-
1
-
-
84920120003
-
Nonalcoholic fatty liver disease in children: recent practice guidelines, where do they take us?
-
COI: 1:CAS:528:DC%2BC2cXpt1Wmsb0%3D, PID: 25088269
-
Aggarwal A, Puri K, Thangada S, Zein N, Alkhouri N. Nonalcoholic fatty liver disease in children: recent practice guidelines, where do they take us? Curr Pediatr Rev. 2014;10(2):151–61.
-
(2014)
Curr Pediatr Rev
, vol.10
, Issue.2
, pp. 151-161
-
-
Aggarwal, A.1
Puri, K.2
Thangada, S.3
Zein, N.4
Alkhouri, N.5
-
2
-
-
33750002388
-
Prevalence of fatty liver in children and adolescents
-
PID: 17015527, This was a landmark study which determined the true prevalence of fatty liver disease in pediatric population for the first time. The authors used a cohort of 742 children aged 2–19 years and determined that fatty liver disease is the most common liver disease in children
-
Schwimmer JB, Deutsch R, Kahen T, Lavine JE, Stanley C, Behling C. Prevalence of fatty liver in children and adolescents. Pediatrics. 2006;118(4):1388–93. This was a landmark study which determined the true prevalence of fatty liver disease in pediatric population for the first time. The authors used a cohort of 742 children aged 2–19 years and determined that fatty liver disease is the most common liver disease in children.
-
(2006)
Pediatrics
, vol.118
, Issue.4
, pp. 1388-1393
-
-
Schwimmer, J.B.1
Deutsch, R.2
Kahen, T.3
Lavine, J.E.4
Stanley, C.5
Behling, C.6
-
3
-
-
36549070161
-
Prevalence of elevated alanine aminotransferase among US adolescents and associated factors: NHANES 1999-2004
-
COI: 1:CAS:528:DC%2BD1cXnt1Kqsw%3D%3D, PID: 18054554
-
Fraser A, Longnecker MP, Lawlor DA. Prevalence of elevated alanine aminotransferase among US adolescents and associated factors: NHANES 1999-2004. Gastroenterology. 2007;133(6):1814–20.
-
(2007)
Gastroenterology
, vol.133
, Issue.6
, pp. 1814-1820
-
-
Fraser, A.1
Longnecker, M.P.2
Lawlor, D.A.3
-
4
-
-
33751519769
-
Alanine aminotransferase levels and fatty liver in childhood obesity: associations with insulin resistance, adiponectin, and visceral fat
-
COI: 1:CAS:528:DC%2BD28Xht1Whur3M, PID: 16912127
-
Burgert TS, Taksali SE, Dziura J, et al. Alanine aminotransferase levels and fatty liver in childhood obesity: associations with insulin resistance, adiponectin, and visceral fat. J Clin Endocrinol Metab. 2006;91(11):4287–94.
-
(2006)
J Clin Endocrinol Metab
, vol.91
, Issue.11
, pp. 4287-4294
-
-
Burgert, T.S.1
Taksali, S.E.2
Dziura, J.3
-
5
-
-
59149094374
-
Treatment of non-alcoholic fatty liver disease with metformin versus lifestyle intervention in insulin-resistant adolescents
-
COI: 1:CAS:528:DC%2BD1MXjsVCnu7c%3D, PID: 18721166
-
Nadeau KJ, Ehlers LB, Zeitler PS, Love-Osborne K. Treatment of non-alcoholic fatty liver disease with metformin versus lifestyle intervention in insulin-resistant adolescents. Pediatr Diabetes. 2009;10(1):5–13.
-
(2009)
Pediatr Diabetes
, vol.10
, Issue.1
, pp. 5-13
-
-
Nadeau, K.J.1
Ehlers, L.B.2
Zeitler, P.S.3
Love-Osborne, K.4
-
6
-
-
0030904688
-
The relationship between fatty liver and hyperinsulinemia in obese Japanese children
-
COI: 1:CAS:528:DyaK2sXjt1artLc%3D, PID: 9138179
-
Kawasaki T, Hashimoto N, Kikuchi T, Takahashi H, Uchiyama M. The relationship between fatty liver and hyperinsulinemia in obese Japanese children. J Pediatr Gastroenterol Nutr. 1997;24(3):317–21.
