Diabetes and insulin therapy, but not metformin, are related to hepatocellular cancer risk

Gastroenterology Research and Practice

Volumn 2015, Issue , 2015, Pages

  Miele, Luca ^a,b   Bosetti, Cristina ^c   Turati, Federica ^c   Rapaccini, Gianlodovico ^a,b   Gasbarrini, Antonio ^a   La Vecchia, Carlo ^d   Boccia, Stefania ^a   Grieco, Antonio ^a  

^a CATHOLIC UNIVERSITY   (Italy)

^b Gastroenterology Unit   (Italy)

^c MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

^d UNIVERSITY OF MILAN   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

INSULIN; METFORMIN; SULFONYLUREA;

ADULT; AGED; ARTICLE; CANCER RISK; CONTROLLED STUDY; DIABETES MELLITUS; DIABETIC PATIENT; DRINKING BEHAVIOR; FEMALE; HEPATITIS B; HEPATITIS C; HUMAN; INSULIN TREATMENT; LIVER CELL CARCINOMA; MAJOR CLINICAL STUDY; MALE; RISK REDUCTION; SMOKING; SMOKING CESSATION;

EID: 84930652301     PISSN: 16876121     EISSN: 1687630X     Source Type: Journal    
DOI: 10.1155/2015/570356     Document Type: Article

References (44)

