Salivary oxytocin concentrations in seven boys with autism spectrum disorder received massage from their mothers: A pilot study

Frontiers in Psychiatry

Volumn 6, Issue APR, 2015, Pages

  Tsuji, Shuji ^a   Yuhi, Teruko ^b   Furuhara, Kazumi ^b   Ohta, Shogo ^b   Shimizu, Yuto ^b   Higashida, Haruhiro ^b  

^a TEZUKAYAMA UNIVERSITY   (Japan)

^b KANAZAWA UNIVERSITY   (Japan)

Author keywords

Autism spectrum disorder; Massage; Mothers; Salivary oxytocin; Touch therapy

Indexed keywords

OXYTOCIN;

ARTICLE; AUTISM; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME IMMUNOASSAY; HUMAN; MALE; MASSAGE; MOTHER; OXYTOCIN SALIVA LEVEL; PHYSICAL MEDICINE; PILOT STUDY; SALIVA LEVEL; SCHOOL CHILD; SPECIAL EDUCATION; TOUCH; TOUCH THERAPY;

EID: 84930661564     PISSN: None     EISSN: 16640640     Source Type: Journal    
DOI: 10.3389/fpsyt.2015.00058     Document Type: Article

References (40)

1. Hazen EP, Stornelli JL, O'Rourke JA, Koesterer K, McDougle CJ. Sensory symptoms in autism spectrum disorders. Harv Rev Psychiatry (2014) 22:112-24. doi:10.1097/01.HRP.0000445143.08773.58.
2. Lai MC, Lombardo MV, Baron-Cohen S. Autism. Lancet (2014) 383:896-910. doi:10.1016/S0140-6736(13)61539-1.
3. Güçlü B, Tanidir C, Mukaddes NM, Unal F. Tactile sensitivity of normal and autistic children. Somatosens Mot Res (2007) 24:21-33. doi:10.1080/08990220601179418.
4. Suarezm MA. Sensory processing in children with autism spectrum disorders and impact on functioning. Pediatr Clin North Am (2012) 59:203-14. doi:10.1016/j.pcl.2011.10.012.
5. Chang YS, Owen JP, Desai SS, Hill SS, Arnett AB, Harris J, et al. Autism and sensory processing disorders: shared white matter disruption in sensory pathways but divergent connectivity in social-emotional pathways. PLoS One (2014) 9:e103038. doi:10.1371/journal.pone.0103038.
6. Marco EJ, Hinkley LB, Hill SS, Nagarajan SS. Sensory processing in autism: a review of neurophysiologic findings. Pediatr Res (2011) 69:48R-54R. doi:10.1203/PDR.0b013e3182130c54.
7. Duhn L. The importance of touch in the development of attachment. Adv Neonatal Care (2010) 10:294-300. doi:10.1097/ANC.0b013e3181fd2263.
8. Feldman R, Zagoory-Sharon O, Weisman O, Schneiderman I, Gordon I, Maoz R, et al. Sensitive parenting is associated with plasma oxytocin and polymorphisms in the OXTR and CD38 genes. Biol Psychiatry (2012) 72:175-81. doi:10.1016/j.biopsych.2011.12.025.
9. Feldman R. Oxytocin and social affiliation in humans. Horm Behav (2012) 61:380-91. doi:10.1016/j.yhbeh.2012.01.008.
10. Escalona A, Field T, Singer-Strunck R, Cullen C, Hartshorn K. Brief report: improvements in the behavior of children with autism following massage therapy. J Autism Dev Disord (2001) 31:513-6. doi:10.1023/A:1012273110194.
11. Cullen-Powell LA, Barlow JH, Cushway D. Exploring a massage intervention for parents and their children with autism: the implications for bonding and attachment. J Child Health Care (2005) 9:245-55. doi:10.1177/1367493505056479.
12. Piravej K, Tangtrongchitri P, Chandarasiri P, Paothong L, Sukprasong S. Effects of Thai traditional massage on autistic children's behavior. J Altern Complement Med (2009) 15:1355-61. doi:10.1089/acm.2009.0258.
13. Lee MS, Kim JI, Ernst E. Massage therapy for children with autism spectrum disorders: a systematic review. J Clin Psychiatry (2011) 72:406-11. doi:10.4088/JCP.09r05848whi.
14. Silva L, Schalock M. Treatment of tactile impairment in young children with autism: results with qigong massage. Int J Ther Massage Bodywork (2013) 6:12-20.
15. Rapaport MH, Schettler P, Bresee C. Preliminary study of the effects of a single session of Swedish massage on hypothalamic-pituitary-adrenal and immune function in normal individuals. J Altern Complement Med (2010) 16:1079-88. doi:10.1089/acm.2009.0634.
16. Jin D, Liu HX, Hirai H, Torashima T, Nagai T, Lopatina O, et al. CD38 is critical for social behaviour by regulating oxytocin secretion. Nature (2007) 446:41-5. doi:10.1038/nature05526.
17. Insel TR. The challenge of translation in social neuroscience: a review of oxytocin, vasopressin, and affiliative behavior. Neuron (2010) 65:768-79. doi:10.1016/j.neuron.2010.03.005.
18. Ebstein RP, Israel S, Chew SH, Zhong S, Knafo A. Genetics of human social behavior. Neuron (2010) 65:831-44. doi:10.1016/j.neuron.2010.02.020.
19. + metabolites and single nucleotide polymorphisms of CD38. Neurochem Int (2012) 61:828-38. doi:10.1016/j.neuint.2012.01.030.
