The effects of phosphodiesterase-5 inhibitor sildenafil against post-resuscitation myocardial and intestinal microcirculatory dysfunction by attenuating apoptosis and regulating microRNAs expression: Essential role of nitric oxide syntheses signaling

Journal of Translational Medicine

Volumn 13, Issue 1, 2015, Pages

  Zhang, Qian ^a   Wang, Guoxing ^b   Yuan, Wei ^a   Wu, Junyuan ^a   Wang, Miaomiao ^a   Li, ChunSheng ^a  

^a CAPITAL MEDICAL UNIVERSITY   (China)

^b CAPITAL MEDICAL UNIVERSITY   (China)

Author keywords

Apoptosis; eNOS; iNOS; MicroRNAs; Post resuscitation myocardial dysfunction; Sildenafil

Indexed keywords

CASPASE 3; CYCLIC GMP; ENDOTHELIAL NITRIC OXIDE SYNTHASE; INDUCIBLE NITRIC OXIDE SYNTHASE; MICRORNA; MICRORNA 1; MICRORNA 133A; NITRIC OXIDE SYNTHASE; PROTEIN BAX; PROTEIN BCL 2; SILDENAFIL; UNCLASSIFIED DRUG; NITRIC OXIDE; PHOSPHODIESTERASE V INHIBITOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTERIAL GAS; ARTICLE; CARDIOVASCULAR PARAMETERS; CONTROLLED STUDY; DEFIBRILLATION; DOWN REGULATION; DRUG MECHANISM; ENZYME INHIBITION; ENZYME SYNTHESIS; GENE EXPRESSION REGULATION; HEART LEFT VENTRICLE FUNCTION; HEART PROTECTION; HEART VENTRICLE FIBRILLATION; HEMODYNAMICS; MALE; MICROANGIOPATHY; MICROCIRCULATORY FLOW INDEX; NONHUMAN; PIG; POST RESUSCITATION MICROCIRCULATORY DYSFUNCTION; POST RESUSCITATION MYOCARDIAL DYSFUNCTION; POST RESUSCITATION PERFUSED VESSEL DENSITY; PROTEIN EXPRESSION; PROTO ONCOGENE; REPERFUSION INJURY; RESUSCITATION; RETURN OF SPONTANEOUS CIRCULATION; SIGNAL TRANSDUCTION; SINGLE DRUG DOSE; SURVIVAL TIME; ANIMAL; BLOOD GAS ANALYSIS; CARDIAC MUSCLE; CARDIAC MUSCLE CELL; DRUG EFFECTS; GENETICS; HEART VENTRICLE FUNCTION; INTESTINE; METABOLISM; MICROCIRCULATION; PATHOLOGY; SURVIVAL ANALYSIS; ULTRASTRUCTURE; VASCULARIZATION;

ANIMALS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BLOOD GAS ANALYSIS; CARDIOPULMONARY RESUSCITATION; CASPASE 3; CYCLIC GMP; HEMODYNAMICS; INTESTINES; MALE; MICROCIRCULATION; MICRORNAS; MYOCARDIUM; MYOCYTES, CARDIAC; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PHOSPHODIESTERASE 5 INHIBITORS; SIGNAL TRANSDUCTION; SILDENAFIL CITRATE; SURVIVAL ANALYSIS; SUS SCROFA; VENTRICULAR FUNCTION;

EID: 84930653933     PISSN: None     EISSN: 14795876     Source Type: Journal    
DOI: 10.1186/s12967-015-0550-9     Document Type: Article

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