-
(1997)
J Pediatr Gastroenterol Nutr
, vol.24
, Issue.3
, pp. 317-321
-
-
Kawasaki, T.1
Hashimoto, N.2
Kikuchi, T.3
Takahashi, H.4
Uchiyama, M.5
-
7
-
-
32044467721
-
Histologic spectrum of nonalcoholic fatty liver disease in morbidly obese adolescents
-
PID: 16469684
-
Xanthakos S, Miles L, Bucuvalas J, Daniels S, Garcia V, Inge T. Histologic spectrum of nonalcoholic fatty liver disease in morbidly obese adolescents. Clin Gastroenterol Hepatol. 2006;4(2):226–32.
-
(2006)
Clin Gastroenterol Hepatol
, vol.4
, Issue.2
, pp. 226-232
-
-
Xanthakos, S.1
Miles, L.2
Bucuvalas, J.3
Daniels, S.4
Garcia, V.5
Inge, T.6
-
8
-
-
34447262549
-
Predictors of non-alcoholic fatty liver disease in obese children
-
COI: 1:CAS:528:DC%2BD2sXnt1WlsLg%3D, PID: 17151586
-
Sartorio A, Del Col A, Agosti F, et al. Predictors of non-alcoholic fatty liver disease in obese children. Eur J Clin Nutr. 2007;61(7):877–83.
-
(2007)
Eur J Clin Nutr
, vol.61
, Issue.7
, pp. 877-883
-
-
Sartorio, A.1
Del Col, A.2
Agosti, F.3
-
9
-
-
70350241227
-
The natural history of non-alcoholic fatty liver disease in children: a follow-up study for up to 20 years
-
COI: 1:STN:280:DC%2BD1MnptlCrtg%3D%3D, PID: 19625277, A landmark study in which authors followed their study cohort for up till as long as 20 years and determined that NAFLD can eventually lead to hepatic fibrosis and cirrhosis which was previously unknown
-
Feldstein AE, Charatcharoenwitthaya P, Treeprasertsuk S, Benson JT, Enders FB, Angulo P. The natural history of non-alcoholic fatty liver disease in children: a follow-up study for up to 20 years. Gut. 2009;58(11):1538–44. A landmark study in which authors followed their study cohort for up till as long as 20 years and determined that NAFLD can eventually lead to hepatic fibrosis and cirrhosis which was previously unknown.
-
(2009)
Gut
, vol.58
, Issue.11
, pp. 1538-1544
-
-
Feldstein, A.E.1
Charatcharoenwitthaya, P.2
Treeprasertsuk, S.3
Benson, J.T.4
Enders, F.B.5
Angulo, P.6
-
10
-
-
70350077457
-
Nonalcoholic steatohepatitis in children: a multicenter clinicopathological study
-
PID: 19637190
-
Carter-Kent C, Yerian LM, Brunt EM, et al. Nonalcoholic steatohepatitis in children: a multicenter clinicopathological study. Hepatology. 2009;50(4):1113–20.
-
(2009)
Hepatology
, vol.50
, Issue.4
, pp. 1113-1120
-
-
Carter-Kent, C.1
Yerian, L.M.2
Brunt, E.M.3
-
11
-
-
24144444669
-
Histopathology of pediatric nonalcoholic fatty liver disease
-
PID: 16116629, The authors determined that type 1 and type 2 NASH are distinct subtypes of pediatric NAFLD, making them very different entities from adult fatty liver disease
-
Schwimmer JB, Behling C, Newbury R, et al. Histopathology of pediatric nonalcoholic fatty liver disease. Hepatology. 2005;42(3):641–9. The authors determined that type 1 and type 2 NASH are distinct subtypes of pediatric NAFLD, making them very different entities from adult fatty liver disease.
-
(2005)
Hepatology
, vol.42
, Issue.3
, pp. 641-649
-
-
Schwimmer, J.B.1
Behling, C.2
Newbury, R.3
-
12
-
-
75449102165
-
Long-term mortality in nonalcoholic fatty liver disease: is liver histology of any prognostic significance?
