Mol Genet 1993 2 803 804
11. Becker KF, Atkinson MJ, Reich U, E-cadherin gene mutations provide clues to diffuse type gastric carcinomas. Cancer Res 1994 54 3845 3852
12. Chen JS, Hsieh PS, Hung SY, Clinical significance of signet ring cell rectal carcinoma. Int J Colorectal Dis 2004 19 102 107
13. Humar B, Blair V, Charlton A, More H, Martin I, Guilford P., E-cadherin deficiency initiates gastric signet-ring cell carcinoma in mice and man. Cancer Res 2009 69 2050 2056
14. Blair V, Martin I, Shaw D, Hereditary diffuse gastric cancer: diagnosis and management. Clin Gastroenterol Hepatol 2006 4 262 275
15. Richards FM, McKee SA, Rajpar MH, Germline E-cadherin gene (CDH1) mutations predispose to familial gastric cancer and colorectal cancer. Hum Mol Genet 1999 8 607 610