1. J. Ferlay, H. R. Shin, F. Bray, D. Forman, C. Mathers, and D. M. Parkin, GLOBOCAN 2008. Cancer Incidence and Mortality Worldwide, IARC CancerBase no. 10, 2008, http://globocan. iarc.fr/.
2. J. Ferlay, H.-R. Shin, F. Bray, D. Forman, C. Mathers, and D. M. Parkin, "Estimates of worldwide burden of cancer in 2008: GLOBOCAN2008", International Journal of Cancer, vol. 127, no. 12, pp. 2893-2917, 2010.
3. T. Rosso, M. Malvezzi, P. Bertuccio, E. Negri, C. La Vecchia, and A. Decarli, "Cancer mortality in Italy, 2008, and predictions for 2012", Tumori, vol. 98, no. 5, pp. 559-567, 2012.
4. S. Stuver and D. Trichopoulos, "Cancer of the liver and biliary tract", in Cancer Epidemiology, H.-O. Adami, D. Hunter, and D. Trichpoulos, Eds., pp. 308-332, Oxford Universiy Press, New York, NY, USA, 2nd edition, 2008.
5. S. Franceschi, M. Montella, J. Polesel et al., "Hepatitis viruses, alcohol, and tobacco in the etiology of hepatocellular carcinoma in Italy", Cancer Epidemiology Biomarkers and Prevention, vol. 15, no. 4, pp. 683-689, 2006.
6. W. T. London and K. A. McGlynn, "Liver cancer", in Cancer Epidemiology and Prevention, D. Schottenfeld and J. F. Fraumeni Jr., Eds., pp. 763-786, Oxford University Press, New York, NY, USA, 3rd edition, 2006.
7. H. B. El-Serag, "Hepatocellular carcinoma", The New England Journal of Medicine, vol. 365, no. 12, pp. 1118-1127, 2011.
8. C. Bosetti, F. Turati, and C. La Vecchia, "Hepatocellular carcinoma epidemiology", Best Practice & Research Clinical Gastroenterology, vol. 28, pp. 753-770, 2014.
9. C. La Vecchia, E. Negri, A. Decarli, and S. Franceschi, "Diabetes mellitus and the risk of primary liver cancer", International Journal of Cancer, vol. 73, no. 2, pp. 204-207, 1997.
10. H. B. El-Serag, T. Tran, and J. E. Everhart, "Diabetes increases the risk of chronic liver disease and hepatocellular carcinoma", Gastroenterology, vol. 126, no. 2, pp. 460-468, 2004.
11. H. B. El-Serag, H. Hampel, and F. Javadi, "The association between diabetes and hepatocellular carcinoma: a systematic review of epidemiologic evidence", Clinical Gastroenterology and Hepatology, vol. 4, no. 3, pp. 369-380, 2006.
12. C. Wang, X. Wang, G. Gong et al., "Increased risk of hepatocellular carcinoma in patients with diabetes mellitus: a systematic review and meta-analysis of cohort studies", International Journal of Cancer, vol. 130, no. 7, pp. 1639-1648, 2012.
13. P. Wang, D. Kang, W. Cao, Y. Wang, and Z. Liu, "Diabetesmellitus and risk of hepatocellular carcinoma: a systematic review and meta-analysis", Diabetes/Metabolism Research and Reviews, vol. 28, no. 2, pp. 109-122, 2012.
14. C. Bosetti, V. Rosato, J. Polesel et al., "Diabetes mellitus and cancer risk in a network of case-control studies", Nutrition and Cancer, vol. 64, no. 5, pp. 643-651, 2012.
15. T. M. Welzel, B. I. Graubard, S. Quraishi et al., "Populationattributable fractions of risk factors for hepatocellular carcinoma in the United States", American Journal of Gastroenterology, vol. 108, no. 8, pp. 1314-1321, 2013.
16. G. C. Connolly, S. Safadjou, R. Chen et al., "Diabetes mellitus is associated with the presence of metastatic spread at disease presentation in hepatocellular carcinoma", Cancer Investigation, vol. 30, no. 10, pp. 698-702, 2012.
17. W.-Y. Shau, Y.-Y. Shao, Y.-C. Yeh et al., "Diabetes mellitus is associated with increased mortality in patients receiving curative therapy for hepatocellular carcinoma", Oncologist, vol. 17, no. 6, pp. 856-862, 2012.
18. D. Soranna, L. Scotti, A. Zambon et al., "Cancer risk associated with use of metformin and sulfonylurea in type 2 diabetes: a meta-analysis", Oncologist, vol. 17, no. 6, pp. 813-822, 2012.
19. C. Bosetti, V. Rosato, D. Buniato, A. Zambon, C. La Vecchia, and G. Corrao, "Cancer risk for patients using thiazolidinediones for type 2 diabetes: a meta-analysis", The Oncologist, vol. 18, no. 2, pp. 148-156, 2013.
20. S. Schlesinger, K. Aleksandrova, T. Pischon et al., "Diabetes mellitus, insulin treatment, diabetes duration, and risk of biliary tract cancer and hepatocellular carcinoma in a European Cohort", Annals of Oncology, vol. 24, no. 9, pp. 2449-2455, 2013.
21. J. Bruix and M. Sherman, "Management of hepatocellular carcinoma", Hepatology, vol. 42, no. 5, pp. 1208-1236, 2005.
22. N. E. Breslow and N. E. Day, Statistical Methods in Cancer Research. Vol. I. The Analysis of Case-Control Studies, IARC Scientific Publications no. 32, IARC, Lyon, France, 1980.
