Molecular biology of endometriosis: From aromatase to genomic abnormalities

Seminars in Reproductive Medicine

Volumn 33, Issue 3, 2015, Pages 220-224

  Bulun, Serdar E ^a   Monsivais, Diana ^a   Kakinuma, Toshiyuki ^a   Furukawa, Yuichi ^a   Bernardi, Lia ^a   Pavone, Mary Ellen ^a   Dyson, Matthew ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

Author keywords

DNA methylation; endometriosis; epigenetics; estrogen; progesterone; steroid receptors

Indexed keywords

AROMATASE; ESTROGEN RECEPTOR BETA; MEMBRANE PROTEIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA; PROGESTERONE RECEPTOR; RETINOIC ACID; RETINOL; RETINOL BINDING PROTEIN 4; SF1 PROTEIN; STEROIDOGENIC FACTOR 1; TRANSCRIPTION FACTOR GATA 6; UNCLASSIFIED DRUG; ESTROGEN; RETINOID;

APOPTOSIS; ARTICLE; CELL DIFFERENTIATION; CELL SURVIVAL; CPG ISLAND; DNA METHYLATION; ENDOMETRIOSIS; ENDOMETRIUM CELL; EPITHELIUM CELL; ESTROGEN ACTIVITY; HUMAN; HUMAN GENOME; MOLECULAR BIOLOGY; SIGNAL TRANSDUCTION; STROMA CELL; CELL PROLIFERATION; ENDOMETRIUM; FEMALE; GENETIC EPIGENESIS; GENETICS; METABOLISM;

AROMATASE; CELL PROLIFERATION; CELL SURVIVAL; DNA METHYLATION; ENDOMETRIOSIS; ENDOMETRIUM; EPIGENESIS, GENETIC; EPITHELIAL CELLS; ESTROGEN RECEPTOR BETA; ESTROGENS; FEMALE; HUMANS; PPAR DELTA; PPAR-BETA; RECEPTORS, PROGESTERONE; RETINOIDS; STEROIDOGENIC FACTOR 1;

EID: 84930646032     PISSN: 15268004     EISSN: 15264564     Source Type: Journal    
DOI: 10.1055/s-0035-1554053     Document Type: Article

References (26)

