XIII. Molecular pathogenesis of transformed lymphomas

Hematological Oncology

Volumn 33, Issue S1, 2015, Pages 70-74

  Rossi, Davide ^a  

^a UNIVERSITY OF EASTERN PIEDMONT   (Italy)

Author keywords

Chronic lymphocytic leukemia; Follicular lymphoma; Richter syndrome; Transformation

Indexed keywords

ARTICLE; CANCER PROGNOSIS; CANCER RESISTANCE; CHRONIC LYMPHATIC LEUKEMIA; CLONAL EVOLUTION; FOLLICULAR LYMPHOMA; GENE MUTATION; HUMAN; LARGE CELL LYMPHOMA; MALIGNANT TRANSFORMATION; MOLECULAR PATHOLOGY; PHENOTYPE; PREDICTION; PRIORITY JOURNAL; RICHTER SYNDROME; SURVIVAL RATE; B CELL LYMPHOMA; FEMALE; GENETICS; MALE; METABOLISM; MUTATION; PATHOLOGY;

TUMOR PROTEIN;

FEMALE; HUMANS; LYMPHOMA, B-CELL; MALE; MUTATION; NEOPLASM PROTEINS;

EID: 84930721927     PISSN: 02780232     EISSN: 10991069     Source Type: Journal    
DOI: 10.1002/hon.2221     Document Type: Article

References (14)

1. Swerdlow SH, Campo E, Harris NL, et al. Jaffe ES, Pileri SA, Stein H, Thiele J, Vardiman JW (eds.) World Health Organization Classification of Tumours, Pathology and Genetics of Tumours of Haematopoietic and Lymphoid Tissues. IARC: Lyon; 2008.
2. Rossi D, Spina V, Deambrogi C, et al. The genetics of Richter syndrome reveals disease heterogeneity and predicts survival after transformation. Blood 2011; 117: 3391-3401.
3. Ohno T, Smir BN, Weisenburger DD, Gascoyne RD, Hinrichs SD, Chan WC. Origin of the Hodgkin/Reed-Sternberg cells in chronic lymphocytic leukemia with Hodgkin's transformation. Blood 1998; 91: 1757-1761.
4. Rossi D, Rasi S, Fabbri G, et al. Mutations of NOTCH1 are an independent predictor of survival in chronic lymphocytic leukemia. Blood 2012; 119: 521-529.
5. Chigrinova E, Rinaldi A, Kwee I, et al. Two main genetic pathways lead to the transformation of chronic lymphocytic leukemia to Richter syndrome. Blood 2013; 122: 2673-2682.
6. Fabbri G, Khiabanian H, Holmes AB, et al. Genetic lesions associated with chronic lymphocytic leukemia transformation to Richter syndrome. J Exp Med 2013; 210: 2273-2288.
7. Okosun J, Bödör C, Wang J, et al. Integrated genomic analysis identifies recurrent mutations and evolution patterns driving the initiation and progression of follicular lymphoma. Nat Genet 2014; 46: 176-181.
8. Pasqualucci L, Khiabanian H, Fangazio M, et al. Genetics of follicular lymphoma transformation. Cell Rep 2014; 6: 130-140.
9. Kridel R, Sehn LH, Gascoyne RD. Pathogenesis of follicular lymphoma. J Clin Invest 2012; 122: 3424-3431.
10. Rossi D, Gaidano G. Richter syndrome. Adv Exp Med Biol 2013; 792: 173-191.
11. Rossi D, Spina V, Cerri M, et al. Stereotyped B-cell receptor is an independent risk factor of chronic lymphocytic leukemia transformation to Richter syndrome. Clin Cancer Res 2009; 15: 4415-4422.
12. Gounari M, Ntoufa S, Chu CC, et al. Promiscuous antigen reactivity may underlie clinical aggressiveness and increased risk for Richter's syndrome in chronic lymphocytic leukemia with stereotyped IGHV4-39/IGKV1(D)-39 B cell receptors. Blood (ASH Annual Meeting Abstracts) 2012; 120: 561.
13. Correia C, Schneider PA, Dai H, et al. BCL2 mutations are associated with increased risk of transformation and shortened survival in follicular lymphoma. Blood 2015; 125: 658-667.
14. O'Shea D, O'Riain C, Gupta M, et al. Regions of acquired uniparental disomy at diagnosis of follicular lymphoma are associated with both overall survival and risk of transformation. Blood 2009; 113: 2298-2301.