20. Lopatina O, Inzhutova A, Salmina AB, Higashida H. The roles of oxytocin and CD38 in social or parental behaviors. Front Neurosci (2013) 6:182. doi:10.3389/fnins.2012.00182.
21. Lieberwirth C, Wang Z. Social bonding: regulation by neuropeptides. Front Neurosci (2014) 8:171. doi:10.3389/fnins.2014.00171.
22. Young LJ. Oxytocin, social cognition and psychiatry. Neuropsychopharmacology (2015) 40:243-4. doi:10.1038/npp.2014.186.
23. Munesue T, Yokoyama S, Nakamura K, Anitha A, Yamada K, Hayashi K, et al. Two genetic variants of CD38 in subjects with autism spectrum disorder and controls. Neurosci Res (2010) 67:181-91. doi:10.1016/j.neures.2010.03.004.
24. Kanat M, Heinrichs M, Domes G. Oxytocin and the social brain: neural mechanisms and perspectives in human research. Brain Res (2014) 1580:160-71. doi:10.1016/j.brainres.2013.11.003.
25. Rapaport MH, Schettler P, Bresee C. A preliminary study of the effects of repeated massage on hypothalamic-pituitary-adrenal and immune function in healthy individuals: a study of mechanisms of action and dosage. J Altern Complement Med (2012) 18:789-97. doi:10.1089/acm.2011.0071.
26. Morhenn V, Beavin LE, Zak PJ. Massage increases oxytocin and reduces adrenocorticotropin hormone in humans. Altern Ther Health Med (2012) 18:11-8.
27. Carter CS, Pournajafi-Nazarloo H, Kramer KM, Ziegler TE, White-Traut R, Bello D, et al. Oxytocin: behavioral associations and potential as a salivary biomarker. Ann N Y Acad Sci (2007) 1098:312-22. doi:10.1196/annals.1384.006.
28. van Ijzendoorn MH, Bhandari R, van der Veen R, Grewen KM, Bakermans-Kranenburg MJ. Elevated salivary levels of oxytocin persist more than 7 h after intranasal administration. Front Neurosci (2012) 6:174. doi:10.3389/fpsyg.2013.00761.
29. Huffmeijer R, Alink LR, Tops M, Grewen KM, Light KC, Bakermans-Kranenburg MJ, et al. Salivary levels of oxytocin remain elevated for more than two hours after intranasal oxytocin administration. Neuro Endocrinol Lett (2012) 33:21-5.
30. Weisman O, Schneiderman I, Zagoory-Sharon O, Feldman R. Salivary vasopressin increases following intranasal oxytocin administration. Peptides (2013) 40:99-103. doi:10.1016/j.peptides.2012.12.004.
31. Feldman R, Weller A, Zagoory-Sharon O, Levine A. Evidence for a neuroendocrinological foundation of human affiliation: plasma oxytocin levels across pregnancy and the postpartum period predict mother-infant bonding. Psychol Sci (2007) 18:965-70. doi:10.1111/j.1467-9280.2007.02010.x.
32. Bhandari R, Bakermans-Kranenburg MJ, van der Veen R, Parsons CE, Young KS, Grewen KM, et al. Salivary oxytocin mediates the association between emotional maltreatment and responses to emotional infant faces. Physiol Behav (2014) 131:123-8. doi:10.1016/j.physbeh.2014.04.028.
33. Fujisawa TX, Tanaka S, Saito DN, Kosaka H, Tomoda A. Visual attention for social information and salivary oxytocin levels in preschool children with autism spectrum disorders: an eye-tracking study. Front Neurosci (2014) 8:295. doi:10.3389/fnins.2014.00295.
34. Koven NS, Max LK. Basal salivary oxytocin level predicts extra-but not intra-personal dimensions of emotional intelligence. Psychoneuroendocrinology (2014) 44:20-9. doi:10.1016/j.psyneuen.2014.02.018.
35. Bello D, White-Traut R, Schwertz D, Pournajafi-Nazarloo H, Carter CS. An exploratory study of neurohormonal responses of healthy men to massage. J Altern Complement Med (2008) 14:387-94. doi:10.1089/acm.2007.0660.
36. Field T. Massage therapy for infants and children. J Dev Behav Pediatr (1995) 16:105-11. doi:10.1097/00004703-199504000-00008.
37. Field T, Diego M. Vagal activity, early growth and emotional development. Infant Behav Dev (2008) 31:361-73. doi:10.1016/j.infbeh.2007.12.008.
38. Porges SW. The polyvagal theory: phylogenetic substrates of a social nervous system. Int J Psychophysiol (2001) 42:123-46. doi:10.1016/S0167-8760(01)00162-3.
39. Maestripieri D, Hoffman CL, Anderson GM, Carter CS, Higley JD. Mother-infant interactions in free-ranging rhesus macaques: relationships between physiological and behavioral variables. Physiol Behav (2009) 96:613-9. doi:10.1016/j.physbeh.2008.12.016.
40. Gordon I, Vander Wyk BC, Bennett RH, Cordeaux C, Lucas MV, Eilbott JA, et al. Oxytocin enhances brain function in children with autism. Proc Nat Acad Sci U S A (2013) 110:20953-8. doi:10.1073/pnas.1312857110.