1. Noble L. S., Simpson E. R., Johns A., Bulun S. E. Aromatase expression in endometriosis. J Clin Endocrinol Metab: 1996; 81 1 174 179
2. Noble L. S., Takayama K., Zeitoun K. M., et al. Prostaglandin E2 stimulates aromatase expression in endometriosis-derived stromal cells. J Clin Endocrinol Metab: 1997; 82 2 600 606
3. Bulun S. E. Endometriosis. N Engl J Med: 2009; 360 3 268 279
4. Attar E., Tokunaga H., Imir G., et al. Prostaglandin E2 via steroidogenic factor-1 coordinately regulates transcription of steroidogenic genes necessary for estrogen synthesis in endometriosis. J Clin Endocrinol Metab: 2009; 94 2 623 631
5. Zeitoun K., Takayama K., Sasano H., et al. Deficient 17beta-hydroxysteroid dehydrogenase type 2 expression in endometriosis: failure to metabolize 17beta-estradiol. J Clin Endocrinol Metab: 1998; 83 12 4474 4480
6. Xue Q., Lin Z., Yin P., et al. Transcriptional activation of steroidogenic factor-1 by hypomethylation of the 5′ CpG island in endometriosis. J Clin Endocrinol Metab: 2007; 92 8 3261 3267
7. Xue Q., Lin Z., Cheng Y. H., et al. Promoter methylation regulates estrogen receptor 2 in human endometrium and endometriosis. Biol Reprod: 2007; 77 4 681 687
8. Monsivais D., Dyson M. T., Yin P., et al. ERβ- and prostaglandin E2-regulated pathways integrate cell proliferation via Ras-like and estrogen-regulated growth inhibitor in endometriosis. Mol Endocrinol: 2014; 28 8 1304 1315
9. Pavone M. E., Dyson M., Reirstad S., et al. Endometriosis expresses a molecular pattern consistent with decreased retinoid uptake, metabolism and action. Hum Reprod: 2011; 26 8 2157 2164
10. Pavone M. E., Reierstad S., Sun H., Milad M., Bulun S. E., Cheng Y. H. Altered retinoid uptake and action contributes to cell survival in endometriosis. J Clin Endocrinol Metab: 2010; 95 11 E300 E309
11. Cheng Y. H., Utsunomiya H., Pavone M. E., Yin P., Bulun S. E. Retinoic acid inhibits endometrial cancer cell growth via multiple genomic mechanisms. J Mol Endocrinol: 2011; 46 2 139 153
12. Ma J. J., Monsivais D., Dyson M. T., et al. Ligand-activated peroxisome proliferator-activated receptor β/δ modulates human endometrial cancer cell survival. Horm Cancer: 2013; 4 358 370
13. Mittal N., Malpani S., Dyson M., et al. Fenretinide: a novel treatment for endometrial cancer. PLoS ONE: 2014; 9 10 e110410
14. Cheng Y. H., Yin P., Xue Q., Yilmaz B., Dawson M. I., Bulun S. E. Retinoic acid (RA) regulates 17beta-hydroxysteroid dehydrogenase type 2 expression in endometrium: interaction of RA receptors with specificity protein (SP) 1/SP3 for estradiol metabolism. J Clin Endocrinol Metab: 2008; 93 5 1915 1923
15. Lin B. C., Suzawa M., Blind R. D., et al. Stimulating the GPR30 estrogen receptor with a novel tamoxifen analogue activates SF-1 and promotes endometrial cell proliferation. Cancer Res: 2009; 69 13 5415 5423
16. Xue Q., Zhou Y. F., Zhu S. N., Bulun S. E. Hypermethylation of the CpG island spanning from exon II to intron III is associated with steroidogenic factor 1 expression in stromal cells of endometriosis. Reprod Sci: 2011; 18 11 1080 1084
17. Xue Q., Xu Y., Yang H., et al. Methylation of a novel CpG island of intron 1 is associated with steroidogenic factor 1 expression in endometriotic stromal cells. Reprod Sci: 2014; 21 3 395 400
18. Dyson M. T., Roqueiro D., Monsivais D., et al. Genome-wide DNA methylation analysis predicts an epigenetic switch for GATA factor expression in endometriosis. PLoS Genet: 2014; 10 3 e1004158
19. Takayama K., Zeitoun K., Gunby R. T., Sasano H., Carr B. R., Bulun S. E. Treatment of severe postmenopausal endometriosis with an aromatase inhibitor. Fertil Steril: 1998; 69 4 709 713
20. Abushahin F., Goldman K. N., Barbieri E., Milad M., Rademaker A., Bulun S. E. Aromatase inhibition for refractory endometriosis-related chronic pelvic pain. Fertil Steril: 2011; 96 4 939 942
21. Dyson M. T., Bulun S. E. Cutting SRC-1 down to size in endometriosis. Nat Med: 2012; 18 7 1016 1018
22. Langoi D., Pavone M. E., Gurates B., Chai D., Fazleabas A., Bulun S. E. Aromatase inhibitor treatment limits progression of peritoneal endometriosis in baboons. Fertil Steril: 2013; 99 3 656 662.e3
23. Pavone M. E., Bulun S. E. Aromatase inhibitors for the treatment of endometriosis. Fertil Steril: 2012; 98 6 1370 1379
24. Bulun S. E., Cheng Y. H., Pavone M. E., et al. Estrogen receptor-beta, estrogen receptor-alpha, and progesterone resistance in endometriosis. Semin Reprod Med: 2010; 28 1 36 43
25. Bulun S. E., Monsavais D., Pavone M. E., et al. Role of estrogen receptor-β in endometriosis. Semin Reprod Med: 2012; 30 1 39 45
26. Attar E., Bulun S. E. Aromatase inhibitors: the next generation of therapeutics for endometriosis? Fertil Steril: 2006; 85 5 1307 1318