The bifunctional liposomes constructed by poly(2-ethyl-oxazoline)-cholesteryl methyl Carbonate: An effectual approach to enhance liposomal circulation time, pH-Sensitivity and endosomal escape

Pharmaceutical Research

Volumn 31, Issue 11, 2014, Pages 3038-3050

  Xu, Huan ^a   Zhang, Wei ^a   Li, Yan ^a   Ye, Fei F ^a   Yin, Peng P ^a   Yu, Xiu ^a   Hu, Mei N ^a   Fu, Yuan S ^b   Wang, Che ^a   Shang, De J ^a  

^a LIAONING NORMAL UNIVERSITY   (China)

^b DALIAN MEDICAL UNIVERSITY   (China)

Author keywords

bifunctional; liposomes; long circulating; pH sensitive; poly(2 ethyl oxazoline)

Indexed keywords

CALCEIN; CALCIUM CHLORIDE; DOXORUBICIN; LIPOSOME; POLY(2 ETHYLOXAZOLINE)CHOLESTERYL METHYL CARBONATE; POLYMER; UNCLASSIFIED DRUG; FLUORESCEIN DERIVATIVE; FORMIC ACID DERIVATIVE; METHYL CARBONATE; POLY(2-ETHYL-2-OXAZOLINE); POLYAMINE;

ACIDITY; ANIMAL EXPERIMENT; ANTINEOPLASTIC ACTIVITY; AREA UNDER THE CURVE; ARTICLE; CELL TRANSPORT; CIRCULATION TIME; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG DOSAGE FORM COMPARISON; ENDOSOME; FLOW CYTOMETRY; HALF LIFE TIME; HUMAN; HUMAN CELL; MALE; NONHUMAN; PH; RAT; ANIMAL; CHEMISTRY; DRUG DELIVERY SYSTEM; DRUG EFFECTS; HELA CELL LINE; METABOLISM; PROCEDURES; TUMOR CELL LINE; WISTAR RAT;

ANIMALS; BLOOD CIRCULATION TIME; CALCIUM CHLORIDE; CELL LINE, TUMOR; DOXORUBICIN; DRUG DELIVERY SYSTEMS; ENDOSOMES; FLUORESCEINS; FORMATES; HELA CELLS; HUMANS; HYDROGEN-ION CONCENTRATION; LIPOSOMES; MALE; POLYAMINES; RATS; RATS, WISTAR;

EID: 84930786046     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-014-1397-0     Document Type: Article

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