N-acetylcysteine overdose after acetaminophen poisoning

International Medical Case Reports Journal

Volumn 8, Issue , 2015, Pages 65-69

  Mahmoudi, Ghafar Ali ^a   Astaraki, Peyman ^a   Mohtashami, Azita Zafar ^a   Ahadi, Maryam ^a  

^a LORESTAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Acetaminophen poisoning; Medication error; N acetylcysteine; Overdose

Indexed keywords

ACETYLCYSTEINE; GLUCOSE 6 PHOSPHATE DEHYDROGENASE; PARACETAMOL;

ACETAMINOPHEN POISONING; ACUTE KIDNEY FAILURE; ADULT; AGITATION; ARTERIAL GAS; ARTICLE; CASE REPORT; CLINICAL EVALUATION; DEATH; DIZZINESS; DROWSINESS; DRUG INTOXICATION; DRUG OVERDOSE; DYSPNEA; EYE EDEMA; FACE EDEMA; FATIGUE; FEMALE; HEMOLYSIS; HUMAN; HYPOTENSION; LABORATORY TEST; LETHARGY; LIVER FUNCTION TEST; LOADING DRUG DOSE; MEDICATION ERROR; NAUSEA; PERIORBITAL EDEMA; SYMPTOMATOLOGY; TACHYPNEA; THROMBOCYTOPENIA; VOMITING; WEAKNESS;

EID: 84930624486     PISSN: None     EISSN: 1179142X     Source Type: Journal    
DOI: 10.2147/IMCRJ.S74563     Document Type: Article

References (34)