-
PID: 20101746
-
Angulo P. Long-term mortality in nonalcoholic fatty liver disease: is liver histology of any prognostic significance? Hepatology. 2010;51(2):373–5.
-
(2010)
Hepatology
, vol.51
, Issue.2
, pp. 373-375
-
-
Angulo, P.1
-
13
-
-
0036735880
-
Obese children with steatohepatitis can develop cirrhosis in childhood
-
PID: 12358273
-
Molleston JP, White F, Teckman J, Fitzgerald JF. Obese children with steatohepatitis can develop cirrhosis in childhood. Am J Gastroenterol. 2002;97(9):2460–2.
-
(2002)
Am J Gastroenterol
, vol.97
, Issue.9
, pp. 2460-2462
-
-
Molleston, J.P.1
White, F.2
Teckman, J.3
Fitzgerald, J.F.4
-
14
-
-
84868008620
-
Noninvasive diagnosis of NASH and liver fibrosis within the spectrum of NAFLD
-
Alkhouri N, McCullough AJ. Noninvasive diagnosis of NASH and liver fibrosis within the spectrum of NAFLD. Gastroenterol Hepatol (N Y). 2012;8(10):661–8.
-
(2012)
Gastroenterol Hepatol (N Y)
, vol.8
, Issue.10
, pp. 661-668
-
-
Alkhouri, N.1
McCullough, A.J.2
-
15
-
-
84930674632
-
-
Dig Dis Sci, One of the most recent study published looking at some non-invasive markers of liver fibrosis used in adults and assessing their utilization in pediatrics population with NAFLD
-
Mansoor S, Yerian L, Kohli R et al. The evaluation of hepatic fibrosis scores in children with nonalcoholic fatty liver disease. Dig Dis Sci. 2014. One of the most recent study published looking at some non-invasive markers of liver fibrosis used in adults and assessing their utilization in pediatrics population with NAFLD.
-
(2014)
The evaluation of hepatic fibrosis scores in children with nonalcoholic fatty liver disease
-
-
Mansoor, S.1
Yerian, L.2
Kohli, R.3
-
16
-
-
84859324858
-
Noninvasive parameters and hepatic fibrosis scores in children with nonalcoholic fatty liver disease
-
COI: 1:CAS:528:DC%2BC38Xls1GisLg%3D, PID: 22509085
-
Yang HR, Kim HR, Kim MJ, Ko JS, Seo JK. Noninvasive parameters and hepatic fibrosis scores in children with nonalcoholic fatty liver disease. World J Gastroenterol. 2012;18(13):1525–30.
-
(2012)
World J Gastroenterol
, vol.18
, Issue.13
, pp. 1525-1530
-
-
Yang, H.R.1
Kim, H.R.2
Kim, M.J.3
Ko, J.S.4
Seo, J.K.5
-
17
-
-
66149168706
-
-
Nobili V, Alisi A, Vania A, Tiribelli C, Pietrobattista A, Bedogni G. The pediatric NAFLD fibrosis index: a predictor of liver fibrosis in children with non-alcoholic fatty liver disease. BMC Med 2009;7:21-7015-7-21. The authors of this study proposed PNFI (pediatric NAFLD fibrosis index), which is the first non-invasive marker of hepatic fibrosis to be designed exclusively for pediatric population
-
Nobili V, Alisi A, Vania A, Tiribelli C, Pietrobattista A, Bedogni G. The pediatric NAFLD fibrosis index: a predictor of liver fibrosis in children with non-alcoholic fatty liver disease. BMC Med 2009;7:21-7015-7-21. The authors of this study proposed PNFI (pediatric NAFLD fibrosis index), which is the first non-invasive marker of hepatic fibrosis to be designed exclusively for pediatric population.
-
-
-
-
18
-
-
84905976072
-
The development of the pediatric NAFLD fibrosis score (PNFS) to predict the presence of advanced fibrosis in children with nonalcoholic fatty liver disease
-
PID: 25121514
-
Alkhouri N, Mansoor S, Giammaria P, Liccardo D, Lopez R, Nobili V. The development of the pediatric NAFLD fibrosis score (PNFS) to predict the presence of advanced fibrosis in children with nonalcoholic fatty liver disease. PLoS One. 2014;9(8), e104558.
