11C-ORM-13070, a novel PET ligand for brain α2C-adrenoceptors: radiometabolism, plasma pharmacokinetics, whole-body distribution and radiation dosimetry in healthy men

European Journal of Nuclear Medicine and Molecular Imaging

Volumn 41, Issue 10, 2014, Pages 1947-1956

  Luoto, Pauliina ^a   Suilamo, Sami ^a,b   Oikonen, Vesa ^a   Arponen, Eveliina ^a   Helin, Semi ^a   Herttuainen, Jukka ^c   Hietamäki, Johanna ^c   Holopainen, Aila ^c   Kailajärvi, Marita ^d   Peltonen, Juha M ^a   Rouru, Juha ^c   Sallinen, Jukka ^c   Scheinin, Mika ^a   Virta, Jere ^a   Virtanen, Kirsi ^a   Volanen, Iina ^a   Roivainen, Anne ^a   Rinne, Juha O ^a,b  

^a UNIVERSITY OF TURKU   (Finland)

^b TURKU UNIVERSITY HOSPITAL   (Finland)

^c ORION CORPORATION   (Finland)

^d GE Healthcare Finland Oy   (Finland)

Author keywords

Antagonist; Carbon 11; Dosimetry; PET; Radiometabolism; Whole body distribution; 2C Adrenoceptor

Indexed keywords

1-(1-(2,3-DIHYDROBENZO(1,4)DIOXIN-2-YL)METHYL)-4-(3-METHOXYMETHYLPYRIDIN-2-YL)PIPERAZINE; ALPHA 2 ADRENERGIC RECEPTOR; DIOXANE DERIVATIVE; LIGAND; PIPERAZINE DERIVATIVE; PROTEIN BINDING; RADIOPHARMACEUTICAL AGENT;

ADULT; BLOOD; BRAIN; DIAGNOSTIC USE; HUMAN; MALE; METABOLISM; POSITRON EMISSION TOMOGRAPHY; RADIATION DOSE; SCINTISCANNING; TISSUE DISTRIBUTION; VALIDATION STUDY;

ADULT; BRAIN; DIOXANES; HUMANS; LIGANDS; MALE; PIPERAZINES; POSITRON-EMISSION TOMOGRAPHY; PROTEIN BINDING; RADIATION DOSAGE; RADIOPHARMACEUTICALS; RECEPTORS, ADRENERGIC, ALPHA-2; TISSUE DISTRIBUTION;

EID: 84930708459     PISSN: 16197070     EISSN: 16197089     Source Type: Journal    
DOI: 10.1007/s00259-014-2782-y     Document Type: Article

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