Optimization of anti-CD20 humanized antibody hu8E4 by site-directed mutation based on epitope analysis

Biochemical and Biophysical Research Communications

Volumn 459, Issue 4, 2015, Pages 617-622

  Chen, Yalin ^a   Chen, Lin ^b   Lu, Qiong ^a   Meng, Yanchun ^c   Wang, Chao ^a   Wang, Linfei ^a   Wang, Huajing ^a   Yu, Xiaojie ^a   Zhang, Yajun ^a   Zhao, Lei ^a   Li, Bohua ^a,d   Guo, Yajun ^a,c,d  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

^b Tongji University   (China)

^c NANKAI UNIVERSITY   (China)

^d National Engineering Research Center for Antibody Medicine   (China)

Author keywords

CD20 B cell lymphoma Humanized antibody Epitope Affinity

Indexed keywords

CD20 ANTIGEN; EPITOPE; MONOCLONAL ANTIBODY;

AMINO ACID SEQUENCE; ANIMAL; ANTIBODY DEPENDENT CELLULAR CYTOTOXICITY; APOPTOSIS; CHEMISTRY; GENETICS; HUMAN; IMMUNOLOGY; MOLECULAR GENETICS; MOUSE; SEQUENCE HOMOLOGY; SITE DIRECTED MUTAGENESIS;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES, MONOCLONAL, HUMANIZED; ANTIBODY-DEPENDENT CELL CYTOTOXICITY; ANTIGENS, CD20; APOPTOSIS; EPITOPES; HUMANS; MICE; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 84930698930     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2015.02.158     Document Type: Article

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