23. K. Rothmann, "Measuring interactions", in Epidemiology: An Introduction, Oxford University Press, Oxford, UK, 2002.
24. D. W. Hosmer and S. Lemeshow, "Confidence interval estimation of interaction", Epidemiology, vol. 3, no. 5, pp. 452-456, 1992.
25. G. Y. Lai, Y. Park, P. Hartge, A. R. Hollenbeck, and N. D. Freedman, "The association between self-reported diabetes and cancer incidence in the NIH-AARP diet and health study", The Journal of Clinical Endocrinology & Metabolism, vol. 98, no. 3, pp. E497-E502, 2013.
26. R. P. Beasley, "Diabetes and hepatocellular carcinoma", Hepatology, vol. 44, no. 6, pp. 1408-1410, 2006.
27. M. Shibata, Y. Kihara, M. Taguchi, M. Tashiro, and M. Otsuki, "Nonalcoholic fatty liver disease is a risk factor for type 2 diabetes in middle-aged Japanese men", Diabetes Care, vol. 30, no. 11, pp. 2940-2944, 2007.
28. S. Tanaka, L. Mohr, E. V. Schmidt, K. Sugimachi, and J. R. Wands, "Biological effects of human insulin receptor substrate-1 overexpression in hepatocytes", Hepatology, vol. 26, no. 3, pp. 598-604, 1997.
29. E. Giovannucci, D. M. Harlan, M. C. Archer et al., "Diabetes and cancer: a consensus report", Diabetes Care, vol. 33, no. 7, pp. 1674-1685, 2010.
30. E. S. Dellon and N. J. Shaheen, "Diabetes and hepatocellular carcinoma: associations, biologic plausibility, and clinical implications", Gastroenterology, vol. 129, no. 3, pp. 1132-1134, 2005.
31. S. A. Oliveria, C. E. Koro, M. U. Yood, and M. Sowell, "Cancer incidence among patients treated with antidiabetic pharmacotherapy", Diabetes and Metabolic Syndrome: Clinical Research and Reviews, vol. 2, no. 1, pp. 47-57, 2008.
32. V. Donadon, M. Balbi, M. D. Mas, P. Casarin, and G. Zanette, "Metformin and reduced risk of hepatocellular carcinoma in diabetic patients with chronic liver disease", Liver International, vol. 30, no. 5, pp. 750-758, 2010.
33. M. M. Hassan, S. A. Curley, D. Li et al., "Association of diabetes duration and diabetes treatment with the risk of hepatocellular carcinoma", Cancer, vol. 116, no. 8, pp. 1938-1946, 2010.
34. M.-S. Lee, C.-C. Hsu, M. L. Wahlqvist, H.-N. Tsai, Y.-H. Chang, and Y.-C. Huang, "Type 2 diabetes increases and metformin reduces total, colorectal, liver and pancreatic cancer incidences in Taiwanese: a representative population prospective cohort study of 800, 000 individuals", BMC Cancer, vol. 11, article 20, 2011.
35. J. Luo, R. Chlebowski, S. Liu et al., "Diabetes mellitus as a risk factor for gastrointestinal cancers among postmenopausal women", Cancer Causes and Control, vol. 24, no. 3, pp. 577-585, 2013.
36. B. Carstensen, D. R. Witte, and S. Friis, "Cancer occurrence in Danish diabetic patients: duration and insulin effects", Diabetologia, vol. 55, no. 4, pp. 948-958, 2012.
37. C.-H. Chang, J.-W. Lin, L.-C. Wu, M.-S. Lai, and L.-M. Chuang, "Oral insulin secretagogues, insulin, and cancer risk in type 2 diabetes mellitus", The Journal of Clinical Endocrinology & Metabolism, vol. 97, no. 7, pp. E1170-E1175, 2012.
38. C. La Vecchia, "Diabetes mellitus, medications for type 2 diabetes mellitus, and cancer risk", Metabolism: Clinical and Experimental, vol. 60, no. 10, pp. 1357-1358, 2011.
39. E. Badrick and A. G. Renehan, "Diabetes and cancer: 5 years into the recent controversy", European Journal of Cancer, vol. 50, pp. 2119-2125, 2014.
40. F. Turati, C. Galeone, M. Rota et al., "Alcohol and liver cancer: a systematic review and meta-analysis of prospective studies", Annals of Oncology, vol. 25, pp. 1526-1535, 2014.
41. E. E. Calle, C. Rodriguez, K. Walker-Thurmond, and M. J. Thun, "Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U. S. adults", The New England Journal of Medicine, vol. 348, no. 17, pp. 1625-1638, 2003.
42. S. C. Larsson and A. Wolk, "Overweight, obesity and risk of liver cancer: a meta-analysis of cohort studies", British Journal of Cancer, vol. 97, no. 7, pp. 1005-1008, 2007.
43. C. Bosetti, A. Tavani, E. Negri, D. Trichopoulos, and C. La Vecchia, "Reliability of data on medical conditions, menstrual and reproductive history provided by hospital controls", Journal of Clinical Epidemiology, vol. 54, no. 9, pp. 902-906, 2001.
44. EPICENTRO, Rapporto nazionale Passi 2009: rischio cardiovascolare, Italian Institute of Public Health, 2010, http://www.epicentro.iss.it/passi/rapporto2009/Cardiovascolare09.asp.