1. Whyte AJ, Kehrl T, Brooks DE, Katz KD, Sokolowski D. Safety and effectiveness of acetadote for acetaminophen toxicity. J Emerg Med. 2010;39:607–611.
2. Clemmesen JO, Ott P, Dalhoff KP, Astrup LB, Tage-Jensen U, Poulsen HE. [Recommendations for treatment of paracetamol poisoning. Danish Medical Society, Study of the Liver]. Ugeskr Laeger. 1996;158:6892–6895.
3. Schmidt LE, Dalhoff K. Risk factors in the development of adverse reactions to N-acetylcysteine in patients with paracetamol poisoning. Br J ClinPharmacol. 2001;51:87–91.
4. Mant TG, Tempowski JH, Volans GN, et al. Adverse reactions to acetylcysteine and effects of overdose. BMJ. 1984;289:217–219.
5. Kerr F, Dawson A, Whyte IM, et al. The Australasian Clinical Toxicology Investigators Collaboration randomized trial of different loading infusion rates of N-acetylcysteine. Ann Emerg Med. 2005;45: 402–408.
6. Atkuri KR, Mantovani JJ, Herzenberg LA, Herzenberg LA. N-Acetylcysteine, a safe antidote for cysteine/glutathione deficiency. Curr Opin Pharmacol. 2007;7:355–359.
7. Mullins ME, Vitkovitsky IV. Hemolysis and hemolytic uremic syndrome following five-fold N-acetylcysteine overdose. Clin Toxicol (Phila). 2011;49:755–759.
8. Haddad LM, Winchester JF. Clinical Management Poisoning and Drug Overdose. Philadelphia, PA, USA: WB Saunders; 1995.
9. Viccelio P, Bania T, Brent J, et al, editors. Emergency Toxicology. Chapter 3. Philadelphia, PA, USA: Lippincott-Raven; 1998.
10. Corcoran GB, Mitchell JR, Vaishnav YN, et al. Evidence that acetaminophen and N-hydroxyacetaminophen form a common arylating intermediate, N-acetyl-p-benzoquinoneimine. Mol Pharmacol. 1980;18:536–542.
11. Buckpitt AR, Rollins DE, Mitchell JR. Varying effects of sulfhydryl nucleophiles on acetaminophen oxidation and sulfhydryl adduct formation. Biochem Pharmacol. 1979;28:2941–2946.
12. Slattery JT, Wilson JM, Kalhorn TF, et al. Dose-dependent pharmacokinetics of acetaminophen: evidence of glutathione depletion in humans. Clin Pharmacol Ther. 1987;41:413–418.
13. Harrison PM, Keays R, Bray-GP, et al. Improved outcome of paracetamol induced hepatic failure by late administration of acetylcysteine. Lancet. 1995;335:1572–1573.
14. Smilkstein MJ, Knapp GL, Kulig KW, Rumack BH. Efficacy of oral N-acetyl cysteine in the treatment of acetaminophen overdose. N Engl J Med. 1988;319:1557–1562.
15. Prescott FF, Illingworth RN, Critchley JA, Stewart MJ, Adam RD. Intravenous treatment is the treatment of choice or paracetamol poisoning. BMJ. 1978;2:1097–1100.
16. Prescott L. Oral or intravenous N-acetylcysteine for acetaminophen poisoning? Ann Emerg Med. 2005;45:409–413.
17. Smilkstein MJ, Bronstein AC, Linden C. Acetaminophen overdose: a 48-hour intravenous N-acetylcysteine treatment protocol. Ann Emerg Med. 1991;20:1058–1063.
18. Bateman DN, Woodhouse KW, Rawlins MD. Adverse reactions to N-acetylcysteine. Hum Toxicol. 1984;3:393398.
19. Schmidt LE, Dalhoff KP. [Side-effects of N-acetylcysteine treatment in patients with paracetamol poisoning]. Ugeskr Laeger. 1999;161:2669–2672. Danish.
20. Dawson AH, Henry DA, McEwan J. Adverse reactions to N-acetylcysteine during treatment for paracetamol poisoning. Med J Aust. 1989;150:329–331.
21. Millea PJ. N-acetylcysteine: multiple clinical applications. Am Fam Physician. 2009;80:265–269.
22. Mazer M, Perrone J. Acetaminophen-induced nephrotoxicity: pathophysiology, clinical manifestations, and management. J Med Toxicol. 2008;4:2–6.
23. Blakely P, McDonald BR. Acute renal failure due to acetaminophen ingestion: a case report and review of the literature. J Am Soc Nephrol. 1995;6:48–53.
24. Kasap B, Türkmen M, Alaygut D, Soylu A, Kavukçu S. Acetaminophen-induced nephrotoxicity in an adolescent girl. Turk Pediatri Arsivi. 2011;46:343–345.
25. Sklar GE. Hemolysis as a potential complication of acetaminophen overdose in a patient with glucose-6-phosphate dehydrogenase deficiency. Pharmacotherapy. 2002;22:656–658.
26. Wright RO, Perry HE, Woolf AD, Shannon MW. Hemolysis after acetaminophen overdose in a patient with glucose-6-phosphate dehydrogenase deficiency. J Toxicol Clin Toxicol. 1996;34:731–734.
27. Heard K, Schaeffer TH. Massive acetylcysteine overdose associated with cerebral edema and seizures. Clin Toxicol. 2011;49:423–425.
28. Kante MZ. Comparisonof oral and iv acetylcysteine in the treatment of acetaminophen poisoning. Am J Health Syst Pharm. 2006;63: 1821–1827.
29. Brok J, Buckley N, Gluud C. Interventions for paracetamol (acetaminophen) overdose. Cochrane Database Syst Rev. 2006;2: CD003328.
30. James LP, Mayeux PR, Hinson JA. Acetaminophen-induced hepatotoxicity. Drug Metab Dispos. 2003;31:1499–1506.
31. Borgström L, Kågedal B, Paulsen O. Pharmacokinetics of N-acetylcysteine in man. Eur J Clin Pharmacol. 1986;31:217–222.
32. Bailey B, Blais R, Letarte A. Status epilepticus after a massive intravenous N-acetylcysteine overdose leading to intracranial hypertension and death. Ann Emerg Med. 2004;44:401–406.
33. Miller LF, Rumack BH. Clinical safety of high oral doses of acetylcysteine. Semin Oncol. 1983;10 Suppl 1:76–85.
34. Kerr F, Dawson A, Whyte IM, et al. The Australasian Clinical Toxicology Investigators Collaboration randomized trial of different loading infusion rates of N-acetylcysteine. Ann Emerg Med. 2005;45:402–408.