-
(2014)
PLoS One
, vol.9
, Issue.8
-
-
Alkhouri, N.1
Mansoor, S.2
Giammaria, P.3
Liccardo, D.4
Lopez, R.5
Nobili, V.6
-
19
-
-
84883740164
-
Serum cytokeratin-18 fragment levels are useful biomarkers for nonalcoholic steatohepatitis in children
-
COI: 1:CAS:528:DC%2BC3sXhsVSks7bK, PID: 23752877
-
Feldstein AE, Alkhouri N, De Vito R, Alisi A, Lopez R, Nobili V. Serum cytokeratin-18 fragment levels are useful biomarkers for nonalcoholic steatohepatitis in children. Am J Gastroenterol. 2013;108(9):1526–31.
-
(2013)
Am J Gastroenterol
, vol.108
, Issue.9
, pp. 1526-1531
-
-
Feldstein, A.E.1
Alkhouri, N.2
De Vito, R.3
Alisi, A.4
Lopez, R.5
Nobili, V.6
-
20
-
-
84860449503
-
Cytokeratin-18 and hyaluronic acid levels predict liver fibrosis in children with non-alcoholic fatty liver disease
-
COI: 1:CAS:528:DC%2BC38Xitl2jtbk%3D, PID: 22140659
-
Lebensztejn DM, Wierzbicka A, Socha P, et al. Cytokeratin-18 and hyaluronic acid levels predict liver fibrosis in children with non-alcoholic fatty liver disease. Acta Biochim Pol. 2011;58(4):563–6.
-
(2011)
Acta Biochim Pol
, vol.58
, Issue.4
, pp. 563-566
-
-
Lebensztejn, D.M.1
Wierzbicka, A.2
Socha, P.3
-
21
-
-
77957309026
-
Hyaluronic acid predicts hepatic fibrosis in children with nonalcoholic fatty liver disease
-
COI: 1:CAS:528:DC%2BC3cXht1Srur7I, PID: 20875899
-
Nobili V, Alisi A, Torre G, et al. Hyaluronic acid predicts hepatic fibrosis in children with nonalcoholic fatty liver disease. Transl Res. 2010;156(4):229–34.
-
(2010)
Transl Res
, vol.156
, Issue.4
, pp. 229-234
-
-
Nobili, V.1
Alisi, A.2
Torre, G.3
-
22
-
-
39549118158
-
Noninvasive markers of fibrosis in nonalcoholic fatty liver disease: validating the European liver fibrosis panel and exploring simple markers
-
PID: 18038452
-
Guha IN, Parkes J, Roderick P, et al. Noninvasive markers of fibrosis in nonalcoholic fatty liver disease: validating the European liver fibrosis panel and exploring simple markers. Hepatology. 2008;47(2):455–60.
-
(2008)
Hepatology
, vol.47
, Issue.2
, pp. 455-460
-
-
Guha, I.N.1
Parkes, J.2
Roderick, P.3
-
23
-
-
9644279531
-
Serum markers detect the presence of liver fibrosis: a cohort study
-
PID: 15578508
-
Rosenberg WM, Voelker M, Thiel R, et al. Serum markers detect the presence of liver fibrosis: a cohort study. Gastroenterology. 2004;127(6):1704–13.
-
(2004)
Gastroenterology
, vol.127
, Issue.6
, pp. 1704-1713
-
-
Rosenberg, W.M.1
Voelker, M.2
Thiel, R.3
-
24
-
-
59849117801
-
Performance of ELF serum markers in predicting fibrosis stage in pediatric non-alcoholic fatty liver disease
-
COI: 1:CAS:528:DC%2BD1MXht1CqsrY%3D, PID: 18992746, The authors designed this study to validate the use of ELF as a diagnostic marker of liver fibrosis in children and adolescent. Before this study, several studies in adults had shown ELF to be an accurate indicator of liver fibrosis. The group’s findings were promising and called for more pediatric studies for external validation of their results
-
Nobili V, Parkes J, Bottazzo G, et al. Performance of ELF serum markers in predicting fibrosis stage in pediatric non-alcoholic fatty liver disease. Gastroenterology. 2009;136(1):160–7. The authors designed this study to validate the use of ELF as a diagnostic marker of liver fibrosis in children and adolescent. Before this study, several studies in adults had shown ELF to be an accurate indicator of liver fibrosis. The group’s findings were promising and called for more pediatric studies for external validation of their results.
-
(2009)
Gastroenterology
, vol.136
, Issue.1
, pp. 160-167
-
-
Nobili, V.1
Parkes, J.2
Bottazzo, G.3
-
25
-
-
84868023884
-
FibroScan (transient elastography) for the measurement of liver fibrosis
-
Afdhal NH. FibroScan (transient elastography) for the measurement of liver fibrosis. Gastroenterol Hepatol (N Y). 2012;8(9):605–7.
-
(2012)
Gastroenterol Hepatol (N Y)
, vol.8
, Issue.9
, pp. 605-607
-
-
Afdhal, N.H.1
-
26
-
-
37349120716
-
Liver stiffness measurement in children using FibroScan: feasibility study and comparison with fibrotest, aspartate transaminase to platelets ratio index, and liver biopsy
-
PID: 18030211
-
de Ledinghen V, Le Bail B, Rebouissoux L, et al. Liver stiffness measurement in children using FibroScan: feasibility study and comparison with fibrotest, aspartate transaminase to platelets ratio index, and liver biopsy. J Pediatr Gastroenterol Nutr. 2007;45(4):443–50.
-
(2007)
J Pediatr Gastroenterol Nutr
, vol.45
, Issue.4
, pp. 443-450
-
-
de Ledinghen, V.1
Le Bail, B.2
Rebouissoux, L.3
-
27
-
-
49649105500
-
Accuracy and reproducibility of transient elastography for the diagnosis of fibrosis in pediatric nonalcoholic steatohepatitis
-
COI: 1:CAS:528:DC%2BD1cXhtVCqt7rN, PID: 18563842
-
Nobili V, Vizzutti F, Arena U, et al. Accuracy and reproducibility of transient elastography for the diagnosis of fibrosis in pediatric nonalcoholic steatohepatitis. Hepatology. 2008;48(2):442–8.
-
(2008)
Hepatology
, vol.48
, Issue.2
, pp. 442-448
-
-
Nobili, V.1
Vizzutti, F.2
Arena, U.3
-
28
-
-
84890829992
-
Use of magnetic resonance elastography to assess hepatic fibrosis in children with chronic liver disease
-
PID: 24064151
-
Xanthakos SA, Podberesky DJ, Serai SD, et al. Use of magnetic resonance elastography to assess hepatic fibrosis in children with chronic liver disease. J Pediatr. 2014;164(1):186–8.
-
(2014)
J Pediatr
, vol.164
, Issue.1
, pp. 186-188
-
-
Xanthakos, S.A.1
Podberesky, D.J.2
Serai, S.D.3
-
29
-
-
34748861747
-
Assessment of hepatic fibrosis with magnetic resonance elastography
-
PID: 17916548, e2
-
Yin M, Talwalkar JA, Glaser KJ, et al. Assessment of hepatic fibrosis with magnetic resonance elastography. Clin Gastroenterol Hepatol. 2007;5(10):1207–13. e2.
-
(2007)
Clin Gastroenterol Hepatol
, vol.5
, Issue.10
, pp. 1207-1213
-
-
Yin, M.1
Talwalkar, J.A.2
Glaser, K.J.3
-
30
-
-
46049100990
-
Magnetic resonance elastography for the noninvasive staging of liver fibrosis
-
PID: 18471441
-
Huwart L, Sempoux C, Vicaut E, et al. Magnetic resonance elastography for the noninvasive staging of liver fibrosis. Gastroenterology. 2008;135(1):32–40.
-
(2008)
Gastroenterology
, vol.135
, Issue.1
, pp. 32-40
-
-
Huwart, L.1
Sempoux, C.2
Vicaut, E.3
-
31
-
-
84876681427
-
Acoustic radiation force impulse imaging-normal values of liver stiffness in healthy children
-
PID: 23247632
-
Hanquinet S, Courvoisier D, Kanavaki A, Dhouib A, Anooshiravani M. Acoustic radiation force impulse imaging-normal values of liver stiffness in healthy children. Pediatr Radiol. 2013;43(5):539–44.
-
(2013)
Pediatr Radiol
, vol.43
, Issue.5
, pp. 539-544
-
-
Hanquinet, S.1
Courvoisier, D.2
Kanavaki, A.3
Dhouib, A.4
Anooshiravani, M.5
-
32
-
-
84862315284
-
Acoustic radiation force impulse-imaging in the assessment of liver fibrosis in children
-
PID: 22002843
-
Noruegas MJ, Matos H, Goncalves I, Cipriano MA, Sanches C. Acoustic radiation force impulse-imaging in the assessment of liver fibrosis in children. Pediatr Radiol. 2012;42(2):201–4.
-
(2012)
Pediatr Radiol
, vol.42
, Issue.2
, pp. 201-204
-
-
Noruegas, M.J.1
Matos, H.2
Goncalves, I.3
Cipriano, M.A.4
Sanches, C.5
-
33
-
-
84870843520
-
Combined paediatric NAFLD fibrosis index and transient elastography to predict clinically significant fibrosis in children with fatty liver disease
-
PID: 23146095
-
Alkhouri N, Sedki E, Alisi A, et al. Combined paediatric NAFLD fibrosis index and transient elastography to predict clinically significant fibrosis in children with fatty liver disease. Liver Int. 2013;33(1):79–85.
-
(2013)
Liver Int
, vol.33
, Issue.1
, pp. 79-85
-
-
Alkhouri, N.1
Sedki, E.2
Alisi, A.3
-
34
-
-
78751705424
-
A combination of the pediatric NAFLD fibrosis index and enhanced liver fibrosis test identifies children with fibrosis
-
PID: 20888433, This study was one of the first studies to assess the combined accuracy of two markers of liver fibrosis in a pediatric cohort, which in their case were PNFI and ELF. Their findings suggested that combination of PNFI and ELF gave the highest accuracy of liver fibrosis on liver biopsy. They also provided a simple clinical algorithm that can be used by clinicians to select patients for biopsy
-
Alkhouri N, Carter-Kent C, Lopez R, et al. A combination of the pediatric NAFLD fibrosis index and enhanced liver fibrosis test identifies children with fibrosis. Clin Gastroenterol Hepatol. 2011;9(2):150–5. This study was one of the first studies to assess the combined accuracy of two markers of liver fibrosis in a pediatric cohort, which in their case were PNFI and ELF. Their findings suggested that combination of PNFI and ELF gave the highest accuracy of liver fibrosis on liver biopsy. They also provided a simple clinical algorithm that can be used by clinicians to select patients for biopsy.
-
(2011)
Clin Gastroenterol Hepatol
, vol.9
, Issue.2
, pp. 150-155
-
-
Alkhouri, N.1
Carter-Kent, C.2
Lopez, R.3
-
35
-
-
84896710127
-
Comparison of acoustic radiation force impulse/serum noninvasive markers for fibrosis prediction in liver transplant
-
COI: 1:CAS:528:DC%2BC2cXjtV2qtbY%3D, PID: 24164902
-
Pinto J, Matos H, Nobre S, et al. Comparison of acoustic radiation force impulse/serum noninvasive markers for fibrosis prediction in liver transplant. J Pediatr Gastroenterol Nutr. 2014;58(3):382–6.
-
(2014)
J Pediatr Gastroenterol Nutr
, vol.58
, Issue.3
, pp. 382-386
-
-
Pinto, J.1
Matos, H.2
Nobre, S.3
-
36
-
-
84901619027
-
Shear wave elastography in the evaluation of liver fibrosis in children
-
COI: 1:CAS:528:DC%2BC2cXovVWgsb0%3D, PID: 24552673
-
Tutar O, Beser OF, Adaletli I, et al. Shear wave elastography in the evaluation of liver fibrosis in children. J Pediatr Gastroenterol Nutr. 2014;58(6):750–5.
-
(2014)
J Pediatr Gastroenterol Nutr
, vol.58
, Issue.6
, pp. 750-755
-
-
Tutar, O.1
Beser, O.F.2
Adaletli, I.3
|